scholarly journals Extra Pulmonary Drug Resistant Tuberculosis Patients Were Less Likely to Lost From Follow-up: a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Assefa Andargie ◽  
Asressie Molla ◽  
Fentaw Tadese ◽  
Segenet Zewdie
Keyword(s):  
Meta Analysis ◽  
Anatomical Site ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
Pooled Prevalence ◽  
Extra Pulmonary ◽  
Lost To Follow Up

Abstract Background: Lost to follow-up is one of the causes of the development of acquired drug resistant tuberculosis. There is a gap in nationally representative information on lost to follow-up among patients with drug-resistant tuberculosis in Ethiopia. Therefore, the objective of this study was to estimate the pooled prevalence and associated factors of lost to follow-up among patients with multi-drug resistant tuberculosis in Ethiopia.Methods: Observational studies searched from PubMed, HINARI and CINAHL were screened for eligibility. After assessing the quality of studies, data were extracted using a checklist. The forest plot, Q-statistics and I2 were used to assess heterogeneity. We employed the random effects meta-analysis model to estimate the pooled prevalence and effects. The sources of heterogeneity were investigated using sub-group analysis and meta regression. Funnel plot with Egger’s and Begg’s tests were employed to detect publication bias. Results: The review was performed among 11 studies of which 9 were cohort studies. The sample sizes ranged from 90 to 612 and comprised a total of 3,510 participants. The pooled prevalence of lost to follow-up was 8.66% (95% CI, 5.01-13.14) with a high heterogeneity (I2=93.49%, p<0.001). Pulmonary drug resistant tuberculosis patients were 50% less likely to loss from follow-up compared to extra pulmonary tuberculosis patients (OR= 0.50, 95% CI 0.27, 0.96). Conclusion: The prevalence of lost to follow-up among drug resistant tuberculosis patients in Ethiopia was substantial. Anatomical site of tuberculosis had a significant effect on lost to follow-up. Strengthening the health care system and patient education should be given a due emphasis.

scholarly journals Lost to follow-up and associated factors among patients with drug resistant tuberculosis in Ethiopia: A systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248687
Author(s):  
Assefa Andargie ◽  
Asressie Molla ◽  
Fentaw Tadese ◽  
Segenet Zewdie
Keyword(s):  
Associated Factors ◽  
Meta Analysis ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
Multi Drug Resistant Tuberculosis ◽  
Pooled Prevalence ◽  
Lost To Follow Up

Background One third of global antmicrobial resistance deaths are attributed to drug resistant tuberculosis. Lost to follow-up is one of the causes of the development of acquired drug resistant tuberculosis. There is a gap in nationally representative reliable information on lost to follow-up among patients with drug-resistant tuberculosis in Ethiopia. Objective To estimate the pooled prevalence and associated factors of lost to follow-up among patients with drug resistant tuberculosis in Ethiopia. Methods Observational studies searched from PubMed, HINARI and CINAHL were screened for eligibility. After assessing the quality of studies, data were extracted using a checklist. Heterogeneity was assessed using forest plot, Q and I2. The random effects meta-analysis model was employed to pull the prevalence of lost to follow-up. Sub-group analysis and meta regression were performed to identify the sources of heterogeneity. Publication bias was assessed using funnel plots with Egger’s and Begg’s tests. Sensitivity analysis was performed to assess the influence of individual studies on the overall estimate. The odds ratios were used to measure associations. Results The review was performed among 11 studies of which 9 were cohort studies. The sample sizes ranged from 90 to 612 and comprised a total of 3,510 participants. The pooled prevalence of lost to follow-up was 8.66% (95% CI, 5.01–13.14) with a high heterogeneity (I2 = 93.49%, p<0.001). Pulmonary multi-drug resistant tuberculosis patients were 50% less likely to loss from follow-up compared to extra pulmonary tuberculosis patients. Conclusion There was a high prevalence of lost to follow-up among multi-drug resistant tuberculosis patients in Ethiopia. Anatomical site of tuberculosis was a significant factor affecting lost to follow-up. Strengthening the health care system and patient education should be given a due emphasis. Registration number CRD42020153326; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=153326.

scholarly journals Time to death and its predictors among adult with drug-resistance tuberculosis patients, in Eastern and East-Central Ethiopia, 2012-2018: A retrospective cohort study

2019 ◽  
Author(s):  
Tsige Gebre ◽  
Mulatu Ayana Hordofa ◽  
Molla Yigzaw Birhanu ◽  
Melkamu Siferih ◽  
Cheru Tesema Leshargie
Keyword(s):  
Weight Loss ◽  
Survival Time ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
East Central ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
History Of ◽  
Extra Pulmonary

Abstract Background Drug-resistant tuberculosis (DRTB) is becoming a global public health problem in developing country including Ethiopia. It poses a greater challenge to the tuberculosis control program. Tuberculosis drugs namely; rifampicin and isoniazid, were the two most effective anti-tuberculosis drugs for which the agent become resistant. Understanding the survival time and the predictors of DRTB patients would be helpful to policy-makers and health practitioners in Ethiopia. However, there is a limited previous study on the aspect. Therefore, this study aimed to estimate the survival time and predictors of adult DRTB patients, in Eastern and East-Central Ethiopia.Methods A retrospective follow-up study was conducted in the Eastern and East-Central part of Ethiopia among adult drug resistance-tuberculosis patients from 1st September 2012 to 30th August 2017. The checklist was used to retrieve information among a total of 362 drug-resistant tuberculosis patients. Kaplan Meier curve method was used to estimate the median survival time with its interquartile range and risks. Multivariable Cox proportional regression modelling was used to investigating predictors of survival time. Hazard ratio with 95% CI was used to report the findings of regression modelling.Result A total of 362 participants were followed for 132,801 person day observation. During the follow-up period, there were 55 deaths with the overall incidence rate of 4 participants per 10,000-person day observation (95%CI: 3.18, 5.39). DRTB related death was higher among patients who had weight loss (AHRa: 9.0, 95%CI:2, 20.5), pulmonary with extra-pulmonary DRTB (AHR:10, 95% CI:3.3, 16), HIV co-infection (AHR:4, 95%CI:2.1,7.5) and comorbidity (AHR:4.40, 95% CI:1.7, 11), patients with BMI<18.5 (AHR:0.22, 95% CI:0.076, 0.63) were less likely to die of MDR-TB. BMI<18.5 patients with a history of relapse (AHR: 4.2, 95% CI: 1.9, 9) and after the failure of re-treatment (AHR: 6.3, 95%CI: 2.6, 13) were predictors of DRTB death.Conclusion To summarize, the survival time of patients with drug-resistant tuberculosis was low. DRTB related death was higher among patients with weight loss, people with extra-pulmonary, HIV co-infection, comorbidity, and history of relapse.

scholarly journals Is One Sputum Specimen as Good as Two during Follow-Up Cultures for Monitoring Multi Drug Resistant Tuberculosis Patients in India?

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45554 ◽  
Author(s):  
Sharath Burugina Nagaraja ◽  
Ajay M. V. Kumar ◽  
Kuldeep Singh Sachdeva ◽  
Ranjani Ramachandran ◽  
Srinath Satyanarayana ◽  
...  
Keyword(s):  
Drug Resistant ◽  
Sputum Specimen ◽  
Drug Resistant Tuberculosis ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
Multi Drug Resistant Tuberculosis

scholarly journals Prevalence of Drug-Resistant Tuberculosis in Sudan: A Systematic Review and Meta-Analysis

Antibiotics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 932
Author(s):  
Khalid Hajissa ◽  
Mahfuza Marzan ◽  
Mubarak Ibrahim Idriss ◽  
Md Asiful Islam
Keyword(s):  
Systematic Review ◽  
Drug Resistance ◽  
Meta Analysis ◽  
Treatment Strategies ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Tb Control ◽  
Resistant Tuberculosis ◽  
Pooled Prevalence ◽  
Critical Issues

Drug-resistant tuberculosis (DR-TB) is still one of the most critical issues impeding worldwide TB control efforts. The aim of this systematic review and meta-analysis was to give an updated picture of the prevalence of DR-TB in Sudan. A comprehensive systematic search was performed on four electronic databases (PubMed, Scopus, Web of Science and Google Scholar) to identify all published studies reporting prevalence data of DR-TB in Sudan. Sixteen eligible studies published during 2002–2020 were included. Using meta-analysis of proportions, the pooled prevalence of TB cases with resistance to any anti-TB drugs was 47.0% (95% CI: 35.5–58.6%). The overall prevalence of mono, multi, poly and extensive drug resistance were estimated to be 16.2% (95% CI: 9.0–23.4%), 22.8% (95% CI: 16.0–29.7%), 6.8% (95% CI: 0.5–13.0%) and 0.7% (95% CI: 0–2.1%), respectively. Considering any first-line anti-TB drugs, the resistance prevalence was highest for isoniazid (32.3%) and streptomycin (31.7%), followed by rifampicin (29.2%). In contrast, resistance against second-line drugs was reported for only two antibiotics, namely, ofloxacin (2.1%) and kanamycin (0.7%). Of note, the resistance profile of the previously treated patients was found to be remarkably high compared with the newly diagnosed TB patients. The relatively high prevalence estimation of anti-TB drug resistance warrants strengthening TB control and treatment strategies in Sudan.

scholarly journals Prevalence of rifampicin resistant mycobacterium tuberculosis and associated factors among presumptive tuberculosis patients in eastern Uttar Pradesh: a cross sectional study

2018 ◽  
Vol 5 (6) ◽  
pp. 2271 ◽  
Author(s):  
Praveen B. Gautam ◽  
Ashwini Mishra ◽  
Santosh Kumar
Keyword(s):  
Cross Sectional Study ◽  
Rifampicin Resistance ◽  
Drug Resistant ◽  
Sectional Study ◽  
Cross Sectional ◽  
Drug Resistant Tuberculosis ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
Previously Treated ◽  
Extra Pulmonary

Background: Drug resistant tuberculosis threatens global TB control and is a major public health problem in several countries and India has the highest tuberculosis in the world. The rifampicin resistance is a good predictor of multidrug resistant tuberculosis. The aim of this study was to determine the prevalence of rifampicin resistance M. tuberculosis and associated factor among presumptive tuberculosis patients in eastern Uttar Pradesh.Methods: A cross-sectional study was conducted from October 2016 to September 2017. Detection of M. tuberculosis and resistance to rifampicin was performed using Gene Xpert MTB/RIF assay. Data was collected using pre-structured questionnaire by face to face interview. The chi-square test was used to assess the statistical significance of each ratio, p<0.05 was considered significant.Results: Out of 510 patients, Mycobacterium tuberculosis was detected in 168 (32.9%). Out of these 168 patients, the prevalence of rifampicin resistance tuberculosis was 44 (26.1%). It was higher among male 38 (30.6%) than female 6 (13.6%). Regarding age distribution, maximum numbers of rifampicin resistance patients were in the age group of 20-40 years 36.7%. The prevalence of rifampicin resistance was 36 (27.6%) and 8 (21.0%) in pulmonary and extra-pulmonary respectively. Out of 44 rifampicin resistant cases, 39 (37.8%) were previously treated and 5 (7.6%) cases were treatment naïve patients. In this study, among presumptive DRTB cases, new 2 (11.7%), relapse 13 (39.3%), failure 23 (46.0%), loss to follow-up 1 (10.0%) and MDR contact 1 (20.0%) respectively were rifampicin resistant and one HIV seropositive patient was found to be rifampicin resistant.Conclusions: Previously treated cases were significantly associated with rifampicin resistance tuberculosis. The Gene Xpert is a good equipment for rapid detection and management of drug resistant tuberculosis for both pulmonary as well as extra-pulmonary tuberculosis.

scholarly journals Drug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: A systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258295
Author(s):  
Getu Diriba ◽  
Habteyes Hailu Tola ◽  
Ayinalem Alemu ◽  
Bazezew Yenew ◽  
Dinka Fikadu Gamtesa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Drug Resistance ◽  
Meta Analysis ◽  
Extrapulmonary Tuberculosis ◽  
Multidrug Resistant ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis

Background Drug-resistant tuberculosis and extrapulmonary tuberculosis are the world major public health issues. Although some primary studies have been reported on the burden of drug-resistant tuberculosis in extrapulmonary tuberculosis patients in Ethiopia, there is no systematic review and meta-analysis that attempt to summarize the available literature. Thus, we aimed to estimates the prevalence of drug-resistance in extrapulmonary tuberculosis patients and summarize the risk factors associated with the occurrence of extrapulmonary tuberculosis in Ethiopia. Methods We conducted a systematic review of the published primary studies on extrapulmonary drug-resistant tuberculosis in Ethiopia. Results Eight observational studies were included in this review from different regions of Ethiopia. The overall pooled prevalence of rifampicin resistance was 6% (95% CI 0.03–0.10), while isoniazid resistance was 7% (95% CI 0.03–0.12). The pooled prevalence of multidrug-resistant tuberculosis was 4% (95% CI 0.01–0.07). Previous tuberculosis treatment history and male gender are frequently reported risk factors for developing drug-resistant tuberculosis in extrapulmonary tuberculosis patients. Conclusion The current review has identified a high proportion of resistance to rifampicin, isoniazid, and multidrug-resistant tuberculosis in patients with extrapulmonary tuberculosis in Ethiopia. Clinicians should request drug susceptibility testing for all patients with presumptive extrapulmonary tuberculosis to detect drug-resistance.

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