scholarly journals The Role of Left-Atrial Mechanics Assessed by Two-Dimensional Speckle-Tracking Echocardiography to Differentiate Hypertrophic Cardiomyopathy from Hypertensive Left-Ventricular Hypertrophy

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 814
Author(s):  
Nicoleta-Monica Popa-Fotea ◽  
Miruna Mihaela Micheu ◽  
Nicoleta Oprescu ◽  
Adriana Alexandrescu ◽  
Maria Greavu ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Ventricular Hypertrophy ◽  
Speckle Tracking Echocardiography ◽  
Left Ventricular ◽  
Two Dimensional ◽  
Booster Pump ◽  
Conduit Function

Hypertrophic cardiomyopathy (HCM) and arterial hypertension (HTN) are conditions with different pathophysiology, but both can result in left-ventricular hypertrophy (LVH). The role of left-atrial (LA) functional changes detected by two-dimensional speckle-tracking echocardiography (STE) in indicating LVH etiology is unknown. Methods: We aimed to characterize LA mechanics using STE in LVH patients with HCM and HTN. LA 2D volumetric and STE parameters were analyzed in 86 LVH patients (43 HCM and 43 isolated HTN subjects) and 33 age- and sex-matched controls. Results: The volumetric study showed that LA reservoir and conduit function were impaired in the HCM group compared to controls, while, in the HTN group, only LA conduit function was deteriorated. The HCM group had all three STE-derived LA functions impaired compared to controls. The HTN group, consistently with volumetric analysis, had solely LA conduit function reduced compared to controls. Ratios of LA booster-pump strain (S) and strain rate (SR) to interventricular septum (IVS) thickness were the most accurate parameters to discriminate between HCM and HTN. The subgroup harboring sarcomeric pathogenic (P)/likely pathogenic (LP) variants had reduced LA booster-pump S and SR compared with the genotype-negative subgroup. Conclusions: LA reservoir, conduit, and pump functions are decreased in HCM compared to HTN patients with similar LVH. We report the ratios between LA contraction S/SR and IVS thickness as novel parameters with high accuracy in discriminating LVH due to HCM. The presence of P/LP variants in sarcomeric or sarcomeric-associated genes could be associated with more severe LA dysfunction.

scholarly journals Assessment of left atrial function in feline hypertrophic cardiomyopathy by using two- dimensional speckle tracking echocardiography

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Arisara Kiatsilapanan ◽  
Sirilak Disatian Surachetpong
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Mean Value ◽  
Control Group ◽  
Two Dimensional ◽  
Healthy Control ◽  
Reproducible Method ◽  
Longitudinal Strains

Abstract Background Left atrial (LA) function plays an important role in diastolic dysfunction in cats with hypertrophic cardiomyopathy (HCM). Two-dimensional speckle tracking echocardiography (2D-STE) is a technique for assessing LA function. This study aimed to evaluate the LA function in HCM cats compared to normal cats, using 2D-STE. Results Seventeen client-owned cats affected with HCM and twenty healthy control cats were studied. Conventional echocardiographic and 2D-STE variables were measured and compared between groups (control and HCM groups). Variability of the peak atrial longitudinal strain (PALS) displayed good reproducibility with 4.7% intra-observer and 14% inter-observer repeatability. The mean value of PALS in the HCM group (13.16 ± 8.64) was lower than that in the control group (28.54 ± 10.31) (P < 0.001). PALS was lowest in the LA roof region. The atrial longitudinal strains of septal and lateral regions were significantly lower in the HCM group than in the normal group. The PALS correlated with the percentage of the LA fractional shortening (LA-FS) (r = 0.538, P = 0.001), the percentage of the LA ejection fraction (LA-EF) (r = 0.797, P < 0.001), and the LA fractional area change (FAC) (r = 0.746, P < 0.001). Conclusions PALS is a feasible and reproducible method to evaluate the LA function in cats affected with HCM.

scholarly journals Assessment of left atrial function in feline hypertrophic cardiomyopathy by using two- dimensional speckle tracking echocardiography

2020 ◽  
Author(s):  
Arisara Kiatsilapanan ◽  
Sirilak Surachetpong
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Longitudinal Strain ◽  
Speckle Tracking Echocardiography ◽  
Mean Value ◽  
Control Group ◽  
P Value ◽  
Two Dimensional ◽  
The Difference

Abstract Background : Left atrial (LA) function plays an important role in diastolic dysfunction in cats with hypertrophic cardiomyopathy (HCM). Two-dimensional speckle tracking echocardiography (2D-STE) is a novel technique for assessing LA function. This study aimedto evaluate changes in the LA function inHCM cats compared to normal cats, using 2D-STE. Results: Seventeen client-owned cats affected with HCM and twenty healthy control cats. Conventional echocardiographic and 2D-STE variables were measured and compared between groups (the normal and HCM groups). The difference between two groups was compared by using the independent Student’s t-test. A p -value less than 0.05 was considered significant. Variability from the 2D-STE variables tests displayed good reproducibility (coefficient of variation ≤15%). The mean value of peak atrial longitudinal strain (PALS) in the HCM group (13.16 ± 8.64) was lower in the control group (28.54 ±10.31) ( p < 0.001). PALS was lowest at the LA roof region. The atrial longitudinal strain of septal and lateral regions was significantly lower in the HCM group than the normal group. PALS correlated with the percentage of the LA fractional shortening (LA-FS) (r=0.538, p =0.001), the percentage of the LA ejection fraction (LA-EF) (r =0.797, p <0.001), and the LA fractional area change (FAC) (r =0.746, p <0.001). Conclusions: PALS can be used to evaluate changes in theLA function in HCM cats. It is a reproducible method for assessing the LA function in cats affected with HCM. Keywords cats; heart; left atrium; strain

scholarly journals Assessment of Left Atrial Function in Essential Hypertension Patients With Normal Left Ventricle Function by Volume-derived Values and Two-dimensional Strain

2021 ◽  
Author(s):  
Jun Huang ◽  
Chao Yang ◽  
Zi-ning Yan ◽  
Li Fan ◽  
Cai-Fang Ni
Keyword(s):  
Essential Hypertension ◽  
Left Atrial ◽  
Speckle Tracking Echocardiography ◽  
Normal Subjects ◽  
Two Dimensional ◽  
Left Ventricle Function ◽  
Booster Pump ◽  
Conduit Function ◽  
Ventricle Function ◽  
Higher Sensitivity

Abstract Background: To investigate left atrial(LA) function in essential hypertension(EHT) patients by using volume-derived values, two-dimensional strain. Methods: 51 normal subjects and 95 EHT patients(without LVH: 50, and with LVH: 45) were enrolled for this research. LA Volume-derived index was measured in apical 4-, 2-chamber views by Simpson′s method. LA strain(S-reservoir, S-conduit, S-booster pump) and strain rate (SR-reservoir, SR-conduit, SR-booster pump), representing the reservoir, conduit and booster pump functions, respectively, were measured by two-dimensional speckle tracking echocardiography(STE).Results: Volume-derived values(contain Total LAEF, passive LAEF and active LAEF) and strain-derived values(S-reservoir, S-conduit, Sr-reservoir, Sr-conduit and Sr-booster pump) in EHT patients were significantly lower than normal subjects. Correlation test showed LA stiffness had a strong correlation with LA conduit function in EHT patients. The AUC values were higher for detection LA conduit function than LA reservoir and booster pump function in EHT patients. LA expansion index and LA stiffness also have the higher AUC with higher sensitivity and specificity values for detection the LA dysfunctions in EHT patients. Conclusions: In this study, we concluded that LA functions were damaged in EHT patients, which could be detect by LA volume-derived values and two-dimensional strain sensitively and reproductively. LA stiffness maybe a predictor for LV remodelling in EHT patients.

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