scholarly journals Clinical and radiological features of patients with 2019 novel coronavirus (SARS-CoV-2) in Haikou, China

2020 ◽  
Author(s):  
Hui Juan Chen ◽  
Jie Qiu ◽  
Biao Wu ◽  
Zhen Ping Wang ◽  
Yang Chen ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Chest Ct ◽  
Ground Glass ◽  
Radiological Findings ◽  
Lung Lesions ◽  
Radiological Features ◽  
Ct Findings ◽  
Imported Cases ◽  
Novel Coronavirus

Abstract To describe the clinical and radiological findings of patients confirmed with 2019 novel coronavirus disease (COVID-19) infection in Haikou, China. A total of 67 patients confirmed with COVID-19 infection were included in this study. 50 were imported cases. Most infected patients presented with fever and cough. The typical CT findings of lung lesions were bilateral, multifocal lung lesions (52[78%]), with subpleural distribution, and more than two lobes involved (51[78%]). 54 (81%) patients of COVID-19 pneumonia had ground glass opacities. Consolidation was in 30 (45%) patients, crazy paving pattern or interlobular thickening in 17 (25%), adjacent pleura thickening in 23 (34%) patients. Additionally, baseline chest CT did not reveal positive CT findings in 7 patients (23%), but 3 patients presented unilateral ground glass opacities at follow-up. Importantly, the follow-up CT findings were fitted well with the clinical outcomes.

scholarly journals Clinical and Radiological Features of Patients with Coronavirus Disease 2019

2020 ◽  
Author(s):  
Hui Juan Chen ◽  
Jie Qiu ◽  
Biao Wu ◽  
Zhen Ping Wang ◽  
Yang Chen ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Treatment Effectiveness ◽  
Chest Ct ◽  
Ground Glass ◽  
Radiological Findings ◽  
Disease Evolution ◽  
Lung Lesions ◽  
Ct Findings ◽  
Imported Cases

Abstract Background: Confirmed cases of coronavirus disease 2019 (COVID-19) is still increasing, detailed analysis of confirmed cases may be beneficial for disease control.Methods: To describe the clinical and radiological findings of patients confirmed with COVID-19 infection in Haikou, China.Results: A total of 67 patients confirmed with COVID-19 infection were included in this study. 50 were imported cases. Most infected patients presented with fever and cough. The typical CT findings of lung lesions were bilateral, multifocal lung lesions (52[78%]), with subpleural distribution, and more than two lobes involved (51[78%]). 54 (81%) patients of COVID-19 pneumonia had ground glass opacities. Consolidation was in 30 (45%) patients, crazy paving pattern or interlobular thickening in 17 (25%), adjacent pleura thickening in 23 (34%) patients. Additionally, baseline chest CT did not reveal positive CT findings in 7 patients (23%), but 3 patients presented unilateral ground glass opacities at follow-up. Importantly, the follow-up CT findings were fitted well with the clinical outcomes.Conclusions: Chest CT could be used as an important tool for early diagnosis of COVID-19, monitoring the disease evolution, judging the treatment effectiveness and predicting the clinical outcomes.

scholarly journals Imaging of COVID-19 pneumonia in children

2020 ◽  
Vol 93 (1113) ◽  
pp. 20200647 ◽  
Author(s):  
Figen Palabiyik ◽  
Suna Ors Kokurcan ◽  
Nevin Hatipoglu ◽  
Sinem Oral Cebeci ◽  
Ercan Inci
Keyword(s):  
Pediatric Patients ◽  
Pediatric Population ◽  
Chest Ct ◽  
Ground Glass ◽  
Pathologic Finding ◽  
Radiological Findings ◽  
X Ray ◽  
Ct Findings ◽  
Chest X Ray ◽  
Single Lesion

Objective: Literature related to the imaging of COVID-19 pneumonia, its findings and contribution to diagnosis and its differences from adults are limited in pediatric patients. The aim of this study was to evaluate chest X-ray and chest CT findings in children with COVID-19 pneumonia. Methods: Chest X-ray findings of 59 pediatric patients and chest CT findings of 22 patients with a confirmed diagnosis of COVID-19 pneumonia were evaluated retrospectively. Results: COVID-19 pneumonia was most commonly observed unilaterally and in lower zones of lungs in chest X-ray examinations. Bilateral and multifocal involvement (55%) was the most observed involvement in the CT examinations, as well as, single lesion and single lobe (27%) involvement were also detected. Pure ground-glass appearance was observed in 41%, ground-glass appearance and consolidation together was in 36%. While peripheral and central co-distribution of the lesions (55%) were frequently observed, the involvement of the lower lobes (69%) was significant. In four cases,the coexistence of multiple rounded multifocal ground-glass appearance and rounded consolidation were observed. Conclusion: COVID-19 pneumonia imaging findings may differ in the pediatric population from adults. In diagnosis, chest X-ray should be preferred, CT should be requested if there is a pathologic finding on radiography that merits further evaluation and if clinically indicated. Advances in knowledge: Radiological findings of COVID-19 observed in children may differ from adults. Chest X-ray should often be sufficient in children avoiding additional irradiation, chest CT needs only be done in cases of clinical necessity.

scholarly journals Computed tomography manifestations in super early stage 2019 novel coronavirus pneumonia

2020 ◽  
pp. 028418512092480
Author(s):  
Shan Hu ◽  
Zhen Li ◽  
Xu Chen ◽  
Chang-Hong Liang
Keyword(s):  
Computed Tomography ◽  
Early Stage ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Ground Glass ◽  
Reticular Pattern ◽  
Initial Stage ◽  
Pr China ◽  
Novel Coronavirus

Background The recent outbreak of pneumonia cases in Wuhan, PR China, was caused by a novel beta coronavirus, the 2019 novel coronavirus (COVID-19). Purpose To summarize chest computed tomography (CT) manifestations of the early stage of COVID-19 infection and provide a piece of reliable imaging evidence for initial screening and diagnosis. Material and Methods From 10 January 2020 to 10 February 2020, we continuously observed chest CT imaging of 14 patients with clinically suspected new coronavirus infection in the two weeks after onset of symptoms. Ground-glass opacity (GGO), consolidation, reticular pattern, and ground-glass mimic nodules in each patient’s chest CT image were recorded. Results We enrolled 14 patients, of which nine patients had the infection confirmed by reverse transcription polymerase chain reaction (RT-PCR). Five patients were highly suspected of infection. All cases had epidemiological evidence. GGO was a dominant imaging manifestation in the initial days of infection. GGO performance accounts for 40% in 1– 2 days, 90% in 3– 6 days, and 85% in 7– 10 days. With disease progression, consolidation appeared on follow-up CT. Consolidation performance accounts for 0% in 1– 2 days, 40% in 3– 6 days, and 71% in 7– 10 days. The lesions are mostly near the pleura. The number of lesions and the extent of the lesions increased as the disease progressed. Conclusion Patients with novel coronavirus pneumonia have characteristic CT features in the initial stage of infection, which can be used as an essential supplement for nucleic acid examination.

scholarly journals Association of CT Findings with clinical severity in Patients with COVID-19, a multicenter Cohort observational study

2020 ◽  
Author(s):  
Min Liu ◽  
Hongxia Zhang ◽  
Nan Yu ◽  
Qing Hou ◽  
Li Zhu ◽  
...  
Keyword(s):  
Clinical Status ◽  
Laboratory Data ◽  
Severe Pneumonia ◽  
Chest Ct ◽  
Clinical Severity ◽  
Reactive Protein ◽  
Ct Findings ◽  
Chest X Ray ◽  
Novel Coronavirus

Abstract Background 2019 Novel Coronavirus disease (COVID-19) may cause critical illness including severe pneumonia and acute respiratory distress syndrome. Our purpose is to was to analyze the radiological features of COVID-19 pneumonia and its association with clinical severity. Methods This retrospective study included 212 patients (122 males, Mean age, 45.6 ± 12.8 years) from 10 hospitals. Chest CT, chest X-ray (CXR), clinical and laboratory data at admission and follow-up CT were collected. Chest CT and CXR were reviewed and CT score of the involved lung was calculated. Results 94.3% patients had pneumonia on the baseline CT at admission. The most CT findings were as follows: GGO (140/200), GGO with consolidation (38/200) and consolidation (16/200) most involving the lower lobes with a predilection for the peripheral aspects. The CT score negatively correlated with Lymphocyte count while it positively correlated with C-reactive protein. ROC curve showed an optimal cutoff value of the CT score of 15 had a sensitivity of 70% and a specificity of 96.5% for the prediction of severe status. Series CT showed GGO or consolidation gradually reduced in 52 patients while 6 patients had reticular opacities. 14 patients showed the normal CXR while GGO were found on CT. Conclusion COVID-19 pneumonia manifests as focal, multifocal ground-glass opacities with/without consolidations. Higher CT score correlated severe clinical status. CXR is yet insufficient for evaluation of COVID-19 pneumonia.

scholarly journals Longitudinal Radiological Findings in Patients With COVID-19 With Different Severities: From Onset to Long-Term Follow-Up After Discharge

2021 ◽  
Vol 8 ◽  
Author(s):  
Yajing Zhao ◽  
Dongdong Wang ◽  
Nan Mei ◽  
Bo Yin ◽  
Xuanxuan Li ◽  
...  
Keyword(s):  
Cox Regression ◽  
Chest Ct ◽  
Pulmonary Lesion ◽  
Ct Scans ◽  
Radiological Findings ◽  
Pulmonary Lesions ◽  
Radiological Features ◽  
Severe Group ◽  
Discharged Patients

Objective: This study aimed to investigate the evolution of radiological findings in the patients with coronavirus disease 2019 (COVID-19) pneumonia with different severities from onset to 1-year follow-up and identify the predictive factors for different pulmonary lesion absorption status in the patients infected with COVID-19.Methods: A retrospective study was performed on the clinical and radiological features of 175 patients with COVID-19 pneumonia hospitalized at three institutions from January 21 to March 20, 2020. All the chest CT scans during hospitalization and follow-ups after discharge were collected. The clinical and radiological features from the chest CT scans both at the peak stage and before discharge from the hospital were used to predict whether the pulmonary lesions would be fully absorbed after discharge by Cox regression. Then, these patients were stratified into two groups with different risks of pulmonary lesion absorption, and an optimal timepoint for the first CT follow-up was selected accordingly.Results: A total of 132 (75.4%) patients were classified into the non-severe group, and 43 (24.6%) patients were classified into the severe group, according to the WHO guidelines. The opacification in both the groups changed from ground-glass opacity (GGO) to consolidation and then from consolidation to GGO. Among the 175 participants, 135 (112 non-severe and 23 severe patients with COVID-19) underwent follow-up CT scans after discharge. Pulmonary residuals could be observed in nearly half of the patients (67/135) with the presentation of opacities and parenchymal bands. The parenchymal bands in nine discharged patients got fully absorbed during the follow-up periods. The age of patient [hazard ratio (HR) = 0.95, 95% CI, 0.95–0.99], level of lactate dehydrogenase (LDH) (HR = 0.99; 95% CI, 0.99–1.00), level of procalcitonin (HR = 8.72; 95% CI, 1.04–73.03), existence of diffuse lesions (HR = 0.28; 95% CI, 0.09–0.92), subpleural distribution of lesions (HR = 2.15; 95% CI, 1.17–3.92), morphology of residuals (linear lesion: HR = 4.58, 95% CI, 1.22–17.11; nodular lesion: HR = 33.07, 95% CI, 3.58–305.74), and pleural traction (HR = 0.41; 95% CI, 0.22–0.78) from the last scan before discharge were independent factors to predict the absorption status of COVID-19-related pulmonary abnormalities after discharge. According to a Kaplan–Meier analysis, the probability of patients of the low-risk group to have pulmonary lesions fully absorbed within 90 days reached 91.7%.Conclusion: The development of COVID-19 lesions followed the trend from GGO to consolidation and then from consolidation to GGO. The CT manifestations and clinical and laboratory variables before discharge could help predict the absorption status of pulmonary lesions after discharge. The parenchymal bands could be fully absorbed in some COVID-19 cases. In this study, a Cox regression analysis indicated that a timepoint of 3 months since onset was optimal for the radiological follow-up of discharged patients.

scholarly journals Dynamic Changes in Chest CT Images Over 167 Days in 11 Patients with COVID-19: A Case Series and Literature Review

Zoonoses ◽  
2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Jianqin Liang ◽  
Guizeng Liu ◽  
Shuzhuang Yu ◽  
Yang Yang ◽  
Yanchun Li ◽  
...  
Keyword(s):  
Early Stage ◽  
Case Series ◽  
Ct Images ◽  
Chest Ct ◽  
Clinical Severity ◽  
Ground Glass ◽  
Fine Mesh ◽  
Ct Findings

Background: Recently, CT findings have been widely reported to be associated with the clinical severity of COVID-19. However, few studies have reported the correlation between CT findings and long-term outcomes in patients with COVID-19. Case presentation: Herein, we conducted a 167 day long-term follow-up of CT examination on 11 patients with COVID-19 to evaluate their long-term prognosis, particularly in severe cases. We found that the course of COVID-19 can be divided into four stages according to the characteristics of CT images: 1) early stage (1–4 days), with chest CT showing quasi-circular ground-glass shadows and fine mesh shadows; 2) progressive stage (5–10 days), showing lesion spread through the axial interstitium along the bronchi and gradual diffusion to the whole lung; 3) recovery stage (11–74 days), showing gradual absorption of the fibre cord, ground-glass, and consolidation shadows; and 4) normal stage (74 days later), indicating no serious permanent lung injuries. Conclusions: Our data indicate that chest CT can enable early detection of COVID-19 and determination of the different stages of COVID-19. Furthermore, mild cases tended to have better prognosis, whereas severe cases still showed cord-like fibrosis in the lungs in follow-up at the 167th day after symptom onset.

scholarly journals Follow-up Chest CT findings from discharged patients with severe COVID-19: an 83-day observational study

2020 ◽  
Author(s):  
Tianhe Ye ◽  
Yanqing Fan ◽  
Jiacheng Liu ◽  
Chongtu Yang ◽  
Songjiang Huang ◽  
...  
Keyword(s):  
Symptom Onset ◽  
Virus Disease ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Ct Scans ◽  
Ground Glass ◽  
Ct Findings ◽  
Lung Abnormalities ◽  
Discharged Patients

Abstract Background: Chest computed tomography (CT) has been used to be a monitoring measure to assess the severity of lung abnormalities in corona virus disease 19 (COVID-19). Up to date, there has been no reports about follow-up chest CT findings from discharge patients with severe COVID-19. This study aims to describe the change pattern of radiological abnormalities from admission, to discharge, and to the last chest CT follow-up through an 83-day retrospective observation, and focuses on follow-up chest CT findings in discharged patients with severe COVID-19.Methods: Twenty-nine discharged patients (17 males, 12 females; median age, 56 years, IQR, 47-67) confirmed with severe COVID-19 from 13 January to 15 February were enrolled in this study. A total of 80 chest CT scans was performed from admission to the last follow-up. Images were mainly evaluated for ground-glass opacity, consolidation, parenchymal bands, and crazy-paving pattern. A semi-quantitative CT scoring system was used for estimating lung abnormalities of each lobe.Results: All patients received nasal cannula or/and high-flow mask oxygen therapy. Admission occurred 9 days (IQR, 5-13) after symptom onset. The median in-hospital period was 18 days (IQR, 11-26). The last follow-up chest CT was performed 66 days (IQR, 61-77) after symptom onset. Total CT scores in follow-up decreased significantly compared to that of performed in-hospital ([3, IQR, 0-5] to [13, IQR, 10-16], P < 0.001). Predominant patterns on follow-up chest CT performed 64 days after symptom onset were subpleural parenchymal bands (47%, 9/19) and complete radiological resolution (37%, 7/19). Consolidation absorbed earlier than ground-glass opacity did, and subpleural parenchymal bands were the longest-lasting feature during radiological resolution.Conclusions: Radiological abnormalities in patients of severe COVID-19 could be completely absorbed with no residual lung injury in more than two months’ follow-up. Serial chest CT scans could be used as a monitoring modality to help clinician better understand the disease course.

scholarly journals Serial computed tomography findings of Coronavirus disease 2019 (COVID-19) pneumonia treated with favipiravir and steroid therapy: report of 11 cases

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Naoki Irizato ◽  
Hiroshi Matsuura ◽  
Atsuya Okada ◽  
Ken Ueda ◽  
Hitoshi Yamamura
Keyword(s):  
Computed Tomography ◽  
Mechanical Ventilation ◽  
Steroid Therapy ◽  
Time Course ◽  
Ground Glass ◽  
Time Points ◽  
Ct Findings ◽  
Mixed Pattern ◽  
Bronchial Dilatation

Abstract Background This study evaluated the time course of computed tomography (CT) findings of patients with COVID-19 pneumonia who required mechanical ventilation and were treated with favipiravir and steroid therapy. Results Eleven patients with severe COVID-19 pneumonia were included. CT findings assessed at the three time points showed that all patients had ground-glass opacities (GGO) and consolidation and mixed pattern at intubation. Consolidation and mixed pattern disappeared in most of the patients whereas GGO persisted in all patients at 1-month follow-up. In addition to GGO, a subpleural line and bronchus distortion and bronchial dilatation were frequent findings. The degree of resolution of GGO varied depending on each patient. The GGO score correlated significantly with the time from symptoms onset to initiation of steroid therapy (ρ = 0.707, p = 0.015). Conclusions At 1-month follow-up after discharge, non-GGO lesions were absorbed almost completely, and GGO were a predominant CT manifestation. Starting steroid therapy earlier after onset of symptoms in severe COVID-19 pneumonia may reduce the extent of GGO at 1-month follow-up.

Stepwise progression from ground-glass opacity towards invasive adenocarcinoma: Long-term follow-up of radiological findings

Lung Cancer ◽  
2008 ◽  
Vol 60 (2) ◽  
pp. 298-301 ◽  
Author(s):  
Hiroshi Soda ◽  
Yoichi Nakamura ◽  
Katsumi Nakatomi ◽  
Nanae Tomonaga ◽  
Hiroyuki Yamaguchi ◽  
...  
Keyword(s):  
Ground Glass Opacity ◽  
Ground Glass ◽  
Radiological Findings ◽  
Invasive Adenocarcinoma ◽  
Long Term Follow Up

Study on the Dynamic Changes in Chest CT Findings of COVID-19 Rehabilitated Patients

2020 ◽  
pp. 1-7
Keyword(s):  
Disease Progression ◽  
Onset Time ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Ground Glass ◽  
Dynamic Changes ◽  
Course Of Disease ◽  
Pleural Thickening ◽  
Ct Findings ◽  
Interlobular Septal Thickening

Objective: To study the dynamic changes in CT findings in COVID-19 (coronavirus disease-19, COVID-19) rehabilitated patients. Methods: A total of 148 chest CT images of 37 patients with COVID-19 were collected. In the first 21 days of the course of disease, 7 stages were performed every 3 days, and the eighth stage was performed after 21 days. Results: In the first chest CT examination, 19 cases were ground glass opacity, and 18 cases were high-density shadows with consolidation. The lesion shape was flaky and patchy in 33 cases. The percentage of consolidation, air bronchogram, fiber cord, interlobular septal thickening, subpleural line and pleural thickening were the highest on days 4-6, 7-9, 7-9, 10-12, 19-21 and 19-21, respectively. The highest percentage of disease progression was 80.00% on days 4-6, and then the percentage of disease progression gradually decreased with the extension of the onset time. The percentage of patients with improvement gradually increased from days 4-6, reaching 83.33% on days 16-18 and 100.00% on day 21. The percentage of lesion range enlargement and density increase was the highest on days 4-6, both of which were 60.00%，Then the percentage of both decreased gradually. The percentage of patients with lesion range reduction and density absorption dilution increased gradually with the onset time. There was no obvious regularity in the number of lesions. Conclusion: Patients with COVID-19 have regular changes in their lung conditions.

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