scholarly journals Epidemiological Trends of Urinary Tract Infections at the Global, Regional, and National Levels from 1990-2017: A Population-Based Study

2021 ◽  
Author(s):  
Cong Zhu ◽  
Qiao Huang ◽  
Li-Sha Luo ◽  
Tong Deng ◽  
Jia-Min Gu ◽  
...  
Keyword(s):  
Urinary Tract ◽  
United Arab Emirates ◽  
Urinary Tract Infections ◽  
Population Based ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Incidence And Mortality ◽  
Disease Study ◽  
Tract Infections ◽  
Incident Cases

Abstract BackgroundUrinary tract infections (UTIs) are some of the most common infections worldwide and consume a lot of medical resources every year. However, there were a lack of available data on its incidence and disease burden. We armed to investigate incidence, mortality, and disability adjusted life-years (DALYs) of urinary tract infections (UTIs) from 1990 to 2017.MethodsWe extracted data from the Global Burden of Disease Study 2017, then calculated estimated annual percentage changes (EAPC) of age-standardized incidence rate (ASIR), age-standardized death rate (ASDR), and age-standardized DALYs rate at global, national, regional, and socio-demographic index (SDI) level.ResultsFrom 1990 to 2017, the globally incident cases (+52.09%), death cases (+140.10%), and DALYs (+69.65%) of UTIs all increased. The ASIR, ASDR, and age-standardized DALYs rate showed upward trends with the EAPC of +0.10 (95%CI: 0.07 to 0.12), +0.72 (95%CI: 0.65-0.78), and +0.06 (95%CI: -0.05 to 0.16), respectively. The ASIR decreased only in the high-middle SDI quantile (-0.26, 95%CI: -0.3 to -0.23). United Arab Emirates had the largest increase of DALYs (+835.04%), but Bulgaria had the largest decrease (-80.74%). EAPC for incidence and mortality were below 0 mainly in Europe and East Asia. In 2017, the incident cases (+3.44 times), the deaths (+1.31 times), and DALYs (+1.21 times) were all higher in females than males. The incident cases were mainly concentrated in 15-49 years old; DALYs and mortality were higher in over 80 age groups.ConclusionsGlobally, the burden of UTIs increased from 1990 to 2017, especially in females; however, distinct varies were observed in different regions and countries. The infants and elders are easier to die when they suffer from UTIs.

scholarly journals Epidemiological Trends of Urinary Tract Infections, Urolithiasis and Benign Prostatic Hyperplasia in 204 Countries and Territories From 1990 to 2019

2021 ◽  
Author(s):  
Cong Zhu ◽  
Dan-Qi Wang ◽  
Hao Zi ◽  
Qiao Huang ◽  
Jia-Min Gu ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Benign Prostatic Hyperplasia ◽  
Urinary Tract Infections ◽  
Disease Burden ◽  
Prostatic Hyperplasia ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Tract Infections ◽  
Epidemiological Characteristics ◽  
Incident Cases

Abstract BackgroundTo investigate the disease burden of urinary tract infections (UTI), urolithiasis, and benign prostatic hyperplasia (BPH) in 204 countries and territories from 1990 to 2019.MethodsData were extracted from the Global Burden of Disease 2019, including incident cases, deaths, disability-adjusted life-years (DALYs) and corresponding age-standardized rate (ASR) from 1990 to 2019. Estimated annual percentage changes (EAPC) were calculated to evaluate the trends of ASR. The associations between disease burden and social development degrees were analyzed by socio-demographic index (SDI).ResultsCompared with 1990, the incident cases of UTI, urolithiasis, and BPH increased by 60.40%, 48.57%, and 105.70% in 2019, respectively. The age-standardized incidence rate (ASIR) of UTI increased (EAPC = 0.08), while urolithiasis (EAPC = -0.83) and BPH (EAPC = -0.03) decreased from 1990 to 2019. In 2019, the age-standardized mortality rate (ASMR) of UTI and urolithiasis was 3.13/100,000 and 0.17/100,000, respectively. BPH had the largest increase (110.56%) in DALYs in past three decades, followed by UTI (68.89%) and urolithiasis (16.95%). The burden of UTI mainly concentrated in South Asia and Tropical Latin America while the burden of urolithiasis and BPH was recorded in Asia and Eastern Europe. Moreover, the ASIR and SDI of urolithiasis in high SDI regions from 1990 to 2019 were negatively correlated, while the opposite trend was in low SDI regions. In 2019, the ASIR of UTI in female was 3.59 times that of male, while the ASIR of urolithiasis in male was 1.96 times higher than female. The incidence was highest in 30-34, 55-59, and 65-69 age group among UTI, urolithiasis, and BPH, respectively. ConclusionsOver the past three decades, the disease burden remains increased in UTI, while decreased in urolithiasis and BPH. The allocation of medical resources should be more based on the epidemiological characteristics and geographical distribution of diseases.

scholarly journals Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Cong Zhu ◽  
Dan-Qi Wang ◽  
Hao Zi ◽  
Qiao Huang ◽  
Jia-Min Gu ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Benign Prostatic Hyperplasia ◽  
Urinary Tract Infections ◽  
Disease Burden ◽  
Prostatic Hyperplasia ◽  
The Past ◽  
Life Years ◽  
Tract Infections ◽  
Epidemiological Characteristics ◽  
Incident Cases

Abstract Background Urinary tract infections (UTI), urolithiasis, and benign prostatic hyperplasia (BPH) are three of the most common nonmalignant conditions in urology. However, there is still a lack of comprehensive and updated epidemiological data. This study aimed to investigate the disease burden of UTI, urolithiasis, and BPH in 203 countries and territories from 1990 to 2019. Methods Data were extracted from the Global Burden of Disease 2019, including incident cases, deaths, disability-adjusted life-years (DALYs) and corresponding age-standardized rate (ASR) from 1990 to 2019. Estimated annual percentage changes (EAPC) were calculated to evaluate the trends of ASR. The associations between disease burden and social development degrees were analyzed using a sociodemographic index (SDI). Results Compared with 1990, the incident cases of UTI, urolithiasis, and BPH increased by 60.40%, 48.57%, and 105.70% in 2019, respectively. The age-standardized incidence rate (ASIR) of UTI increased (EAPC = 0.08), while urolithiasis (EAPC = − 0.83) and BPH (EAPC = − 0.03) decreased from 1990 to 2019. In 2019, the age-standardized mortality rate (ASMR) of UTI and urolithiasis were 3.13/100,000 and 0.17/100,000, respectively. BPH had the largest increase (110.56%) in DALYs in the past three decades, followed by UTI (68.89%) and urolithiasis (16.95%). The burden of UTI was mainly concentrated in South Asia and Tropical Latin America, while the burden of urolithiasis and BPH was recorded in Asia and Eastern Europe. Moreover, the ASIR and SDI of urolithiasis in high-SDI regions from 1990 to 2019 were negatively correlated, while the opposite trend was seen in low-SDI regions. In 2019, the ASIR of UTI in females was 3.59 times that of males, while the ASIR of urolithiasis in males was 1.96 times higher than that in females. The incidence was highest in the 30–34, 55–59, and 65–69 age groups among the UTI, urolithiasis, and BPH groups, respectively. Conclusion Over the past three decades, the disease burden has increased for UTI but decreased for urolithiasis and BPH. The allocation of medical resources should be based more on the epidemiological characteristics and geographical distribution of diseases.

scholarly journals The global, regional, and national burden of acute pancreatitis in 204 countries and territories, 1990–2019

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chang-li Li ◽  
Meng Jiang ◽  
Chun-qiu Pan ◽  
Jian Li ◽  
Li-gang Xu
Keyword(s):  
Acute Pancreatitis ◽  
Gastrointestinal Disease ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Global Age ◽  
National Burden ◽  
Geographically Targeted ◽  
Disease Study ◽  
Incident Cases ◽  
Standardized Mortality Rate

Abstract Background Acute pancreatitis is a common and potentially lethal gastrointestinal disease, but literatures for the disease burden are scarce for many countries. Understanding the current burden of acute pancreatitis and the different trends across various countries is essential for formulating effective preventive intervenes. We aimed to report the incidence, mortality, and disability-adjusted life-years (DALYs) caused by acute pancreatitis in 204 countries and territories between 1990 and 2019. Methods Estimates from the Global Burden of Disease Study 2019 (GBD 2019) were used to analyze the epidemiology of acute pancreatitis at the global, regional, and national levels. We also reported the correlation between development status and acute pancreatitis’ age-standardized DALY rates, and calculated DALYs attributable to alcohol etiology that had evidence of causation with acute pancreatitis. All of the estimates were shown as counts and age-standardized rates per 100,000 person-years. Results There were 2,814,972.3 (95% UI 2,414,361.3–3,293,591.8) incident cases of acute pancreatitis occurred in 2019 globally; 1,273,955.2 (1,098,304.6–1,478,594.1) in women and 1,541,017.1 (1,307,264.4–1,814,454.3) in men. The global age-standardized incidence rate declined from 37.9/100,000 to 34.8/100,000 during 1990–2019, an annual decrease of 8.4% (5.9–10.4%). In 2019, there were 115,053.2 (104,304.4–128,173.4) deaths and 3,641,105.7 (3,282,952.5–4,026,948.1) DALYs due to acute pancreatitis. The global age-standardized mortality rate decreased by 17.2% (6.6–27.1%) annually from 1.7/100,000 in 1990 to 1.4/100,000 in 2019; over the same period, the age-standardized DALY rate declined by 17.6% (7.8–27.0%) annually. There were substantial differences in the incidence, mortality and DALYs across regions. Alcohol etiology attributed to a sizable fraction of acute pancreatitis-related deaths, especially in the high and high-middle SDI regions. Conclusion Substantial variation existed in the burden of acute pancreatitis worldwide, and the overall burden remains high with aging population. Geographically targeted considerations are needed to tailor future intervenes to relieve the burden of acute pancreatitis in specific countries, especially for Eastern Europe.

Community-onset Urinary Tract Infections: A Population-based Assessment

Infection ◽  
2007 ◽  
Vol 35 (3) ◽  
pp. 150-153 ◽  
Author(s):  
K. B. Laupland ◽  
T. Ross ◽  
J. D. D. Pitout ◽  
D. L. Church ◽  
D. B. Gregson
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Population Based ◽  
Tract Infections ◽  
Community Onset

scholarly journals 1485Trends and attributable burden of raised low-density lipoprotein cholesterol in South Africa

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Ian Neethling ◽  
Nasheeta Peer ◽  
Annibale Cois ◽  
Beatrice Nojilana ◽  
Rosana Pacella ◽  
...  
Keyword(s):  
South Africa ◽  
Burden Of Disease ◽  
Disease Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Population Based ◽  
Relative Risks ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Disease Study

Abstract Background LDL-C is a key contributor to cardiovascular disease (CVD), but the exact attributable disease risk in South Africa is not known. This study aimed to quantify the burden of disease attributable to LDL-C in South Africa for 2000, 2006 and 2012. Methods National mean LDL-C estimates were derived from 14 observational studies using a meta-regression model. LDL-C estimates together with relative risks from the Global Burden of Disease Study 2017 were used to calculate a potential impact fraction (PIF) and applied to IHD and ischaemic stroke estimates to calculate attributable deaths and disability-adjusted life years (DALYs). Uncertainty analysis was performed using Monte Carlo simulation. Results LDL-C declined between 2000 and 2012 in males (2.74 mmol/L to 2.58 mmol) and females (3.05 mmol/L to 2.91 mmol/L). Attributable DALYs increased between 2000 (N = 286 712) and 2006 (N = 315 125) but decreased thereafter in 2012 (N = 270 829). Attributable age-standardised death rates declined between 2000 and 2012 in males (98 per 100 000 to 78 per 100 000) and females (81 per 100 000 to 58 per 100 000). Conclusions The decreasing trend in the age-standardised attributable burden due to LDL-C can be lowered further with the introduction of additional population-based CVD prevention strategies. Key messages This study highlights that high LDL-C in South Africa is responsible for a large proportion of the emerging CVD and should be targeted by health planners to reduce disease burden.

A Trade-off Analysis of Routine Newborn Circumcision

PEDIATRICS ◽  
2000 ◽  
Vol 105 (Supplement_2) ◽  
pp. 246-249
Author(s):  
Dimitri A. Christakis ◽  
Eric Harvey ◽  
Danielle M. Zerr ◽  
Chris Feudtner ◽  
Jeffrey A. Wright ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Penile Cancer ◽  
International Classification Of Diseases ◽  
Population Based ◽  
Complication Rates ◽  
Safe Procedure ◽  
Trade Offs ◽  
Classification Of Diseases ◽  
Tract Infections

Background. The risks associated with newborn circumcision have not been as extensively evaluated as the benefits. Objectives. The goals of this study were threefold: 1) to derive a population-based complication rate for newborn circumcision; 2) to calculate the number needed to harm for newborn circumcision based on this rate; and 3) to establish trade-offs based on our complication rates and published estimates of the benefits of circumcision including the prevention of urinary tract infections and penile cancer. Methods. Using the Comprehensive Hospital Abstract Reporting System for Washington State, we retrospectively examined routine newborn circumcisions performed over 9 years (1987–1996). We used International Classification of Diseases, Ninth Revision codes to identify both circumcisions and complications and limited our analyses to children without other surgical procedures performed during their initial birth hospitalization. Results. Of 354 297 male infants born during the study period, 130 475 (37%) were circumcised during their newborn stay. Overall 287 (.2%) of circumcised children and 33 (.01%) of uncircumcised children had complications potentially associated with circumcision coded as a discharge diagnosis. Based on our findings, a complication can be expected in 1 out every 476 circumcisions. Six urinary tract infections can be prevented for every complication endured and almost 2 complications can be expected for every case of penile cancer prevented. Conclusions. Circumcision remains a relatively safe procedure. However, for some parents, the risks we report may outweigh the potential benefits. This information may help parents seeking guidance to make an informed decision.

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