Bilateral diffuse uveal melanocytic proliferation: A case report and literature review

2020 ◽  
Author(s):  
Nianting Tong ◽  
Liangyu Wang ◽  
Nan Wang ◽  
Zhanyu Zhou
Keyword(s):  
Retinal Detachment ◽  
Exudative Retinal Detachment ◽  
Histopathologic Examination ◽  
Cataract Formation ◽  
Case Presentation ◽  
Melanocytic Tumors ◽  
Ophthalmic Manifestations ◽  
Underlying Malignancy ◽  
History Of ◽  
Shallow Anterior Chamber

Abstract Background Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumors. Case presentation Here, we presented a patient, whose clinical manifestation was diffusely thickened choroid, shallow anterior chamber, cataract formation and exudative retinal detachment. Histopathologic examination for the biopsies from the choroid during the surgery showed the the tissue might be originated from melanocytes and with the benign biologic behavior. Therefore, the diagnosis for this patient was BDUMP, although there was no obvious history of malignancy until we prepared for this article. Conclusions This was a rare BDUMP clarified by ophthalmic manifestations and histopathologic examination, without clear history of systematic malignancy.

scholarly journals A case report of ultrasonographic findings in bilateral diffuse Uveal melanocytic proliferation

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jingli Guo ◽  
Wenyi Tang ◽  
Wei Liu ◽  
Min Zhou ◽  
Qing Chang ◽  
...  
Keyword(s):  
Case Report ◽  
Retinal Detachment ◽  
High Frequency ◽  
Ciliary Body ◽  
Case Series ◽  
Ultrasound Biomicroscopy ◽  
The Other ◽  
Exudative Retinal Detachment ◽  
Case Presentation ◽  
Choroidal Nevi

Abstract Background To report undescribed characteristics of patients with bilateral diffuse uveal melanocytic proliferation (BDUMP) on ultrasound biomicroscopy (UBM) and high-frequency B-scan ultrasonography. Case presentation Two of four participants presented with worsening bilateral vision after previously diagnosed primary pulmonary or ovarian carcinoma. The other two patients were diagnosed with lung carcinoma after presentation with BDUMP. All patients had ciliary body nevi-like lesion in combination with iris or ciliary body cysts, and uveal thickening on UBM. Focally elevated choroidal nevi-like lesion and exudative retinal detachment with choroidal thickening were detected with B-scan ultrasonography. Conclusions Our case series demonstrates the uveal characteristics of patients with BDUMP based on high-frequency B-scan ultrasonography and UBM. Ultrasonographic findings are crucial in the diagnosis of BDUMP because it is occult in nature.

scholarly journals Resolution of Retinal Bleeding And Exudative Retinal Detachment After Chemotherapy with Melphalan In Multiple Myeloma

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Ari Andayani ◽  
I Putu Budhiastra ◽  
I Wayan Losen Adnyana ◽  
Made Paramita Wijayati
Keyword(s):  
Multiple Myeloma ◽  
Retinal Detachment ◽  
Gamma Globulin ◽  
Plasma Cells ◽  
Exudative Retinal Detachment ◽  
Laboratory Examination ◽  
Ophthalmic Manifestations ◽  
Hematologic Cancer ◽  
Retinal Bleeding ◽  
The Right

Introduction: Multiple myeloma is the second most common hematologic cancer. It is characterized by the clonal proliferation of malignant plasma cells and associated organ dysfunction. Ophthalmic manifestations include hyperviscosity retinopathy and retinal detachment. The aim of this study is to report retinal manifestation in Multiple Myeloma. Methods: A man 45 years old, complained loss of vision on both eyes especially left eye over 1 month. He also feels weakness and 3 times spontaneous nose bleeding. His visual acquity is 6/12 on the right and 2/60 left eye with Retinal Bleeding and Retinal Detachment. His Laboratory examination result increase in WBC 65.91 x 103/µL (Neutrophil, Monocyte, Basophil and Lymphocyte) decrease RBC 3 x 106/µL, HGB 6.85 g/dL, normal PLT 193.60 103/µL, Normal Bleeding and Clotting Time and increase ESR 140 mm/hour. Multiple myeloma was diagnosed by Internal Department with bone marrow biopsy and increase of Gamma Globulin. Results: The patient was treated with melphalan 3 tablet 2 times a day and prednisone 4 mg 3 times a day for 5 days every 28 days.  After 8 month the VA 6/6 on the right and 6/10 on the left with complete resolution of on the right eye and there are resolution on the left eye with fibrosis, the laboratory examination normal WBC 3.8 x 103/µL with Neutrophil 59.3%, Monocyte 6.1 %, Eosinophil 6.3 %, Basophil 0.3 % and Lymphocyte 28.0 %, normal RBC 4.6 x 106/µL, slightly decrease HGB 12.8 g/dL, normal PLT 177.0 x 103/µL and decrease Gamma Globulin. Discussion: This case of bilateral Retinal Bleeding and Exudative Retinal Detachment are remarkable for both its presentation and response to melphalan therapy. Treatment with melphalan and prednison alone was sufficient to clear the Retinal Bleeding and restoration of Exudative Retinal Detachment. Conclusion: Complication of Multiple Myeloma can caused organ disfunction such as retinal bleeding and exudative retinal detachment. Early Diagnosis  is very crucial. In our case combination cemotheraphy with  Melphalan and Prednison showed clinically significant resolution. Workship Internal Department and Ophthalmology Department are very important for management and monitoring ophthalmology manifestation in multiple myeloma.

scholarly journals Resolution of Retinal Bleeding And Exudative Retinal Detachment After Chemotherapy with Melphalan In Multiple Myeloma

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Ari Andayani ◽  
I Putu Budhiastra ◽  
I Wayan Losen Adnyana ◽  
Made Paramita Wijayati
Keyword(s):  
Multiple Myeloma ◽  
Retinal Detachment ◽  
Gamma Globulin ◽  
Plasma Cells ◽  
Exudative Retinal Detachment ◽  
Laboratory Examination ◽  
Ophthalmic Manifestations ◽  
Hematologic Cancer ◽  
Retinal Bleeding ◽  
The Right

Introduction: Multiple myeloma is the second most common hematologic cancer. It is characterized by the clonal proliferation of malignant plasma cells and associated organ dysfunction. Ophthalmic manifestations include hyperviscosity retinopathy and retinal detachment. The aim of this study is to report retinal manifestation in Multiple Myeloma. Methods: A man 45 years old, complained loss of vision on both eyes especially left eye over 1 month. He also feels weakness and 3 times spontaneous nose bleeding. His visual acquity is 6/12 on the right and 2/60 left eye with Retinal Bleeding and Retinal Detachment. His Laboratory examination result increase in WBC 65.91 x 103/µL (Neutrophil, Monocyte, Basophil and Lymphocyte) decrease RBC 3 x 106/µL, HGB 6.85 g/dL, normal PLT 193.60 103/µL, Normal Bleeding and Clotting Time and increase ESR 140 mm/hour. Multiple myeloma was diagnosed by Internal Department with bone marrow biopsy and increase of Gamma Globulin. Results: The patient was treated with melphalan 3 tablet 2 times a day and prednisone 4 mg 3 times a day for 5 days every 28 days.  After 8 month the VA 6/6 on the right and 6/10 on the left with complete resolution of on the right eye and there are resolution on the left eye with fibrosis, the laboratory examination normal WBC 3.8 x 103/µL with Neutrophil 59.3%, Monocyte 6.1 %, Eosinophil 6.3 %, Basophil 0.3 % and Lymphocyte 28.0 %, normal RBC 4.6 x 106/µL, slightly decrease HGB 12.8 g/dL, normal PLT 177.0 x 103/µL and decrease Gamma Globulin. Discussion: This case of bilateral Retinal Bleeding and Exudative Retinal Detachment are remarkable for both its presentation and response to melphalan therapy. Treatment with melphalan and prednison alone was sufficient to clear the Retinal Bleeding and restoration of Exudative Retinal Detachment. Conclusion: Complication of Multiple Myeloma can caused organ disfunction such as retinal bleeding and exudative retinal detachment. Early Diagnosis  is very crucial. In our case combination cemotheraphy with  Melphalan and Prednison showed clinically significant resolution. Workship Internal Department and Ophthalmology Department are very important for management and monitoring ophthalmology manifestation in multiple myeloma.

Pathological Findings of Synchysis Scintillans Secondary to Familial Exudative Vitreoretinopathy With Chronic Exudative Retinal Detachment

2019 ◽  
Vol 4 (2) ◽  
pp. 163-166
Author(s):  
James Lin ◽  
Armando Garcia ◽  
Ying Chen ◽  
Sander Dubovy ◽  
Wendy Lee ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Anterior Chamber ◽  
Vitreous Hemorrhage ◽  
Exudative Retinal Detachment ◽  
Slit Lamp ◽  
Pathological Findings ◽  
Unique Case ◽  
Familial Exudative Vitreoretinopathy ◽  
Pathological Correlation ◽  
History Of

Purpose: We describe a unique case of synchysis scintillans in a 23-year-old woman with a history of chronic exudative retinal detachment in the setting of familial exudative vitreoretinopathy. Methods: Fundus and slit-lamp photographs were obtained at presentation, and pathological studies were performed on the enucleated specimen to confirm the diagnosis. Results: Synchysis scintillans is a degenerative condition of cholesterol deposition that affects severely damaged eyes, often as a result of chronic vitreous hemorrhage or retinal detachment. In this case, synchysis scintillans presented as crystals in the anterior chamber in the setting of a chronic retinal detachment. After enucleation, there were noted to be cholesterol slits on pathological correlation, confirming the diagnosis. Conclusions: This case demonstrates the importance of clinical pathological correlation in the diagnosis of synchysis scintillans migrating into the anterior chamber.

scholarly journals BAP1 tumor predisposition syndrome case report: pathological and clinical aspects of BAP1-inactivated melanocytic tumors (BIMTs), including dermoscopy and confocal microscopy

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Bianca Costa Soares de Sá ◽  
Mariana Petaccia de Macedo ◽  
Giovana Tardin Torrezan ◽  
Juliana Casagrande Tavoloni Braga ◽  
Felipe Fidalgo ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Clinical Aspects ◽  
Cutaneous Lesions ◽  
Case Presentation ◽  
Melanocytic Tumors ◽  
Increased Risk ◽  
Risk Patients ◽  
History Of ◽  
Aggressive Tumors

Abstract Background BRCA1 associated-protein 1 (BAP1) tumor predisposition syndrome is associated with an increased risk for malignant mesotheliomas, uveal and cutaneous melanomas, renal cell carcinomas, and singular cutaneous lesions. The latter are referred to as BAP1-inactivated melanocytic tumors (BIMTs). When multiple BIMTs manifest, they are considered potential markers of germline BAP1 mutations. Case presentation Here, we report a novel pathogenic BAP1 germline variant in a family with a history of BIMTs, cutaneous melanomas, and mesotheliomas. We also describe singular pathological aspects of the patient’s BIMT lesions and their correlation with dermoscopic and reflectance confocal microscopy findings. Conclusions This knowledge is crucial for the recognition of BIMTs by dermatologists and pathologists, allowing the determination of appropriate management for high-risk patients, such as genetic investigations and screening for potentially aggressive tumors.

scholarly journals Exudative Retinal Detachment Treatment in a Patient with Thrombotic Thrombocytopenic Purpura

2016 ◽  
Vol 7 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Magali Sampo ◽  
Gaëlle Ho Wang Yin ◽  
Louis Hoffart ◽  
Danièle Denis ◽  
Vincent Soler ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Rare Complication ◽  
Exudative Retinal Detachment ◽  
Radiological Assessment ◽  
Rapid Improvement ◽  
Thrombocytopenic Purpura ◽  
History Of ◽  
Total Disappearance

Purpose: We report a case of unilateral exudative retinal detachment in a patient with thrombotic thrombocytopenic purpura (TTP), without associated hypertension, successfully treated with plasmapheresis. Case Report: A 46-year-old woman with a medical history of TTP presented with unilateral exudative retinal detachment. Biological and radiological assessment eliminated other causes of exudative retinal detachment, including hypertension. Plasma exchange was performed, followed by a rapid improvement in visual acuity and total disappearance of serous detachment. Conclusion: Exudative unilateral retinal detachment is a rare complication of TTP and can be successfully treated by plasma exchange.

scholarly journals Shallow Anterior Chamber in a Severe Case of Unilateral Acute Central Serous Retinal Detachment

2017 ◽  
Vol 8 (2) ◽  
pp. 326-333 ◽  
Author(s):  
Ahmet Colakoglu ◽  
Banu Cosar
Keyword(s):  
Retinal Detachment ◽  
Anterior Chamber ◽  
Serous Retinal Detachment ◽  
Anterior Chamber Depth ◽  
Severe Case ◽  
Case Presentation ◽  
Eye Pain ◽  
Spectral Domain Oct ◽  
Shallow Anterior Chamber ◽  
Clinically Significant

Background: Atypical serous chorioretinopathy can present with symptoms similar to those of other pachychoroid diseases; however, a proper differential diagnosis will prevent unnecessary intensive treatments. To this end, we report on the shallowness of anterior chamber and transitory anterior vitreous cells in a patient with atypical severe serous retinal detachment. Case Presentation: A 42-year-old woman presented with unilateral visual loss accompanied by mild, vague eye pain for 4 days. Spectral-domain OCT scans of the left eye showed macular and peripapillary serous detachment. Optical biometry showed the clinically significant shallow anterior chamber. Conclusions: Severe central serous chorioretinopathy can show up in an atypical fashion with macular, extramacular, juxtapapillary serous detachments, temporary existence of anterior vitreous cells, clinically detectable decreased anterior chamber depth, and mild eye pain of short duration.

Silicone Oil–Associated Extensive Intraocular Ossification: A case report

2020 ◽  
pp. 112067212092578
Author(s):  
Yinhao Wang ◽  
Wei Cui ◽  
Rongjun Liu ◽  
Yanjie Tian ◽  
Wei Ni ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Silicone Oil ◽  
Deposition Process ◽  
Calcium Deposition ◽  
Histopathological Analysis ◽  
Case Presentation ◽  
Phthisis Bulbi ◽  
Computed Tomography Scanning ◽  
History Of ◽  
Tomography Scanning

Background: Intraocular ossification is an uncommon calcium deposition process associated with trauma, chronic inflammation, tumor, and long-standing retinal detachment. This is the first reported extensive intraocular bone formation associated with silicone oil. Case presentation: A 30-year-old Han Chinese man came to us with complaint of red, painful blind right eye. He had a history of ocular trauma, retinal detachment, and two failed retinal reattachment surgeries with silicone oil left in the eye. On examination, conjunctiva congestion, band keratopathy, silicone oil emulsification, and limbus neovascularization were found. B-scan ultrasound and computed tomography scanning demonstrated retinal detachment and calcification of the eyeball wall. Histopathological analysis indicated ossification overlying the choroid. Evisceration was finally operated to relieve the pain. Conclusion: The retention of silicone oil in the eye probably accelerates the ossification. Timely silicone oil removal and evisceration should be recommended if necessary for phthisis bulbi.

scholarly journals Probable Vogt-Koyanagi-Harada's Syndrome associated with tonic pupils

1970 ◽  
Vol 2 (2) ◽  
pp. 154-156 ◽  
Author(s):  
S Narang ◽  
S Sood
Keyword(s):  
Retinal Detachment ◽  
Fluorescein Angiography ◽  
Exudative Retinal Detachment ◽  
Healthy Male ◽  
Pupillary Reaction ◽  
Incomplete Form ◽  
History Of ◽  
Vkh Disease ◽  
Systemic Associations

Background: Pupillary abnormalities with complete or incomplete form of VKH have rarely been reported. We report a case of "probable" Vogt- Koyanagi-Haradas (VKH) disease associated with tonic pupils. Case: A young healthy male presented with 15 days' history of bilateral decrease in vision. The patient had bilateral panuveitis with exudative retinal detachment associated with tonic pupils. There were no other systemic associations. The ultrasonography and fluorescein angiography findings were consistent with VKH disease. Conclusion: Pupillary reaction abnormalities though uncommon could be seen in association with "probable" VKH disease. Keywords: probable Vogt-Koyanagi-Harada's disease; pupillary abnormalities   DOI: 10.3126/nepjoph.v2i2.3723 Nep J Oph 2010;2(2) 154-156

scholarly journals Legionnaire’s disease presenting as bilateral central scotomata: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sho Yamada ◽  
Takamasa Kitajima ◽  
Satoshi Marumo ◽  
Motonari Fukui
Keyword(s):  
Retinal Detachment ◽  
Legionella Pneumophila ◽  
Subretinal Fluid ◽  
Community Acquired Pneumonia ◽  
Exudative Retinal Detachment ◽  
Case Presentation ◽  
Pulmonary Infiltrates ◽  
Ocular Lesions ◽  
Legionnaire's Disease ◽  
Legionnaire’S Disease

Abstract Background Legionnaire’s disease is one of the major causes of community-acquired pneumonia and is occasionally complicated by neurological symptoms. However, reports of ocular lesions due to Legionnaire’s disease are limited. Case presentation We report the case of a patient with Legionnaire’s disease presenting as bilateral central scotomata due to retinal lesions. The patient consulted due to fever and bilateral central scotomata, as well as other extrapulmonary symptoms. Optical coherence tomography (OCT) showed bilateral accumulations of fluid under the retina, and the patient was diagnosed with bilateral exudative retinal detachment. Later, Legionnaire’s disease was confirmed by pulmonary infiltrates on chest imaging and positive urinary antigen for Legionella pneumophila. After administration of antibiotics, the bilateral central scotomata and bilateral subretinal fluid accumulations completely resolved, as did the other extrapulmonary symptoms and the pulmonary infiltrates. Thus, the bilateral central scotomata due to exudative retinal detachment were thought to be caused by Legionnaire’s disease. Conclusions This case demonstrates that Legionnaire’s disease can present as bilateral central scotomata. We may consider the possibility of extrapulmonary involvement complicating Legionnaire’s disease when we encounter bilateral ocular lesions in patients with fever and pneumonia.

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