scholarly journals The Prediction of Maternal Serum Alpha Fetoprotein Level and Fetal Nuchal Translucency, Forcases Involving Preterm Prelabor Rupture of Membranes

2021 ◽  
Author(s):  
Yiming Chen ◽  
Yijie Chen ◽  
Lei Chen ◽  
Wenwen Ning ◽  
Xiaoying Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Binary Logistic Regression ◽  
Nuchal Translucency ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Second Trimester Screening ◽  
Significant Difference ◽  
Serum Alpha Fetoprotein ◽  
Prelabor Rupture Of Membranes

Abstract Objective: To investigate whether the values of maternal serum alpha-fetoprotein (AFP) and fetal nuchal translucency (NT) during the first and second trimesters can predict preterm prelabor rupture of membranes (PPROM). Methods: This retrospective case-control study analyzed the first and second trimester screening indicators and maternal outcomes of gravidas who were divided into the Non-PPROM group (594) and the PPROM group (591). Binary logistic regression analysis was used to calculate the OR and 95% CI. ROC and AUC were used for screening performance of AFP and NT. Results: The values of NT and AFP in the PPROM group were higher than the control group and the difference was statistically significant (all P<0.05). There was no significant difference with respect to PAPP-A, free-β hCG, and the calculated risk of trisomy 18 (all P>0.05). Binary logistic regression showed that NT and AFP MoM were risk factors for PPROM, with ORs of 1.719 and 3.549, respectively. The AUC according to the ROC for NT, AFP MoM and maternal weight in the first trimester +NT+AFP were 0.552, 0.618 and 0.630. Conclusions: NT and AFP during the first and second trimesters were identified as risk factors for PPROM and valuable markers to predict PPROM in late pregnancy. Multi-index joint prediction was more effective.

scholarly journals The association of lipoprotein(a) and intraplaque neovascularization in patients with carotid stenosis: a retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shuang Xia ◽  
Weida Qiu ◽  
Anping Cai ◽  
Bo Kong ◽  
Lan Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Carotid Stenosis ◽  
Density Lipoprotein ◽  
Binary Logistic Regression ◽  
Plasma Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Comorbid Conditions ◽  
Lipoprotein A ◽  
Significant Difference

Abstract Background Lipoprotein(a) is genetically determined and increasingly recognized as a major risk factor for arteriosclerotic cardiovascular disease. We examined whether plasma lipoprotein(a) concentrations were associated with intraplaque neovascularization (IPN) grade in patients with carotid stenosis and in terms of increasing plaque susceptibility to haemorrhage and rupture. Methods We included 85 patients diagnosed with carotid stenosis as confirmed using carotid ultrasound who were treated at Guangdong General Hospital. Baseline data, including demographics, comorbid conditions and carotid ultrasonography, were recorded. The IPN grade was determined using contrast-enhanced ultrasound through the movement of the microbubbles. Univariate and multivariate binary logistic regression analyses were used to evaluate the association between lipoprotein(a) and IPN grade, with stepwise adjustment for covariates including age, sex, comorbid conditions and statin therapy (model 1), total cholesterol, triglyceride, low-density lipoprotein cholesterol calculated by Friedwald's formula, high-density lipoprotein cholesterol, apolipoprotein A and apolipoprotein B (model 2), maximum plaque thickness and total carotid maximum plaque thickness, degree of carotid stenosis and internal carotid artery (ICA) occlusion (model 3). Results Lipoprotein(a) was a significant predictor of higher IPN grade in binary logistic regression before adjusting for other risk factors (odds ratio [OR] 1.238, 95% confidence interval [CI] (1.020, 1.503), P = 0.031). After adjusting for other risk factors, lipoprotein(a) still remained statistically significant in predicting IPN grade in all model. (Model 1: OR 1.333, 95% CI 1.074, 1.655, P = 0.009; Model 2: OR 1.321, 95% CI 1.059, 1.648, P = 0.014; Model 3: OR 1.305, 95% CI 1.045, 1.628, P = 0.019). Lp(a) ≥ 300 mg/L is also significantly related to IPN compare to < 300 mg/L (OR 2.828, 95% CI 1.055, 7.580, P = 0.039) as well as in model 1, while in model 2 and model 3 there are not significant difference. Conclusions Plasma lipoprotein(a) concentrations were found to be independently associated with higher IPN grade in patients with carotid stenosis. Lowering plasma lipoprotein(a) levels may result in plaque stabilization by avoiding IPN formation.

Very Low Second-Trimester Maternal Serum Alpha-fetoprotein

2002 ◽  
Vol 99 (4) ◽  
pp. 531-536 ◽  
Author(s):  
Ahmet A. Baschat ◽  
Chris R. Harman ◽  
Gehan Farid ◽  
Bernard N. Chodirker ◽  
Jane A. Evans
Keyword(s):  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Second Trimester ◽  
Serum Alpha Fetoprotein

MATERNAL SERUM ALPHA-FETOPROTEIN IN DIABETIC PREGNANCY: CORRELATION WITH BLOOD GLUCOSE CONTROL

The Lancet ◽  
1987 ◽  
Vol 330 (8553) ◽  
pp. 275 ◽  
Author(s):  
E.Albert Reece ◽  
Nicole Davis ◽  
MauriceJ. Mahoney ◽  
Alexander Baumgarten
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Blood Glucose Control ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Diabetic Pregnancy ◽  
Serum Alpha Fetoprotein

Use of neutrophil/lymphocyte ratio as a marker in patients with suspicious diaphragmatic attenuation artifact

2021 ◽  
Vol 8 (12) ◽  
pp. 706-710
Author(s):  
Kemal Göçer ◽  
Ahmet Çağrı Aykan ◽  
Bayram Öztürk ◽  
Alihan Erdoğan
Keyword(s):  
Risk Factors ◽  
Binary Logistic Regression ◽  
Myocardial Perfusion Spect ◽  
Binary Logistic Regression Analysis ◽  
Inferior Wall ◽  
Roc Curve Analysis ◽  
Neutrophil Lymphocyte Ratio ◽  
Significant Difference ◽  
Attenuation Artifact ◽  
Artery Disease

Objective: This study aimed to evaluate whether neutrophil/lymphocyte (N/L) ratio assists in the diagnosis of coronary artery disease (CAD) in patients with suspected diaphragmatic attenuation artifact (DAA) on myocardial perfusion SPECT (MP-SPECT). Material and Methods: A total of 255 patients undergoing coronary angiography between 2015-2020 due to unclear DAA of the inferior wall on MP-SPECT were included in this retrospective study. Patients were divided into two groups (CAD and non-CAD) according to angiographic images. Significant CAD was defined as ≥50% stenosis of coronary arteries feeding the inferior wall. White blood cell count, biochemical parameters, and risk factors for CAD were compared between the two groups. Results: There was no statistically significant difference between the two groups in terms of age (p = 0.055), gender (p = 0.482), and body mass index (p = 0.305). N/L ratio (OR = 1.397 p = 0.002 95% Cl = 1.128-1.732) and left ventricle ejection fraction (OR = 0.896 p = 0.023 95% Cl = 0.815-0.985) were independent risk factors for CAD in multivariate binary logistic regression analysis. Receiver Operating Characteristic (ROC) curve analysis showed that a cut-off value of ≥2 for N/L ratio predicted the presence of CAD (sensitivity=63.5%, specificity=60.7%, AUC=0.668, 95% CI=0.596 – 0.740, p<0.001). Conclusion: N/L ratio is a simple and accessible test and may increase the diagnostic accuracy of MP-SPECT for CAD in patients with suspicious diaphragmatic attenuation on MP-SPECT.

scholarly journals Horse-related incidents and factors for predicting injuries to the head

2018 ◽  
Vol 4 (1) ◽  
pp. e000398 ◽  
Author(s):  
Lauren Meredith ◽  
Robert Ekman ◽  
Robert Thomson
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Head Injury ◽  
Soft Tissue ◽  
Head Injuries ◽  
Binary Logistic Regression ◽  
Soft Tissue Injuries ◽  
Dental Services ◽  
Incident Type ◽  
Local Healthcare

ObjectivesHead injuries are the leading cause of death in horse-related injury events and, even since the introduction of helmets, represent a sizeable proportion of all horse-related injuries. Falls from horseback and kicks to the head are the most frequent type of incident causing head injuries, but it is unknown whether these incidents are predictors of head injury. This study aimed to investigate head injuries and the association between incident type and head injury.MethodRetrospective review of 7815 horse-related injury events was conducted. Data were gathered from hospitals, local healthcare centres and public dental services in Skaraborg, Sweden. Binary logistic regression was used to analyse the association between the incident type and occurrence of head injury while controlling for risk factors.ResultsApproximately 20% of riders sustained a head injury, mostly soft tissue injuries (56.3%) and concussions (33.4%). A fall from or with the horse was the primary cause of head injury (63.9%). Those who fell from a carriage or other height or who were injured through contact with the horse had no difference in the likelihood of head injury when compared with those that fell from or with the horse. However, those who sustained an injury without any horse contact had lower odd of head injury (OR: 0.640, p<0.00005, 95% CI 0.497 to 0.734). Additionally, the older the rider, the lower the odds of head injury (OR=0.989, p<0.00005, 95% CI 0.985 to 0.993).ConclusionImproved protection for those suffering falls from horseback as well as those who are kicked in the head should be investigated.

CORRECTION FORMULA FOR MATERNAL SERUM ALPHA-FETOPROTEIN

The Lancet ◽  
1984 ◽  
Vol 324 (8406) ◽  
pp. 812 ◽  
Author(s):  
A.Myron Johnson ◽  
Lauren Lingley
Keyword(s):  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Correction Formula ◽  
Serum Alpha Fetoprotein
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