scholarly journals Transcriptome Analysis of Spleen in Chickens Administered β-glucan Derived From Yeast Cell Wall

Author(s):  
Liting Cao ◽  
Jianrong Zhang ◽  
Yiwen Qu ◽  
Weihao Li ◽  
Yue Ma ◽  
...  

Abstract Background: Our previous study shown that oral administration of a product contained yeast cell wall polysaccharides enhanced immune responses elicited by Newcastle disease virus and changed microbial community of cecum in chickens.Results: The present study was design to investigate the potential molecular mechanism in relation to the immunomodulation of β-glucan in chickens. Using RNA-sequence (RNA-seq) technique, we identified 198 DEGs in spleen in chickens after oral administration of β-glucan. In addition, these DEGs were significantly enriched in 205 GO terms and 7 KEGG pathways. Conclusions: β-glucan might regulate chicken immune system by regulating expression of genes involved in cognition, cytokines, binding, enzyme activities and multiple signaling pathway.

1976 ◽  
Vol 36 (3) ◽  
pp. 471-478 ◽  
Author(s):  
Blanche D. E. Gaillard ◽  
E. J. Van Weerden

1. The digestibility of the cell wall polysaccharides of an alkane-grown yeast in different parts of the digestive tract of two veal calves fitted with re-entrant cannulas at the end of the ileum was studied by replacing part of the skim-milk powder of their ‘normal’, milk-substitute (all-milk-protein) diet by yeast (yeast diet).2. The lactose and glucose of both the all-milk-protein diet and the yeast diet were almost completely digested before the end of the ileum. During this digestion a small amount of oligosaccharides composed of galactose and glucose was synthesized. These oligosaccharides were digested again in the large intestine.3. The constituent sugars of the water-soluble fraction of the yeast cell wall carbohydrates were glucose and mannose. The 0.5 m-sulphuric acid-hydrolysate of the water-insoluble fraction contained glucose and mannose and the 12 m-H2SO4-hydrolysate only glucose.4. Digestibilities of these fractions over the whole gastrointestinal tract ranged from 0.77 to 0.90. Digestibilities measured at the end of the ileum varied considerably between the two animals and averaged only about 0.40.5. These findings suggest that the cell wall polysaccharides of yeast are digested very little by the normal digestive enzymes of the calf's small intestine, but are used as a substrate by the bacterial flora which are mainly concentrated in the large intestine.


Author(s):  
Giulia Maria Pires dos Santos ◽  
Gustavo Ramalho Cardoso dos Santos ◽  
Mariana Ingrid Dutra da Silva Xisto ◽  
Rodrigo Rollin-Pinheiro ◽  
Andréa Regina de Souza Baptista ◽  
...  

2008 ◽  
Vol 56 (24) ◽  
pp. 11854-11861 ◽  
Author(s):  
Rémi Pradelles ◽  
Herve Alexandre ◽  
Anne Ortiz-Julien ◽  
David Chassagne

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