Linear Dose Response of Acrocentric Chromosome Associations (Aca) To Gamma Irradiation In Human Lymphocytes

2021 ◽  
Author(s):  
Ravindra M Samarth ◽  
Puneet Gandhi ◽  
Nabo Kumar Chaudhury
Keyword(s):  
Gamma Irradiation ◽  
Dose Response ◽  
Acrocentric Chromosome ◽  
Linear Trend ◽  
Human Lymphocytes ◽  
Regression Equation ◽  
Dicentric Chromosomes ◽  
Healthy Donors ◽  
Chromosome Associations ◽  
Dose Dependent Increase

Abstract Purpose: The frequency of acrocentric chromosome associations (ACA) was studied to determine the possible dose-response relation with low doses of gamma irradiation in lymphocytes. Methods: Peripheral blood collected from three healthy donors were irradiated with 0, 0.1, 0.25, 0.5, 0.75, and 1 Gy gamma radiation. Chromosomal preparations were made after 48 hrs culture as per the standard guidelines. Results: The average number of ACA and ACA % were increased significantly with an increase in a dose. The D-G and D-D type of association was most prominent and showed a dose-dependent increase. The ACA frequency in irradiated lymphocytes showed an increase concerning the dose. The fitted regression equation was y=0.4759x+0.1663 (R2=0.9635; p=0.0005). An assessment of dicentric chromosomes (DC) was carried for the same slides. The correlation curve was prepared for ACA frequencies versus DC frequencies, resulting in a regression equation as y=8.659x+0.2.37 (R2=0.8275; p=0.0119). Conclusion: Our results showed an increase in frequencies of ACA in irradiated lymphocytes with an increase in radiation dose and followed a similar linear trend with DC frequency, thus, ACA may serve as a candidate cytogenetic biomarker for radiation biodosimetry especially for low radiation doses.

scholarly journals Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Ning Liu ◽  
Yang Peng ◽  
Xinguang Zhong ◽  
Zheng Ma ◽  
Suiping He ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Ionizing Radiation ◽  
Dose Response ◽  
Low Dose ◽  
Linear Trend ◽  
Hematological Parameters ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Spline Models ◽  
Cumulative Radiation Dose

Abstract Background Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. Methods Using a prospective cohort study design, we collected health examination reports and personal dose monitoring data from medical workers and used Poisson regression and restricted cubic spline models to assess the correlation between changing hematological parameters and cumulative radiation dose and determine the dose-response relationship. Results We observed that changing platelet of 1265 medical workers followed up was statistically different among the cumulative dose groups (P = 0.010). Although the linear trend tested was not statistically significant (Ptrend = 0.258), the non-linear trend tested was statistically significant (Pnon-linear = 0.007). Overall, there was a correlation between changing platelets and cumulative radiation dose (a change of βa 0.008 × 109/L during biennially after adjusting for gender, age at baseline, service at baseline, occupation, medical level, and smoking habits; 95% confidence interval [CI] = 0.003,0.014 × 109/L). Moreover, we also found positive first and then negative dose-response relationships between cumulative radiation dose and changing platelets by restricted cubic spline models, while there were negative patterns of the baseline service not less than 10 years (− 0.015 × 109/L, 95% CI = − 0.024, − 0.007 × 109/L) and radiation nurses(− 0.033 × 109/L, 95% CI = − 0.049, − 0.016 × 109/L). Conclusion We concluded that although the exposure dose was below the limit, medical workers exposed to low-dose ionizing radiation for a short period of time might have increased first and then decreased platelets, and there was a dose-response relationship between the cumulative radiation dose and platelets changing.

The Dose Response of Chromosome Aberrations in Human Lymphocytes InducedIn Vitroby Very Low-Dose γ Rays

2011 ◽  
Vol 175 (2) ◽  
pp. 208-213 ◽  
Author(s):  
Toshiyasu Iwasaki ◽  
Yoshio Takashima ◽  
Toshikazu Suzuki ◽  
Mitsuaki A. Yoshida ◽  
Isamu Hayata
Keyword(s):  
Dose Response ◽  
Chromosome Aberrations ◽  
Low Dose ◽  
Human Lymphocytes ◽  
Γ Rays

Micronuclei in human lymphocytes: the Co-60 gamma-ray dose-response

1996 ◽  
Vol 359 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Güler Köksal ◽  
Deniz Öner Dalcí ◽  
Funda Sibel Pala
Keyword(s):  
Dose Response ◽  
Gamma Ray ◽  
Human Lymphocytes

scholarly journals Dose-Response Curve of Chromosome Aberrations in Human Lymphocytes Induced by Gamma-Rays

2014 ◽  
Vol 39 (3) ◽  
pp. 124
Author(s):  
Y. Lusiyanti ◽  
Z. Alatas ◽  
M. Lubis ◽  
V.A. Suvifan ◽  
D. Ramadhani ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Dose Response ◽  
Chromosome Aberrations ◽  
Response Curve ◽  
Human Lymphocytes ◽  
Dose Response Curve

Effects of pulsed ultrasound and ultraviolet radiation on Vitamin E and olive oil

1994 ◽  
Vol 102 ◽  
pp. 265-268
Author(s):  
M. Muzzoli ◽  
M. C. Chicca ◽  
S. Pinamonti
Keyword(s):  
Vitamin E ◽  
Ultraviolet Radiation ◽  
Olive Oil ◽  
Human Lymphocytes ◽  
Dna Unwinding ◽  
Pulsed Ultrasound ◽  
Radical Species ◽  
Fluorescent Analysis ◽  
Healthy Donors

SynopsisThe effects of ultrasound and ultraviolet radiation on Vitamin E and its pharmacological excipient, olive oil, were tested by fluorescent analysis of DNA unwinding (FADU) on DNA extracted from human lymphocytes of healthy donors. The results show that Vitamin E may be inactivated and behave as a radical species, while olive oil appears unaffected by treatment either with ultrasound or with ultraviolet radiation.

scholarly journals Coffee Consumption and Risk of Dementia and Alzheimer’s Disease: A Dose-Response Meta-Analysis of Prospective Studies

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1501 ◽  
Author(s):  
Susanna Larsson ◽  
Nicola Orsini
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Relative Risk ◽  
Confidence Interval ◽  
Dose Response ◽  
Prospective Studies ◽  
Linear Trend ◽  
Meta Analysis ◽  
Coffee Consumption ◽  
Increased Risk

Coffee consumption is associated with a reduced risk of several diseases but uncertainty remains about the influence of coffee consumption on the risk of dementia. We performed a dose-response meta-analysis to summarize the prospective data on coffee consumption and associated risk of dementia and Alzheimer’s disease. We identified studies by searching PubMed (from January 1966) and Web of Science (from January 1945) through 4 October 2018 and by scrutinizing the reference lists of pertinent publications. Two researchers independently reviewed the literature. Results were combined using a restricted cubic spline random-effects dose-response meta-analysis based on a one-stage approach. Eight relevant prospective studies were identified. These studies included 7486 dementia cases diagnosed among 328,885 individuals during an average follow-up of 4.9–25 years. Meta-analysis of all eight studies indicated no statistically significant association between coffee consumption and the risk of dementia and no deviations from a linear trend (p = 0.08). The relative risk of dementia per 1 cup/day increment of coffee consumption was 1.01 (95% confidence interval (CI) 0.98–1.05; p = 0.37). Meta-analysis of five studies that focused on Alzheimer’s disease revealed no association between coffee consumption and Alzheimer’s disease and no deviations from a linear trend (p = 0.79). The relative risk of Alzheimer’s disease per 1 cup/day increment of coffee consumption was 1.01 (95% confidence interval 0.95–1.07; p = 0.80). These results do not support an association between coffee consumption and an increased risk of overall dementia or Alzheimer’s disease specifically, but further research on the association of coffee consumption with dementia risk is needed.

Dose-response of photographic emulsions under gamma irradiation

2006 ◽  
Vol 3 (1) ◽  
pp. 88 ◽  
Author(s):  
Tran Dai Nghiep ◽  
Do Thi Nguyet Minh ◽  
Le Van Minh
Keyword(s):  
Gamma Irradiation ◽  
Dose Response ◽  
Photographic Emulsions
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