scholarly journals Correlation Between 25-Hydroxy-Vitamin D and Parkinson's Disease: A Case-Control Study

2020 ◽  
Author(s):  
Ming Xia ◽  
Wenjuan Xiu ◽  
Xuliang Wang ◽  
Tingting Wu ◽  
Yingying Zheng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Vitamin D ◽  
Parkinson's Disease ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Case Control ◽  
Lower Serum ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Control Study

Abstract Background: Previous cross-sectional studies have shown that Parkinson’s disease (PD) patients have lower serum 25- hydroxy vitamin D (25(OH)D) concentrations than controls. whether the research in other regions findings are generalizable to China populations remains untested in other studies. In this case-control study we examined the Correlation between 25-hydroxy-vitamin D and Parkinson's disease.Methods: We establish an association between deficiency of 25-hydroxy-vitamin D and PD in a case-control study of 100 PD patients and 100 control subjects free of neurologic disease in the First Affliated Hospital of Xinjiang Medical University.Results: Total 25-hydroxy-vitamin D levels, were deficient in 21% of patients with PD compared with 4% of controls. In univariate analyses Plasma levels of 25-hydroxy-vitamin D were associated with PD(p<0.001), respectively. In multivariate analyses, Vitamin D deficiency(25(OH)D <20 ng/mL) were significant associated with PD (p=0.008,OR=17.13,95% CI, 2.082-141.075). Individuals with levels in the lowest quartile of 25(OH)D values had the highest prevalence of PD(p =0.026,OR=11.786,95%CI,1.342-103.51)compared with individuals with values in the highest quartile.Conclusions: Our study reveals an association between 25-hydroxy-vitamin D and PD.Patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls, High-risk PD patients with vitamin D deficiency who have not yet developed exercise impairment, these populations should undergo vitamin D measurement and vitamin D treatment as soon as possible.

scholarly journals Correlation Between 25-hydroxy-Vitamin D and Parkinson's Disease:A Case-Control study

2020 ◽  
Author(s):  
ming xia ◽  
wenjuan Xiu ◽  
Xuliang Wang ◽  
Tingting Wu ◽  
Yingying Zheng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Vitamin D ◽  
Parkinson's Disease ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Case Control ◽  
Lower Serum ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Control Study

Abstract Background: Previous cross-sectional studies have shown that Parkinson’s disease (PD) patients have lower serum 25- hydroxy vitamin D (25(OH)D) concentrations than controls. whether the research in other regions findings are generalizable to China populations remains untested in other studies. In this case-control study we examined the Correlation between 25-hydroxy-vitamin D and Parkinson's disease.Methods:We establish an association between deficiency of 25-hydroxy-vitamin D and PD in a case-control study of 100 PD patients and 100 control subjects free of neurologic disease in the First Affliated Hospital of Xinjiang Medical University.Results:Total 25-hydroxy-vitamin D levels, were deficient in 21% of patients with PD compared with 4% of controls. In univariate analyses Plasma levels of 25-hydroxy-vitamin D were associated with PD(p<0.001), respectively. In multivariate analyses, Vitamin D deficiency(25(OH)D <20 ng/mL) were significant associated with PD (p=0.008,OR=17.13,95% CI, 2.082-141.075). Individuals with levels in the lowest quartile of 25(OH)D values had the highest prevalence of PD(p =0.026,OR=11.786,95%CI,1.342-103.51)compared with individuals with values in the highest quartile.Conclusions:Our study reveals an association between 25-hydroxy-vitamin D and PD.Patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls, High-risk PD patients with vitamin D deficiency who have not yet developed exercise impairment, these populations should undergo vitamin D measurement and vitamin D treatment as soon as possible.

scholarly journals No Vitamin D Deficiency in Patients With Parkinson’s Disease

2021 ◽  
Author(s):  
Wilfried Kuhn ◽  
Georg Karp ◽  
Thomas Müller
Keyword(s):  
Parkinson’S Disease ◽  
Vitamin D ◽  
Parkinson's Disease ◽  
Disease Severity ◽  
Case Control Study ◽  
Case Control ◽  
Vitamin D Supplementation ◽  
Mineral Density ◽  
Vitamin D Levels ◽  
Control Study

Abstract Previous trials describe a decrease of vitamin D levels in patients with Parkinson’s disease and relationships to clinical disease severity. This case control study found not significant but higher 25-OH-vitamin D plasma levels in patients with Parkinson’s disease patients compared with age and sex matched controls and no associations to clinical parameters, such as rating scores of disease severity or assessments of cognitive function. A certain variability of vitamin D concentration was observed in both cohorts. These outcomes put into perspective the emerging discussion on the importance of vitamin D in patients with Parkinson’s disease. Our results warrant further confirmatory research with a strict matching design of patients and controls, which has not been done in previous investigations. We stress that this case control study does not allow any comment on the putative beneficial effects of vitamin D supplementation, i.e. on bone mass or bone mineral density in patients with Parkinson’s disease.

scholarly journals Association of vitamin D levels with simple febrile seizures in under five children: a case control study

2019 ◽  
Vol 6 (2) ◽  
pp. 365
Author(s):  
Virender Singh ◽  
Preeti Sharma ◽  
Deepika Dewan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Febrile Seizure ◽  
Case Control Study ◽  
Febrile Seizures ◽  
Case Control ◽  
First Episode ◽  
Age Group ◽  
Vitamin D Levels ◽  
Control Study

Background: There is increasing concern that vitamin D deficiency may play etiological role in Febrile seizures. Few studies have reported vitamin D deficiency in children with recurrent febrile seizures and hypocalcemia seizures.  The objective of this study is to explore vitamin D status in children aged 6 months to 5 years with first episode of febrile seizure and to find the association between vitamin D levels and febrile seizure.Methods: A hospital-based case control study was conducted in sub district hospital, Katra over a period of three years. Cases were children of age group 6 months to 5 years presenting with first episode of simple febrile seizure to the casualty or OPD. For each case, a control was selected with similar age group and same sex who came for short duration fever (<2 days) but without seizures. A 5ml of blood sample for measurement of 25 hydroxy vitamin D was taken from the peripheral vein of each participant by trained laboratory technician. In order to categorise various degrees of vitamin D deficiency, Indian Academy of paediatrics criteria was used. Results were presented in the form of percentages and Odds ratio was calculated as measure of association.Results: A total of 75 cases and 75 controls were included in the study. Cases and controls were comparable as per baseline characteristics. Strong and significant (p<0.01) association of febrile seizures with vit D levels was observed.Conclusions: There was a high prevalence of vitamin D insufficiency among cases of simple febrile seizure.

scholarly journals THE POSSIBLE LINK BETWEEN VITAMIN D LEVELS AND RESTLESS LEG SYNDROME: A HOSPITAL-BASED CASE-CONTROL STUDY FROM KASHMIR, INDIA

2021 ◽  
Vol 9 (5) ◽  
pp. 1362-1367
Author(s):  
Rehana Amin ◽  
◽  
Seema Batool ◽  
Yuman Kawoos ◽  
Masood Maqbool ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Case Control ◽  
Nervous System Development ◽  
Control Group ◽  
P Value ◽  
Restless Leg Syndrome ◽  
Vitamin D Levels ◽  
Control Study

Background & Objectives: Various pathophysiological mechanisms and risk factors have been identified in patients with restless leg syndrome and there exist other factors also that are yet to be identified and are under-researched. Evidence suggests a possible link between Vitamin D deficiency and Restless leg syndrome.The aim was to study the Vitamin D levels in patients diagnosed with RLS and to find a correlation between Vitamin D and RLS. Methods: This was a case-control study carried out in the outpatient department of the Institute of Mental Health and Neurosciences Kashmir.A total of 144 subjects were enrolled in the study. Fifty-one were diagnosed cases of RLS and 93 were healthy controls.The Vitamin D levels were analysed by the chemiluminescent immunoassay method in both cases as well as controls.The descriptive statistics were used for various socio-demographic and clinical variables.The data were analysed by chi-square test, t-test and multivariate logistic regression analysis. Results: The vitamin D levels were significantly low in the RLS group in comparison to the control group. There was a significant correlation between vitamin D levels, vitamin D deficiency and restless leg syndrome (OR= 1.01, p-value 0.005 and OR= 5.40, p-value <0.0001 respectively). Interpretation &conclusions: Vitamin D levels were low in patients with RLS. This signifies vitamin D may have some role in the pathophysiology of RLS.Vitamin D regulates the nervous system development and function therefore, its use can be considered in the management of RLS when other modalities cannot prove as a promising agent.

scholarly journals Vitamin D deficiency is associated with higher hospitalisation risk from COVID-19: a retrospective case-control study

2021 ◽  
Author(s):  
Edward B Jude ◽  
Stephanie F Ling ◽  
Rebecca Allcock ◽  
Beverly X Y Yeap ◽  
Joseph M Pappachan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Case Control ◽  
Normal Serum ◽  
Retrospective Case ◽  
Median Serum ◽  
Hospitalised Patients ◽  
Vitamin D Levels ◽  
Control Study

Abstract CONTEXT One of the risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is postulated to be vitamin D deficiency. To understand better the role of vitamin D deficiency in the disease course of COVID-19, we undertook a retrospective case-control study in the North West of England (NWE). OBJECTIVE To examine whether hospitalisation with COVID-19 is more prevalent in individuals with lower vitamin D levels. METHODS The study included individuals with results of serum 25-hydroxyvitamin D (25[OH]D) between 1 st April 2020 and 29th January 2021. Patients were recruited from two districts in NWE. The last 25(OH)D level in the previous 12 months was categorised as ‘deficient’ if less than 25 nmol/L and ‘insufficient’ if 25-50 nmol/L. RESULTS 80,670 participants were entered into the study. Of these, 1,808 were admitted to hospital with COVID-19, of whom 670 died. In a primary cohort, median serum 25(OH)D in participants who were not hospitalised with COVID-19 was 50.0 [interquartile range, IQR 34.0-66.7] nmol/L versus 35.0 [IQR 21.0-57.0] nmol/L in those admitted with COVID-19 (p &lt;0.005). There were similar findings in a validation cohort (median serum 25(OH)D 47.1 [IQR 31.8-64.7] nmol/L in non-hospitalised versus 33.0 [IQR 19.4-54.1] nmol/L in hospitalised patients). Age-, sex- and seasonal variation-adjusted odds ratios for hospital admission were 2.3-2.4 times higher among participants with serum 25(OH)D &lt;50 nmol/L, compared to those with normal serum 25(OH)D levels, without any excess mortality risk. CONCLUSIONS Vitamin D deficiency is associated with higher risk of COVID-19 hospitalisation. Widespread measurement of serum 25(OH)D and treating any unmasked insufficiency or deficiency through testing may reduce this risk.

scholarly journals Vitamin D Deficiency and Depression in Obese Adults: A Case- Control Study 

2021 ◽  
Author(s):  
Leila Kamalzadeh ◽  
Atefeh Ghanbari Jolfaei ◽  
Malihe Saghafi
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Serum Vitamin ◽  
Case Control ◽  
Control Groups ◽  
Obese Adults ◽  
Vitamin D Levels ◽  
And Control ◽  
Control Study

Abstract Background: Depression is one of the most prevalent psychiatric disorders reported in obese population. Amongst the contributing factors of depression, vitamin D deficiency has increasingly drawn attention in recent years. This paper seeks to examine the association between serum vitamin D level and depression in patients with obesity.Methods: This case-control study included 173 depressed obese patients and 174 non-depressed controls. Structured Clinical Interview for DSM-5 (SCID-5) was used to confirm the diagnosis of depression. 25-Hydroxyvitamin D [25(OH)D], Thyroid stimulating hormone (TSH), fasting blood sugar (FBS), parathyroid hormone (PTH) levels, and BMI were assessed in both groups. The statistical analyses included T-test, Chi-squared test, and multivariable logistic regression.Results: The mean 25(OH)D levels were significantly different between the case and control groups (20.43 ± 15.37 vs. 26.55 ± 13.17, P < .001). Vitamin D insufficiency/deficiency was detected in 77.6% and 67.4% of the case and control groups, respectively, which was significantly different (P = .034). Being female, greater age and lower vitamin D levels were associated with greater odds of developing depression (OR = 3.57, 95% CI = 1.82-7.02; OR = 1.05, 95% CI = 1.02-1.07; OR = 1.51, 95%CI = 1.16-1.96, respectively).Conclusion: The present study provides additional evidence with respect to the hypothesis that low vitamin D serum concentration is associated with depression in obese adults, and highlights the need for further research to determine whether this association is causal.

Role of Vitamin-D Deficiency in Term Neonates with Late-Onset Sepsis: A Case–Control Study

2019 ◽  
Vol 65 (6) ◽  
pp. 609-616 ◽  
Author(s):  
Amit Agrawal ◽  
Aekta Gupta ◽  
Jyotsna Shrivastava
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Late Onset ◽  
Tertiary Care ◽  
Case Control ◽  
Term Neonates ◽  
Late Onset Sepsis ◽  
Vitamin D Levels ◽  
Control Study

Abstract Objective To find the relationship between vitamin-D levels and late-onset sepsis (LOS) in term neonates. Methods This case–control study was conducted in neonatal intensive care unit of a tertiary care teaching institution in central India. Full-term neonates with culture-proven LOS were taken as cases. Maternal and neonatal demography, clinical examination and investigations were recorded. Correlation of vitamin-D deficiency (<20 ng/ml) with LOS was assessed. Results Total 225 term neonates including 175 cases and 50 controls were included. Maternal and neonatal demographic profile was comparable. The mean vitamin-D level in cases (12.28 ± 6.11 ng/ml) was significantly lower than that in controls (14.88 ± 7.2 ng/ml) (p = 0.002). Total 151 (86.29%) neonates out of 175 cases and 37 (74%) out of 50 controls had the vitamin-D deficiency (p = 0.00003). On multiple regression analysis, neonatal sepsis (p = 0.00003) was found to be significantly associated with vitamin-D deficiency. Conclusion This study shows that vitamin-D deficiency in term neonates may predispose them to LOS.

scholarly journals Preeclampsia at delivery is associated with lower serum vitamin D and higher antiangiogenic factors: a case control study

2022 ◽  
Vol 20 (1) ◽  
Author(s):  
David B. Seifer ◽  
Geralyn Lambert-Messerlian ◽  
Glenn E. Palomaki ◽  
Robert M. Silver ◽  
Corette Parker ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Serum Vitamin ◽  
Case Control ◽  
Maternal Serum ◽  
Research Network ◽  
Lower Serum ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Control Study

Abstract Background Preeclampsia is characterized by decreased trophoblastic angiogenesis leading to abnormal invasion of spiral arteries, shallow implantation and resulting in compromised placentation with poor uteroplacental perfusion. Vitamin D plays an important role in pregnancy influencing implantation, angiogenesis and placental development. The objective of this study was to determine whether there is an association between serum vitamin D levels, and anti-angiogenic factors at the time of delivery and the occurrence of preeclampsia. Methods This nested case control study analyzed frozen serum samples at the time of delivery and related clinical data from women with singleton liveborn pregnancies who had participated in studies of the NICHD Stillbirth Collaborative Research Network. Women with a recorded finding of preeclampsia and who had received magnesium sulfate treatment prior to delivery were considered index cases (N = 56). Women without a finding of preeclampsia were controls (N = 341). Results Women with preeclampsia had 14.5% lower serum vitamin D levels than women in the control group (16.5 ng/ml vs. 19 ng/ml, p = 0.014) with 64.5% higher sFlt-1 levels (11,600 pg/ml vs. 7050 pg/ml, p < 0.001) and greater than 2 times higher endoglin levels (18.6 ng/ml vs. 8.7 ng/ml, < 0.001). After controlling for gestational age at delivery and maternal BMI, vitamin D levels were 0.88 times lower (P = 0.051), while endoglin levels were 2.5 times higher and sFlt-1 levels were 2.1 times higher than in control pregnancies (P < 0.001). Conclusions Women with preeclampsia at time of delivery have higher maternal antiangiogenetic factors and may have lower maternal serum vitamin D levels. These findings may lead to a better understanding of the underlying etiology of preeclampsia as well as possible modifiable treatment options which could include assuring adequate levels of maternal serum vitamin D prior to pregnancy.

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