PM2.5 exposure on daily cardio-respiratory mortality in Lima, Peru, from 2010 to 2016.

Abstract Background: There have been no studies of air pollution and mortality in Lima, Peru. We evaluate whether daily environmental PM 2.5 exposure is associated to respiratory and cardiovascular mortality in Lima during 2010 to 2016. Methods: We analyzed 86,970 deaths from respiratory and cardiovascular diseases in Lima from 2010-2016. Estimated daily PM 2.5 was assigned based on district of residence. Poisson regression was used to estimate associations between daily district-level PM 2.5 exposures and daily counts of deaths. Results: An increase in 10 µg/m 3 PM 2.5 on the day before was significantly associated with daily all-cause (respiratory and circulatory) mortality (RR 1.029; CI 95% CI: 1.01 – 1.05) across all ages and in the age group over 65 (RR 1.04; 95% CI: 1.005 – 1.09) which included 74% of all deaths. We also observed associations with circulatory deaths for all age groups (RR 1.06; 95% CI: 1.01 – 1.11), and those over 65 (RR 1.06; 95% CI 1.00 - 1.12). A borderline significant trend was seen (RR 1.05; 95% CI 0.99 – 1.06; p = 0.10) for respiratory deaths in persons aged over 65. Trends were driven by the highest quintile of exposure. Conclusions: PM 2.5 exposure is associated with daily all-cause, cardiovascular and respiratory mortality in Lima, especially for older people. Our data suggest that the existing limits on air pollution exposure are too high.

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PM2.5 exposure on daily cardio-respiratory mortality in Lima, Peru, from 2010 to 2016.

10.21203/rs.2.23559/v1 ◽

2020 ◽

Author(s):

Vilma Tapia ◽

Kyle Steenland ◽

Bryan Vu ◽

Yang Liu ◽

Vanessa Vasquez ◽

...

Keyword(s):

Air Pollution ◽

Cardiovascular Diseases ◽

Poisson Regression ◽

Age Groups ◽

Age Group ◽

Respiratory Mortality ◽

Air Pollution Exposure ◽

All Cause Mortality ◽

Pm2.5 Exposure ◽

Pollution Exposure

Abstract Background: There have been no studies of air pollution and mortality in Lima, Peru. We evaluate whether daily environmental PM2.5 exposure is associated to respiratory and cardiovascular mortality in Lima during 2010 to 2016.Methods: We analyzed 86,970 deaths from respiratory and cardiovascular diseases in Lima from 2010-2016. Estimated daily PM2.5 was assigned based on district of residence. Poisson regression was used to estimate associations between daily district-level PM2.5 exposures and daily counts of deaths. Results: An increase in one interquartile range in PM2.5 (6.2 ug/m3) on the day before was significantly associated with daily all-cause mortality (RR 1.018; CI 95%: 1.005 – 1.032) across all ages and in the age group over 65 (RR 1.034; CI 95%: 1.003 – 1.057) which included 74% of all deaths. We also observed associations with circulatory deaths for all age groups (RR 1.037; CI 95%: 1.005 – 1.069), and those over 65 (RR 1.038; IC 95% 1.001 - 1.077). A borderline significant trend was seen (RR 1.029; IC 95% 0.99 – 1.06; p= 0.06) for respiratory deaths in persons aged over 65. Trends were driven by the highest quintile of exposure.Conclusions: PM2.5 exposure is associated with daily all-cause, cardiovascular and respiratory mortality in Lima, especially for older people. Our data suggest that the existing limits on air pollution exposure are too high.

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Long-term air pollution exposure and risk factors for cardiovascular diseases among the elderly in Taiwan

Occupational and Environmental Medicine ◽

10.1136/oem.2009.052704 ◽

2010 ◽

Vol 68 (1) ◽

pp. 64-68 ◽

Cited By ~ 153

Author(s):

K.-J. Chuang ◽

Y.-H. Yan ◽

S.-Y. Chiu ◽

T.-J. Cheng

Keyword(s):

Risk Factors ◽

Air Pollution ◽

Cardiovascular Diseases ◽

The Elderly ◽

Air Pollution Exposure ◽

Pollution Exposure

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Long-term air pollution exposure and cardio- respiratory mortality: a review

Environmental Health ◽

10.1186/1476-069x-12-43 ◽

2013 ◽

Vol 12 (1) ◽

Cited By ~ 840

Author(s):

Gerard Hoek ◽

Ranjini M Krishnan ◽

Rob Beelen ◽

Annette Peters ◽

Bart Ostro ◽

...

Keyword(s):

Air Pollution ◽

Respiratory Mortality ◽

Air Pollution Exposure ◽

Pollution Exposure

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Effectiveness of traffic-related elements in tree bark and pollen abortion rates for assessing air pollution exposure on respiratory mortality rates

Environment International ◽

10.1016/j.envint.2016.09.008 ◽

2017 ◽

Vol 99 ◽

pp. 161-169 ◽

Cited By ~ 8

Author(s):

Regiani Carvalho-Oliveira ◽

Luís F. Amato-Lourenço ◽

Tiana C.L. Moreira ◽

Douglas R. Rocha Silva ◽

Bruna D. Vieira ◽

...

Keyword(s):

Air Pollution ◽

Mortality Rates ◽

Tree Bark ◽

Pollen Abortion ◽

Respiratory Mortality ◽

Air Pollution Exposure ◽

Pollution Exposure

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Monitoring air pollution effects on children for supporting public health policies (MAPEC_LIFE study)

European Journal of Public Health ◽

10.1093/eurpub/ckz187.131 ◽

2019 ◽

Vol 29 (Supplement_4) ◽

Author(s):

E Ceretti ◽

F Donato ◽

D Feretti ◽

A Carducci ◽

M Moretti ◽

...

Keyword(s):

Air Pollution ◽

Air Quality ◽

Poisson Regression ◽

Air Pollutants ◽

Ambient Air ◽

Buccal Cells ◽

Early Effect ◽

Risk Increase ◽

Air Pollution Exposure ◽

Pollution Exposure

Abstract Background Children are at high risk of suffering health consequences of air pollution and childhood exposure can increase the risk of developing chronic diseases in adulthood. The MAPEC_LIFE project, funded by EU Life+ Programme (LIFE12 ENV/IT/000614), aimed to evaluate the association between air pollution exposure and biomarkers of early effect in children and to propose guidance for implementing environmental policies. Methods The study was carried out on 6-8-year-old children. Micronucleus (MN) frequency was investigated in buccal cells of children and its association with air pollution exposure was assessed applying multiple Poisson regression mixed models, including socio-demographic and lifestyle factors as confounders. We also dichotomize air pollutants concentration according to the EU Ambient Air Quality Directives and WHO Air Quality Guidelines in all Poisson regression models to assess their risk predictive capacity. Results The project involved 1149 children providing buccal cells in winter and spring. 2139 biological samples were included in the analysis (1093 collected in winter, 1046 in spring). The analysis of the association between MN frequency and air quality parameters found positive associations for PM10, PM2.5, benzene, SO2 and ozone. Considering EU Directives, an association was found between MN frequency and PM10 exposure higher than the annual limit value, with an increase of the risk of 17.9% (95%CIs: 0.6-38.1%). Considering WHO Guidelines, the exposures to levels of PM10, benzene and BaP higher than the annual limits were associated with MN frequency, with a risk increase of 22.5%, 27.8% and 59.8% (95%CIs: 3.9-44.3%, 3.8-57.3%, 21.0-111.1%), respectively. Conclusions The analyses conducted showed an association between MN frequency in buccal cells of children and levels of some air pollutants, even at concentration below EU and WHO thresholds, which hence seemed to be insufficient for protecting children from this type of damage. Key messages Air pollution exposure induced chromosomal damage in buccal cells of children, even at concentration below the law limits. Early biological damage detected might be predictive of the occurrence of future harmful effects in humans, at a population level.

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