scholarly journals Case Series: Refractory Cases of Hyper-serum IgE Achieve Transformative Decrease by TCM Therapy

2021 ◽  
Author(s):  
Johnathan Neshiwat ◽  
Tory Mcknight ◽  
Serife Uzun ◽  
Paul Ehrlich ◽  
Danna Chung ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Pediatric Population ◽  
Case Series ◽  
Food Allergies ◽  
Future Research ◽  
Hypersensitivity Reactions ◽  
Safe Alternative ◽  
Serum Ige ◽  
Ige Mediated

Abstract Background:Chronic conditions from IgE-mediated hypersensitivity reactions affect over 150 million Americans, but affordable and effective treatment options remain largely unavailable to the pediatric population. Traditional Chinese medicine has been shown to reduce IgE levels in refractory cases of hyper-serum IgE and have transformative effects in pediatric patients with chronic allergic inflammation.Presentation:Here we present ten patients with chronic atopic conditions and refractory hyper-serum IgE who were treated with TCM therapy. The patients had at least two atopic conditions as well as multiple allergic sensitivities to foods and environmental allergens: all of the patients presented with food allergies (FA) and atopic dermatitis (AD), 60% of patients presented with an environmental allergy (EA), 40% of patients presented with asthma (AS), 10% had celiac disease (Celiac), and 10% had eosinophilic esophagitis (EoE). All of the affected patients had IgE levels greater than 5,000kIU/L (normal =300kIU/L) prior to treatment. None of the patients had an IgE of greater than 5,000kIUL after treatment. We treated 10 children with IgE-mediated hypersensitivity reactions using topical and oral TCM and found an average reduction of 3,723kIU/L IgE per patient (p=0.01) or 79%. Conclusion:We present a ten-patient case series on the effective lowering of hyper-serum IgE using Traditional Chinese Medicine in otherwise refractory pediatric cases of chronic atopic inflammation. TCM is an affordable and safe alternative for chronic atopic conditions compounded with hyper-serum IgE. Future research via random controlled trials should be used to test the efficacy of TCM.

scholarly journals Successful management of extremely frequent hives in children with multiple food allergies with integrative traditional Chinese medicine therapy

2020 ◽  
Author(s):  
Fan Xiawen ◽  
Misu Paul ◽  
Tory McKnight ◽  
Song Park ◽  
Danna Chung ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Pediatric Patients ◽  
Pediatric Population ◽  
Specific Ige ◽  
Food Allergies ◽  
Dramatic Improvement ◽  
Total Ige ◽  
Curative Therapy ◽  
Epinephrine Injection

Abstract BackgroundFood allergy is becoming increasingly common among the pediatric population. Despite strict avoidance of food allergens, a subgroup of sensitive individuals still develop frequent, persistent and difficult to treat hives (FPDTH) for which there is no curative therapy. Although these cases are rare, these patients are in most need of therapy.Case DescriptionThis is a retrospective review of 3 pediatric patients with highly sensitive food allergy who initially presented with hives daily or every other day, but achieved marked remission after traditional Chinese medicine (TCM) therapies. Patient 1 (P1) is a 5-year-old who had experienced 140 reactions in his lifetime. Reactions were mostly hives with 4 episodes of anaphylaxis. P1 had used Prednisone 20 times, had an Epinephrine injection 4 times and had 3 emergency room (ER) visits. Patient 2 (P2) is a 12-year-old who had experienced hives since age 3. Despite daily antihistamine use, P2 had > 730 reactions in his lifetime at the time of presentation including 2 episodes of anaphylaxis. He had been prescribed prednisone 4 times, an Epinephrine injection 2 times and had 1 ER visit. Patient 3 (P3) is a 20-month-old girl who had experienced > 120 reactions including 1 episode of anaphylaxis. She was on daily desonide and frequently used and antihistamine, yet still had required a course of prednisone once, an Epinephrine injection once and had 1 ER visit to manage her reaction. After presenting to our clinic, patients received internal and external TCM treatments, including herbal bath and creams (Remedy A-D) as basic remedies to reduce food reactions, including but not limited to frequent hives. Within 7–9 months of TCM treatment, remarkably all patients had complete remission of atopic symotoms. All three patients also experienced improvement in other conditions including food intolerance, diarrhea, anxiety, eczema, environmental allergies. After 1 year of treatment, all three patients had reductions in food-specific IgE levels that had been previously elevated, and additionally, P1 and P3, who initially had high total IgE levels, experienced marked decrease in total IgE levels as well. All three patients continued to introduce foods into their diet that they previously had reactions to, and all 3 patients remain symptom-free.ConclusionsThree pediatric patients with known history of multiple food sensitivities and physician diagnosed food allergies that presented with FPDTH underwent TCM regimen and experienced dramatic improvement in symptoms and reduction in their IgE levels. This regimen appears to be effective in FPDTH population although further study in a controlled clinical setting is required.

scholarly journals A Classic Herbal Formula Danggui Beimu Kushen Wan for Chronic Prostatitis: From Traditional Knowledge to Scientific Exploration

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Hong Li ◽  
Andrew Hung ◽  
Angela Wei Hong Yang
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Studies ◽  
Chronic Prostatitis ◽  
Assessment Tool ◽  
Conventional Medicine ◽  
Experimental Studies ◽  
Case Series ◽  
Risk Of Bias ◽  
Future Research

Chronic prostatitis (CP) is a chronic inflammation in the prostate with unsatisfactory management. Danggui Beimu Kushen Wan (DBKW) is a classic formula developed 1800 years ago for patients with difficult urination and it has been widely utilized for CP in modern days. However, scientific understanding of DBKW on CP has not been systematically reviewed. First, we searched the Encyclopedia of Traditional Chinese Medicine for the etiologies and pathogeneses of CP-like symptoms and DBKW and compared their similarities and differences from traditional Chinese medicine and conventional medicine perspectives. Then, we searched 21 electronic databases to identify potential clinical and experimental studies. Characteristics of included studies, ingredients, herb frequency, and possible mechanisms of actions were descriptively summarized. Risk of bias of randomized controlled trials (RCTs) was evaluated using the Cochrane risk of bias assessment tool. A total of 290 studies were identified. Six clinical studies, including four RCTs and two case series, and eight experimental studies were included. Clinical studies indicated that DBKW used alone or as an adjunct therapy significantly reduced the CP symptom scores and decreased the expressed prostatic secretions-pH when compared to antibiotics or α-blocker. Most RCTs have high or unclear risk of bias. Experimental studies revealed that DBKW may have effects on anti-inflammation, antibacteria, antioxidation, sex hormone regulation, and immunoregulation. DBKW demonstrated a great potential in the treatment of CP. High-quality RCTs and network pharmacological studies should be considered for future research.

Ulcers Related to Acupuncture and Traditional Chinese Medicine: A Case Series and Review of the Literature

2009 ◽  
Vol 145 (4) ◽  
Author(s):  
Lynn H. Y. Teo ◽  
Mark B. Y. Tang ◽  
Audrey Wei-Hsia Tan ◽  
Hiok-Hee Tan ◽  
See-Ket Ng
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Case Series ◽  
Review Of The Literature

Gag Reflex Control through Acupuncture: A Case Series

2014 ◽  
Vol 32 (1) ◽  
pp. 24-27 ◽  
Author(s):  
Giuseppa Bilello ◽  
Antonella Fregapane
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Case Series ◽  
Inclusion Criteria ◽  
History Of ◽  
Gag Reflex ◽  
Reflex Control ◽  
Dental Appointments

Background Many patients avoid dental appointments because of severe gagging when they have work performed, such as taking impressions. There are several methods known to alleviate gagging, and some studies have suggested that acupuncture may be effective in reducing gag reflex. The aim of the present study therefore was to evaluate whether acupuncture can produce a reduction of the gag reflex. Methods A total of 20 patients, aged between 19 and 80 years, with history of gag reflex on taking dental impressions, were recruited. All patients fulfilling the inclusion criteria had an upper and lower dental alginate impression taken without acupuncture, and a second upper and lower alginate impression taken immediately after acupuncture based on traditional Chinese medicine. After each impression, the patients recorded their emetic sensation using a visual analogue scale (VAS). Results The results showed a significant (p<0.05) reduction in the gag reflex scores after acupuncture. For upper impressions, they fell from 6.8 (1.1) to 1.1 (1.1); and for lower impressions, from 5.45 (1.0) to 0.4 (0.7) (mean (SD)). Conclusions The findings from our study suggest that acupuncture may be useful for preventing and treating gag reflex, and justifies further study.

scholarly journals Strychnine poisoning due to traditional Chinese medicine: a case series

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 924
Author(s):  
Hok-Fung Tong ◽  
Candace Yim Chan ◽  
Sau-Wah Ng ◽  
Tony Wing-Lai Mak
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Features ◽  
Drugs Of Abuse ◽  
Case Series ◽  
Case Fatality ◽  
Reference Laboratory ◽  
History Of ◽  
Different Origins ◽  
Different Parts

Background: Strychnine poisoning is rare but possibly fatal. The most reported sources of strychnine poisoning include rodenticides and adulterated street heroin. Here we report a case series of an unusual cause of strychnine poisoning – Strychni semen, a herb known as “maqianzi” in traditional Chinese medicine (TCM). Methods: All cases of strychnine poisoning confirmed by the Hospital Authority Toxicology Reference Laboratory (HATRL, the highest-level clinical toxicology laboratory in Hong Kong) between May 2005 and May 2018 were reviewed. Results: Twelve cases of strychnine poisoning were recorded, and Strychni semen was the exclusive source. Ten (83%) patients presented with muscle spasms, and four (33%) developed typical conscious convulsions. The poisoning was severe in two (17%) patients, moderate in three (25%) and mild in eight (58%). No case fatality was recorded. Three (25%) patients were TCM practitioners and two (17%) were laymen who bought the herb themselves without a proper prescription. Conclusion: The practice of TCM is becoming popular in different parts of the world amid the COVID-19 pandemic. The spectrum of clinical features of strychnine poisoning secondary to Strychni semen are similar to those arising from different origins. Eliciting a history of TCM use, apart from exposure to rodenticides and drugs of abuse, may allow timely diagnosis in patients with compatible clinical features. Enhancement of TCM safety could minimize the hazard.

scholarly journals An evidence mapping of systematic reviews and meta-analysis on traditional Chinese medicine for ulcerative colitis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yu-Xin Sun ◽  
Xiao Wang ◽  
Xing Liao ◽  
Jing Guo ◽  
Wen-Bin Hou ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Systematic Reviews ◽  
Methodological Quality ◽  
Route Of Administration ◽  
Current Evidence ◽  
Future Research ◽  
Evidence Mapping

Abstract Background Traditional Chinese Medicine (TCM) has been a proposed treatment option for ulcerative colitis (UC), however it has been difficult to understand the breadth and depth of evidence as various Chinese medicine therapies may produce effects differently. The aim of this evidence mapping is to visually understand the available evidence in the use of TCM in the treatment of UC, and to identify gaps in evidence to inform priorities of future research. Methods A systematic electronic literature search of six databases were performed to identify systematic reviews (SRs) on different Chinese medicine therapies in the treatment in UC. Methodological quality of the included SRs was assessed using AMSTAR 2. Results The mapping was based on 73 SRs, which included nine interventions that met eligibility criteria. The quality of the included SRs was very low. The diseases stages of patients with UC varied greatly, from active to remission, to non-acute outbreak, to not reported. The results mostly favored the method of intervention. Oral administration combined with enema was the most widely used route of administration in secondary research. Conclusion Based on the current evidence, the treatment of UC with TCM can only be recommended cautiously. A majority of included SRs did not report the location of the disease, the disease classification, and the route of administration of the intervention. Further research is needed on the effectiveness of Chinese medicine alone in the treatment of UC. The effectiveness of combined Chinese and conventional medicine combined with different routes of administration cannot be confirmed. Attention should be paid to the methodological quality of the systematic review. Unifies the outcome indicators used in the evaluation of effectiveness.

scholarly journals First case series of the transradial approach for neurointerventional procedures in pediatric patients

2020 ◽  
Vol 25 (5) ◽  
pp. 492-496 ◽  
Author(s):  
Neil Majmundar ◽  
Pratit Patel ◽  
Vincent Dodson ◽  
Ivo Bach ◽  
James K. Liu ◽  
...  
Keyword(s):  
Ultrasound Guidance ◽  
Pediatric Patients ◽  
Pediatric Population ◽  
Case Series ◽  
Transfemoral Approach ◽  
Safe Alternative ◽  
Transradial Approach ◽  
Clinical Events ◽  
First Case ◽  
Neurointerventional Procedures

OBJECTIVEThe transradial approach (TRA) has been widely adopted by interventional cardiologists but is only now being accepted by neurointerventionalists. The benefits of the TRA over the traditional transfemoral approach (TFA) include reduced risk of adverse clinical events and faster recovery. The authors assessed the safety and feasibility of the TRA for neurointerventional cases in the pediatric population.METHODSPediatric patients undergoing cerebrovascular interventions since implementation of the TRA at the authors’ institution were retrospectively reviewed. Pertinent patient information, procedure indications, vessels catheterized, fluoroscopy time, and complications were reviewed.RESULTSThere were 4 patients in this case series, and their ages ranged from 13 to 15 years. Each patient tolerated the procedure performed using the TRA without any postprocedural issues, and only 1 patient experienced radial artery spasm, which resolved with the administration of intraarterial verapamil. None of the patients required conversion to the TFA.CONCLUSIONSThe TRA can be considered a safe alternative to the TFA for neurointerventional procedures in the pediatric population and provides potential advantages. However, as pediatric patients require special consideration due to their smaller-caliber arteries, routine use of ultrasound guidance is advised when attempting the TRA.

scholarly journals P.110 Systematic review of civilian pediatric intracranial gunshot wounds

2019 ◽  
Vol 46 (s1) ◽  
pp. S42
Author(s):  
T Duda ◽  
A Sharma ◽  
Y Ellenbogen ◽  
H Shakil ◽  
S Sharma
Keyword(s):  
Systematic Review ◽  
Prognostic Factors ◽  
Pediatric Population ◽  
Case Series ◽  
Gunshot Wounds ◽  
Epidemiological Studies ◽  
Future Research ◽  
Treatment Considerations ◽  
Newcastle Ottawa Scale ◽  
Treatment Priorities

Background: Pediatric craniocerebral gunshot wounds occur in the context of both accidental and intentional trauma. Unique physiologic factors merited research into prognostic factors and treatment priorities in the pediatric population. Methods: A systematic search of MEDLINE, EMBASE, Web of Science, LILACS, Cochrane Registered Trials and Systematic Reviews, ISRCTN, and ClinicalTrials.gov was conducted. Selection criteria included all studies published in any language since 2000 which described intracranial isolated gunshot wounds in a civilian individual or population of pediatric age. Post-mortem and epidemiological studies were excluded. Screening was conducted through Covidence. Results: Initial database search revealed 349 unique studies for abstract and title screening. Fifty studies were selected for full text screening. Nine studies were included in the final review. Study quality was assessed with the Newcastle-Ottawa Scale. Case series noted bullet migration, pituitary deficiency, neurovascular and neuropsychological concerns. Three single-center retrospective studies of 71, 30, and 48 pediatric patients suggested multiple negative prognostic signs on initial presentation. Early aggressive surgical treatment was recommended by some authors. Conclusions: This systematic review analyzed the best current understanding of evidence for prognostic factors and treatment considerations of intracranial gunshot wounds in the pediatric neurotrauma context. Areas for future research with larger multi-center studies were highlighted.

scholarly journals Homeopathic Clinical Features of 18 Patients in COVID-19 Outbreaks in Hong Kong

Homeopathy ◽  
2020 ◽  
Vol 109 (03) ◽  
pp. 146-162 ◽  
Author(s):  
Ka Lun Aaron To ◽  
Yuen Ying Yvonne Fok
Keyword(s):  
Hong Kong ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Features ◽  
Conventional Treatment ◽  
Symptomatic Relief ◽  
Case Series ◽  
The Common ◽  
Gelsemium Sempervirens

Abstract Background Hong Kong is geographically located in the province of Guangdong which, after Hubei, has been the region of China second-most affected by the COVID-19 pandemic. Compared to the pathognomonic symptoms of the named disease, homeopathic symptoms are always more helpful for homeopathic prescriptions. Aim This study reports and summarizes the homeopathic symptoms observed in 18 confirmed/suspected epidemiologically related cases in cluster outbreaks of COVID-19 in Hong Kong in early 2020. Methods Homeopathic symptoms from this case series were collected from 18 consecutive patients who, in addition to their concurrent conventional treatment or traditional Chinese medicine, actively sought help from homeopathy as an adjunctive measure for symptomatic relief from COVID-19. Cases were categorized according to outbreak clusters, focusing mainly on the homeopathic symptoms. In the analysis, frequency of all homeopathic medicines, common rubrics in all the cases, common rubrics in each of the top-ranked remedies, and differentiating symptoms for each top-ranked remedy were determined. Results Homeopathic symptoms of 18 cases, each identified as mild and belonging to one of six separate clusters, are reported. Eighteen common symptoms screened out of 79 selected rubrics constituted two sets of homeopathic symptom pictures: Bryonia alba (n = 4) and Gelsemium sempervirens (n = 12). Eight and seven differentiating features, respectively, were identified for Bryonia alba and Gelsemium sempervirens. Conclusion The common symptoms of 18 mild COVID-19 cases constituted two sets of homeopathic symptom pictures, indicating Bryonia alba or Gelsemium sempervirens; they were indicated in 4 and 12 cases, respectively, out of the 18 in total.

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