A Classic Herbal Formula Danggui Beimu Kushen Wan for Chronic Prostatitis: From Traditional Knowledge to Scientific Exploration

Chronic prostatitis (CP) is a chronic inflammation in the prostate with unsatisfactory management. Danggui Beimu Kushen Wan (DBKW) is a classic formula developed 1800 years ago for patients with difficult urination and it has been widely utilized for CP in modern days. However, scientific understanding of DBKW on CP has not been systematically reviewed. First, we searched the Encyclopedia of Traditional Chinese Medicine for the etiologies and pathogeneses of CP-like symptoms and DBKW and compared their similarities and differences from traditional Chinese medicine and conventional medicine perspectives. Then, we searched 21 electronic databases to identify potential clinical and experimental studies. Characteristics of included studies, ingredients, herb frequency, and possible mechanisms of actions were descriptively summarized. Risk of bias of randomized controlled trials (RCTs) was evaluated using the Cochrane risk of bias assessment tool. A total of 290 studies were identified. Six clinical studies, including four RCTs and two case series, and eight experimental studies were included. Clinical studies indicated that DBKW used alone or as an adjunct therapy significantly reduced the CP symptom scores and decreased the expressed prostatic secretions-pH when compared to antibiotics or α-blocker. Most RCTs have high or unclear risk of bias. Experimental studies revealed that DBKW may have effects on anti-inflammation, antibacteria, antioxidation, sex hormone regulation, and immunoregulation. DBKW demonstrated a great potential in the treatment of CP. High-quality RCTs and network pharmacological studies should be considered for future research.

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Case Series: Refractory Cases of Hyper-serum IgE Achieve Transformative Decrease by TCM Therapy

10.21203/rs.3.rs-235076/v1 ◽

2021 ◽

Author(s):

Johnathan Neshiwat ◽

Tory Mcknight ◽

Serife Uzun ◽

Paul Ehrlich ◽

Danna Chung ◽

...

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Pediatric Population ◽

Case Series ◽

Food Allergies ◽

Future Research ◽

Hypersensitivity Reactions ◽

Safe Alternative ◽

Serum Ige ◽

Ige Mediated

Abstract Background:Chronic conditions from IgE-mediated hypersensitivity reactions affect over 150 million Americans, but affordable and effective treatment options remain largely unavailable to the pediatric population. Traditional Chinese medicine has been shown to reduce IgE levels in refractory cases of hyper-serum IgE and have transformative effects in pediatric patients with chronic allergic inflammation.Presentation:Here we present ten patients with chronic atopic conditions and refractory hyper-serum IgE who were treated with TCM therapy. The patients had at least two atopic conditions as well as multiple allergic sensitivities to foods and environmental allergens: all of the patients presented with food allergies (FA) and atopic dermatitis (AD), 60% of patients presented with an environmental allergy (EA), 40% of patients presented with asthma (AS), 10% had celiac disease (Celiac), and 10% had eosinophilic esophagitis (EoE). All of the affected patients had IgE levels greater than 5,000kIU/L (normal =300kIU/L) prior to treatment. None of the patients had an IgE of greater than 5,000kIUL after treatment. We treated 10 children with IgE-mediated hypersensitivity reactions using topical and oral TCM and found an average reduction of 3,723kIU/L IgE per patient (p=0.01) or 79%. Conclusion:We present a ten-patient case series on the effective lowering of hyper-serum IgE using Traditional Chinese Medicine in otherwise refractory pediatric cases of chronic atopic inflammation. TCM is an affordable and safe alternative for chronic atopic conditions compounded with hyper-serum IgE. Future research via random controlled trials should be used to test the efficacy of TCM.

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Predicting Postpartum Haemorrhage: A systematic review of prognostic models

10.22541/au.162527682.23952317/v1 ◽

2021 ◽

Author(s):

Bethany Carr ◽

Maryam Jahangirifar ◽

Ann Nicholson ◽

Ben Mol ◽

Wentao Li ◽

...

Keyword(s):

Prognostic Model ◽

Postpartum Haemorrhage ◽

Assessment Tool ◽

Data Extraction ◽

Experimental Studies ◽

Risk Of Bias ◽

Prognostic Models ◽

Cochrane Library ◽

Future Research ◽

Mortality And Morbidity

Background: Postpartum Haemorrhage (PPH) remains a leading cause of maternal mortality and morbidity worldwide, and the rate is increasing. Using a reliable predictive model could identify those at risk, support management and treatment, and improve maternal outcomes. Objectives: To systematically identify and appraise existing prognostic models for PPH and ascertain suitability for clinical use. Search strategy: MEDLINE, CINAHL, Embase, and the Cochrane Library were searched using combinations of terms and synonyms including ‘postpartum haemorrhage’, ‘prognostic model’, and ‘risk factors’ that were developed from a scoping review. Selection Criteria: Observational or experimental studies describing a prognostic model for risk of PPH, published in English. Data Collection and Analysis: The Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies checklist informed data extraction and Prediction Model Risk of Bias Assessment Tool guided analysis. Main Results: 16 studies met the inclusion criteria after screening 1612 records. All studies were hospital settings from 8 different countries. Models were developed for women who experienced vaginal birth (n=7), caesarean birth(n=2), any type of birth(n=2), hypertensive disorders(n=1) and those with placental abnormalities(n=4). All studies were at high risk of bias due to use of inappropriate analysis methods or omission of important statistical considerations or suboptimal validation. Conclusions: No existing prognostic models for PPH are ready for clinical application. Future research is needed to externally validate existing models and potentially develop a new model that is reliable and applicable to clinical practice. Funding: This study received no funding. Keywords: Postpartum haemorrhage, prognostic model, prediction tool.

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Clinical Studies with Traditional Chinese Medicine in the Past Decade and Future Research and Development

Planta Medica ◽

10.1055/s-0030-1250456 ◽

2010 ◽

Vol 76 (17) ◽

pp. 2048-2064 ◽

Cited By ~ 62

Author(s):

Miao Jiang ◽

Jing Yang ◽

Chi Zhang ◽

Baoyan Liu ◽

Kelvin Chan ◽

...

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Research And Development ◽

Clinical Studies ◽

Future Research ◽

The Past

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Tri-Response Police, Ambulance, Mental Health Crisis Models in Reducing Involuntary Detentions of Mentally Ill People: Protocol for a Systematic Review

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18158230 ◽

2021 ◽

Vol 18 (15) ◽

pp. 8230

Author(s):

Julia Heffernan ◽

Ewan McDonald ◽

Elizabeth Hughes ◽

Richard Gray

Keyword(s):

Mental Health ◽

Systematic Review ◽

Assessment Tool ◽

Public Health Practice ◽

Grey Literature ◽

Risk Of Bias ◽

Future Research ◽

Mental Health Crisis ◽

Health Crisis ◽

Response Models

Police, ambulance and mental health tri-response services are a relatively new model of responding to people experiencing mental health crisis in the community, but limited evidence exists examining their efficacy. To date there have been no systematic reviews that have examined the association between the tri-response model and rates of involuntary detentions. A systematic review examining co-response models demonstrated possible reduction in involuntary detention, however, recommended further research. The aim of this protocol is to describe how we will systematically review the evidence base around the relationship of the police, ambulance mental health tri-response models in reducing involuntary detentions. We will search health, policing and grey literature databases and include clinical evaluations of any design. Risk of bias will be determined using the Effective Public Health Practice Project Quality Assessment Tool and a narrative synthesis will be undertaken to synthesis key themes. Risk of bias and extracted data will be summarized in tables and results synthesis tabulated to identify patterns within the included studies. The findings will inform future research into the effectiveness of tri-response police, ambulance, and mental health models in reducing involuntary detentions.

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The Anti-Neuroinflammatory Effect of Fuzi and Ganjiang Extraction on LPS-Induced BV2 Microglia and Its Intervention Function on Depression-Like Behavior of Cancer-Related Fatigue Model Mice

Frontiers in Pharmacology ◽

10.3389/fphar.2021.670586 ◽

2021 ◽

Vol 12 ◽

Author(s):

Songwei Yang ◽

Yantao Yang ◽

Cong Chen ◽

Huiqin Wang ◽

Qidi Ai ◽

...

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Inflammatory Mediators ◽

Critical Role ◽

Chinese Herb ◽

Experimental Studies ◽

Research Results ◽

Cancer Related Fatigue

The Chinese herb couple Fuzi and Ganjiang (FG) has been a classic combination of traditional Chinese medicine that is commonly used clinically in China for nearly 2000 years. Traditional Chinese medicine suggests that FG can treat various ailments, including heart failure, fatigue, gastrointestinal upset, and depression. Neuroinflammation is one of the main pathogenesis of many neurodegenerative diseases in which microglia cells play a critical role in the occurrence and development of neuroinflammation. FG has been clinically proven to have an efficient therapeutic effect on depression and other neurological disorders, but its mechanism remains unknown. Cancer-related fatigue (CRF) is a serious threat to the quality of life of cancer patients and is characterized by both physical and psychological fatigue. Recent studies have found that neuroinflammation is a key inducement leading to the occurrence and development of CRF. Traditional Chinese medicine theory believes that extreme fatigue and depressive symptoms of CRF are related to Yang deficiency, and the application of Yang tonic drugs such as Fuzi and Ganjiang can relieve CRF symptoms, but the underlying mechanisms remain unknown. In order to define whether FG can inhibit CRF depression-like behavior by suppressing neuroinflammation, we conducted a series of experimental studies in vitro and in vivo. According to the UPLC-Q-TOF/MSE results, we speculated that there were 49 compounds in the FG extraction, among which 30 compounds were derived from Fuzi and 19 compounds were derived from Ganjiang. Our research data showed that FG can effectively reduce the production of pro-inflammatory mediators IL-6, TNF-α, ROS, NO, and PGE2 and suppress the expression of iNOS and COX2, which were related to the inhibition of NF-κB/activation of Nrf2/HO-1 signaling pathways. In addition, our research results revealed that FG can improve the depression-like behavior performance of CRF model mice in the tail suspension test, open field test, elevated plus maze test, and forced swimming test, which were associated with the inhibition of the expression of inflammatory mediators iNOS and COX2 in the prefrontal cortex and hippocampus of CRF model mice. Those research results suggested that FG has a satisfactory effect on depression-like behavior of CRF, which was related to the inhibition of neuroinflammation.

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A survey on experimental studies on traditional Chinese medicine treatment of chronic renal failure

Chinese Journal of Integrative Medicine ◽

10.1007/bf02934264 ◽

1996 ◽

Vol 2 (3) ◽

pp. 232-235

Author(s):

Lei Wang ◽

Mian-Zhi Wang

Keyword(s):

Renal Failure ◽

Chronic Renal Failure ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Experimental Studies ◽

Traditional Chinese Medicine Treatment ◽

Chinese Medicine Treatment

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Modern research on purgation method of traditional Chinese medicine — Application of the method in acute abdominal diseases and experimental studies

Chinese Journal of Integrated Traditional and Western Medicine ◽

10.1007/bf02935037 ◽

1998 ◽

Vol 4 (1) ◽

pp. 5-8

Author(s):

Wu Xianzhong

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Experimental Studies ◽

Medicine Application

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LO29: Interventions at triage to improve emergency department throughput: a systematic review

CJEM ◽

10.1017/cem.2020.85 ◽

2020 ◽

Vol 22 (S1) ◽

pp. S17-S17

Author(s):

K. Grant ◽

C. Bayley ◽

E. Lang ◽

G. Innes

Keyword(s):

Emergency Department ◽

Assessment Tool ◽

Care Quality ◽

Risk Of Bias ◽

Future Research ◽

Controlled Trials ◽

Cochrane Central Register ◽

Meaningful Improvement ◽

Study Results ◽

Statistical Heterogeneity

Introduction: Emergency Department (ED) crowding is the primary threat to emergency care quality. Input and outflow factors are important factors, but EDs must optimize throughput efficiency by improving internal processes from triage to disposition, and triage is the first throughput phase. Triage throughput interventions exclude strategies that direct patients away from the ED (these modify input rather than throughput). Previous research has described physicians in triage, team triage, telemedical triage, and nurse practitioner (NP) or physician assistant (PA) led triage, but their impact has never been systematically evaluated. Methods: We conducted systematic database searches in Medline, Embase, CINAHL, and the Cochrane Central Register of Controlled Trials without the use of filters or language restrictions of all triage interventions that effected ED throughput (PROSPERO:CRD42019125651). Two independent reviewers screened studies. Study quality was assessed using the Cochrane Risk of Bias tool (version 2) for randomized controlled trials, and the National Heart, Lung, and Blood Institute quality assessment tool for other designs. Results: 18 studies met inclusion criteria (Cohen's k = 0.69). Study results were not pooled due to high statistical heterogeneity as assessed by chi-squared and I-squared statistics. Studies were grouped into physician led, NP or PA led, and team triage interventions. Six physician in triage interventions reported LOS changes between -82 and + 18 minutes. Five NP/PA led triage interventions resulted in LOS changes of -106 to + 19 minutes. Five team triage interventions reported LOS reductions of 4 to 34 minutes. One telemedicine triage study reported a non-significant 8 minute increase in LOS. Six physician at triage interventions yielded significant LWBS rate improvement (relative risk {RR}= 0.29-0.82). Team triage interventions generated LWBS rate changes ranging from meaningful improvement (RR = 0.58) to substantial deterioration (RR = 1.68). Five studies have low risk of bias, 11 studies have some risk of bias, and 2 studies have high risk of bias (Cohen's kappa = 0.58). Conclusion: Fourteen of 18 triage interventions reduced EDLOS and/or LWBS rate. Physician, NP and PA led triage were the most effective triage interventions. To aid widespread adoption, future research should focus on interrupted time series or RCT designs, and more comprehensive descriptions of the contextual factors affecting implementation of these interventions.

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