scholarly journals Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

2020 ◽  
Author(s):  
hanyue xu ◽  
Ling Qin ◽  
Yifan Zhang ◽  
Yinan Xiao ◽  
Ming Zhang
Keyword(s):  
Functional Outcomes ◽  
Meta Analysis ◽  
Epiretinal Membranes ◽  
Random Effects Models ◽  
Corrected Visual Acuity ◽  
Significant Difference ◽  
Surgery Outcomes ◽  
The Stability ◽  
Lamellar Hole

Abstract Purpose: Given the two different kind of epiretinal membranes, this study aimed to compare both the structural and functional outcomes of lamellar macular hole (LMH) with and without lamellar hole-associated epiretinal proliferation (LHEP) after surgery. Method: Publications up to July 2020 that compared the surgical outcomes of LMH patients with and without LHEP were included. Forest plots were created by using a weighted summary of proportion meta-analysis. Fixed or random effects models were used based on I2 heterogeneity estimates. Meanwhile, to evaluate the stability of the meta-analysis, sensitivity analysis was carried out.Result: Eight pertinent publications were included, which contained a total of 176 eyes without LHEP and 173 eyes with LHEP. They were all retrospective studies and had a follow-up of at least 6 months. In all studies, the preoperative best corrected visual acuity (BCVA) had no significant differences between the two groups and improved in both groups after surgery. Pooled results of the improved BCVA was 0.18 (95 % CI, 0.10 to 0.26; P< 0.01) between the with and without LHEP groups. The odds ratio of restored ellipsoid zone (REZ) was 0.80 (95% CI, 0.26 to 2.44; p = 0.69) among the group with LHEP and without LHEP.In conclusion, patients without LHEP had better postoperative BCVA than patients with LHEP. No significant difference was found in REZ among the two groups.

scholarly journals Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

2020 ◽  
Author(s):  
hanyue xu ◽  
Ling Qin ◽  
Yifan Zhang ◽  
Ming Zhang
Keyword(s):  
Functional Outcomes ◽  
Retrospective Studies ◽  
Meta Analysis ◽  
Lamellar Macular Hole ◽  
Corrected Visual Acuity ◽  
Significant Difference ◽  
Surgery Outcomes ◽  
The Stability ◽  
Lamellar Hole

Abstract Purpose: This study aimed at comparing both the structural and functional outcomes of lamellar macular hole (LMH) with and without lamellar hole-associated epiretinal proliferation (LHEP) after surgery. Method: Publications up to July 2020 that compared the surgical outcomes of LMH patients with and without LHEP were included. Forest plots were created using a weighted summary of proportion meta-analysis. Fixed or random effects modes were used based on I2 heterogeneity estimates. To evaluate the stability of the meta-analysis, sensitivity analysis was carried out. Result: Eight pertinent publications containing a total of 176 eyes without LHEP and 173 eyes with LHEP were included. They were all retrospective studies and had a mean follow-up of at least 6 months. In all studies, the preoperative best corrected visual acuity (BCVA) had no significant differences between the two groups and BCVA improved in both groups after surgery. Pooled results of the improved BCVA was 0.18 (95 % CI, 0.10 to 0.26; P< 0.01) between with and without LHEP groups. However, the odd ratio of restored ellipsoid zone was 0.80 (95% CI, 0.26 to 2.44; p = 0.69) among the group with LHEP and the group without LHEP. In conclusion, patients without LHEP had better postoperative BCVA than patients with LHEP. No significant difference was found in REZ among the two groups. The necessity of surgery for patients with LHEP needs more studies to identify.

scholarly journals Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

2020 ◽  
Author(s):  
hanyue xu ◽  
Ling Qin ◽  
Yifan Zhang ◽  
Ming Zhang
Keyword(s):  
Retrospective Studies ◽  
Meta Analysis ◽  
Lamellar Macular Hole ◽  
Pooled Data ◽  
Corrected Visual Acuity ◽  
Significant Difference ◽  
Surgery Outcomes ◽  
The Stability ◽  
Lamellar Hole

Abstract Background: To compare the visual outcomes and rate of restored ellipsoid zone (REZ) after surgery of lamellar macular hole (LMH) with and without lamellar hole-associated epiretinal proliferation (LHEP). Method: Publications up to November 2019 that compared the outcomes of LMH patients with and without LHEP who were managed by surgery were included. Forest plots were created using a weighted summary of proportion meta-analysis. A random effects mode was used and I2 heterogeneity estimates were calculated. Sensitivity analysis was carried out to evaluate the stability of the meta-analysis. Result: Eight pertinent publications studying a total of 176 eyes without LHEP and 173 eyes with LHEP were identified. They were all retrospective studies and had a mean follow-up of at least 6 months. In all studies, the best corrected visual acuity (BCVA) had no significant differences before surgery and improved in both groups, and in two studies the post-operative BCVA had no significant differences between two groups. The rate of REZ were different among studies included. Meta-analytic pooling of the improved BCVA between with and without LHEP groups was 0.18 (95 % CI, 0.10 to 0.26; P< 0.01), and the pooled data revealed an odd ratio of 0.80 (95% CI, 0.26 to 2.44; p = 0.69) in the rate of REZ, comparing the group without LHEP and the group with LHEP. In conclusion, patients without LHEP had better postoperative BCVA than patients with LHEP. No significant difference was found in REZ among the two groups.

scholarly journals Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

2020 ◽  
Author(s):  
hanyue xu ◽  
Ling Qin ◽  
Yifan Zhang ◽  
Yinan Xiao ◽  
Ming Zhang
Keyword(s):  
Visual Acuity ◽  
Meta Analysis ◽  
Epiretinal Membranes ◽  
Random Effects Models ◽  
Ellipsoid Zone ◽  
Corrected Visual Acuity ◽  
Significant Difference ◽  
The Stability ◽  
Best Corrected Visual Acuity ◽  
Lamellar Hole

Abstract Background: Given the two different kinds of epiretinal membranes, this study aimed to compare both the structural and functional outcomes of lamellar macular holes with and without lamellar hole-associated epiretinal proliferation (LHEP) after surgery.Method: Publications up to July 2020 that compared the surgical outcomes of lamellar macular hole with and without LHEP were included. Forest plots were created by using a weighted summary of proportion meta-analysis. Fixed or random effects models were used on the basis of I2 heterogeneity estimates. Meanwhile, to evaluate the stability of the meta-analysis, a sensitivity analysis was carried out.Results: Eight pertinent publications that contained a total of 176 eyes without LHEP and 173 eyes with LHEP were included. They were all retrospective studies and had a follow-up of at least 6 months. In all studies, the preoperative best corrected visual acuity showed no significant differences between the two groups, and the visual acuity improved in both groups after surgery. The pooled result for the improved best corrected visual acuity was 0.18 (95% confidence interval (CI), 0.10 to 0.26; P< 0.01) between the with and without LHEP groups. The restored ellipsoid zone odds ratio was 0.80 (95% CI, 0.26 to 2.44; P= 0.69) for the group with LHEP compared to the group without LHEP.Conclusion: Patients without LHEP had better postoperative visual acuity than patients with LHEP. No significant difference in restored ellipsoid zone was found between the two groups.

scholarly journals Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

2020 ◽  
Author(s):  
hanyue xu ◽  
Ling Qin ◽  
Yifan Zhang ◽  
Ming Zhang
Keyword(s):  
Retrospective Studies ◽  
Meta Analysis ◽  
Ellipsoid Zone ◽  
Pooled Data ◽  
Corrected Visual Acuity ◽  
Significant Difference ◽  
Surgery Outcomes ◽  
The Stability ◽  
Lamellar Hole

Abstract Background: To compare the visual outcomes and rate of restored ellipsoid zone (REZ) after surgery of lamellar macular hole (LMH) with and without lamellar hole-associated epiretinal proliferation (LHEP). Method: Publications up to November 2019 that compared the outcomes of LMH patients with and without LHEP who were managed by surgery were included. Forest plots were created using a weighted summary of proportion meta-analysis. A random effects mode was used and I2 heterogeneity estimates were calculated. Sensitivity analysis was carried out to evaluate the stability of the meta-analysis.Result:Four pertinent publications studying a total of 157 patients with 99 eyes without LHEP and 58 eyes with LHEP were identified. They were all retrospective studies and had a mean follow-up of at least 6 months. In all studies, the best corrected visual acuity (BCVA) had no significant differences before surgery and improved in both groups, and in two studies the post-operative BCVA had no significant differences between two groups. The rate of restored ellipsoid zone (REZ) was different among studies included. Meta-analytic pooling of the improved BCVA between with and without LHEP groups was 0.15 (95 % CI, 0.02 to 0.27; P=0.02), and the pooled data revealed an odd ratio of 2.67 (95% CI, 0.50 to 14.25; p = 0.25) in the rate of REZ, comparing the group without LHEP and the group with LHEP.Conclusion: Patients without LHEP had better postoperative BCVA than patients with LHEP, while no significant difference was found in REZ among the two groups.

scholarly journals Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

2019 ◽  
Author(s):  
hanyue xu ◽  
Ling Qin ◽  
Yifan Zhang ◽  
Ming Zhang
Keyword(s):  
Visual Acuity ◽  
Retrospective Studies ◽  
Meta Analysis ◽  
Ellipsoid Zone ◽  
Pooled Data ◽  
Corrected Visual Acuity ◽  
Surgery Outcomes ◽  
The Stability ◽  
Lamellar Hole

Abstract Purpose: To compare the visual outcomesand rate of restored ellipsoid zone (REZ) after surgery of lamellar macular hole (LMH) with and without lamellar hole-associated epiretinal proliferation (LHEP). To determine whether all patients with LMH need surgery.Method: Publications up to November 2019 that compared the outcomes of LMH patients with and without LHEP who were managed by surgery were included. Forest plots were created using a weighted summary of proportion meta-analysis. A random effects mode was used and I2 heterogeneity estimates were calculated. Sensitivity analysis was carried out to evaluate the stability of the meta-analysis.Result: Four pertinent publications studying a total of 157 patients were identified. They were all retrospective studies and had a mean follow-up of at least 6 months. In all studies, the best corrected visual acuity (BCVA) had no significant differences before surgery and improved in both groups. The rate of REZ were different among studies included. Meta-analytic pooling of the improved BCVA between with and without LHEP groups was 0.15 (95 % CI, 0.02 to 0.27; p=0.02), and the pooled data revealed an odd ratio of 5.79 (95% CI, 1.15 to 29.18; p = 0.03) in the rate of restored ellipsoid zone, comparing the group without LHEP and the group with LHEP.Conclusion: Patients with LHEP were more likely to gain restored ellipsoid zone after surgery but had lower postoperative BCVA. The surgery of LMH with LHEP appeared to be useless for improving visual acuity.

scholarly journals Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

2019 ◽  
Author(s):  
hanyue xu ◽  
Ling Qin ◽  
Yifan Zhang ◽  
Ming Zhang
Keyword(s):  
Visual Acuity ◽  
Retrospective Studies ◽  
Meta Analysis ◽  
Ellipsoid Zone ◽  
Pooled Data ◽  
Corrected Visual Acuity ◽  
Surgery Outcomes ◽  
The Stability ◽  
Lamellar Hole

Abstract Background: To compare the visual outcomesand rate of restored ellipsoid zone (REZ) after surgery of lamellar macular hole (LMH) with and without lamellar hole-associated epiretinal proliferation (LHEP). To determine whether all patients with LMH need surgery. Method: Publications up to November 2019 that compared the outcomes of LMH patients with and without LHEP who were managed by surgery were included. Forest plots were created using a weighted summary of proportion meta-analysis. A random effects mode was used and I2 heterogeneity estimates were calculated. Sensitivity analysis was carried out to evaluate the stability of the meta-analysis. Result: Four pertinent publications studying a total of 157 patients were identified. They were all retrospective studies and had a mean follow-up of at least 6 months. In all studies, the best corrected visual acuity (BCVA) had no significant differences before surgery and improved in both groups, and in two studies the post-operative BCVA had no significant differences between two groups. The rate of REZ were different among studies included. Meta-analytic pooling of the improved BCVA between with and without LHEP groups was 0.15 (95 % CI, 0.02 to 0.27; p=0.02), and the pooled data revealed an odd ratio of 5.79 (95% CI, 1.15 to 29.18; p = 0.03) in the rate of restored ellipsoid zone, comparing the group without LHEP and the group with LHEP. Patients with LHEP were more likely to gain restored ellipsoid zone after surgery but had lower postoperative BCVA. The surgery of LMH with LHEP appeared to be useless for improving visual acuity.

scholarly journals Keratorefractive Surgery Outcomes in Keratoconus Suspect Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Milad Abdolahian ◽  
Mohammad Ali Moalem ◽  
Mohammadreza Jahady Hoseiny ◽  
Farsad Noorizadeh ◽  
Athar Zareei
Keyword(s):  
Corneal Thickness ◽  
Mean Values ◽  
Corrected Visual Acuity ◽  
Surgical Methods ◽  
Significant Difference ◽  
The Mean ◽  
Keratorefractive Surgery ◽  
Surgery Outcomes ◽  
Orbscan Ii

Purpose. To examine the outcomes of keratorefractive surgeries in keratoconus suspect patients. Methods. This study included 192 keratoconus suspects (351 eyes), treated with photorefractive keratectomy (PRK) (211 eyes), Lasik (96 eyes), and Femto-Lasik (44 eyes) surgeries in an eye clinic. The best spectacle-corrected visual acuity (BSCVA) and subjective refraction were evaluated preoperatively and postoperatively (three months and five years after the procedure). The Orbscan II topography system was also used preoperatively and five years after the procedure. Results. The patients’ mean age was 31.6 ± 5.49 years (range: 21–47 years) in the last follow-up. There was no significant difference between the preoperative and postoperative mean values of BSCVA in any of the surgical methods ( P  = 0.49). The mean spherical equivalent, cylindrical power, corneal curvature, the thinnest corneal thickness, and the central corneal thickness decreased significantly in the last follow-up ( P  < 0.001). Four patients (3.50%) in the PRK group and one patient (1.85%) in the Lasik group needed glasses in the last follow-up. Eleven cases of corneal ectasia were detected in the last follow-up (six eyes of four patients [2.84%] and five eyes of four patients [5.20%] in the PRK and Lasik groups, respectively). Conclusion. In the present study, the high risk of postoperative ectasia was detected in keratoconus suspects following PRK and Lasik surgeries. According to the results, it can be concluded that Femto-Lasik surgery provides better outcomes than Lasik and PRK. Overall, the surgical criteria are suggested to be evaluated case by case, and the patients must be followed up over time to assess the corneal topography and refraction stability.

Does Kinematic Alignment Improve Short-Term Functional Outcomes after Total Knee Arthroplasty Compared with Mechanical Alignment? A Systematic Review and Meta-analysis

2017 ◽  
Vol 31 (01) ◽  
pp. 078-086 ◽  
Author(s):  
Yanhong Li ◽  
Yuliang Wang ◽  
Mingxuan Yang ◽  
Shuanke Wang
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Functional Outcomes ◽  
Mechanical Axis ◽  
Meta Analysis ◽  
Mechanical Alignment ◽  
Short Term ◽  
Significant Difference ◽  
Total Knee

AbstractThis meta-analysis was conducted to study whether kinematically aligned total knee arthroplasty (TKA) improves short-term functional outcomes compared with mechanical alignment without changing the hip–knee–ankle angle. Prospective cohort studies were searched from electronic literature databases, including PubMed, Web of Science, Embase (Ovid interface), and Cochrane Library (Ovid interface). Total 1,159 records were identified. Six trials involving 561 patients were eligible for data extraction and meta-analysis. The included studies recorded outcomes in the follow-up range from 6 to 34 months. Primary outcomes were to assess the functional outcomes in follow-up, and KA group achieved better performance on WOMAC score (mean difference [MD] = −18.82, 95% CI: −16.06 to −5.58), knee function score (MD = 7.23, 95% CI: 0.52–13.94), Oxford knee score (MD = 4.76, 95% CI: 0.40–9.12), and knee range of flexion (MD = 4.48, 95% CI: 2.09–6.86), whereas other parameters including Knee Society score, knee range of extension, VAS pain score, and the occurrence of the complications were without significant difference (p > 0.05). Second outcomes evaluated the perioperative clinic indexes. Our meta-analysis showed that KA group had a shorter time of operation (MD = −15.44, 95% CI: −27.47 to −3.71) and a longer walk distance before discharge (MD = 53.24, 95% CI: 21.32–85.15) when compared with the MA group, whereas the change in hemoglobin, incision length, knee range of flexion before discharge, and length of stays were without significant difference (p > 0.05). Third outcomes were used to analyze the alignment data. Our study showed that KA had larger angles of femoral component and mechanical axis of the femur (MD = −1.95,95% CI: −2.77 to −1.13), tibial component and mechanical axis of tibia (MD = 2.06, 95% CI: 1.43–2.70), anatomic knee angle (MD = −0.72, 95% CI: −1.33 to −0.11), and operative limb alignment (MD = −1.97, 95% CI: −2.50 to −1.45,) compared with the MA group, but the hip–knee–ankle angles between the two groups were similar. KA provided better functional outcomes and better flexion following short-term follow-up of TKA. However, longer-term follow-up and larger sample studies are needed to put into research in the future.

scholarly journals Simultaneous implant placement with autogenous onlay bone grafts: a systematic review and meta-analysis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Guoqiang Ma ◽  
Chaoan Wu ◽  
Miaoting Shao
Keyword(s):  
Meta Analysis ◽  
Survival Rates ◽  
Bone Grafts ◽  
Implant Survival ◽  
Analysis Model ◽  
Implant Placement ◽  
Significant Difference ◽  
Delayed Implant Placement ◽  
Onlay Grafts

AbstractSeveral authors have suggested that implants can be placed simultaneously with onlay bone grafts without affecting outcomes. Therefore, the purpose of this study was to answer the following clinical questions: (1) What are the outcomes of implants placed simultaneously with autogenous onlay bone grafts? And (2) is there a difference in outcomes between simultaneous vs delayed placement of implants with autogenous onlay bone grafts? Databases of PubMed, Embase, and Google Scholar were searched up to 15 November 2020. Data on implant survival was extracted from all the included studies (single arm and comparative) to calculate point estimates with 95% confidence intervals (CI) and pooled using the DerSimonian–Laird meta-analysis model. We also compared implant survival rates between the simultaneous and delayed placement of implants with data from comparative studies. Nineteen studies were included. Five of them compared simultaneous and delayed placement of implants. Dividing the studies based on follow-up duration, the pooled survival of implant placed simultaneously with onlay grafts after <2.5 years of follow-up was 93.1% (95% CI 82.6 to 97.4%) and after 2.5–5 years was 86% (95% CI 78.6 to 91.1%). Implant survival was found to be 85.8% (95% CI 79.6 to 90.3%) with iliac crest grafts and 95.7% (95% CI 83.9 to 93.0%) with intra-oral grafts. Our results indicated no statistically significant difference in implant survival between simultaneous and delayed placement (OR 0.43, 95% 0.07, 2.49, I2=59.04%). Data on implant success and bone loss were limited. Data indicates that implants placed simultaneously with autogenous onlay grafts have a survival rate of 93.1% and 86% after a follow-up of <2.5 years and 2.5–5years respectively. A limited number of studies indicate no significant difference in implant survival between the simultaneous and delayed placement of implants with onlay bone grafts. There is a need for randomized controlled trials comparing simultaneous and delayed implant placement to provide robust evidence.

Appendectomy Does Not Increase the Risk of Future Emergence of Parkinson’s Disease: A Meta-analysis

2021 ◽  
pp. 000313482198903
Author(s):  
Mitsuru Ishizuka ◽  
Norisuke Shibuya ◽  
Kazutoshi Takagi ◽  
Hiroyuki Hachiya ◽  
Kazuma Tago ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Random Effects Models ◽  
Significant Difference ◽  
The Cochrane Library ◽  
The Impact ◽  
The Relationship ◽  
Observation Period

Objective To explore the impact of appendectomy history on emergence of Parkinson’s disease (PD). Background Although there are several studies to investigate the relationship between appendectomy history and emergence of PD, the results are still controversial. Methods We performed a comprehensive electronic search of the literature (the Cochrane Library, PubMed, and the Web of Science) up to April 2020 to identify studies that had employed databases allowing comparison of emergence of PD between patients with and those without appendectomy history. To integrate the impact of appendectomy history on emergence of PD, a meta-analysis was performed using random-effects models to calculate the risk ratio (RR) and 95% confidence interval (CI) for the selected studies, and heterogeneity was analyzed using I2 statistics. Results Four studies involving a total of 6 080 710 patients were included in this meta-analysis. Among 1 470 613 patients with appendectomy history, 1845 (.13%) had emergences of PD during the observation period, whereas among 4 610 097 patients without appendectomy history, 6743 (.15%) had emergences of PD during the observation period. These results revealed that patients with appendectomy history and without appendectomy had almost the same emergence of PD (RR, 1.02; 95% CI, .87-1.20; P = .83; I2 = 87%). Conclusion This meta-analysis has demonstrated that there was no significant difference in emergence of PD between patients with and those without appendectomy history.

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