scholarly journals The clinical significance of interleukin-6, C-reactive protein, and procalcitonin in the early recognition of nosocomial infections in preterm infants

2021 ◽  
Author(s):  
Xuewei Cui ◽  
Yongyan Shi ◽  
Xinyi Zhao ◽  
Xindong Xue ◽  
Jianhua Fu
Keyword(s):  
Preterm Infants ◽  
Interleukin 6 ◽  
Nosocomial Infections ◽  
Early Recognition ◽  
Sepsis Group ◽  
C Reactive Protein ◽  
Clinical Value ◽  
Roc Curve Analysis ◽  
Reactive Protein ◽  
Cutoff Values

Abstract Background: This study assessed the clinical value of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) for early recognition of nosocomial infections in preterm infants.Methods: 120 neonates were finally analyzed, 89 with sepsis were compared with 31 noninfected controls. IL-6, CRP and PCT were measured at certain stages. Receiver-operating characteristic (ROC) curve analysis was used to determine the best cutoff values of IL-6, CRP, and PCT for diagnosing sepsis.Results: In the sepsis group, IL-6 peaked 6 hours after the infection onset and dropped to normal 24–48 hours after the infection was controlled. The best cutoff values of IL-6, CRP, and PCT were >99.6 pg/mL, >9.27 mg/L, and >2.33 ng/mL, respectively. The areas under the ROC curves were 0.888, 0.823, and 0.953, respectively. When PCT was combined with IL-6 or IL-6 and CRP, the sensitivity and specificity were >85%.Conclusion: IL-6, CRP, and PCT are reliable indicators for early diagnosis of nosocomial infections in preterm infants. Combining PCT and IL-6, CRP with IL-6 and PCT levels could improve the accuracy of clinical diagnosis.

scholarly journals The Clinical Significance of Interleukin-6, C-reactive Protein, and Procalcitonin in the Early Recognition of Nosocomial Infections in Preterm Infants

2020 ◽  
Author(s):  
Xuewei Cui ◽  
Yongyan Shi ◽  
Xinyi Zhao ◽  
Xindong Xue ◽  
Jianhua Fu
Keyword(s):  
Preterm Infants ◽  
Interleukin 6 ◽  
Nosocomial Infections ◽  
Early Recognition ◽  
Sepsis Group ◽  
Control Group ◽  
C Reactive Protein ◽  
Roc Curve Analysis ◽  
Reactive Protein ◽  
Cutoff Values

Abstract Background: This study assessed the clinical value of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) for early recognition of nosocomial infections in preterm infants.Methods: 120 neonates were enrolled, 89 with sepsis were compared with 31 noninfected controls. IL-6, CRP and PCT were measured at certain stages of infection. Receiver-operating characteristic (ROC) curve analysis was used to determine the best cutoff values of IL-6, CRP, and PCT for diagnosing sepsis.Results: The levels of IL-6, CRP, and PCT in the sepsis group were significantly higher than those in the control group before antibiotic treatment. In the sepsis group, IL-6 peaked 6 hours after the infection onset and dropped to normal 24–48 hours after the infection was controlled. The best cutoff values of IL-6, CRP, and PCT were >99.6 pg/mL, >9.27 mg/L, and >2.33 ng/mL, respectively. The areas under the ROC curves were 0.888, 0.823, and 0.953, respectively.When PCT was combined with IL-6 or IL-6 and CRP, the sensitivity and specificity were >85%.Conclusion: IL-6, CRP, and PCT are reliable indicators for early diagnosis of nosocomial infections in preterm infants. Combining PCT and IL-6 CRP, IL-6, and PCT levels could improve the accuracy of clinical diagnosis.

Kinetics of procalcitonin, interleukin 6 and C-reactive protein after cardiopulmonary-bypass in children

2003 ◽  
Vol 13 (2) ◽  
pp. 161-167 ◽  
Author(s):  
Maurice Beghetti ◽  
Peter C. Rimensberger ◽  
Afksendiyos Kalangos ◽  
Walid Habre ◽  
Alain Gervaix
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Interleukin 6 ◽  
Early Recognition ◽  
P Value ◽  
Specific Marker ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Valuable Marker ◽  
R Value

Cardiopulmonary bypass induces a generalized inflammatory response, with fever and leukocytes, which is difficult to differentiate from an infection. Recently, procalcitonin has been proposed as an early and specific marker of bacterial infection. The influence of cardiopulmonary bypass on production of procalcitonin, therefore, must be assessed before considering this molecule as a valuable marker of infection after cardiac surgery in children. With this in mind, we measured levels of procalcitonin, interleukin 6, and C-reactive protein before and 6 h, 1, 3 and 5 days after cardiopulmonary bypass, in 25 children undergoing cardiac surgery. Cardiopulmonary-bypass induced a transient increase in procalcitonin, with a peak at 24 h, with a median of 1.13 μg/l, a 25th and 75th interquartile of 0.68–2.25, and a p value of less than 0.001. The value had returned to normal in the majority of the children by the third day after surgery. Peak values correlated with the duration of cardiopulmonary-bypass, with a r-value of 0.58 and a p value of 0.003; cross-clamp time, with a r-value of 0.62 and a p value of 0.001; days of mechanical ventilation, with a r-value of 0.62 and a p value of 0.001; and days of stay in intensive care, with a r-value of 0.68, and a p value of 0.0003. The value returned to normal after 3 days in 83% of the patients. Levels of interleukin 6 and C-reactive protein also increased significantly after surgery, and remained elevated for up to 5 days.Thus, in contrast to other markers, levels of procalcitonin in the serum are only slightly and transiently influenced by cardiopulmonary bypass, and may prove to be useful in the early recognition of an infection subsequent to cardiopulmonary bypass.

Patterns of increases in interleukin-6 and C-reactive protein as predictors for white matter injury in preterm infants

2014 ◽  
Vol 56 (6) ◽  
pp. 851-855 ◽  
Author(s):  
Kei Inomata ◽  
Masami Mizobuchi ◽  
Satoshi Tanaka ◽  
Sota Iwatani ◽  
Hitomi Sakai ◽  
...  
Keyword(s):  
White Matter ◽  
Preterm Infants ◽  
Interleukin 6 ◽  
White Matter Injury ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Evaluation of Procalcitonin, C-Reactive Protein, and Interleukin-6 as Early Markers for Diagnosis of Neonatal Sepsis

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Emad A. Morad ◽  
Rehab A. Rabie ◽  
Mohamed A. Almalky ◽  
Manar G. Gebriel
Keyword(s):  
16S Rdna ◽  
Interleukin 6 ◽  
Neonatal Sepsis ◽  
Neonatal Intensive Care ◽  
Cross Sectional Study ◽  
Sepsis Group ◽  
C Reactive Protein ◽  
University Hospitals ◽  
Cross Sectional ◽  
Reactive Protein

Background. Neonatal sepsis diagnosis is a challenge because of its nonspecific presentation together with low sensitivity of the time-consuming bacterial cultures. So, many sepsis markers, like C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6), are emerging to improve its diagnosis. Aim. This study was done to investigate the role of CRP, PCT, and IL-6 in promoting the early diagnosis of neonatal sepsis in an attempt to decrease morbidity and mortality. Methods. This cross-sectional study was conducted on 50 neonates suspected with sepsis enrolled from the neonatal intensive care unit (NICU) of Zagazig University Hospitals, Egypt. Blood cultures for these neonates were done before starting antibiotics. Also, bacterial DNA was revealed from the blood by broad-range 16S rDNA polymerase chain reaction (PCR). Measurements of CRP using the immunoturbidimetry method, PCT using fluorescence immunoassay quantitative method, and IL-6 using commercially available ELISA kit were done to all enrolled neonates. Results. Forty-one neonates with proved sepsis were found to be positive in blood culture and/or PCR for bacterial 16S rDNA. The most common isolated organisms were Klebsiella (61.3%), followed by E. coli (9.7%) and CONS (9.7%). We detected much significant higher levels of PCT, CRP, and IL-6 in the proved sepsis group than the suspected neonatal sepsis cases (p≤0.001, 0.001, and 0.004, respectively). Serum PCT levels showed the highest sensitivity, specificity, PPV, NPV, and accuracy of 97.6%, 89%, 97%, 88.9%, and 96% than other studied sepsis markers. Conclusion. PCT has satisfactory characteristics as a good marker than IL-6 and CRP for the diagnosis of neonatal sepsis.

scholarly journals Simultaneous Serum Assays of Lipase and Interleukin-6 for Early Diagnosis and Prognosis of Acute Pancreatitis

1999 ◽  
Vol 45 (10) ◽  
pp. 1762-1767 ◽  
Author(s):  
Raffaele Pezzilli ◽  
Antonio Maria Morselli-Labate ◽  
Rita Miniero ◽  
Bahjat Barakat ◽  
Manuela Fiocchi ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Acute Abdomen ◽  
Interleukin 6 ◽  
C Reactive Protein ◽  
Serum Lipase ◽  
Reactive Protein ◽  
Diagnosis And Prognosis ◽  
Cutoff Values ◽  
Combined Use ◽  
Mild Acute Pancreatitis

Abstract Background: There are no systems for the rapid diagnosis and prognosis of acute pancreatitis in the Emergency Department. Our aim was to evaluate whether the combined use of serum lipase and interleukin-6 or serum lipase and C-reactive protein is able to simultaneously establish both the diagnosis and the prognosis of acute pancreatitis. Methods: Eighty patients with acute abdomen were studied on admission to the Emergency Room. Forty patients had nonpancreatic acute abdomen, and 40 had acute pancreatitis (25 had mild acute pancreatitis and 15 had severe pancreatitis). Forty healthy subjects comparable for sex and age were also studied as controls. Lipase, interleukin-6, and C-reactive protein were determined on serum in all subjects. Results: Using lipase to discriminate between patients with nonpancreatic acute abdomen and patients with acute pancreatitis (cutoff values ranging from 419 to 520 U/L), one patient with acute pancreatitis was not identified correctly. To discriminate between patients with severe acute pancreatitis and those with mild pancreatitis in the remaining 39 patients, interleukin-6 (cutoff value, <3.7 μg/L) had a sensitivity of 100% (15 of 15) and a specificity of 83% (20 of 24); 75 of 80 (94%) patients were classified correctly. C-reactive protein (cutoff values ranging from 6 to 7 mg/L) showed a lower prognostic efficiency than interleukin-6: sensitivity of 87% (13 of 15) and specificity of 46% (11 of 24). Sixty-four of 80 patients (80%) were classified correctly. The area under the ROC curve for interleukin-6 (0.911 ± 0.049) was significantly (P = 0.013) greater than that for C-reactive protein (0.685 ± 0.090). Conclusion: The combined use of serum lipase and interleukin-6 is useful in simultaneously establishing both the diagnosis and the prognosis of acute pancreatitis.

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