scholarly journals Precise engineering of ultrasound-mediated cerium oxide nanoparticles: Investigations on antioxidant, antibacterial activity and human osteomyelitis

Author(s):  
Xiusong Dai ◽  
Xiaopan Wang ◽  
Xiaotian Chen ◽  
Longfei Ye ◽  
Min Wu

Abstract In this study, the antibacterial activity of cerium oxide nanoparticles on two Gram-negative and three Gram-positive foodborne pathogens was investigated. CeO2 nanoparticles (CeO2 NPs) were synthesized by a Wet Chemical Synthesis route, using the precipitation method and the Simultaneous Addition of reactants (WCS–SimAdd). The as-obtained precursor powders were investigated by thermal analysis (TG–DTA), to study their decomposition process and to understand the CeO2 NPs formation. The composition, structure, and morphology of the thermally treated sample were investigated by FTIR, Raman spectroscopy, X-ray diffraction, TEM, and DLS. The cubic structure and average particle size ranging between 5 and 15 nm were evidenced. Optical absorption measurements (UV–Vis) reveal that the band gap of CeO2 NPs is 2.61 eV, which is smaller than the band gap of bulk ceria. The antioxidant effect of CeO2 NPs was determined, and the antibacterial test was carried out both in liquid and on solid growth media against five pathogenic microorganisms, namely Escherichia coli, Salmonella typhimurium, Listeria monocytogenes, Staphylococcus aureus, and Bacillus cereus. Cerium oxide nanoparticles showed growth inhibition toward all five pathogens tested with notable results. This paper highlights the CeO2 NPs showed antibacterial activity with significant variations due to the differences in the membrane structure and cell wall composition among the two groups tested. Consequently, synthesized CeO2 NPs can be potential candidates for the treatment of osteomyelitis.

Nanomaterials ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1614
Author(s):  
Oana L. Pop ◽  
Amalia Mesaros ◽  
Dan C. Vodnar ◽  
Ramona Suharoschi ◽  
Flaviu Tăbăran ◽  
...  

In this study, the antibacterial activity of cerium oxide nanoparticles on two Gram-negative and three Gram-positive foodborne pathogens was investigated. CeO2 nanoparticles (CeO2 nps) were synthesized by a Wet Chemical Synthesis route, using the precipitation method and the Simultaneous Addition of reactants (WCS–SimAdd). The as-obtained precursor powders were investigated by thermal analysis (TG–DTA), to study their decomposition process and to understand the CeO2 nps formation. The composition, structure, and morphology of the thermally treated sample were investigated by FTIR, Raman spectroscopy, X-ray diffraction, TEM, and DLS. The cubic structure and average particle size ranging between 5 and 15 nm were evidenced. Optical absorption measurements (UV–Vis) reveal that the band gap of CeO2 is 2.61 eV, which is smaller than the band gap of bulk ceria. The antioxidant effect of CeO2 nps was determined, and the antibacterial test was carried out both in liquid and on solid growth media against five pathogenic microorganisms, namely Escherichia coli, Salmonella typhimurium, Listeria monocytogenes, Staphylococcus aureus, and Bacillus cereus. Cerium oxide nanoparticles showed growth inhibition toward all five pathogens tested with notable results. This paper highlights the perspectives for the synthesis of CeO2 nps with controlled structural and morphological characteristics and enhanced antibacterial properties, using a versatile and low-cost chemical solution method.


2020 ◽  
Vol 185 (Supplement_1) ◽  
pp. 103-109
Author(s):  
Beverly A Rzigalinski ◽  
Holly M Giovinco ◽  
Byron J Cheatham

ABSTRACT Introduction Blood is a precious commodity, with storage limited to 42 days under refrigeration. Degradative changes in red blood cells (RBCs) begin as early as 11–21 days after collection, and compromise their function. Materials that extend the life of RBCs will improve blood utilization in the field, as well as in hospital settings. Cerium oxide nanoparticles (CeONPs) are widely used in the materials industry to counteract oxidative stress and improve oxygen storage. We have previously shown that CeONPs extended the lifespan of cells in culture and counteract oxidative stress in vitro and in vivo. Here, we test the hypothesis that CeONPs extend the lifespan of RBCs in whole stored blood. Materials and Methods Rat whole blood was collected with sodium citrate and stored at 4°C. Groups consisted of control (no CeONPs), and 10 and 100 nM CeONPs (average particle size 10 nm) added. Aliquots of stored blood were removed weekly and analyzed for different blood parameters. Results Results demonstrate that CeONPs improve storage and functional lifespan of RBCs in stored whole blood. Conclusions This work suggests that CeONPs may be a promising additive for extending storage and function of blood and blood products.


2022 ◽  
Author(s):  
R. ChithraDevi ◽  
S. Surendhiran ◽  
A. Balamurugan ◽  
P. Bhoopathy ◽  
K. Kandasamy ◽  
...  

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e47827 ◽  
Author(s):  
Vishal Shah ◽  
Shreya Shah ◽  
Hirsh Shah ◽  
Fred J. Rispoli ◽  
Kevin T. McDonnell ◽  
...  

Optik ◽  
2015 ◽  
Vol 126 (24) ◽  
pp. 5830-5835 ◽  
Author(s):  
E. Gopinathan ◽  
G. Viruthagiri ◽  
N. Shanmugam ◽  
S. Sathiya priya

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Gowthami R ◽  
Keerthana G

The UV- Vis spectroscopy determines the band gap of calcium oxide nanoparticles and also the calcium oxide nanoparticles shows excellent antibacterial activity due to its degradation property.


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