scholarly journals An Analysis of Eight Family Cluster Cases in Wuhan, China: Peripheral Blood Lymphocyte Count May Predict COVID-19 Mortality

2020 ◽  
Author(s):  
Wenzhu Wang ◽  
Dandan Cui ◽  
Lijuan Zhang ◽  
Xiwen Zhu ◽  
Heng Fan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Blood Lymphocyte ◽  
Family Cluster ◽  
Global Pandemic ◽  
The World ◽  
Union Hospital ◽  
Novel Coronavirus

Abstract Importance: Since December 2019, a novel coronavirus (SARS-CoV-2) causing COVID-19 has spread across the world in a global pandemic. Tens of thousands of people were infected, several thousand patients died. However, key risk factors for predicting mortality remain unclear.Objective: To identify the key risk factors for COVID-19 mortality.Design, Setting, Participants: Retrospective, randomly selected eight family clusters consisting of 21 individual cases who had been confirmed positive for SARS-CoV-2 and admitted to the Wuhan Union Hospital, Wuhan, China, from February 6 to March 3 2020. This study aims to analyze the differences in mortal risk factors between fatal and non-fatal cases within each family.

scholarly journals An analysis of eight family cluster cases in Wuhan, China: Peripheral blood lymphocyte count may predict Covid-19 mortality

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Wenzhu Wang ◽  
◽  
Dandan Cui ◽  
Lijuan Zhang ◽  
Xiwen Zhu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Stable Condition ◽  
Absolute Count ◽  
Elderly Individuals ◽  
Predictive Risk Factor ◽  
Family Cluster ◽  
The Absolute

Background: Since December 2019, a novel coronavirus (SARSCoV-2) causing COVID-19 has spread across the world in a global pandemic. Tens of thousands of people were infected, several thousand patients died. However, key risk factors for predicting mortality remain unclear. This study aims to analyze the differences in mortal risk factors between fatal and non-fatal cases within each family, to identify the key risk factors for COVID-19 mortality. Method: Retrospective, randomly selected eight family clusters consisting of 21 individual cases who had been confirmed positive for SARS-CoV-2 and admitted to the Wuhan Union Hospital, Wuhan, China, from February 6 to March 3, 2020. Clinical characteristics and demographic data were tracked up to March 3. Results: Among all 8 family cluster cases, 4 families had death cases. All deaths were elderly individuals (range, 77-88 years), all ICU and severe cases were also elderly individuals (72-88 years). Patient 2-M1, who was the oldest of all cases and first confirmed with COVID-19 on January 10, had four critical comorbid conditions including colon cancer, COPD, hypertension, and coronary disease. But he remains in stable condition after more than 50 days of inpatient treatment. We observed that the absolute count of peripheral blood lymphocyte dropped to less than 0.8G/L of all death and ICU cases, ranging from 0.22 G/L to 0.81 G/L. Conclusions: We found that elderly age is one of the main risk factors for mortality, comorbidities were not predictive of mortality due to COVID-19, although they may extend disease duration. Importantly, we discovered that within our study population the absolute count of peripheral blood lymphocyte is a predictive risk factor for mortality due to COVID-19, establishing that it may be a very important factor for judging a patient’s prognosis. Keywords: COVID-19; Family clusters; Mortality; Risk factors.

scholarly journals Association Between Peripheral Blood Lymphocyte Count (PBLC) and Outcome in Patients with Solid Tumors Treated with Ngr-Htnf

2012 ◽  
Vol 23 ◽  
pp. ix172
Author(s):  
A. Bulotta ◽  
V. Gregorc ◽  
G. Rossoni ◽  
G. Todisco ◽  
M.G. Viganò ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Blood Lymphocyte

Application of Peripheral Blood Lymphocyte Count in Prediction of the Presence of Atypical Lymphocytes

2020 ◽  
Vol 66 (06/2020) ◽  
Author(s):  
Juan Lv ◽  
Ming Gao ◽  
Hong Zong ◽  
Guobin Ma ◽  
Xiuzhen Wei ◽  
...  
Keyword(s):  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Blood Lymphocyte

scholarly journals Effects of Short-Term Low-Dose Glucocorticoids for Patients with Mild COVID-19

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Hai-Yan Fu ◽  
Yu Luo ◽  
Jian-Peng Gao ◽  
Lin Wang ◽  
Hong-Juan Li ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Nucleic Acid ◽  
Peripheral Blood Lymphocyte ◽  
Effect Size ◽  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Blood Lymphocyte ◽  
Short Term ◽  
The Absolute

Objectives. To evaluate the role of short-term low-dose glucocorticoids in mild COVID-19 patients. Methods. We conducted a retrospective, cross-sectional, single-center study in Kunming, China. A total of 33 mild COVID-19 cases were divided into two treatment groups (with and without glucocorticoids, methylprednisolone, were used in this setting), and the absolute value of peripheral blood lymphocyte count; CD3+, CD4+, and CD8+ T cell counts; and the time to achieve negative transformation of a nucleic acid pharyngeal swab were recorded. Peripheral blood lymphocyte and T cell counts were compared between the treatment group and 25 healthy individuals. At the point of time when there was a 50% accumulation conversion rate (positive to negative nucleic acid on pharyngeal swab), and the nucleic acid turned negative in half of the patients in two groups, the peripheral blood lymphocyte and T cell counts were compared between treatment groups. Results. The mean cumulative time for the 50% negative conversion rate of the nucleic acid in the pharyngeal swab was 17.7±5.1 days and 13.9±5.4 days in the glucocorticoid group and the nonglucocorticoid group, respectively. The absolute peripheral blood lymphocyte count and the T cell subset count in the glucocorticoid group were lower than those in the nonglucocorticoid group. When the nucleic acid turned negative in half of the patients, the absolute value of peripheral blood lymphocyte count and CD4+ T cells of the glucocorticoid group and the nonglucocorticoid group was not significantly different; the CD3+ and CD8+ T cells in the glucocorticoid group were lower than those in the nonglucocorticoid group. The absolute peripheral blood lymphocyte count, CD3+ T cells, and CD4+ T cells in the glucocorticoid group were lower than those of the healthy group during the whole disease period, and CD8+ T cells returned to normal at 19-21 days of the disease period. There was no significant difference between the nonglucocorticoid group and the healthy group for absolute peripheral blood lymphocyte and CD8+ T cells; moreover, CD3+ T cells and CD4+ T cells were lower in the nonglucocorticoid group than those in the healthy group from the day of admission to the 18th day and returned to normal at the period of 19-21 days. The absolute peripheral lymphocyte count (P=0.048, effect size d=0.727) and T cell subset count (CD3: P=0.042, effect size d=0.655; CD4: P<0.01, effect size d=0.599; and CD8: P=0.034, effect size d=0.550) in the nonglucocorticoid group were higher than those in the glucocorticoid group, and the difference between the groups was statistically significant. Conclusions. This study found that the use of short-term, low-dose glucocorticoids does not negatively influence the clinical outcome, without affecting the final clearance of viral nucleic acid in mild COVID-19 patients.

scholarly journals Peripheral Lymphocyte Count, Free/Total PSA Ratio, LUTS Predict The Severity of Prostatic Inflammation in BPH Patients

2021 ◽  
Author(s):  
Shun Wan ◽  
Xiao-Hong Sun ◽  
Yong-Shuai Lin ◽  
Fang-Ming Du ◽  
Gong-Jun Guo ◽  
...  
Keyword(s):  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Blood Lymphocyte ◽  
Clinical Laboratory ◽  
Multivariate Logistic Regression Analysis ◽  
Peripheral Blood Lymphocytes ◽  
Pathological Examination ◽  
Total Psa ◽  
Prostatic Inflammation

Abstract Objective To study the correlation between peripheral blood lymphocytes, f/t PSA and LUTS symptoms, and prostatic inflammation in BPH patients.Materials and Methods From May 2020 to October 2020, 120 patients (aged 56-85 years) with BPH undergoing elective transurethral resection of the prostate (TURP) were selected. Peripheral blood lymphocyte counts and f/t PSA values were measured preoperatively, and IPSS scores were assessed. Postoperative prostate tissues were sent for pathological examination, and the relationship between peripheral blood lymphocyte count, TPSA, f/t PSA values, relevant clinical laboratory parameters, and relevant LUTS symptoms and the distribution of prostate tissue inflammation was analyzed.Results with the aggravation of prostatic inflammation, IPSS score and TPSA value were lower, while f/t PSA value and lymphocyte count were lower. Multivariate logistic regression analysis of 120 BPH patients showed that age (> = 60) [odds ratio (OR) = 0.29, 95% CI = 0.31-2.10; P = 0.02], IPSS score [OR = 1.24, 95% CI = 1.13-1.37; P < 0.01], TPSA [OR = 1.10, 95% CI = 1.02-1.19; P = 0.02], f/t PSA [OR = 1.03, 95% CI = 0.01-0.15; P = 0.02], and lymphocytes [OR = 1.70, 95% CI = 0.78-3.77; P = 0.04] were related to the formation of prostatic inflammation in BPH patients. Conclusion Peripheral blood lymphocyte count, TPSA, LUTS severity, and f/t PSA ratio can predict the severity of prostatic inflammation, which may be used as diagnostic markers for BPH patients with LUTS symptoms who have prostatitis and promote the development of drug treatment for LUTS symptoms in BPH patients with prostatitis.

scholarly journals Leflunomide-induced lung injury that developed after its withdrawal, coinciding with peripheral blood lymphocyte count decrease

2008 ◽  
Vol 18 (1) ◽  
pp. 96-99 ◽  
Author(s):  
Takeshi Otsuka ◽  
Takako Koyama ◽  
Ryoko Ohtani ◽  
Hiroaki Niiro ◽  
Seiji Yoshizawa ◽  
...  
Keyword(s):  
Lung Injury ◽  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Blood Lymphocyte
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