Assessment of left atrial function in feline hypertrophic cardiomyopathy by using two- dimensional speckle tracking echocardiography

Left Atrial ◽

Speckle Tracking ◽

Longitudinal Strain ◽

Mean Value ◽

Control Group ◽

P Value ◽

Two Dimensional ◽

The Difference

Abstract Background : Left atrial (LA) function plays an important role in diastolic dysfunction in cats with hypertrophic cardiomyopathy (HCM). Two-dimensional speckle tracking echocardiography (2D-STE) is a novel technique for assessing LA function. This study aimedto evaluate changes in the LA function inHCM cats compared to normal cats, using 2D-STE. Results: Seventeen client-owned cats affected with HCM and twenty healthy control cats. Conventional echocardiographic and 2D-STE variables were measured and compared between groups (the normal and HCM groups). The difference between two groups was compared by using the independent Student’s t-test. A p -value less than 0.05 was considered significant. Variability from the 2D-STE variables tests displayed good reproducibility (coefficient of variation ≤15%). The mean value of peak atrial longitudinal strain (PALS) in the HCM group (13.16 ± 8.64) was lower in the control group (28.54 ±10.31) ( p < 0.001). PALS was lowest at the LA roof region. The atrial longitudinal strain of septal and lateral regions was significantly lower in the HCM group than the normal group. PALS correlated with the percentage of the LA fractional shortening (LA-FS) (r=0.538, p =0.001), the percentage of the LA ejection fraction (LA-EF) (r =0.797, p <0.001), and the LA fractional area change (FAC) (r =0.746, p <0.001). Conclusions: PALS can be used to evaluate changes in theLA function in HCM cats. It is a reproducible method for assessing the LA function in cats affected with HCM. Keywords cats; heart; left atrium; strain

Assessment of left atrial function in feline hypertrophic cardiomyopathy by using two- dimensional speckle tracking echocardiography

10.21203/rs.3.rs-17226/v2 ◽

2020 ◽

Author(s):

Arisara Kiatsilapanan ◽

Sirilak Surachetpong

Keyword(s):

Left Atrial ◽

Speckle Tracking ◽

Longitudinal Strain ◽

Mean Value ◽

Control Group ◽

P Value ◽

Two Dimensional ◽

The Difference

Assessment of left atrial function in feline hypertrophic cardiomyopathy by using two- dimensional speckle tracking echocardiography

BMC Veterinary Research ◽

10.1186/s12917-020-02557-3 ◽

2020 ◽

Vol 16 (1) ◽

Author(s):

Arisara Kiatsilapanan ◽

Sirilak Disatian Surachetpong

Keyword(s):

Left Atrial ◽

Speckle Tracking ◽

Mean Value ◽

Control Group ◽

Two Dimensional ◽

Healthy Control ◽

Reproducible Method ◽

Longitudinal Strains

Abstract Background Left atrial (LA) function plays an important role in diastolic dysfunction in cats with hypertrophic cardiomyopathy (HCM). Two-dimensional speckle tracking echocardiography (2D-STE) is a technique for assessing LA function. This study aimed to evaluate the LA function in HCM cats compared to normal cats, using 2D-STE. Results Seventeen client-owned cats affected with HCM and twenty healthy control cats were studied. Conventional echocardiographic and 2D-STE variables were measured and compared between groups (control and HCM groups). Variability of the peak atrial longitudinal strain (PALS) displayed good reproducibility with 4.7% intra-observer and 14% inter-observer repeatability. The mean value of PALS in the HCM group (13.16 ± 8.64) was lower than that in the control group (28.54 ± 10.31) (P < 0.001). PALS was lowest in the LA roof region. The atrial longitudinal strains of septal and lateral regions were significantly lower in the HCM group than in the normal group. The PALS correlated with the percentage of the LA fractional shortening (LA-FS) (r = 0.538, P = 0.001), the percentage of the LA ejection fraction (LA-EF) (r = 0.797, P < 0.001), and the LA fractional area change (FAC) (r = 0.746, P < 0.001). Conclusions PALS is a feasible and reproducible method to evaluate the LA function in cats affected with HCM.

Assessment of left atrial function in feline hypertrophic cardiomyopathy by using two- dimensional speckle tracking echocardiography

10.21203/rs.3.rs-17226/v3 ◽

2020 ◽

Author(s):

Arisara Kiatsilapanan ◽

Sirilak Surachetpong

Keyword(s):

Left Atrial ◽

Speckle Tracking ◽

Mean Value ◽

Control Group ◽

Two Dimensional ◽

Healthy Control ◽

Reproducible Method ◽

Longitudinal Strains

Abstract Background: Left atrial (LA) function plays an important role in diastolic dysfunction in cats with hypertrophic cardiomyopathy (HCM). Two-dimensional speckle tracking echocardiography (2D-STE) is a technique for assessing LA function. This study aimed to evaluate the LA function in HCM cats compared to normal cats, using 2D-STE.Results: Seventeen client-owned cats affected with HCM and twenty healthy control cats were studied. Conventional echocardiographic and 2D-STE variables were measured and compared between groups (control and HCM groups). Variability of the peak atrial longitudinal strain (PALS) displayed good reproducibility with 4.7% intra-observer and 14% inter-observer repeatability. The mean value of PALS in the HCM group (13.16 ± 8.64) was lower than that in the control group (28.54 ±10.31) (P < 0.001). PALS was lowest in the LA roof region. The atrial longitudinal strains of septal and lateral regions were significantly lower in the HCM group than in the normal group. The PALS correlated with the percentage of the LA fractional shortening (LA-FS) (r=0.538, P =0.001), the percentage of the LA ejection fraction (LA-EF) (r =0.797, P <0.001), and the LA fractional area change (FAC) (r =0.746, P <0.001). Conclusions: PALS is a feasible and reproducible method to evaluate the LA function in cats affected with HCM.

Assessment of left atrial function in feline hypertrophic cardiomyopathy by using two- dimensional speckle tracking echocardiography

10.21203/rs.3.rs-17226/v4 ◽

2020 ◽

Author(s):

Arisara Kiatsilapanan ◽

Sirilak Surachetpong

Keyword(s):

Left Atrial ◽

Speckle Tracking ◽

Mean Value ◽

Control Group ◽

Two Dimensional ◽

Healthy Control ◽

Reproducible Method ◽

Longitudinal Strains

Abstract Background: Left atrial (LA) function plays an important role in diastolic dysfunction in cats with hypertrophic cardiomyopathy (HCM). Two-dimensional speckle tracking echocardiography (2D-STE) is a technique for assessing LA function. This study aimed to evaluate the LA function in HCM cats compared to normal cats, using 2D-STE.Results: Seventeen client-owned cats affected with HCM and twenty healthy control cats were studied. Conventional echocardiographic and 2D-STE variables were measured and compared between groups (control and HCM groups). Variability of the peak atrial longitudinal strain (PALS) displayed good reproducibility with 4.7% intra-observer and 14% inter-observer repeatability. The mean value of PALS in the HCM group (13.16 ± 8.64) was lower than that in the control group (28.54 ±10.31) (P < 0.001). PALS was lowest in the LA roof region. The atrial longitudinal strains of septal and lateral regions were significantly lower in the HCM group than in the normal group. The PALS correlated with the percentage of the LA fractional shortening (LA-FS) (r=0.538, P =0.001), the percentage of the LA ejection fraction (LA-EF) (r =0.797, P <0.001), and the LA fractional area change (FAC) (r =0.746, P <0.001). Conclusions: PALS is a feasible and reproducible method to evaluate the LA function in cats affected with HCM.

The Role of Left-Atrial Mechanics Assessed by Two-Dimensional Speckle-Tracking Echocardiography to Differentiate Hypertrophic Cardiomyopathy from Hypertensive Left-Ventricular Hypertrophy

Diagnostics ◽

10.3390/diagnostics11050814 ◽

2021 ◽

Vol 11 (5) ◽

pp. 814

Author(s):

Nicoleta-Monica Popa-Fotea ◽

Miruna Mihaela Micheu ◽

Nicoleta Oprescu ◽

Adriana Alexandrescu ◽

Maria Greavu ◽

...

Keyword(s):

Left Atrial ◽

Speckle Tracking ◽

Ventricular Hypertrophy ◽

Left Ventricular ◽

Two Dimensional ◽

Booster Pump ◽

Conduit Function

Hypertrophic cardiomyopathy (HCM) and arterial hypertension (HTN) are conditions with different pathophysiology, but both can result in left-ventricular hypertrophy (LVH). The role of left-atrial (LA) functional changes detected by two-dimensional speckle-tracking echocardiography (STE) in indicating LVH etiology is unknown. Methods: We aimed to characterize LA mechanics using STE in LVH patients with HCM and HTN. LA 2D volumetric and STE parameters were analyzed in 86 LVH patients (43 HCM and 43 isolated HTN subjects) and 33 age- and sex-matched controls. Results: The volumetric study showed that LA reservoir and conduit function were impaired in the HCM group compared to controls, while, in the HTN group, only LA conduit function was deteriorated. The HCM group had all three STE-derived LA functions impaired compared to controls. The HTN group, consistently with volumetric analysis, had solely LA conduit function reduced compared to controls. Ratios of LA booster-pump strain (S) and strain rate (SR) to interventricular septum (IVS) thickness were the most accurate parameters to discriminate between HCM and HTN. The subgroup harboring sarcomeric pathogenic (P)/likely pathogenic (LP) variants had reduced LA booster-pump S and SR compared with the genotype-negative subgroup. Conclusions: LA reservoir, conduit, and pump functions are decreased in HCM compared to HTN patients with similar LVH. We report the ratios between LA contraction S/SR and IVS thickness as novel parameters with high accuracy in discriminating LVH due to HCM. The presence of P/LP variants in sarcomeric or sarcomeric-associated genes could be associated with more severe LA dysfunction.

Clinical implication of disturbed left atrial phasic functions in the heterogeneous population associated with hypertension or atrial fibrillation

Cardiovascular Ultrasound ◽

10.1186/s12947-019-0175-x ◽

2019 ◽

Vol 17 (1) ◽

Author(s):

Mengruo Zhu ◽

Haiyan Chen ◽

Yang Liu ◽

Xianhong Shu

Keyword(s):

Atrial Fibrillation ◽

Differential Diagnosis ◽

Healthy Subjects ◽

Left Atrial ◽

Speckle Tracking ◽

Longitudinal Strain ◽

Heterogeneous Population ◽

Two Dimensional ◽

Hypertensive Patients

Abstract Background To evaluate left atrial (LA) phasic functions in patients with hypertension and/or paroxysmal atrial fibrillation (PAF) and its clinical significance. Methods LA strain was studied in 77 patients (25 hypertension, 24 lone AF, and 28 with both hypertension and PAF) and 28 controls using two-dimensional speckle-tracking echocardiography (2D STE). The following indexes during atrial reservoir, conduit and pump phase were analyzed respectively: (1) peak atrial longitudinal strain (PALS) and strain rate (PALSR), (2) the standard deviation of time to PALS and PALSR of all LA segments (TpS-SD% and TpSR-SD%). Results Compared with controls, PALSres, PALScond and PALSRcond were significantly reduced in patients with isolated hypertension (all P < 0.01) but no significant differences were observed in PALSpump, PALSRpump and TpSpump-SD% between them (all P > 0.05). PALSpump, PALSRpump and PALSRres were significantly lower in patients with both hypertension and PAF than in those with isolated hypertension (all P < 0.05). PALS and PALSR were significantly decreased, and TpS-SD% was significantly increased during each phase in lone AF patients than in controls (all P < 0.05), and PALSRpump was further depressed in patients with both hypertension and PAF (P = 0.029). PALSRcond ≤ 1.475 s− 1 combined with TpSpump-SD% ≥ 3.25% (sensitivity, 85%; specificity, 71%; AUC = 0.845, P < 0.001) could distinguish lone AF from healthy subjects effectively, while in hypertensive patients, PALSpump ≤ 14.2% was found to be an independent differentiator for occurrence of AF or not with sensitivity of 81% and specificity of 84% (AUC = 0.838, P < 0.001). LAVI≥29.3 mL/m2 was an independent characteristic for reflecting different LA remodeling in lone AF or hypertension with AF. Conclusions The impairment of LA phasic functions was varied in patients with hypertension and/or AF. The disturbed LA phasic functions were proved to have independent abilities of differential diagnosis in this heterogeneous population associated with hypertension or AF.

Left atrial remodeling postseptal myectomy for severe obstructive hypertrophic cardiomyopathy: Analysis by two‐dimensional speckle‐tracking echocardiography

Echocardiography ◽

10.1111/echo.14226 ◽

2019 ◽

Vol 36 (2) ◽

pp. 276-284 ◽

Cited By ~ 1

Author(s):

Adaya Weissler‐Snir ◽

Waseem Hindieh ◽

Gil Moravsky ◽

Anthony Ralph‐Edwards ◽

Lynne Williams ◽

...

Keyword(s):

Left Atrial ◽

Speckle Tracking ◽

Obstructive Hypertrophic Cardiomyopathy

Atrial Remodeling ◽

Two Dimensional ◽

Left Atrial Remodeling ◽

Subclinical Myocardial Dysfunction Revealed by Two-dimensional Speckle Tracking Echocardiography in Chronic Alcoholic Patients

10.21203/rs.3.rs-783432/v1 ◽

2021 ◽

Author(s):

Magdalena Kaznica-Wiatr ◽

Klaudia Pacia ◽

Marta Hat ◽

Monika Noga ◽

Piotr Podolec ◽

...

Keyword(s):

Alcohol Consumption ◽

Speckle Tracking ◽

Longitudinal Strain ◽

Myocardial Injury ◽

Global Longitudinal Strain ◽

Control Group ◽

Dependent Manner ◽

Two Dimensional ◽

The Mean

Abstract Background and aim:Alcohol is a potent risk factor for heart diseases. Alcohol consumption can damage myocytes earlier than overt LV dysfunction occurs. We aimed that two-dimensional speckle tracking echocardiography (2DSTE) can be used for early detection of heart failure caused by alcohol intake.Methods:A 100 chronic alcoholics were enrolled into the study. All patients underwent physical examination, biochemical analysis and echocardiography. Following parameters were assessed: LV diameters, LV systolic and diastolic function. Also RV diameters, LA and RA volumes were measured. LV and RV global longitudinal strain (GLS), LA and RA strain were calculated. The results were compared with control group, composed of 20 healthy subjects.Results:The mean LVEF was 57.55±6.99%, the mean E/A ratio 1.09±0.32 and E/E` 7.36±2.4 in the study group. Mean LA volume was 35.4±10.78 mL, RA volume 34.7±10.25 mL. The 2DSTE of LA was 29.1±10.0, LVGLS was -15.03±2.07. The RA strain was 30.46±10.25 and RVGLS -16.22±6.27. All strain parameters were lower than in the control group. Graded reduction of global longitudinal strain of the both ventricles and both atria in dose-dependent manner was found, lower strain was observed in heavy alcoholics than light/moderate drinkers. Conclusions:The study proved that chronic alcohol consumption leads to myocardial injury in dose-depended manner, the deterioration of global strain of the ventricles and atria can be the sensitive marker of myocardial injury.

The Difference of Left Atrial Function Between Ischemic and Dilated Cardiomyopathy: A Two Dimensional-Speckle Tracking Imaging Study

Ultrasound in Medicine & Biology ◽

10.1016/j.ultrasmedbio.2013.02.389 ◽

2013 ◽

Vol 39 (5) ◽

pp. S82

Author(s):

R.Q. Guo ◽

S. Cao

Keyword(s):

Dilated Cardiomyopathy ◽

Left Atrial ◽

Speckle Tracking ◽

Imaging Study ◽

Atrial Function ◽

Left Atrial Function ◽

Two Dimensional ◽

Speckle Tracking Imaging ◽

The Difference

Determination of multidirectional myocardial deformations in cats with hypertrophic cardiomyopathy by using two-dimensional speckle-tracking echocardiography

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x17691896 ◽

2017 ◽

Vol 19 (12) ◽

pp. 1283-1289 ◽

Cited By ~ 7

Author(s):

Ryohei Suzuki ◽

Yohei Mochizuki ◽

Hiroki Yoshimatsu ◽

Takahiro Teshima ◽

Hirotaka Matsumoto ◽

...

Keyword(s):

Speckle Tracking ◽

Contractile Function ◽

Radial Strain ◽

Clinical Signs ◽

Myocardial Deformation ◽

Radial Deformation ◽

Two Dimensional

Objectives Hypertrophic cardiomyopathy, a primary disorder of the myocardium, is the most common cardiac disease in cats. However, determination of myocardial deformation with two-dimensional speckle-tracking echocardiography in cats with various stages of hypertrophic cardiomyopathy has not yet been reported. This study was designed to measure quantitatively multidirectional myocardial deformations of cats with hypertrophic cardiomyopathy. Methods Thirty-two client-owned cats with hypertrophic cardiomyopathy and 14 healthy cats serving as controls were enrolled and underwent assessment of myocardial deformation (peak systolic strain and strain rate) in the longitudinal, radial and circumferential directions. Results Longitudinal and radial deformations were reduced in cats with hypertrophic cardiomyopathy, despite normal systolic function determined by conventional echocardiography. Cats with severely symptomatic hypertrophic cardiomyopathy also had lower peak systolic circumferential strain, in addition to longitudinal and radial strain. Conclusions and relevance Longitudinal and radial deformation may be helpful in the diagnosis of hypertrophic cardiomyopathy. Additionally, the lower circumferential deformation in cats with severe hypertrophic cardiomyopathy may contribute to clinical findings of decompensation, and seems to be related to severe cardiac clinical signs. Indices of multidirectional myocardial deformations by two-dimensional speckle-tracking echocardiography may be useful markers and help to distinguish between cats with hypertrophic cardiomyopathy and healthy cats. Additionally, they may provide more detailed assessment of contractile function in cats with hypertrophic cardiomyopathy.