No Vitamin D Deficiency in Patients With Parkinson’s Disease

Abstract Previous trials describe a decrease of vitamin D levels in patients with Parkinson’s disease and relationships to clinical disease severity. This case control study found not significant but higher 25-OH-vitamin D plasma levels in patients with Parkinson’s disease patients compared with age and sex matched controls and no associations to clinical parameters, such as rating scores of disease severity or assessments of cognitive function. A certain variability of vitamin D concentration was observed in both cohorts. These outcomes put into perspective the emerging discussion on the importance of vitamin D in patients with Parkinson’s disease. Our results warrant further confirmatory research with a strict matching design of patients and controls, which has not been done in previous investigations. We stress that this case control study does not allow any comment on the putative beneficial effects of vitamin D supplementation, i.e. on bone mass or bone mineral density in patients with Parkinson’s disease.

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Correlation Between 25-hydroxy-Vitamin D and Parkinson's Disease:A Case-Control study

10.21203/rs.3.rs-38762/v1 ◽

2020 ◽

Author(s):

ming xia ◽

wenjuan Xiu ◽

Xuliang Wang ◽

Tingting Wu ◽

Yingying Zheng ◽

...

Keyword(s):

Parkinson’S Disease ◽

Vitamin D ◽

Parkinson's Disease ◽

Vitamin D Deficiency ◽

Case Control Study ◽

Case Control ◽

Lower Serum ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D ◽

Control Study

Abstract Background: Previous cross-sectional studies have shown that Parkinson’s disease (PD) patients have lower serum 25- hydroxy vitamin D (25(OH)D) concentrations than controls. whether the research in other regions findings are generalizable to China populations remains untested in other studies. In this case-control study we examined the Correlation between 25-hydroxy-vitamin D and Parkinson's disease.Methods:We establish an association between deficiency of 25-hydroxy-vitamin D and PD in a case-control study of 100 PD patients and 100 control subjects free of neurologic disease in the First Affliated Hospital of Xinjiang Medical University.Results:Total 25-hydroxy-vitamin D levels, were deficient in 21% of patients with PD compared with 4% of controls. In univariate analyses Plasma levels of 25-hydroxy-vitamin D were associated with PD(p<0.001), respectively. In multivariate analyses, Vitamin D deficiency(25(OH)D <20 ng/mL) were significant associated with PD (p=0.008,OR=17.13,95% CI, 2.082-141.075). Individuals with levels in the lowest quartile of 25(OH)D values had the highest prevalence of PD(p =0.026,OR=11.786,95%CI,1.342-103.51)compared with individuals with values in the highest quartile.Conclusions:Our study reveals an association between 25-hydroxy-vitamin D and PD.Patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls, High-risk PD patients with vitamin D deficiency who have not yet developed exercise impairment, these populations should undergo vitamin D measurement and vitamin D treatment as soon as possible.

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Correlation Between 25-Hydroxy-Vitamin D and Parkinson's Disease: A Case-Control Study

10.21203/rs.3.rs-50643/v1 ◽

2020 ◽

Author(s):

Ming Xia ◽

Wenjuan Xiu ◽

Xuliang Wang ◽

Tingting Wu ◽

Yingying Zheng ◽

...

Keyword(s):

Parkinson’S Disease ◽

Vitamin D ◽

Parkinson's Disease ◽

Vitamin D Deficiency ◽

Case Control Study ◽

Case Control ◽

Lower Serum ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D ◽

Control Study

Abstract Background: Previous cross-sectional studies have shown that Parkinson’s disease (PD) patients have lower serum 25- hydroxy vitamin D (25(OH)D) concentrations than controls. whether the research in other regions findings are generalizable to China populations remains untested in other studies. In this case-control study we examined the Correlation between 25-hydroxy-vitamin D and Parkinson's disease.Methods: We establish an association between deficiency of 25-hydroxy-vitamin D and PD in a case-control study of 100 PD patients and 100 control subjects free of neurologic disease in the First Affliated Hospital of Xinjiang Medical University.Results: Total 25-hydroxy-vitamin D levels, were deficient in 21% of patients with PD compared with 4% of controls. In univariate analyses Plasma levels of 25-hydroxy-vitamin D were associated with PD(p<0.001), respectively. In multivariate analyses, Vitamin D deficiency(25(OH)D <20 ng/mL) were significant associated with PD (p=0.008,OR=17.13,95% CI, 2.082-141.075). Individuals with levels in the lowest quartile of 25(OH)D values had the highest prevalence of PD(p =0.026,OR=11.786,95%CI,1.342-103.51)compared with individuals with values in the highest quartile.Conclusions: Our study reveals an association between 25-hydroxy-vitamin D and PD.Patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls, High-risk PD patients with vitamin D deficiency who have not yet developed exercise impairment, these populations should undergo vitamin D measurement and vitamin D treatment as soon as possible.

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Bone Mineral Density in Hip-Fracture Patients With Parkinson’s Disease: A Case-Control Study

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2006.07.265 ◽

2006 ◽

Vol 87 (11) ◽

pp. 1459-1462 ◽

Cited By ~ 24

Author(s):

Marco Di Monaco ◽

Fulvia Vallero ◽

Roberto Di Monaco ◽

Rosa Tappero ◽

Alberto Cavanna

Keyword(s):

Bone Mineral Density ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Hip Fracture ◽

Bone Mineral ◽

Case Control Study ◽

Case Control ◽

Mineral Density ◽

Control Study

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A case control study on bone mineral density in Chinese patients with Parkinson’s disease

Parkinsonism & Related Disorders ◽

10.1016/j.parkreldis.2010.05.002 ◽

2010 ◽

Vol 16 (7) ◽

pp. 471-474 ◽

Cited By ~ 8

Author(s):

Kuen Lam ◽

Martin Li ◽

Vincent Mok ◽

Andrew Hui ◽

Jean Woo

Keyword(s):

Bone Mineral Density ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Bone Mineral ◽

Case Control Study ◽

Case Control ◽

Chinese Patients ◽

Mineral Density ◽

Control Study

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Lack of association of dairy food, calcium, and vitamin D intake with the risk of Parkinson’s disease: A case-control study in Japan

Parkinsonism & Related Disorders ◽

10.1016/j.parkreldis.2010.11.018 ◽

2011 ◽

Vol 17 (2) ◽

pp. 112-116 ◽

Cited By ~ 28

Author(s):

Y. Miyake ◽

K. Tanaka ◽

W. Fukushima ◽

S. Sasaki ◽

C. Kiyohara ◽

...

Keyword(s):

Parkinson’S Disease ◽

Vitamin D ◽

Parkinson's Disease ◽

Case Control Study ◽

Case Control ◽

Dairy Food ◽

Vitamin D Intake ◽

Control Study

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Study of cognitive impairment and genetic polymorphism of SLC41A1 (rs11240569 allele) in Parkinson’s disease in Upper Egypt: case-control study

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-021-00341-0 ◽

2021 ◽

Vol 57 (1) ◽

Author(s):

Hamdy N. El-Tallawy ◽

Tahia H. Saleem ◽

Wafaa M. Farghaly ◽

Heba Mohamed Saad Eldien ◽

Ashraf Khodaery ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Impairment ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Motor Symptoms ◽

And Control ◽

Non Motor Symptoms ◽

Control Study

Abstract Background Parkinson’s disease is one of the neurodegenerative disorders that is caused by genetic and environmental factors or interaction between them. Solute carrier family 41 member 1 within the PARK16 locus has been reported to be associated with Parkinson’s disease. Cognitive impairment is one of the non-motor symptoms that is considered a challenge in Parkinson’s disease patients. This study aimed to investigate the association of rs11240569 polymorphism; a synonymous coding variant in SLC41A1 in Parkinson’s disease patients in addition to the assessment of cognitive impairment in those patients. Results In a case -control study, rs11240569 single nucleotide polymorphisms in SLC41A1, genes were genotyped in 48 Parkinson’s disease patients and 48 controls. Motor and non-motor performance in Parkinson's disease patients were assessed by using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). The genotype and allele frequencies were compared between the two groups and revealed no significant differences between case and control groups for rs11240569 in SLC41A1 gene with P value .523 and .54, respectively. Cognition was evaluated and showed the mean ± standard deviation (SD) of WAIS score of PD patients 80.4 ± 9.13 and the range was from 61 to 105, in addition to MMSE that showed mean ± SD 21.96 ± 3.8. Conclusion Genetic testing of the present study showed that rs11240569 polymorphism of SLC41A1 gene has no significant differences in distributions of alleles and genotypes between cases and control group, in addition to cognitive impairment that is present in a large proportion of PD patients and in addition to the strong correlation between cognitive impairment and motor and non-motor symptoms progression.

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1.128 Are there multisensory defcits in early Parkinson's disease? A case-control study

Parkinsonism & Related Disorders ◽

10.1016/s1353-8020(08)70399-7 ◽

2007 ◽

Vol 13 ◽

pp. S40-S41

Author(s):

V. Pieri ◽

M. Vaillant ◽

S. Blyth ◽

G. Hipp ◽

N.J. Diederich

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Case Control Study ◽

Case Control ◽

Early Parkinson’S Disease ◽

Control Study

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Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study

Children ◽

10.3390/children8050419 ◽

2021 ◽

Vol 8 (5) ◽

pp. 419

Author(s):

Carmen Muntean ◽

Maria Săsăran

Keyword(s):

Vitamin D ◽

Urinary Tract ◽

Case Control Study ◽

Case Control ◽

Study Group ◽

Recurrent Utis ◽

Vitamin D Levels ◽

Tract Infections ◽

First Time ◽

Control Study

Vitamin D has emerged as a key factor in innate immunity. Its involvement in the pathogenesis of urinary tract infections (UTIs) has gained a lot of attention recently. The objective of this study is to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) levels and first-time or recurrent UTIs in children. A prospective, case-control study was conducted on 101 pediatric patients, who were divided into two groups: 59 patients with UTIs and 42 age-matched healthy controls. Serum 25(OH)D was determined in each child and expressed in ng/mL. Vitamin D presented significantly lower values in study group subjects than in healthy controls (p < 0.01). Moreover, a significantly higher prevalence of vitamin D insufficiency and deficiency was found in children with UTIs (p < 0.01). Patients with recurrent UTIs presented significantly lower levels of vitamin D than those with first-time UTIs (p = 0.04). Urinary tract abnormalities did not seem to exercise an additional effect upon vitamin D levels within the study group. In conclusion, first-time and recurrent UTIs are associated with lower vitamin D levels. Further studies are necessary to validate our findings, as well as future longitudinal research regarding efficacy of vitamin D supplementation in children with UTIs.

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