scholarly journals Diagnostic Test Accuracy of New Generation Tympanic Thermometry in Children: A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Dan Shi ◽  
Liyuan Zhang ◽  
Haixia Li
Keyword(s):  
Pediatric Patients ◽  
Web Of Science ◽  
Meta Analysis ◽  
Internal Validity ◽  
Youden Index ◽  
Test Accuracy ◽  
Optimal Cutoff ◽  
High Diagnostic Accuracy ◽  
New Generation ◽  
Review Manager

Abstract Purposes: The purposes of this review were to compare sensitivity and specificity of the new generation tympanic thermometry under different cutoffs and to give the optimal cutoff. Methods: Articles were derived from a systematic search in PubMed, Web of science, and Embase, and were assessed for internal validity by QUADAS-Ⅱ. The figure of risk of bias was drew by Review Manager 5.3 and data were synthesized by MetaDisc 1.4. Results: Nineteen diagnostic studies, involving 4,639 pediatric patients, were included. The cut-offs varied from 37.0℃ to 38.0℃ among these studies. The cut-off 37.8 was with the highest sROC AUC (0.97) and Youden Index (0.83) and was deemed to be the optimal cutoff. Conclusion: New Generation Tympanic Thermometry is with high diagnostic accuracy in pediatric patients and can be an alternative for rectal measurements.

scholarly journals Diagnostic Test Accuracy of New Generation Tympanic Thermometry in Children under Different Cutoffs: A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Dan Shi ◽  
Liyuan Zhang ◽  
Haixia Li
Keyword(s):  
Diagnostic Accuracy ◽  
Pediatric Patients ◽  
Web Of Science ◽  
Meta Analysis ◽  
Internal Validity ◽  
Youden Index ◽  
Test Accuracy ◽  
Optimal Cutoff ◽  
New Generation ◽  
Review Manager

Abstract Purposes: To identify and quantify studies reporting the diagnostic accuracy of the new generation of infrared tympanic thermometer (IRTT) in children and to compare the sensitivity and specificity of IRTT under different cutoffs and give the optimal cutoff. Methods: Articles were derived from a systematic search in PubMed, Web of Science Core Collection, and Embase, and were assessed for internal validity by the Quality Assessment of Diagnostic Accuracy Studies-2　（QUADAS-Ⅱ）. The figure of risk of bias was created by Review Manager 5.3 and data were synthesized by MetaDisc 1.4. Results: Nineteen diagnostic studies, involving 4,639 pediatric patients, were included. The cut-offs varied from 37.0℃ to 38.0℃ among these studies. The cut-off 37.8℃ was with the highest sROC AUC (0.97) and Youden Index (0.83) and was deemed to be the optimal cutoff. Conclusion: The optimal cutoff for infrared tympanic thermometers is 37.8℃. New Generation Tympanic Thermometry is with high diagnostic accuracy in pediatric patients and can be an alternative for fever screening in children.

scholarly journals Diagnostic Test Accuracy of New Generation Tympanic Thermometry in Children under different cutoffs: A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Dan Shi ◽  
Liyuan Zhang ◽  
Haixia Li
Keyword(s):  
Diagnostic Accuracy ◽  
Pediatric Patients ◽  
Web Of Science ◽  
Meta Analysis ◽  
Internal Validity ◽  
Youden Index ◽  
Test Accuracy ◽  
Optimal Cutoff ◽  
New Generation ◽  
Review Manager

Abstract Purposes: To identify and quantify studies reporting the diagnostic accuracy of the new generation of infrared tympanic thermometer (IRTT) in children and to compare the sensitivity and specificity of IRTT under different cutoffs and give the optimal cutoff. Methods: Articles were derived from a systematic search in PubMed, Web of Science Core Collection, and Embase, and were assessed for internal validity by the Quality Assessment of Diagnostic Accuracy Studies-2　（QUADAS-Ⅱ）. The figure of risk of bias was created by Review Manager 5.3 and data were synthesized by MetaDisc 1.4. Results: Nineteen diagnostic studies, involving 4,639 pediatric patients, were included. The cut-offs varied from 37.0℃ to 38.0℃ among these studies. The cut-off 37.8℃ was with the highest sROC AUC (0.97) and Youden Index (0.83) and was deemed to be the optimal cutoff. Conclusion: The optimal cutoff for infrared tympanic thermometers is 37.8℃. New Generation Tympanic Thermometry is with high diagnostic accuracy in pediatric patients and can be an alternative for fever screening in children.

scholarly journals Diagnostic Test Accuracy of New Generation Tympanic Thermometry in Children under Different Cutoffs: A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Dan Shi ◽  
Liyuan Zhang ◽  
Haixia Li
Keyword(s):  
Diagnostic Accuracy ◽  
Pediatric Patients ◽  
Web Of Science ◽  
Meta Analysis ◽  
Internal Validity ◽  
Youden Index ◽  
Test Accuracy ◽  
Optimal Cutoff ◽  
New Generation ◽  
Review Manager

Abstract Purposes: To identify and quantify studies reporting the diagnostic accuracy of the new generation of infrared tympanic thermometer (IRTT) in children and to compare the sensitivity and specificity of IRTT under different cutoffs and give the optimal cutoff. Methods: Articles were derived from a systematic search in PubMed, Web of Science Core Collection, and Embase, and were assessed for internal validity by the Quality Assessment of Diagnostic Accuracy Studies-2　（QUADAS-Ⅱ）. The figure of risk of bias was created by Review Manager 5.3 and data were synthesized by MetaDisc 1.4. Results: Nineteen diagnostic studies, involving 4,639 pediatric patients, were included. The cut-offs varied from 37.0℃ to 38.0℃ among these studies. The cut-off 37.8℃ was with the highest sROC AUC (0.97) and Youden Index (0.83) and was deemed to be the optimal cutoff. Conclusion: The optimal cutoff for infrared tympanic thermometers is 37.8℃. New Generation Tympanic Thermometry is with high diagnostic accuracy in pediatric patients and can be an alternative for fever screening in children.

scholarly journals Association between CYP3A5 Polymorphism and Statin-Induced Adverse Events: A Systemic Review and Meta-Analysis

2021 ◽  
Vol 11 (7) ◽  
pp. 677
Author(s):  
Jeong Yee ◽  
Hamin Kim ◽  
Yunhee Heo ◽  
Ha-Young Yoon ◽  
Gonjin Song ◽  
...  
Keyword(s):  
Adverse Events ◽  
Web Of Science ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Systemic Review ◽  
Event Risk ◽  
Total Data ◽  
Lipophilic Statin ◽  
The Relationship ◽  
Review Manager

Purpose: Cytochrome P450 (CYP) is involved in the metabolism of statins; CYP3A5 is the main enzyme responsible for lipophilic statin metabolism. However, the evidence of the association between CYP3A5*3 polymorphism and the risk of statin-induced adverse events remains unclear. Therefore, this study aimed to perform a systematic review and meta-analysis to investigate the relationship between the CYP3A5*3 polymorphism and the risk of statin-induced adverse events. Methods: The PubMed, Web of Science, and EMBASE databases were searched for qualified studies published until August 2020. Observational studies that included the association between statin-induced adverse events and the CYP3A5*3 polymorphism were reviewed. The odds ratios (ORs) and 95% confidence intervals (CIs) were evaluated to assess the strength of the relationship. The Mantel–Haenszel method was used to provide the pooled ORs. Heterogeneity was estimated with I2 statistics and publication bias was determined by Begg’s and Egger’s test of the funnel plot. Data analysis was performed using Review Manager (version 5.4) and R Studio (version 3.6). Results: In total, data from 8 studies involving 1614 patients were included in this meta-analysis. The CYP3A5*3 polymorphism was found to be associated with the risk of statin-induced adverse events (*3/*3 vs. *1/*1 + *1/*3: OR = 1.40, 95% CI = 1.08–1.82). For myopathy, the pooled OR was 1.30 (95% CI: 0.96–1.75). The subgroup analysis of statin-induced myopathy revealed a trend, which did not achieve statistical significance. Conclusions: This meta-analysis demonstrated that the CYP3A5*3 polymorphism affected statin-induced adverse event risk. Therefore, CYP3A5 genotyping may be useful to predict statin toxicity.

Return of the lesion: a meta-analysis of 1134 angiographically cured pediatric arteriovenous malformations

2021 ◽  
pp. 1-8
Author(s):  
David C. Lauzier ◽  
Ananth K. Vellimana ◽  
Arindam R. Chatterjee ◽  
Joshua W. Osbun ◽  
Christopher J. Moran ◽  
...  
Keyword(s):  
Arteriovenous Malformations ◽  
Pediatric Patients ◽  
Web Of Science ◽  
Meta Analysis ◽  
Study Cohort ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Risk Of Rupture ◽  
Brain Avms ◽  
Prospective Database

OBJECTIVE Brain arteriovenous malformations (AVMs) carry a risk of rupture and subsequent morbidity or mortality unless fully treated. AVMs in pediatric patients are known to occasionally recur after obliteration. The objective of this study was to characterize the risk of AVM recurrence following angiographically confirmed obliteration in children. METHODS Consecutive pediatric AVMs treated at a single center were identified from a prospective database. Patients with angiographically confirmed AVM obliteration following treatment were included in this study. Associations between AVM recurrence and patient or procedural factors were characterized using the two-tailed Fisher exact test or Mann-Whitney U-test. A literature search was conducted using PubMed, Scopus, Embase, and the Clarivate Web of Science with defined search criteria, and eligible studies were included alongside this study cohort in a meta-analysis. Rates of AVM recurrence following obliteration were pooled across studies with a random-effects model and reported with 95% confidence intervals (CIs). RESULTS Recurrence after angiographic confirmation of AVM obliteration was observed in 10.4% (7/67) of pediatric AVMs treated at the authors’ center. Patients with recurrent AVMs were significantly younger than those without recurrence (p = 0.002). In the meta-analysis, which included 1134 patients across 24 studies, the rate of recurrence was 4.8% (95% CI 3.0%–6.7%). The rate of AVM recurrence following radiosurgery was 0.7% (95% CI 0%–1.6%), which was significantly lower than the 8.5% rate (95% CI 5.0%–12.0%) following microsurgery. CONCLUSIONS Recurrence of obliterated brain AVMs is common in children. Recurrence is more common in young children and following microsurgery.

scholarly journals Post COVID-19 Organizing Pneumonia: A Systematic Review and Meta-analysis

2021 ◽  
pp. 259-270
Author(s):  
Talal Khalid Abdullah Alanazi ◽  
Nasser Faris Ali Alahmari ◽  
Faris Essa Ibrahim Qubays ◽  
Solaiman Hosaian ibraheem Alenezi ◽  
Meshal Faleh Mofadhe Alenezi
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Web Of Science ◽  
Case Reports ◽  
Meta Analysis ◽  
Organizing Pneumonia ◽  
Eligible Study ◽  
Data Synthesis ◽  
Electronic Search ◽  
Review Manager

Introduction: Several observational studies have found parallels between COVID-19 pneumonia and organizing pneumonia (OP). This study aims to investigate the published literature of OP related to COVID-19, estimates the prevalence of OP among COVID-19 patients, and assesses the risk or COVID-19 severity associated with OP. Methodology: This was a systematic review and meta-analysis. A systematic electronic search through PubMed, Web of Science, Science Direct, EBSCO, and Google Scholar was conducted to include relevant and eligible literature. The authors used Review Manager 5.4 to perform quantitative data synthesis for the condition of interest analyses. Results: A total of 9 eligible study articles and 12 case reports were included in this study. The estimated pooled organizing pneumonia prevalence among COVID-19 patients was 45.6% [23.1%-68.2%]. The association between OP and severe COVID-19 infection revealed a pooled OR [95% CI] of 5.22 [-0.96-11.41]. Conclusion: COVID-19 patients had a rather high OP prevalence (43%). Surprisingly, cancer patients with COVID-19 infection had the lowest OP prevalence. OP was identified as a possible risk factor for the severity of COVID-19 infection.

scholarly journals Marijuana smoking and asthma: a protocol for a meta-analysis

BMJ Open ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. e047324
Author(s):  
Jincheng Lei ◽  
Mingjie Shao
Keyword(s):  
Clinical Decision Making ◽  
Web Of Science ◽  
Current Knowledge ◽  
Meta Analysis ◽  
Clinical Decision ◽  
Comprehensive Plan ◽  
Quality Scale ◽  
Registration Number ◽  
Current Knowledge Base ◽  
Review Manager

IntroductionRecent studies have raised the concern on the risk of asthma in marijuana smokers; however, the results remain controversial and warrant further investigation. With a growing number of marijuana smokers, examining the association between marijuana smoking and asthma and quantifying such association through meta-analysis have important implications for public health and clinical decision-making. In view of this, the present protocol aims to detail a comprehensive plan of meta-analysis on the association aforementioned. The findings are expected to strengthen the current knowledge base pertaining to the potential adverse effects of marijuana smoking on pulmonary health and to facilitate the development of prevention strategies for asthma.Methods and analysisThe MEDLINE/PubMed, Web of Science and EMBASE databases will be searched systematically from inception to 1 September 2021 to retrieve the relevant observational studies focusing on the association between marijuana smoking and asthma. Both unadjusted and adjusted effect sizes, such as OR, relative risk, HR and the corresponding 95% CIs will be extracted for pooled analyses. Heterogeneity and publication bias across the included studies will be examined. The Newcastle-Ottawa Quality Scale will be used to assess the quality and risk of bias. Statistical software Review Manager V.5.3 and Stata V.11.0 will be used for statistical analyses.Ethics and disseminationSince no private and confidential patient data will be included in the reporting, approval from an ethics committee is not required. The results will be published in a peer-reviewed journal or disseminated in the relevant conferences. The study raises no ethical issue.OSF registration number10.17605/OSF.IO/UPTXC.

scholarly journals Association of the CYP17 (T-34C) Polymorphism and the Risk of Acne Vulgaris: A Meta-Analysis

2018 ◽  
Author(s):  
Mazaher Ramezani ◽  
Elisa Zavattaro ◽  
Masoud Sadeghi
Keyword(s):  
Web Of Science ◽  
Skin Diseases ◽  
Genetic Relationships ◽  
Meta Analysis ◽  
Acne Vulgaris ◽  
Cochrane Library ◽  
Asian Ethnicity ◽  
Common Skin ◽  
The Relationship ◽  
Review Manager

Acne vulgaris is one of the most common skin diseases and genetic relationships have been documented. The aim was to evaluate the association of CYP17 (T-34C) polymorphism related to the risk of acne in a meta-analysis study. The databases (Scopus, Web of Science, PubMed, and Cochrane Library) were searched until September 2018 to check the relationship between acne risk and CYP17 (T-34C) polymorphism and impact of this polymorphism on severity of acne. We used Review Manager 5.3 software to analyze the data using OR and 95% CI to check this relationship. Four studies were included and analyzed in the meta-analysis. The OR in analysis of C versus T in acne patients compared to the healthy controls was 1.42 (P=0.02), in CC vs. TT was 1.54 (P=0.04), in TC vs. TT was 1.46 (P=0.12), in TC + CC vs. TT was 1.55 (P=0.04), and in CC vs. TT + TC was 1.39 (P=0.06). There was no acne risk related to CYP17 (T-34C) in none of genetic models in Caucasian ethnicity, whereas in Asian ethnicity, there was higher acne risk related to CYP17 (T-34C) without heterogeneity. The results of the present meta-analysis showed the presence of C allele and CC genotype of CYP17 polymorphism can be risk factors for acne, mainly in the Asian ethnicity.

scholarly journals Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: A meta-analysis

2020 ◽  
Author(s):  
Roohollah Sharifi ◽  
Sajjad Jahedi ◽  
Hamid Reza Mozaffari ◽  
Mohammad Moslem Imani ◽  
Masuod Sadeghi ◽  
...  
Keyword(s):  
Dental Caries ◽  
Web Of Science ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Control Group ◽  
Case Group ◽  
Caries Risk ◽  
Increased Risk ◽  
Dental Caries Susceptibility ◽  
Review Manager

Abstract Background This meta-analysis evaluated the association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility.Methods We searched the Scopus, PubMed/Medline, Web of Science, and Cochrane Library databases to retrieve articles published by October 2019. Review Manager 5.3 software was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). The results of publication bias tests were retrieved by Comprehensive Meta-Analysis 2.0 software.Results A total of 150 relevant records were identified; out of which, 16 were entered into the analysis (4 studies assessed LTF, 11 ENAM, and 11 AMELX polymorphisms). Of all polymorphisms, there was a significant association only between ENAM rs3796704 polymorphism and dental caries susceptibility. Both ENAM rs3796704 and AMELX rs17878486 polymorphisms had a significant association with dental caries risk in the Caucasian ethnicity and the studies including caries-free control group.Conclusions The results of this meta-analysis showed that the G allele and the GG genotype of ENAM rs3796704 were associated with an increased risk of caries in the case group compared with the control group. But there was no association between LTF rs1126478, ENAM (rs1264848 and rs3796703), and AMELX (rs946252, rs17878486, and rs2106416) polymorphisms and dental caries susceptibility.

scholarly journals Clinicopathologic Relevance of Claudin 18.2 Expression in Gastric Cancer: A Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Bogdan Silviu Ungureanu ◽  
Cristian-Virgil Lungulescu ◽  
Daniel Pirici ◽  
Adina Turcu-Stiolica ◽  
Dan Ionut Gheonea ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Targeted Therapy ◽  
Odds Ratio ◽  
Web Of Science ◽  
Meta Analysis ◽  
Pathological Features ◽  
Potential Efficacy ◽  
The Relationship ◽  
Review Manager

An increasing number of tumor markers have been discovered to have potential efficacy as diagnostic and prognostic tools in gastric cancer. We aimed to assess putative correlations between claudin 18.2 expression and pathological or prognosis features in patients with gastric cancer. MEDLINE, Web of Science, EBSCO, and ClinicalTrials.gov were used to search for relevant studies from their inception to 30 October 2020. Finally, a total of six articles were included in this meta-analysis. Review Manager 5 software was applied to examine the heterogeneity among the studies and to calculate the odds ratio with 95% CI by selecting corresponding models, in evaluating the strength of the relationship. Publication bias test was also conducted. No bias and no significant correlations were found between CLDN 18.2 and TNM stages, Lauren classification, HER2, grading, or overall survival. This meta-analysis expounded that the relationship with CLDN 18.2 and pathological features depends on the percentage of staining of tumor cells for which CLDN 18.2 is considered positive. Our pooled outcomes suggest that targeted therapy for CLDN 18.2 could be effective if certain criteria were established.

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