Comparison of the effect of rapeseed oil or amaranth seed oil supplementation on weight loss, body composition, and changes in the metabolic profile of obese patients following 3-week body mass reduction program: a randomized clinical trial
Abstract Background: Amaranth seed oil (ASO) and rapeseed oil (RSO) are representative functional food with glucose and cholesterol-lowering, antioxidant, and hepatoprotective properties. We aimed to determine whether compared to RSO, ASO supplementation can improve the weight loss and metabolic parameters when consumed as a part of a 3-week weight loss program.Methods: Eighty-one obese subjects (BMI > 30 kg/m 2 ) aged 25−70 years enrolled in a 3-week body mass reduction program based on calorie-restricted diet and physical activity. The participants were randomly administered 20 ml/d of ASO (AO group) or 20 ml/d of RSO (RO group), or were assigned to the control (C) group. Anthropometric and metabolic parameters were measured at baseline and at endpoint.Results: At the end of the study, significant ( P < 0.05) decrease in weight, BMI, WC (waist circumference), HC (hip circumference), FM (fat mass), LBM (lean body mass), VFM (visceral fat mass), and TBW% (total body water) were observed in all the studied groups. There were no significant improvements in clinical parameters in the C group, while reduction in fasting insulin ( P = 0.001 and P = 0.005) and HOMA-IR ( P = 0.02 and P = 0.03) were observed in the RO and AO groups. Compared to the RO group, we observed significant improvement in fasting glucose ( P = 0.03), total cholesterol ( P = 0.03), non-HDL cholesterol ( P = 0.01), TG/HDL ratio ( P = 0.03), LDL cholesterol ( P = 0.04), and triglycerides ( P = 0.000008) in the AO group.Conclusions: The 3-week body mass reduction intervention resulted in statistically significant reduction in weight, BMI, WC, HC, FM, and VFM in all the studied groups. The fasting insulin level and HOMA-IR improved in both AO and RO groups. In contrast to the RO group, positive changes in glucose and lipid levels were observed in the AO group. Compared to the AO and RO groups, subjects without oil supplementation did not show improvement in clinical parameters. Thus, edible oils may improve metabolic parameters during weight loss programs.