scholarly journals Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection.

2020 ◽  
Author(s):  
Manfred S Green ◽  
Naama Schwartz ◽  
Victoria Peer
Keyword(s):  
Sex Differences ◽  
Vaccine Development ◽  
Meta Analysis ◽  
Age Groups ◽  
Incidence Rates ◽  
Age Group ◽  
Male Predominance ◽  
Time Period ◽  
Meta Regression ◽  
Time Periods

Abstract Background . There is evidence that males have higher incidence rates (IR) of campylobacteriosis than femlaes. The objectives of this study were to determine whether the sex differences differ between age groups and are consistent over different countries and over different time periods. Methods. We obtained data on incidence rates of campylobacteriosis by sex and age group over a period of 11-26 years from seven countries. Male to female incidence rate ratios (IRR) were computed by age group, country and time period. For each age group, we used meta-analytic methods to combine the IRRs. Sensitivity analysis was used to test whether the results are robust to differences between countries and time periods. Meta-regression was conducted to estimate the different effects of age, country, and time period on the IRR. Results . In the age groups <1, 1-4, 5-9, 10-14, 15-44, 45-64 and 65+ years old, the pooled IRRs (with 95% CI) were 1.31 (1.26-1.37), 1.34 (1.31-1.37), 1.35 (1.32-1.38), 1.73 (1.68-1.79), 1.10 (1.08-1.12), 1.19(1.17-1.21) and 1.27 (1.24-1.30), respectively. For each age group, the excess campylobacteriosis incidence rates in males differed at different age groups. However, despite some quantitative differences between countries, the excess was consistently present over long time-periods. In meta-regression analysis, age group was responsible for almost all the variation in the IRRs. Conclusions . The male predominance in campylobacteriosis incidence rates starts in infancy. This suggests that this is due, at least in part, to physiological or genetic differences and not just behavioural factors. These findings can provide clues to the mechanisms of the infection and could lead to more targeted treatments and vaccine development.

scholarly journals Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection.

2020 ◽  
Author(s):  
Manfred S Green ◽  
Naama Schwartz ◽  
Victoria Peer
Keyword(s):  
Sex Differences ◽  
Vaccine Development ◽  
Meta Analysis ◽  
Age Groups ◽  
Incidence Rates ◽  
Age Group ◽  
Male Predominance ◽  
Time Period ◽  
Meta Regression ◽  
Time Periods

Abstract Background . There is evidence that males have higher incidence rates (IR) of campylobacteriosis than femlaes. The objectives of this study were to determine whether the sex differences differ between age groups and are consistent over different countries and over different time periods. Methods. We obtained data on incidence rates of campylobacteriosis by sex and age group over a period of 11-26 years from seven countries. Male to female incidence rate ratios (IRR) were computed by age group, country and time period. For each age group, we used meta-analytic methods to combine the IRRs. Sensitivity analysis was used to test whether the results are robust to differences between countries and time periods. Meta-regression was conducted to estimate the different effects of age, country, and time period on the IRR. Results . In the age groups <1, 1-4, 5-9, 10-14, 15-44, 45-64 and 65+ years old, the pooled IRRs (with 95% CI) were 1.31 (1.26-1.37), 1.34 (1.31-1.37), 1.35 (1.32-1.38), 1.73 (1.68-1.79), 1.10 (1.08-1.12), 1.19(1.17-1.21) and 1.27 (1.24-1.30), respectively. For each age group, the excess campylobacteriosis incidence rates in males differed at different age groups. However, despite some quantitative differences between countries, the excess was consistently present over long time-periods. In meta-regression analysis, age group was responsible for almost all the variation in the IRRs. Conclusions . The male predominance in campylobacteriosis incidence rates starts in infancy. This suggests that this is due, at least in part, to physiological or genetic differences and not just behavioural factors. These findings can provide clues to the mechanisms of the infection and could lead to more targeted treatments and vaccine development.

scholarly journals Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection.

2020 ◽  
Author(s):  
Manfred S Green ◽  
Naama Schwartz ◽  
Victoria Peer
Keyword(s):  
Sex Differences ◽  
Vaccine Development ◽  
Meta Analysis ◽  
Age Groups ◽  
Incidence Rates ◽  
Age Group ◽  
Male Predominance ◽  
Time Period ◽  
Meta Regression ◽  
Time Periods

Abstract Background . There is evidence that males have higher incidence rates (IR) of campylobacteriosis than femlaes. The objectives of this study were to determine whether the sex differences differ between age groups and are consistent over different countries and over different time periods. Methods. We obtained data on incidence rates of campylobacteriosis by sex and age group over a period of 11-26 years from seven countries. Male to female incidence rate ratios (IRR) were computed by age group, country and time period. For each age group, we used meta-analytic methods to combine the IRRs. Sensitivity analysis was used to test whether the results are robust to differences between countries and time periods. Meta-regression was conducted to estimate the different effects of age, country, and time period on the IRR. Results . In the age groups <1, 1-4, 5-9, 10-14, 15-44, 45-64 and 65+ years old, the pooled IRRs (with 95% CI) were 1.31 (1.26-1.37), 1.34 (1.31-1.37), 1.35 (1.32-1.38), 1.73 (1.68-1.79), 1.10 (1.08-1.12), 1.19(1.17-1.21) and 1.27 (1.24-1.30), respectively. For each age group, the excess campylobacteriosis incidence rates in males differed at different age groups. However, despite some quantitative differences between countries, the excess was consistently present over long time-periods. In meta-regression analysis, age group was responsible for almost all the variation in the IRRs. Conclusions . The male predominance in campylobacteriosis incidence rates starts in infancy. This suggests that this is due, at least in part, to physiological or genetic differences and not just behavioural factors. These findings can provide clues to the mechanisms of the infection and could lead to more targeted treatments and vaccine development.

scholarly journals Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection.

2020 ◽  
Author(s):  
Manfred S Green ◽  
Naama Schwartz ◽  
Victoria Peer
Keyword(s):  
Vaccine Development ◽  
Meta Analysis ◽  
Age Groups ◽  
Incidence Rates ◽  
Age Group ◽  
Male Predominance ◽  
Time Period ◽  
Meta Regression ◽  
Time Periods ◽  
Rate Ratios

Abstract Background. There is evidence of an excess of males in the incidence rates of campylobacteriois. The objectives of this study were to determine whether these observations differ between age groups and are consistent over different countries and during different time periods. Methods. We obtained data on incidence rates of campylobacteriosis by sex and age group over a period of 11-26 years from seven countries. Male to female incidence rate ratios (IRR) were computed by age group, country and time period. For each age group, we used meta-analytic methods to combine the IRRs. Sensitivity analysis was used to test whether the results are robust to differences between countries and time periods. Meta-regression was conducted to estimate the different effects of age, country, and time period on the IRR. Results. In the age groups <1, 1-4, 5-9, 10-14, 15-44, 45-64 and 65+ years old, the pooled IRRs (with 95% CI) were 1.31 (1.26-1.37), 1.34 (1.31-1.37), 1.35 (1.32-1.38), 1.73 (1.68-1.79), 1.10 (1.08-1.12), 1.19(1.17-1.21) and 1.27 (1.24-1.30), respectively. For each age group, the excess campylobacteriosis incidence rates in males differed at different age groups. However, despite some quantitative differences between countries, the excess was consistently present over long time-periods. In meta-regression analysis, age group was responsible for almost all the variation in the IRRs. Conclusions. The male predominance in campylobacteriosis incidence rates starts in infancy. This suggests that this is due, at least in part, to physiological or genetic differences and not just behavioural factors. These findings can provide clues to the mechanisms of the infection and could lead to more targeted treatments and vaccine development.

scholarly journals Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection.

2019 ◽  
Author(s):  
Manfred S Green ◽  
Naama Schwartz ◽  
Victoria Peer
Keyword(s):  
Sex Differences ◽  
Vaccine Development ◽  
Meta Analysis ◽  
Age Groups ◽  
Incidence Rates ◽  
Age Group ◽  
Male Predominance ◽  
Time Period ◽  
Different Ages ◽  
Meta Regression

Abstract Background There is evidence that females mount a more efficient immune response to gram-negative bacteria. The objectives of this study were to determine whether there are consistent sex differences in the incidence rates of campylobacteriosis at different ages in different countries.Methods We obtained data on incidence rates of campylobacteriosis by sex and age group over a period of 11-26 years from seven countries Male to female incidence rate ratios (IRR) were computed by age group, country and time period. For each age group, we used meta-analytic methods to combine the IRRs. Sensitivity analysis was used to test whether the results are stable and robust. Meta-regression was conducted to the estimate the effects of age, country, and time period on the IRR.Results In the age groups <1, 1-4, 5-9, 10-14, 15-44, 45-64 and 65+ years old, the pooled IRRs (with 95% CI) were 1.31 (1.26-1.37), 1.34 (1.31-1.37), 1.35 (1.32-1.38), and 1.73 (1.68-1.79), 1.10 (1.08-1.12), 1.19(1.17-1.21), 1.27 (1.24-1.30), respectively. For each age group, the excess campylobacteriosis incidence rates in males is remarkably consistent for countries and time-periods, and in meta-regression analysis, age group was responsible for almost all the variation in the IRRs.Conclusions The male predominance in campylobacteriosis incidence rates starts in infancy. This suggests that this is due, at least in part, to physiological or genetic differences and not just behavioural factors. These findings can provide clues to the mechanisms of the infection, and could lead to more targeted treatments and vaccine development.

scholarly journals Sex differences in shigellosis incidence rates: analysis of national data from nine countries using meta-analytic method

2020 ◽  
Vol 30 (5) ◽  
pp. 974-981 ◽  
Author(s):  
Victoria Peer ◽  
Naama Schwartz ◽  
Manfred S Green
Keyword(s):  
Sex Differences ◽  
Vaccine Development ◽  
Age Groups ◽  
Incidence Rates ◽  
Age Group ◽  
Behavioral Factors ◽  
National Data ◽  
Time Period ◽  
Meta Regression ◽  
Rate Ratios

Abstract Background Sex differences in the incidence of infectious diseases can provide insight to the biological mechanism of infection, disease susceptibility, severity and vaccine development. The consistency of age-specific sex differences in the incidence rates (IRs) of shigellosis is unclear. Methods National data on cases of shigellosis by sex, age group and calendar year were obtained from nine countries, for a period of 6–25 years. The male to female incidence rate ratios (RR) were calculated by country, years and age group. For each age group, meta-analytic methods were used for computing pooled incidence RRs by country and years. Meta-regression was performed to estimate the contribution of age, country and time period to the differences in the male : female RRs. Results In the age groups &lt;1, 1–4, 5–9 and 10–14, there were excess IRs in males. The pooled incidence RRs (with 95% CI) were 1.21 (1.14–1.28), 1.17 (1.12–1.22), 1.04 (1.00–1.09) and 1.09 (1.01–1.18), respectively. In young adults, there was excess IR in females with RR = 0.80 (0.72–0.9). In middle aged and older adults, there was a slight excess in males with RR = 1.01 (0.89–1.15) and RR = 1.18 (1.09–1.28), respectively. In the meta-regression, age was the only variable that significantly contributed to the variation in the RRs. Conclusions The higher IRs in male infants and young children does not appear to be related to behavioral factors and genetic and hormonal factors could be important. In the older age groups, the higher rates in adult females may be due to behavioral factors.

scholarly journals A meta-analytic evaluation of sex differences in meningococcal disease incidence rates in 10 countries

2020 ◽  
Vol 148 ◽  
Author(s):  
Manfred S. Green ◽  
Naama Schwartz ◽  
Victoria Peer
Keyword(s):  
Sex Differences ◽  
Meningococcal Disease ◽  
Disease Incidence ◽  
Age Groups ◽  
Incidence Rates ◽  
Age Group ◽  
Young Males ◽  
Time Period ◽  
Meta Regression ◽  
Male To Female

Abstract The magnitude and consistency of the sex differences in meningococcal disease incidence rates (IR) have not been systematically examined in different age groups, countries and time periods. We obtained national data on meningococcal disease IR by sex, age group and time period, from 10 countries. We used meta-analytic methods to combine the male to female incidence rate ratios (IRRs) by country and year for each age group. Meta-regression analysis was used to assess the contribution of age, country and time period to the variation in the IRRs. The pooled male to female IRRs (with 95% CI) for ages 0–1, 1–4, 5–9, 10–14 and 15–44, were 1.25 (1.19–1.32), 1.24 (1.20–1.29), 1.13 (1.07–1.20), 1.21 (1.13–1.29) and 1.15 (1.10–1.21), respectively. In the age groups 45−64 and over 65, the IR were lower in males with IRRs of 0.83 (0.78–0.88) and 0.64 (0.60–0.69), respectively. Sensitivity analysis and meta-regression confirmed that the results were robust. The excess meningococcal IR in young males and the higher rates in females at older ages were consistent in all countries, except the Czech Republic. While behavioural factors could explain some of the sex differences in the older age groups, the excess rates in very young males suggest that genetic and hormonal differences could be important.

scholarly journals Sex Differences in Salmonellosis Incidence Rates—An Eight-Country National Data-Pooled Analysis

2021 ◽  
Vol 10 (24) ◽  
pp. 5767
Author(s):  
Victoria Peer ◽  
Naama Schwartz ◽  
Manfred S. Green
Keyword(s):  
Sex Differences ◽  
Age Groups ◽  
Pooled Analysis ◽  
Incidence Rates ◽  
National Data ◽  
Time Period ◽  
Meta Regression ◽  
Rate Ratios ◽  
Male To Female ◽  
Country Specific

Background: There are few studies on sex differences in the incidence rates (IR) for salmonellosis over several countries by age and time period. The purpose of this study was to explore the extent and consistency of the sex and age-specific differences. Methods: We analyzed national data from eight countries between 1994 and 2016. We computed country-specific male to female incidence rate ratios (IRRs) for each age group and pooled the data using meta-analytic methods. Variations of the IRRs by age, country and time period were evaluated using meta-regression. Results: The pooled male to female incidence RRs for ages 0–1, 1–4, 5–9 and 10–14, were 1.04 (1.02–1.06), 1.02 (1.01–1.03), 1.07 (1.05–1.08) and 1.28 (1.23–1.33), respectively. For the ages 15–44 and 45–64, the incidence rates were significantly higher in females. Meta-regression analyses indicate that age groups contributed most of the variation in the male to female IRRs. Conclusions: We suggest that genetic and hormonal factors and interactions between hormones and gut microbiota could contribute to the sex differences observed in young children. These findings should provide clues about the mechanisms of the infection, and should be useful in targeting treatments and development of vaccines. Highlights: (1) This manuscript provides consistent estimates of the excess salmonellosis incidence rates in male children up to age 15, which suggests an impact of sex hormones or genetic differences. (2) Our findings should promote the further investigations on sex-related determinants of infectious diseases.

Temporal Incidence Trends of Pediatric Venous Thromboembolism: A Population-Based Cohort Study

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 1138-1138
Author(s):  
Christine A. Sabapathy ◽  
Susan R. Kahn ◽  
Robert W Platt ◽  
Vicky Tagalakis
Keyword(s):  
Sex Differences ◽  
Venous Thromboembolism ◽  
Incidence Rate ◽  
Conflicts Of Interest ◽  
Age Groups ◽  
Incidence Rates ◽  
Age Group ◽  
Incidence Trends ◽  
Incident Cases ◽  
Temporal Incidence

Abstract Abstract 1138 Background: Pediatric venous thromboembolism (VTE), although rare, is associated with significant morbidity and mortality. Published incidence rates in this age group vary from 0.07 to 0.49 VTE per 10 000 children/year and there is currently a paucity of studies evaluating temporal incidence trends. Objectives: To describe the age-adjusted incidence rates of pediatric VTE and its trend over time in a large pediatric cohort. Methods: A retrospective cohort of all children (ages 1–17 inclusive) with a first time diagnosis of VTE in the province of Quebec, Canada over an eleven-year period, from January 1st, 1994 to December 31st, 2004, was obtained from a comprehensive administrative hospital database (Med-Echo). Quebec census estimates were used to calculate age-standardized incidence rates (IR) of pediatric VTE. The incidence rate trend was then analyzed over the eleven-year study period using Poisson linear regression. Sex differences in incidence rates at the population level stratified by age group as a confounder as well as baseline characteristics of the cases were also evaluated. Results: In total, 487 incident cases of VTE in children 1–17 years of age were documented during the study period. Based on the estimated provincial census person-years during the study period, the age-standardized IR was 0.29 VTE per 10 000 person-years (95% confidence interval (CI) 0.26–0.31). Females overall had a statistically significant higher VTE incidence rate with an incidence rate ratio of 1.75 (95% CI 1.46–2.11) when controlled for age groups, as compared to males. When analyzed by age group, the age-standardized IRs were as follows: 1–5 year olds 0.04 VTE per 10 000 person-years (95% CI 0.03–0.05); 6–10 year olds 0.03 VTE per 10 000 person-years (95% CI 0.02–0.04); 11–14 year olds 0.06 VTE per 10 000 person-years (95% CI 0.05–0.07); 15–17 year olds 0.16 VTE per 10 000 person-years (95% CI 0.14–0.18). Trend analysis of the age-standardized IRs over the 11-year period showed no significant change in incidence rates whether using time as a continuous (yearly) or categorical variable (time-periods). Conclusions: Pediatric VTE is more frequent than previously described, however the rate is stable. As shown by others, children in their late-teen years have a higher risk of VTE than primary school-aged children. Unlike prior studies, females were more prone to VTE than males. Future studies that address sex differences in the incidence of pediatric VTE are needed to help determine effective primary thromboprophylaxis strategies in children at high risk for VTE. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Sex differences in the case-fatality rates for COVID-19—A comparison of the age-related differences and consistency over seven countries

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250523
Author(s):  
Manfred S. Green ◽  
Dorit Nitzan ◽  
Naama Schwartz ◽  
Yaron Niv ◽  
Victoria Peer
Keyword(s):  
Sex Differences ◽  
Age Groups ◽  
Case Fatality ◽  
Age Group ◽  
Related Factors ◽  
Female Ratio ◽  
Age Related ◽  
Incidence And Mortality ◽  
Meta Regression ◽  
Male To Female

Background Early in the COVID-19 pandemic, it was noted that males seemed to have higher case-fatality rates than females. We examined the magnitude and consistency of the sex differences in age-specific case-fatality rates (CFRs) in seven countries. Methods Data on the cases and deaths from COVID-19, by sex and age group, were extracted from the national official agencies from Denmark, England, Israel, Italy, Spain, Canada and Mexico. Age-specific CFRs were computed for males and females separately. The ratio of the male to female CFRs were computed and meta-analytic methods were used to obtained pooled estimates of the male to female ratio of the CFRs over the seven countries, for all age-groups. Meta-regression and sensitivity analysis were conducted to evaluate the age and country contribution to differences. Results The CFRs were consistently higher in males at all ages. The pooled M:F CFR ratios were 1.71, 1.88, 2.11, 2.11, 1.84, 1.78 and 1.49, for ages 20–29, 30–39, 40–49, 50–59, 60–69, 70–79, 80+ respectively. In meta-regression, age group and country were associated with the heterogeneity in the CFR ratios. Conclusions The sex differences in the age-specific CFRs are intriguing. Sex differences in the incidence and mortality have been found in many infectious diseases. For COVID-19, factors such as sex differences in the prevalence of underlying diseases may play a part in the CFR differences. However, the consistently greater case-fatality rates in males at all ages suggests that sex-related factors impact on the natural history of the disease. This could provide important clues as to the mechanisms underlying the severity of COVID-19 in some patients.

scholarly journals The male excess case-fatality rates for COVID-19 – A meta-analytic study of the age-related differences and consistency over six countries

2020 ◽  
Author(s):  
Manfred S Green ◽  
Naama Schwartz ◽  
Dorit Nitzan ◽  
Victoria Peer
Keyword(s):  
Sex Differences ◽  
Age Groups ◽  
Case Fatality ◽  
The United States ◽  
Incidence Rates ◽  
Male Dominance ◽  
Age Group ◽  
Female Ratio ◽  
Age Related ◽  
Male To Female

AbstractBackgroundEarly in the COVID-19 pandemic, it was noted that males seemed to be more affected than females. We examined the magnitude and consistency of the sex differences in age-specific case-fatality rates (CFRs) in six countries.MethodsData on the cases and deaths from COVID-19, by sex and age group, were extracted from the published reports from Denmark, England, Israel, Italy, Spain, and the United States. Age-specific CFRs were computed for males and females separately. The ratio of the male to female CFRs were computed and meta-analytic methods were used to obtained pooled estimates of the male to female ratio of the CFRs over the six countries, for seven age-groups.FindingsThe CFRs were consistently higher in males at all ages. The differences were greater in the younger age groups. The pooled M:F CFR ratios were 2.53, 2.92, 2.57, 1.83, 1.57, 1.58 and 1.48 for ages 0-39, 40-49, 50-59, 60-69, 70-79, 80-89 and 90+. There was remarkable consistency between countries in the magnitude of the M:F CFRs, in each age group. In meta-regression, age group explained almost all the heterogeneity in the CFR ratios.ConclusionsThe sex differences in the CFRs are intriguing and are compatible with the male dominance in the incidence rates of many infectious diseases. For COVID-19, factors such as sex differences in the prevalence of underlying diseases may play a part in the CFR differences. However, the greater severity of the disease in males, particularly at younger ages, may be part of the disease mechanism and should be explored further.FundingNo funding was provided for this study. The authors declare no conflict of interests

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