scholarly journals Exploration of candidate serum biomarkers potentially related to the chronic pain condition in Medication Overuse Headache (MOH)

2019 ◽  
Author(s):  
Lanfranco Pellesi ◽  
Elisa Bellei ◽  
Simona Guerzoni ◽  
Maria Michela Cainazzo ◽  
Carlo Baraldi ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Correlation Coefficient ◽  
Trigeminal Nerve ◽  
Chronic Headache ◽  
Medication Overuse ◽  
Medication Overuse Headache ◽  
Serum Levels ◽  
Apolipoprotein A1 ◽  
Serum Concentrations ◽  
Healthy Individuals

Abstract Background Medication Overuse Headache (MOH) is a prevalent and disabling disorder resulting from the overuse of analgesic drugs, triptans or other acute headache medications. In previous proteomic studies, several proteins have been found at high concentrations in the urine of MOH patients and in the serum of rats with neuropathic pain. The aim of this study was to compare the serum levels of lipocalin-type Prostaglandin D2 synthase (L-PGDS), Vitamin D-binding protein (VDBP), apolipoprotein E (APOE) and apolipoprotein A1 (APOA1) in MOH patients and healthy individuals, further exploring their relationship with cutaneous pain thresholds (CPTs) in the territories innervated by the trigeminal nerve. Methods 69 MOH patients and 42 age- and sex-matched healthy volunteers were enrolled in the study. Von Frey-like filaments were applied to the skin territories innervated by the trigeminal nerve, to determine the CPTs. L-PGDS, VDBP, APOE and APOA1 were quantified in the serum by Enzyme-linked Immunosorbent Assay (ELISA). Clinical and laboratory data were collected. Comparisons between MOH patients and healthy individuals were performed using independent t test or χ2 test. To correlate serum proteins with CPTs, Pearson correlation coefficient or Spearman's rank correlation coefficient were used. Results CPTs were lower among MOH patients. L-PGDS, VDBP and APOE had significantly different serum concentrations between groups (p < 0.01), but no correlation was found with CPTs. APOA1 serum concentrations did not differ between patients and healthy individuals. Conclusions L-PGDS, VDBP and APOE had abnormal serum levels in MOH patients, confirming their alteration in some conditions of chronic headache and neuropathic pain. The in-depth study of target proteins represents a promising approach for a better understanding of MOH, as well as the detection of candidate biomarkers for chronic headache or the risks associated with overuse medications.

scholarly journals Exploration of candidate serum biomarkers potentially related to the chronic pain condition in Medication–overuse headache

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Lanfranco Pellesi ◽  
Elisa Bellei ◽  
Simona Guerzoni ◽  
Maria Michela Cainazzo ◽  
Carlo Baraldi ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Correlation Coefficient ◽  
Trigeminal Nerve ◽  
Chronic Headache ◽  
Serum Proteins ◽  
Medication Overuse ◽  
Medication Overuse Headache ◽  
Serum Levels ◽  
Serum Concentrations ◽  
Healthy Individuals

Abstract Background Medication Overuse Headache (MOH) is a prevalent and disabling disorder resulting from the overuse of analgesic drugs, triptans or other acute headache medications. In previous proteomic studies, several proteins have been found at high concentrations in the urine of MOH patients and in the serum of rats with neuropathic pain. The aim of this study was to compare the serum levels of lipocalin-type Prostaglandin D2 synthase (L-PGDS), Vitamin D-binding protein (VDBP), apolipoprotein E (APOE) and apolipoprotein A1 (APOA1) in MOH patients and healthy individuals, further exploring their relationship with cutaneous pain thresholds (CPTs) in the territories innervated by the trigeminal nerve. Methods Sixty-nine MOH patients and 42 age- and sex-matched healthy volunteers were enrolled in the study. Von Frey-like filaments were applied to the skin territories innervated by the trigeminal nerve, to determine the CPTs. L-PGDS, VDBP, APOE and APOA1 were quantified in the serum by Enzyme-linked Immunosorbent Assay (ELISA). Clinical and laboratory data were collected. Comparisons between MOH patients and healthy individuals were performed using independent t test or χ2 test. To correlate serum proteins with CPTs, Pearson correlation coefficient or Spearman’s rank correlation coefficient were used. Results CPTs were lower among MOH patients. L-PGDS, VDBP and APOE had significantly different serum concentrations between groups (p < 0.01), but no correlation was found with CPTs. APOA1 serum concentrations did not differ between patients and healthy individuals. Conclusions L-PGDS, VDBP and APOE had abnormal serum levels in MOH patients, confirming their alteration in some conditions of chronic headache and neuropathic pain. However, they had no relationship with CPTs. The in-depth study of serum proteins represents a promising approach for a better understanding of MOH, as well as the detection of candidate biomarkers for chronic headache or the risks associated with overuse medications.

scholarly journals Exploration of candidate serum biomarkers potentially related to the chronic pain condition in Medication Overuse Headache

2019 ◽  
Author(s):  
Lanfranco Pellesi ◽  
Elisa Bellei ◽  
Simona Guerzoni ◽  
Maria Michela Cainazzo ◽  
Carlo Baraldi ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Correlation Coefficient ◽  
Trigeminal Nerve ◽  
Chronic Headache ◽  
Serum Proteins ◽  
Medication Overuse ◽  
Medication Overuse Headache ◽  
Serum Levels ◽  
Serum Concentrations ◽  
Healthy Individuals

Abstract Background Medication Overuse Headache (MOH) is a prevalent and disabling disorder resulting from the overuse of analgesic drugs, triptans or other acute headache medications. In previous proteomic studies, several proteins have been found at high concentrations in the urine of MOH patients and in the serum of rats with neuropathic pain. The aim of this study was to compare the serum levels of lypocalin-type Prostaglandin D2 synthase (L-PGDS), Vitamin D-binding protein (VDBP), apolipoprotein E (APOE) and apolipoprotein A1 (APOA1) in MOH patients and healthy individuals, further exploring their relationship with cutaneous pain thresholds (CPTs) in the territories innervated by the trigeminal nerve. Methods 69 MOH patients and 42 age- and sex-matched healthy volunteers were enrolled in the study. Von Frey-like filaments were applied to the skin territories innervated by the trigeminal nerve, to determine the CPTs. L-PGDS, VDBP, APOE and APOA1 were quantified in the serum by Enzyme-linked Immunosorbent Assay (ELISA). Clinical and laboratory data were collected. Comparisons between MOH patients and healthy individuals were performed using independent t test or χ2 test. To correlate serum proteins with CPTs, Pearson correlation coefficient or Spearman's rank correlation coefficient were used. Results CPTs were lower among MOH patients. L-PGDS, VDBP and APOE had significantly different serum concentrations between groups (p < 0.01), but no correlation was found with CPTs. APOA1 serum concentrations did not differ between patients and healthy individuals. Conclusions L-PGDS, VDBP and APOE had abnormal serum levels in MOH patients, confirming their alteration in some conditions of chronic headache and neuropathic pain. However, they had no relationship with CPTs. The in-depth study of serum proteins represents a promising approach for a better understanding of MOH, as well as the detection of candidate biomarkers for chronic headache or the risks associated with overuse medications.

Prevalence of Secondary Chronic Headaches in a Population-Based Sample of 30-44-Year-Old Persons. The Akershus Study of Chronic Headache

Cephalalgia ◽  
2008 ◽  
Vol 28 (7) ◽  
pp. 705-713 ◽  
Author(s):  
K Aaseth ◽  
RB Grande ◽  
KJ Kvárner ◽  
P Gulbrandsen ◽  
C Lundqvist ◽  
...  
Keyword(s):  
Chronic Headache ◽  
Response Rate ◽  
Medication Overuse ◽  
Medication Overuse Headache ◽  
Participation Rate ◽  
Population Based ◽  
Cervicogenic Headache ◽  
Questionnaire Response ◽  
Chronic Headaches

We studied secondary chronic headaches (≥ 15 days/month for at least 3 months) in a random sample of 30 000 persons aged 30-44 years. They received a mailed questionnaire. Those with self-reported chronic headache within the last month and/or year were invited to an interview and examination by a neurological resident. The criteria of the International Classification of Headache Disorders (ICHD-II) were applied. The questionnaire response rate was 71%, and the participation rate of the interview was 74%. Of the 633 participants, 298 had a secondary chronic headache. The 1-year prevalence of secondary chronic headache was 2.14%, i.e. chronic posttraumatic headache 0.21%, chronic headache attributed to whiplash injury 0.17%, post-craniotomy headache 0.02%, medication-overuse headache (MOH) 1.72%, cervicogenic headache 0.17%, headache attributed to chronic rhinosinusitis 0.33% and miscellaneous headaches 0.04%. The majority of those with ICHD-II-defined secondary chronic headache had MOH, while about one-third had other secondary headaches often in combination with MOH.

scholarly journals Remission of chronic headache: An 11-year follow-up study. Data from the Nord-Trøndelag Health Surveys 1995–1997 and 2006–2008

Cephalalgia ◽  
2018 ◽  
Vol 38 (14) ◽  
pp. 2026-2034 ◽  
Author(s):  
Knut Hagen ◽  
Espen Saxhaug Kristoffersen ◽  
Bendik Slagvold Winsvold ◽  
Lars Jacob Stovner ◽  
John-Anker Zwart
Keyword(s):  
Cohort Study ◽  
Chronic Headache ◽  
Response Rate ◽  
Medication Overuse ◽  
Medication Overuse Headache ◽  
Population Based ◽  
Study Data ◽  
Health Study ◽  
Musculoskeletal Complaints

Objectives To estimate remission rates of chronic headache and predictors of remission. Methods In this longitudinal population-based cohort study, we used validated headache questionnaire data from the second (1995–1997, baseline; n = 51,856 aged ≥ 20 years, response rate: 55%) and third wave (2006–2008, follow-up, response rate: 42%) of the Nord-Trøndelag Health Study. Chronic headache was defined as ≥15 headache days/month during the last year. Chronic headache remission was defined as headache less than 15 days/month at follow-up. Potential predictors of remission were evaluated using logistic regression. Results At baseline, 1266 (2.4%) participants reported chronic headache. Of these, 605 (48%) answered headache questions at follow-up. Remission was observed in 452 (74.7%), the proportion being almost identical in men and women (74.4% vs. 74.9, p = 0.92). In analyses adjusting for age, gender and education level, remission at follow-up was more than two times more likely among individuals without medication overuse headache (OR = 2.4, 95% CI 1.7–3.6) and without chronic musculoskeletal complaints (OR = 2.9, 95% CI 1.5–5.0) at baseline. Conclusions In this longitudinal population-based cohort study, three-quarters of chronic headache participants remitted from chronic headache. Remission was associated with no medication overuse headache and no chronic musculoskeletal complaints at baseline.

Reduction in medication-overuse headache after short information. The Akershus study of chronic headache

2010 ◽  
Vol 18 (1) ◽  
pp. 129-137 ◽  
Author(s):  
R. B. Grande ◽  
K. Aaseth ◽  
J. Š. Benth ◽  
C. Lundqvist ◽  
M. B. Russell
Keyword(s):  
Chronic Headache ◽  
Medication Overuse ◽  
Medication Overuse Headache

scholarly journals Comparison of the Diagnostic Accuracy of theMSLNGene Products, Mesothelin and Megakaryocyte Potentiating Factor, as Biomarkers for Mesothelioma in Pleural Effusions and Serum

2013 ◽  
Vol 35 ◽  
pp. 119-127 ◽  
Author(s):  
Jenette Creaney ◽  
Sophie Sneddon ◽  
Ian M. Dick ◽  
Hanne Dare ◽  
Neil Boudville ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Serum Levels ◽  
Gene Products ◽  
Serum Concentrations ◽  
Receiver Operator Curve ◽  
Healthy Individuals ◽  
Pleural Effusions ◽  
Significant Difference ◽  
Highly Correlated ◽  
Operator Curve

TheMSLNgene products, soluble mesothelin and megakaryocyte potentiating factor (MPF), are being investigated as biomarkers for the asbestos-related cancer malignant mesothelioma (MM). Pleural fluid biomarkers of MM can be elevated when serum levels remain normal. The aim of this study was to determine if this was true for MPF and to compare levels of mesothelin. Biomarker concentrations were compared in 66 MM patients, 39 patients with other malignancies, 37 with benign disease, 18 asbestos-exposed healthy individuals, and 53 patients with chronic kidney disease. In pleural effusions, MPF and soluble mesothelin concentrations were both significantly elevated in MM patients relative to controls. No significant difference between the area under the receiver operator curve (AUC) for MPF (0.945±0.02) and mesothelin (0.928±0.03) when distinguishing MM from all other causes of effusion was observed. MPF and mesothelin serum concentrations were highly correlated and of equivalent diagnostic accuracy with AUCs of0.813±0.04and0.829±0.03, respectively. Serum levels of both markers increased with decreasing kidney function. In conclusion, MPF is elevated in the pleural effusions of MM patients similar to that of mesothelin. Mesothelin and MPF convey equivalent diagnostic information for distinguishing MM from other diseases in pleural effusions as well as serum.

scholarly journals Medication overuse and drug addiction: a narrative review from addiction perspective

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Tatiane Teru Takahashi ◽  
◽  
Raffaele Ornello ◽  
Giuseppe Quatrosi ◽  
Angelo Torrente ◽  
...  
Keyword(s):  
High Risk ◽  
Drug Addiction ◽  
Chronic Headache ◽  
Medication Overuse ◽  
Medication Overuse Headache ◽  
Medication Use ◽  
Primary Headache ◽  
Point Of View ◽  
Secondary Headache ◽  
Acute Migraine

AbstractChronic headache is particularly prevalent in migraineurs and it can progress to a condition known as medication overuse headache (MOH). MOH is a secondary headache caused by overuse of analgesics or other medications such as triptans to abort acute migraine attacks. The worsening of headache symptoms associated with medication overuse (MO) generally ameliorates following interruption of regular medication use, although the primary headache symptoms remain unaffected. MO patients may also develop certain behaviors such as ritualized drug administration, psychological drug attachment, and withdrawal symptoms that have been suggested to correlate with drug addiction. Although several reviews have been performed on this topic, to the authors best knowledge none of them have examined this topic from the addiction point of view. Therefore, we aimed to identify features in MO and drug addiction that may correlate. We initiate the review by introducing the classes of analgesics and medications that can cause MOH and those with high risk to produce MO. We further compare differences between sensitization resulting from MO and from drug addiction, the neuronal pathways that may be involved, and the genetic susceptibility that may overlap between the two conditions. Finally, ICHD recommendations to treat MOH will be provided herein.

scholarly journals MEDICATION OVERUSE HEADACHE, WHY IT HAPPENED?

2020 ◽  
Vol 5 (1) ◽  
pp. 391
Author(s):  
Restu Susanti
Keyword(s):  
Quality Of Life ◽  
Early Diagnosis ◽  
Chronic Headache ◽  
Medication Overuse ◽  
Medication Overuse Headache ◽  
Secondary Headache ◽  
Headache Attack ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

<p><em>Medication Overuse Headache (MOH) is a secondary headache -- worsening condition of preexisting headache (usually primary hedache). MOH occurs due to medication overuse to relief the pain or to treat the headache attack. The etiology of MOH is the excessive use of </em><em>single and combined analgesics, nonsteroidal anti-inflammatory drugs, caffeine, opioids, ergotamine, triptans and barbiturates. MOH is a chronic headache which need to recognize early. Diagnosis, accurate therapy, and management of comorbidities must be done to improve patient’s productivity and quality of life. </em></p>

scholarly journals The lived experience of chronic headache: a systematic review and synthesis of the qualitative literature

BMJ Open ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. e019929 ◽  
Author(s):  
Vivien P Nichols ◽  
David R Ellard ◽  
Frances E Griffiths ◽  
Atiya Kamal ◽  
Martin Underwood ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lived Experience ◽  
Thematic Analysis ◽  
Chronic Headache ◽  
Medication Overuse ◽  
Medication Overuse Headache ◽  
Headache Disorder ◽  
Headache Disorders ◽  
Chronic Headaches ◽  
Qualitative Literature

ObjectiveTo systematically review the qualitative literature of the lived experience of people with a chronic headache disorder.BackgroundChronic headaches affect 3%–4% of the population. The most common chronic headache disorders are chronic migraine, chronic tension-type headache and medication overuse headache. We present a systematic review and meta-ethnographic synthesis of the lived experience of people with chronic headache.MethodsWe searched seven electronic databases, hand-searched nine journals and used a modified Critical Appraisal Skills Programme checklist to appraise study quality. Following thematic analysis we synthesised the data using a meta-ethnographic approach.ResultsWe identified 3586 unique citations; full texts were examined for 86 studies and 4 were included in the review. Included studies differed in their foci: exploring, patient-centred outcomes, chronic headache as a socially invisible disease, psychological processes mediating impaired quality of life, and the process of medication overuse. Initial thematic analysis and subsequent synthesis gave three overarching themes: ‘headache as a driver of behaviour’ (directly and indirectly), ‘the spectre of headache’ and ‘strained relationships’.ConclusionThis meta-synthesis of published qualitative evidence demonstrates that chronic headaches have a profound effect on people’s lives, showing similarities with other pain conditions. There were insufficient data to explore the similarities and differences between different chronic headache disorders.

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