One-minute Sit-to-stand Test Is Practical to Assess and Follow the Muscle Weakness in Cystic Fibrosis.

Abstract Background: Quadriceps muscle weakness and reduced exercise tolerance are prevalent in patients with cystic fibrosis (CF) and associated with a worse prognosis. The one-minute sit-to-stand test (1STST) has been proposed to evaluate exercise capacity and assess quadriceps strength. The aim of the study was to correlate the 1STST and the maximal isometric voluntary contraction of the quadriceps (MVCQ) evaluated by the dynamometer in stable patients with CF and to evaluate the impact of intravenous (IV) antibiotherapy.Methods: MVCQ and exercise capacity (dynamometer and 1STST) were measured in stable patients with CF at a routine visit, at the admission and the discharge of an IV antibiotherapy. Patients wore an activity monitor during 72h during IV treatment. Results: 51 stable patients with CF at a routine visit and 30 treated with IV antibiotherapy were recruited. In stable patients, the number of repetitions was reduced to 2101nxkg±657 (mean±SD), representing 79% of the predicted values (%PV) (7;142) (median (min;max)) as well as the MVCQ to 78.64N-m (23.21;170.34), representing 57%PV±26. The 1STST was correlated to MVCQ (r=0.536;p<0.0001) and lung function (r=0.508;p=0.0001). Over the IV antibiotherapy course, the 1STST improves significantly like lung function and body mass index while a positive trend for MVCQ was observed. The gain of 1STST was correlated to the change in MVCQ (r=0.441;p=0.015) and was significantly higher in hospitalized patients versus home therapy.Conclusions: The 1STST is a good alternative to the dynamometer to evaluate and assess muscular weakness for the routine visit and IV antibiotherapy.

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The 1-Minute Sit-to-Stand Test in Adults With Cystic Fibrosis: Correlations With Cardiopulmonary Exercise Test, 6-Minute Walk Test, and Quadriceps Strength

Respiratory Care ◽

10.4187/respcare.04821 ◽

2016 ◽

Vol 61 (12) ◽

pp. 1620-1628 ◽

Cited By ~ 13

Author(s):

M. Gruet ◽

L. A. Peyre-Tartaruga ◽

L. Mely ◽

J.-M. Vallier

Keyword(s):

Cystic Fibrosis ◽

Exercise Test ◽

Quadriceps Strength ◽

Cardiopulmonary Exercise Test ◽

Walk Test ◽

Stand Test ◽

Cardiopulmonary Exercise ◽

Sit To Stand ◽

6 Minute Walk Test ◽

Minute Walk

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Comparison between the 1-minute sit-to-stand test and quadriceps strength in patients with cystic fibrosis

10.1183/13993003.congress-2018.oa4991 ◽

2018 ◽

Cited By ~ 1

Author(s):

Sophie Hardy ◽

Silvia Berardis ◽

Gregory Reychler ◽

Sophie Gohy

Keyword(s):

Cystic Fibrosis ◽

Quadriceps Strength ◽

Stand Test ◽

Sit To Stand

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Measurement properties of the one-minute sit-to-stand test in children and adolescents with cystic fibrosis: A multicenter randomized cross-over trial

PLoS ONE ◽

10.1371/journal.pone.0246781 ◽

2021 ◽

Vol 16 (2) ◽

pp. e0246781

Author(s):

Yann Combret ◽

Fairuz Boujibar ◽

Charlotte Gennari ◽

Clément Medrinal ◽

Sophie Sicinski ◽

...

Keyword(s):

Cystic Fibrosis ◽

Muscle Strength ◽

Children And Adolescents ◽

Exercise Capacity ◽

Measurement Properties ◽

Stand Test ◽

Sit To Stand ◽

Functional Exercise ◽

Functional Exercise Capacity ◽

Respiratory Responses

Background Functional exercise capacity assessment is recommended in children with cystic fibrosis (CF). The six-minute walk test (6MWT) is a valid evaluation of exercise capacity but can be technically complex. Inversely, the sit-to-stand test (STST) is a simple method to evaluate exercise capacity, and is validated in healthy children and adults with CF. This study aimed to evaluate STST measurement properties in children and adolescents with CF. Methods In this multicenter study, children with CF (6 to 18 years) performed two iterations of both the STST and the 6MWT in a randomized order. Criterion validity was determined by assessing correlations between STST repetitions and 6MWT distance (6MWD). Intra-rater reliability, test-retest repeatability, mean bias and limits of agreement were also assessed. Relationships with other outcomes (i.e. respiratory and quadriceps muscle strength) and cardio-respiratory responses were analysed for both tests. Results Thirty-six children with CF were included (mean age 12.0 ±3.5 years and FEV1 95.8 ±25.0%). On average, 39.6 ±10.5 repetitions were performed during the STST and mean 6MWD was 596.0 ±102.6 meters. STST number of repetitions was significantly correlated with 6MWD (r = 0.48; p<0.01). Both tests had very good intra-rater reliability (ICCSTST = 0.91 (95%CI 0.76–0.96) and ICC6MWT = 0.94 (95%CI 0.85–0.97)), and a significant test-retest learning effect. The number of STST repetitions was not correlated with quadriceps or respiratory muscle strength test, and the STST induced fewer cardio-respiratory responses than the 6MWT. Conclusions The STST is an easy-to-use functional test with moderate criterion validity when compared to the 6MWT in children with CF, probably because both tests measure different components of functional exercise capacity. The STST is useful when the 6MWT is unfeasible, however further investigations are required to explore the clinical implications of STST results in children with CF. Clinical trial registration NCT03069625.

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Influence of sex gap on muscle strength and functional mobility in patients with cystic fibrosis

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2019-0484 ◽

2020 ◽

Vol 45 (4) ◽

pp. 387-392 ◽

Cited By ~ 2

Author(s):

María del M. Martínez-García ◽

Juan J. Rodríguez-Juan ◽

Juan D. Ruiz-Cárdenas

Keyword(s):

Cystic Fibrosis ◽

Muscle Strength ◽

Lung Function ◽

Muscle Weakness ◽

Walking Speed ◽

Handgrip Strength ◽

Pancreatic Insufficiency ◽

Functional Mobility ◽

Healthy Controls ◽

Sit To Stand

The objectives of this study were to determine whether there were differences in handgrip strength and functional mobility between patients with cystic fibrosis (CF) and healthy controls with regard to sex and to ascertain whether these differences were related to lung function. Thirty-eight patients with CF (21 women) and 38 healthy controls aged 18–65 years were included. Muscle weakness and functional mobility were assessed through handgrip strength; walking speed; and time, velocity, and power derived from a single sit-to-stand (STS) test. Patients with CF showed differences for STS variables and walking speed but not for handgrip strength, compared with healthy controls. Considering sex differences, female patients showed differences for all variables analyzed while males with CF only exhibited differences for STS variables, compared with healthy controls. Females with CF showed moderate relationship between muscle weakness, functional mobility, and lung function (|r| = 0.45–0.49; p ≤ 0.05) whereas no relationships were observed for males with CF. The influence of chronic infection with Pseudomonas aeruginosa and pancreatic insufficiency on muscle weakness and functional mobility was similar in both sexes. Differences in muscle strength and functional mobility were predominantly observed in females with CF. These results suggest an important effect of sex gap on muscle weakness and functional mobility in patients with CF. Novelty The influence of sex gap on muscle weakness in CF has been shown. Muscle weakness was predominantly observed in females with CF.

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Inspiratory Muscle Training Improves Lung Function and Exercise Capacity in Adults With Cystic Fibrosis

Yearbook of Pulmonary Disease ◽

10.1016/s8756-3452(08)70051-3 ◽

2006 ◽

Vol 2006 ◽

pp. 56-57

Author(s):

Sandra K. Willsie

Keyword(s):

Cystic Fibrosis ◽

Lung Function ◽

Exercise Capacity ◽

Inspiratory Muscle ◽

Inspiratory Muscle Training ◽

Muscle Training

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WS04.3 Lung function as a determinant of the evolution of exercise capacity over a three-year follow-up period in patients with cystic fibrosis

Journal of Cystic Fibrosis ◽

10.1016/s1569-1993(21)00935-8 ◽

2021 ◽

Vol 20 ◽

pp. S7-S8

Author(s):

N. Evangelista Campos ◽

F.M. Vendrusculo ◽

I. Silveira de Almeida ◽

N. Acosta Becker ◽

M.V. Fagundes Donadio

Keyword(s):

Cystic Fibrosis ◽

Lung Function ◽

Exercise Capacity

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Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function

Scientific Reports ◽

10.1038/s41598-020-75886-w ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Uta Düesberg ◽

Julia Wosniok ◽

Lutz Naehrlich ◽

Patience Eschenhagen ◽

Carsten Schwarz

Keyword(s):

Risk Factors ◽

Cystic Fibrosis ◽

Lung Function ◽

Aspergillus Fumigatus ◽

Age Groups ◽

Antibiotic Use ◽

Lower Lung ◽

Lung Infections ◽

The Impact

Abstract Airway inflammation and chronic lung infections in cystic fibrosis (CF) patients are mostly caused by bacteria, e.g. Pseudomonas aeruginosa (PA). The role of fungi in the CF lung is still not well elucidated, but evidence for a harmful and complex role is getting stronger. The most common filamentous fungus in CF is Aspergillus fumigatus (AF). Age and continuous antibiotic treatment have been discussed as risk factors for AF colonisation but did not differentiate between transient and persistent AF colonisation. Also, the impact of co-colonisation of PA and AF on lung function is still under investigation. Data from patients with CF registered in the German Cystic Fibrosis Registry database in 2016 and 2017 were retrospectively analysed, involving descriptive and multivariate analysis to assess risk factors for transient or persistent AF colonisation. Age represented an independent risk factor for persistent AF colonisation. Prevalence was low in children less than ten years, highest in the middle age and getting lower in higher age (≥ 50 years). Continuous antibiotic lung treatment was significantly associated with AF prevalence in all age groups. CF patients with chronic PA infection had a lower lung function (FEV1%predicted), which was not influenced by an additional AF colonisation. AF colonisation without chronic PA infection, however, was significantly associated with a lower function, too. Older age up to 49 years and continuous antibiotic use were found to be the main risk factors for AF permanent colonisation. AF might be associated with decrease of lung function if not disguised by chronic PA infection.

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Lung function over the life course of paediatric and adult patients with cystic fibrosis from a large multi-centre registry

Scientific Reports ◽

10.1038/s41598-020-74502-1 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Arul Earnest ◽

Farhad Salimi ◽

Claire E. Wainwright ◽

Scott C. Bell ◽

Rasa Ruseckaite ◽

...

Keyword(s):

Cystic Fibrosis ◽

Lung Function ◽

Mixed Model ◽

Linear Mixed Model ◽

Pancreatic Insufficiency ◽

Forced Expiratory Volume ◽

Rate Of Change ◽

Data Registry ◽

Mortality Outcome ◽

The Impact

Abstract A key measure of lung function in people with Cystic Fibrosis (CF) is Forced Expiratory Volume in the first second FEV1 percent predicted (FEV1pp). This study aimed to address challenges in identifying predictors of FEV1pp, specifically dealing with non-linearity and the censoring effect of death. Data was obtained from a large multi-centre Australian Cystic Fibrosis Data Registry (ACFDR). A linear mixed model was used to study FEV1pp as the endpoint. There were 3655 patients (52.4% male) included in our study. Restricted cubic splines were used to fit the non-linear relationship between age of visit and FEV1pp. The following predictors were found to be significant in the multivariate model: age of patient at visit, BMI z-score, age interaction with lung transplantation, insulin dependent diabetes, cirrhosis/portal hypertension, pancreatic insufficiency, Pseudomonas aeruginosa infection and baseline variability in FEV1pp. Those with P. aeruginosa infection had a lower mean difference in FEV1pp of 4.7 units, p < 0.001 compared to those who did not have the infection. Joint modelling with mortality outcome did not materially affect our findings. These models will prove useful for to study the impact of CFTR modulator therapies on rate of change of lung function among patients with CF.

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