scholarly journals Synergic Fabrication of Naringin Molecule into Polymeric Nanoparticles for the Treatment and Nursing Care of Lung Cancer Therapy

2021 ◽  
Author(s):  
Lingqiao Yan ◽  
Hui Chen ◽  
Mindan Xie
Keyword(s):  
Lung Cancer ◽  
Polymeric Nanoparticles ◽  
Cost Effective ◽  
The United States ◽  
Hydroxyl Group ◽  
Electron Microscopic ◽  
Anticancer Properties ◽  
Clinical Evaluations ◽  
Cost Effective Method ◽  
Lung Cancer Therapy

Abstract Lung cancer is the third most common cause of death and the main factor of cancer-related deaths in both males and females in the United States to the rest of the world. Diagnosis at an important level is associated with high mortality in the population of cases. Herein, we present a very easy and cost-effective method that incorporates drugs reconstruction, tumor-specific targeting supramolecular nanoassembly, and therapeutically to overcome the different challenges raised by the distribution of the pharmaceutical potential anticancer drug Naringin. On covalent conjugations of hydrophobic linoleic acid by hydroxyl group, the Naringin prodrugs were skilled in impulsively nanoassembly into extremely steady nanoparticles size (~100 nm). Electron microscopic techniques have verified the newly synthesized morphology of Naringin-NPs. The anticancer properties of Naringin and Naringin-NPs against A549 and HEL-299 (lung carcinoma) cancer cell lines have been evaluated after successful synthesis. Other research, such as dual staining acridine orange/ethidium bromide, Hoechst 33344 and flow cytometry study on the apoptosis mechanisms have shown that proliferation in lung cancer cells is associated with apoptosis. Compared to Naringin, Naringin-NPs demonstrate excellent biocompatibility, this study clarified the Naringin-NPs as a healthy and positive lung cancer treatment and care chemotherapeutics technique and deserve further clinical evaluations.

scholarly journals Precise Engineering of Cisplatin Prodrug Into Supramolecular Nanoparticles: Enhanced on in Vitro Antiproliferative Activity and Treatment and Care of in Vivo Renal Injury 

2021 ◽  
Author(s):  
Zhenyun Zhou ◽  
Xiaoxiao Chen
Keyword(s):  
Cancer Cells ◽  
Anticancer Drug ◽  
Clinical Care ◽  
Kidney Tissue ◽  
Cost Effective ◽  
Electron Microscopic ◽  
Anticancer Properties ◽  
Cost Effective Method

Abstract Renal cell carcinoma (RCC) is a widespread type of urological tumor that derives from the highly heterogeneous epithelium of the kidney tissue. For the past decade, the treatment of kidney cancer cells has changed clinical care for RCC. Herein, we present a very easy and cost-effective method that incorporates tumor-specific targeting supramolecular nanoassembly, and therapeutically to overcome the different challenges raised by the distribution of the pharmaceutical potential anticancer drug Cisplatin (CIS-PT). On covalent conjugations of hydrophobic linoleic acid by carboxylic group, the CIS-PT prodrugs were skilled in impulsively nanoassembly into extremely steady nanoparticles size (~100 nm). Electron microscopic techniques have verified the newly synthesized morphology of CIS-PT-NPs. The anticancer properties of CIS-PT and CIS-PT-NPs against Caki-1 and A-498 (renal carcinoma) cancer cell lines have been evaluated after successful synthesis. Other research, such as dual staining acridine orange/ethidium bromide, Hoechst 33344 and flow cytometry study on the apoptosis mechanisms, have shown that proliferation in renal cancer cells is associated with apoptosis. Further the In vivo toxicity results displays the CIS-PT-NPs remarkably alleviated the toxicity of the potential anticancer drug CIS-PT In vivo while conserving the Pharmaceutical activity. Compared to CIS-PT, CIS-PT-NPs demonstrate excellent In vitro and In vivo property, this study clarified the CIS-PT-NPs as a healthy and positive RCC care chemotherapeutics technique and deserve further clinical evaluations.

Synthesis and anticancer properties of phenyl benzoate derivatives possessing a terminal hydroxyl group

2014 ◽  
Vol 2 (10) ◽  
pp. 1335-1343 ◽  
Author(s):  
Yukako Fukushi ◽  
Hironori Yoshino ◽  
Junya Ishikawa ◽  
Masanobu Sagisaka ◽  
Ikuo Kashiwakura ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Death ◽  
Cell Membrane ◽  
Liquid Crystalline ◽  
Hydroxyl Group ◽  
Phenyl Benzoate ◽  
Induce Cell Death ◽  
Anticancer Properties ◽  
A549 Lung ◽  
Benzoate Derivatives

Liquid-crystalline molecules organize into a spherical particle to penetrate the cell membrane in A549 lung cancer cells and the molecules interact with the nucleus via the hydroxyl and ester groups to induce cell death.

scholarly journals Hepatitis C Variability, Patterns of Resistance, and Impact on Therapy

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Cristina Simona Strahotin ◽  
Michael Babich
Keyword(s):  
Hepatitis C ◽  
Antiviral Agents ◽  
Cost Effective ◽  
Standard Of Care ◽  
The United States ◽  
Resistance Mechanisms ◽  
Cost Effective Method ◽  
New Treatments ◽  
Cure Rates ◽  
Effective Treatments

Hepatitis C (HCV), a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma, is the most common indication for liver transplantation in the United States. Although annual incidence of infection has declined since the 1980s, aging of the currently infected population is expected to result in an increase in HCV burden. HCV is prone to develop resistance to antiviral drugs, and despite considerable efforts to understand the virus for effective treatments, our knowledge remains incomplete. This paper reviews HCV resistance mechanisms, the traditional treatment with and the new standard of care for hepatitis C treatment. Although these new treatments remain PEG-IFN-α- and ribavirin-based, they add one of the newly FDA approved direct antiviral agents, telaprevir or boceprevir. This new “triple therapy” has resulted in greater viral cure rates, although treatment failure remains a possibility. The future may belong to nucleoside/nucleotide analogues, non-nucleoside RNA-dependent RNA polymerase inhibitors, or cyclophilin inhibitors, and the treatment of HCV may ultimately parallel that of HIV. However, research should focus not only on effective treatments, but also on the development of a HCV vaccine, as this may prove to be the most cost-effective method of eradicating this disease.

Novel Targets for Lung Cancer Therapy: Part II

2002 ◽  
Vol 20 (13) ◽  
pp. 3016-3028 ◽  
Author(s):  
Grace K. Dy ◽  
Alex A. Adjei
Keyword(s):  
United States ◽  
Lung Cancer ◽  
Protein Trafficking ◽  
Clinical Information ◽  
The United States ◽  
Survival Pathways ◽  
Systemic Treatments ◽  
Lung Cancer Therapy ◽  
Breast And Prostate Cancer ◽  
Cycle Regulation

ABSTRACT: Lung cancer is the second most common form of cancer in the United States, and although it accounts for 15% of all cancers, it is the most lethal, accounting for approximately 28% of cancer deaths. In 2002, it is estimated that 177,000 new cases of lung cancer will be diagnosed in the United States, and an estimated 160,000 men and women will die from the disease. This mortality rate is greater than that attributable to colorectal, breast, and prostate cancer combined. Systemic treatments for lung cancer with standard chemotherapy agents are still relatively ineffective. Agents targeting novel proliferative and survival pathways in lung cancer are needed to improve treatment outcomes. In recent years, numerous agents inhibiting aberrant processes in tumor cells have undergone clinical evaluation. This review is the second of a two-part series that summarizes pertinent preclinical and clinical information on novel drugs that target critical abnormalities in lung cancer. In this article, agents that were developed to inhibit various aspects of tumor protein trafficking and protein degradation, cell cycle regulation, angiogenesis, and antigenicity are described. Future approaches to treatment are suggested.

scholarly journals Precise Engineering of Nanoassembled Corilagin Small Molecule into Supramolecular Nanoparticles for the Treatment and Care against Cervical Carcinoma

2021 ◽  
Author(s):  
Xiujuan Li ◽  
Yan Gao ◽  
Yongai Zhang ◽  
Jing Li ◽  
Haimiao Zhang
Keyword(s):  
Cervical Cancer ◽  
Cervical Carcinoma ◽  
Electron Microscopic ◽  
Anticancer Properties ◽  
Clinical Evaluations ◽  
Cervical Cancer Cells ◽  
Supramolecular Nanoparticles ◽  
Severe Adverse Reactions ◽  
Microscopic Techniques ◽  
Dual Staining

Abstract Cervical cancer is one of the most frequently diagnosed tumors in the world and responsible for a significant percentage of women's deaths. In spite of advances in clinical and medical techniques, cervical cancer is indeed a big challenge. Latest treatments to breast cancer include surgical reduction, radiotherapy, estrogen treatment and the use of multiple chemotherapeutic medications. However, drug resistance, related severe adverse reactions, metastases and recurrence risks do need to be tackled, involving safe and alternate methods. Herein, we present tumor-specific targeting supramolecular nanoassembly, and therapeutically to overcome the different challenges raised by the distribution of the pharmaceutical potential anticancer drug Corilagin. On covalent conjugations of hydrophobic linoleic acid by carboxylic group, the Corilagin prodrugs were skilled in impulsively nanoassembly into extremely stable nanoparticles size (~ 100 nm). Electron microscopic techniques have examined the newly synthesized morphology of Corilagin-NPs. The anticancer properties of Corilagin and Corilagin-NPs against CaSki and HeLa (cervical carcinoma) cancer cell lines have been evaluated after successful synthesis. Other research, such as dual staining acridine orange/ethidium bromide, Hoechst 33344 and flow cytometry study on the apoptosis mechanisms, have shown that proliferation in cervical cancer cells is associated with apoptosis. Compared to Corilagin, Corilagin-NPs demonstrate excellent biocompatibility, this study clarified the Corilagin-NPs as a healthy and cervical cancer care chemotherapeutics technique and deserve further clinical evaluations.

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