Maternal exposure to life events during pregnancy and congenital heart disease in offspring: a case-control study in a Chinese population

Abstract Background: Previous studies have suggested that maternal stress could increase the risk of some adverse pregnancy outcomes but evidence on congenital heart disease (CHD) is limited. We aimed to explore the association between maternal exposure to life events during pregnancy and CHD in offspring.Methods: The data was based on an unmatched case-control study about CHD conducted in Shaanxi province of China from 2014 to 2016. We included 2280 subjects, 699 in case group and 1581 in control group. The life events were assessed by Life Events Scale for Pregnant Women, and were divided into positive and negative events for synchronous analysis. A directed acyclic graph was drawn to screen the confounders. Logistic regression was employed to estimate odds ratio and 95% confidence interval for the effects of life events on CHD.Results: With confounders adjusted, pregnant women with positive events experienced had 62% lower odds of CHD in offspring than those without (OR =0.38, 95%CI: 0.30~0.48). Those exposed to negative events were 1.64 times odds to have CHD that of those without (OR =1.64, 95%CI: 1.31~2.05). The both effects showed dose-response association. Besides, positive events could weaken the risk impact of negative events on CHD.Conclusion: It may suggest that maternal exposure to negative life events could increase the risk of CHD in offspring, while experiencing positive events could play a potential protective role.

Download Full-text

Maternal exposure to life events during pregnancy and congenital heart disease in offspring: a case-control study in a Chinese population

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-04154-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Jing Li ◽

Yujiao Du ◽

Yini Liu ◽

Jiaoyang Du ◽

Ruo Zhang ◽

...

Keyword(s):

Congenital Heart Disease ◽

Pregnant Women ◽

Life Events ◽

Congenital Heart ◽

Case Control Study ◽

Case Control ◽

Maternal Exposure ◽

Negative Events ◽

Positive Events ◽

Control Study

Abstract Background Previous studies have suggested that maternal stress could increase the risk of some adverse pregnancy outcomes, but evidence on congenital heart disease (CHD) is limited. We aimed to explore the association between maternal exposure to life events during pregnancy and CHD in offspring. Methods The data was based on an unmatched case-control study about CHD conducted in Shaanxi province of China from 2014 to 2016. We included 2280 subjects, 699 in the case group and 1581 in the control group. The cases were infants or fetuses diagnosed with CHD, and the controls were infants without any birth defects. The life events were assessed by the Life Events Scale for Pregnant Women, and were divided into positive and negative events for synchronous analysis. A directed acyclic graph was drawn to screen the confounders. Logistic regression was employed to estimate the odds ratio and 95% confidence interval for the effects of life events on CHD. Results After controlling for the potential confounders, the pregnant women experiencing the positive events during pregnancy had lower risk of CHD in offspring than those without positive events (OR = 0.38, 95%CI: 0.30 ~ 0.48). The risk of CHD in offspring could increase by 62% among the pregnant women experiencing the negative events compared to those without (OR = 1.62, 95%CI: 1.29 ~ 2.03). Both effects showed a certain dose-response association. Besides, the positive events could weaken the risk impact of negative events on CHD. Conclusion It may suggest that maternal exposure to negative life events could increase the risk of CHD in offspring, while experiencing positive events could play a potential protective role.

Download Full-text

Association between maternal exposure to housing renovation and offspring with congenital heart disease: a multi-hospital case–control study

Environmental Health ◽

10.1186/1476-069x-12-25 ◽

2013 ◽

Vol 12 (1) ◽

Cited By ~ 17

Author(s):

Zhen Liu ◽

Xiaohong Li ◽

Nana Li ◽

Shengli Li ◽

Kui Deng ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart ◽

Case Control Study ◽

Case Control ◽

Maternal Exposure ◽

Hospital Case ◽

Control Study

Download Full-text

Risk Factors Associated with Congenital Heart Disease in Patients Presenting to Aljalila Cardiology Clinic between January 2020- May 2020: A Case Control Study

Journal of Cardiology Research Review & Reports ◽

10.47363/jcrrr/2021(3)143 ◽

2021 ◽

pp. 1-6

Author(s):

Samah Alasrawi ◽

◽

Hessa Almansoori ◽

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Heart Disease ◽

Maternal Smoking ◽

Congenital Heart ◽

Case Control Study ◽

Maternal Diabetes ◽

Case Control ◽

Cardiology Clinic ◽

Control Study

Objective: To investigate the association of maternal diabetes, maternal smoking and syndromes with congenital heart disease (CHD) in patients attending Aljalila cardiology clinic between January 2020 and May of 2020. Methods: A case control study to assess the association of maternal diabetes, maternal smoking and syndromes with CHD. All patients that presented to the clinic between January 2020 and May of 2020 were included. An interviewer administered questionnaire was used to record the presence of maternal diabetes, maternal smoking, and the type of syndrome and type of CHD. Patients with CHD were included in the case group and patients who did not have CHD were in the control group. Age, gender, and nationality were also collected from the hospital records. Fisher exact test and logistic regression was used to analyze the results. Results: A total of 177 cases and 211 controls were recruited. All the risk factors increase the risk of CHD, with maternal diabetes (OR 6.3, 95% CI 2.7-14.6) having the strongest association, then syndromes (OR 5.1, 95% CI 2.3-11.3) and lastly maternal smoking (OR 4.0, 95% CI 1.0-16.3). The most common type of CHD is ventricular septal defect. Conclusion: Maternal diabetes, maternal smoking and syndromes are significant risk factors of CHD in children visiting Aljalila cardiology clinic. Action needs to be taken in order to decrease these risk factors and so, decrease the incidence of CHD in the future. Clearly, more research is needed in order to identify other risk factors for patients in the United Arab Emirates (UAE)

Download Full-text

Association of MTHFD Gene Polymorphisms and Maternal Smoking With Risk of Congenital Heart Disease: A Hospital-Based Case-Control Study

10.21203/rs.3.rs-650881/v1 ◽

2021 ◽

Author(s):

Xinli Song ◽

Qiongxuan Li ◽

Jingyi Diao ◽

Jinqi Li ◽

Yihuan Li ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Maternal Smoking ◽

Congenital Heart ◽

Case Control Study ◽

Interaction Effects ◽

Case Control ◽

Tobacco Exposure ◽

Maternal Tobacco Exposure ◽

Control Study

Abstract Background: MTHFD may affect the embryonic development by elevated homocysteine levels, DNA synthesis and DNA methylation, but limited number of genetic variants of MTHFD was focused on the association with congenital heart disease (CHD). This study examined the role of MTHFD and maternal smoking in CHD risk, and investigated their interaction effects in Chinese populations. Methods: A case-control study of 464 mothers of CHD infants and 504 mothers of health controls was performed. The exposures of interest were maternal tobacco exposure, single nucleotide polymorphisms (SNPs) of maternal MTHFD gene. The logistic regression model was used for accessing the strength of association.Results: Mothers exposed to secondhand smoke during three months before pregnancy (adjusted odds ratio [aOR] = 1.56; 95% confidence interval [CI]: 1.13-2.15) and in the first trimester of pregnancy (aOR = 2.24; 95%CI: 1.57-3.20) were observed an increased risk of CHD. Our study also found that polymorphisms of maternal MTHFD gene at rs1950902 (AA vs. GG: aOR = 1.73, 95% CI: 1.01-2.97), rs2236222 (GG vs. AA: aOR = 2.38, 95% CI: 1.38-4.12), rs1256142 (GA vs.GG: aOR = 1.57, 95% CI: 1.01-2.45) and rs11849530 (GG vs. AA: aOR = 1.68, 95% CI: 1.02-2.77) were significantly associated with higher risk of CHD. Furthermore, we found the different degrees of interaction effects between polymorphisms of the MTHFD gene including rs1950902, rs2236222, rs1256142, rs11849530 and rs2236225, and maternal tobacco exposure.Conclusions: Maternal polymorphisms of MTHFD gene at rs1950902, rs2236222, rs1256142 and rs11849530, maternal tobacco exposure and their interactions are significantly increased the risk of CHD in offspring. However, more studies in different ethnic populations with a larger sample and prospective designs are required to confirm our findings.Trial registration: Registration number: ChiCTR1800016635; http://www.chictr.org.cn/edit.aspx?pid=28300&htm=4

Download Full-text