scholarly journals Maximal lymph nodal diameter in staging system of nasopharyngeal carcinoma

2020 ◽  
Author(s):  
Xin-Bin Pan ◽  
Song Qu ◽  
Ling Li ◽  
Long Chen ◽  
Shi-Xiong Liang ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Nasopharyngeal Carcinoma ◽  
Multivariate Regression ◽  
Staging System ◽  
Multivariate Regression Analysis ◽  
Seer Database ◽  
Training Set ◽  
Cancer Specific Survival ◽  
Nodal Diameter ◽  
N Stage

Abstract Background: The value of maximal lymph nodal diameter in staging system of nasopharyngeal carcinoma (NPC) is not well established.Methods: NPC patients were extracted from SEER database between 2004 and 2016. Overall survival (OS) and cancer-specific survival (CSS) were compared among three groups based on the maximal lymph nodal diameter: ≤3.0 cm, >3.0-6.0 cm, and >6.0 cm. Included patients were randomly divided into training set and validated set with 1:1 ratio. In training set, X-tile plots were created by dividing maximal lymph nodal diameter into three populations. All possible divisions of the maximal lymph nodal diameter were assessed. Two cut-off values were calculated by the X-tile plots in training set. The two cut-off values were evaluated in validated set.Results: The 10-year OS and CSS were different between the three groups. Multivariate regression analysis revealed that maximal lymph nodal diameter >6.0 cm was an independent risk prognostic factor for OS (hazard ratio [HR]=1.91, 95% confidence interval [CI]: 1.51-2.43; P<0.001) and CSS (HR=1.99, 95% CI: 1.51-2.61; P<0.001). The cut-off values of maximal lymph nodal diameter were 1.3 cm and 5.0 cm using X-tile plots in the training set. In the validated set, the maximal lymph nodal diameter >5.0 cm was a risk prognostic factor for OS and CSS.Conclusions: The maximal lymph nodal diameter of 5.0 cm may be a reasonable cut-off value for N stage.

scholarly journals Efficacy of Chemotherapy in Survival of Stage I Nasopharyngeal Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Jia-Lin Ma ◽  
Shi-Ting Huang ◽  
Yan-Ming Jiang ◽  
Xin-Bin Pan
Keyword(s):  
Overall Survival ◽  
Nasopharyngeal Carcinoma ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Stage I ◽  
Cancer Specific Survival ◽  
Radiotherapy Group ◽  
Kaplan Meier ◽  
Before And After ◽  
Radiotherapy Alone

PurposeTo identify whether chemoradiotherapy improves survival of stage I nasopharyngeal carcinoma (NPC).Materials and MethodsNPC patients were extracted from the Surveillance, Epidemiology, and End Results database between 2010 and 2015. Pathologically confirmed stage T1N0M0 (the 7th edition AJCC) were investigated. Overall survival (OS) and cancer-specific survival (CSS) were compared between the radiotherapy and chemoradiotherapy groups using the Kaplan-Meier method and propensity score matching (PSM) analyses.ResultsThis study included 91 (40.27%) patients in the chemoradiotherapy group and 135 (59.73%) patients in the radiotherapy group. Before PSM, chemoradiotherapy was associated with worse 3-year OS (74.31 vs 87.23%; P = 0.025) and 5-year OS (64.28 vs 83.12%; P = 0.001) compared to those associated with radiotherapy. Similarly, chemoradiotherapy showed worse 3-year CSS (87.01 vs 96.97%; P = 0.028) and 5-year CSS (80.39 vs. 96.97%; P = 0.002) than those of radiotherapy. After PSM, chemoradiotherapy revealed worse 5-year OS (63.10 vs. 82.49%; P = 0.031) and CSS (80.95 vs. 93.70%; P = 0.016) than radiotherapy. The multivariate regression analysis revealed that chemoradiotherapy was an independent risk prognostic factor for OS and CSS before and after PSM.ConclusionRadiotherapy alone is recommended for stage I NPC patients.

scholarly journals Role of Surgical Treatment in Primary Intestinal Non-Hodgkin Lymphomas: A SEER Population-Based Survival Analysis

2021 ◽  
Author(s):  
Cuifen Zhang ◽  
Xiaohong Zhang ◽  
Zeyu Liu ◽  
Jiahao Tao ◽  
Lizhu Lin ◽  
...  
Keyword(s):  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Population Based ◽  
Confounding Factors ◽  
Seer Database ◽  
Cancer Specific Survival ◽  
Non Hodgkin Lymphoma ◽  
Before And After ◽  
Specific Impact

Abstract Evidence regarding the need for surgery for primary intestinal non-Hodgkin lymphoma (PINHL) patients with chemotherapy is limited and controversial. We aimed to investigate the specific impact of surgery on survival of PINHL patients. Data from PINHL patients (aged >18 years) with chemotherapy between 1983 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We concerned about overall survival (OS) and improved cancer-specific survival (CSS). Propensity score matching (PSM) analysis was also used to explore the reliability of the results to further control for confounding factors. Finally, we screened 3537 patients. Multivariate regression analysis showed that patients with surgery and chemotherapy had better OS (hazard ratio [HR], 0·83; 95% confidence interval [CI], 0·75–0·93; P=0·0009) and CSS (HR, 0·87; 95% CI, 0·77–0·99; P=0·0404) compared with the non-operation group after adjusting for confounding factors. After PSM analysis, compared with non-surgery, surgery remained associated with improved OS (HR, 0·77; 95% CI, 0·68–0·87; P<0·0001) and improved CSS (HR, 0·82; 95% CI, 0·72–0·95; P=0·008) adjusted for baseline differences. In the large cohort of PINHL patients with chemotherapy older than 18 years, surgery was associated with significantly improved OS and CSS before and after PSM analysis.

scholarly journals Development and Validation of a Prognostic Nomogram for Hypopharyngeal Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Shu Tian ◽  
Qin Li ◽  
Ruichen Li ◽  
Xinyu Chen ◽  
Zhonghua Tao ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Calibration Curve ◽  
Multivariate Regression ◽  
External Validation ◽  
Locally Advanced ◽  
Multivariate Regression Analysis ◽  
Tnm Stage ◽  
Seer Database ◽  
Training Set ◽  
Validation Set

Hypopharyngeal squamous-cell carcinoma (HSCC) is a relatively rare head and neck cancer, with great variation in patient outcomes. This study aimed to develop a prognostic nomogram for patients with HSCC. From the Surveillance, Epidemiology, and End Results (SEER) database, we retrieved the clinical data of 2198 patients diagnosed with HSCC between 2010 and 2016. The patients were randomly assigned at a 4:1 ratio to the training set or the validation set. An external validation was performed by a set of 233 patients with locally advanced HSCC treated at our center. A Cox proportional hazards regression model was used to assess the relationship between each variable and overall survival (OS). Cox multivariate regression analysis was performed, and the results were used to develop a prognostic nomogram. The calibration curve and concordance index (C-index) were used to evaluate the accuracy of the prognostic nomogram. With a median overall follow-up time of 41 months (interquartile range: 20 to 61), the median OS for the entire cohort of SEER database was 24 months. The 3-year and 5-year OS rates were 41.3% and 32.5%, respectively. The Cox multivariate regression analysis of the training set showed that age, marital status, race, T stage, N stage, M stage, TNM stage, local treatment, and chemotherapy were correlated with OS. The nomogram showed a superior C-index over TNM stage (training set: 0.718 vs 0.627; validation set: 0.708 vs 0.598; external validation set: 0.709 vs 0.597), and the calibration curve showed a high level of concordance between the predicted OS and the actual OS. The nomogram provides a relatively accurate and applicable prediction of the survival outcome of patients with HSCC.

scholarly journals Retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0253424
Author(s):  
Xin-Bin Pan ◽  
Shi-Ting Huang ◽  
Song Qu ◽  
Kai-Hua Chen ◽  
Yan-Ming Jiang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Nasopharyngeal Carcinoma ◽  
Lymph Node Metastasis ◽  
Staging System ◽  
Cancer Staging ◽  
Retropharyngeal Lymph Node ◽  
Cancer Specific Survival ◽  
Node Metastasis ◽  
Kaplan Meier ◽  
N Stage

Purposes To evaluate retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma (NPC). Methods NPC patients were extracted from the Surveillance, Epidemiology, and End Results database between 2004 and 2016. Pathologically confirmed patients with complete data of retropharyngeal lymph node metastasis were investigated. The included patients were divided into N1a and N1b groups. Overall survival (OS) and cancer-specific survival (CSS) were assessed using the Kaplan–Meier method and propensity score matching (PSM) analyses. Results This retrospective cohort study examined 759 patients: 70 who were stage N1a and 689 who were stage N1b. Before PSM, N1a group was associated with similar 5-year OS (77.7% vs. 72.4%; P = 0.15) and CSS (85.6% vs. 79.9%; P = 0.09) compared to N1b group. After PSM, a similar OS (75.0% vs. 60.7%; P = 0.12) was found between the radiotherapy and chemoradiotherapy groups. However, N1a group showed a better 5-year CSS (83.8% vs. 71.1%; P = 0.04) compared to N1b group. Stage N1b was an independent risk prognostic factor for CSS (hazard ratio = 2.54, 95% confidence interval: 1.02–6.34; P = 0.04). Conclusions OS was not different between N1a and N1b groups. Retropharyngeal lymph node metastasis defined as stage N1 of the 8th edition American Joint Committee on Cancer staging system is reasonable.

scholarly journals The Effect of Marital Status on Survival of Patients with Gastrointestinal Stromal Tumors: A SEER Database Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Wei Song ◽  
Chuan Tian
Keyword(s):  
Prognostic Factor ◽  
Marital Status ◽  
Gastrointestinal Stromal Tumors ◽  
Cox Regression ◽  
Seer Database ◽  
Cancer Specific Survival ◽  
Stromal Tumors ◽  
Kaplan Meier ◽  
Risk Of Cancer ◽  
The Impact

Background. Marital status has been reported to be a prognostic factor in multiple malignancies. However, its prognostic value on gastrointestinal stromal tumors (GISTs) have not yet been determined. The objective of the present analysis was to assess the effects of marital status on survival in patients with GISTs. Methods. The Surveillance, Epidemiology, and End Results (SEER) database was used to analyze 6195 patients who were diagnosed with GISTs from 2001 to 2014. We also use Kaplan-Meier analysis and Cox regression to analyze the impact of marital status on cancer-specific survival (CSS). Results. Patients in the married group had more frequency in white people, more high/moderate grade tumors, and were more likely to receive surgery. Widowed patients had a higher proportion of women, a greater proportion of older patients (>60 years), and more common site of the stomach. Multivariate analysis demonstrated that marital status was an independent prognostic factor for GISTs (P<0.001). Married patients had better CSS than unmarried patients (P<0.001). Subgroup analysis suggested that widowed patients had the lowest CSS compared with all other patients. Conclusions. Marital status is a prognostic factor for survival in patients with GISTs, and widowed patients are at greater risk of cancer-specific mortality.

scholarly journals Conditional Survival After Surgical Resection of Appendiceal Tumors: a Population-based Study

2021 ◽  
Author(s):  
Shutao Zhao ◽  
Chang Lu ◽  
Junan Li ◽  
Chao Zhang ◽  
Xudong Wang
Keyword(s):  
Prognostic Factors ◽  
Cox Regression ◽  
Population Based ◽  
Conditional Survival ◽  
Seer Database ◽  
Cancer Specific Survival ◽  
Population Based Study ◽  
Factors Affecting ◽  
Probability Of Survival ◽  
N Stage

Abstract Background: This study aimed to evaluate the conditional survival (CS) of appendiceal tumors (ATs) after surgery.Methods: A total of 3,031 patients with ATs who underwent surgery were included in the Surveillance Epidemiology and End Results (SEER) database from 2004 to 2016. A multivariate Cox regression model was used to analyze the prognostic factors affecting overall survival (OS) and cancer-specific survival (CSS). CS was used to calculate the probability of survival for another 3 years after the patient had survived x years. The formulas were COS3 = OS (x + 3) /OS (x), and CCS3 = CSS (x + 3)/CSS (x).Results: The 1-year, 3-year, and 5-year OSs for all patients were 95.6%, 83.3%, and 73.9%, respectively, while the 1-year, 3-year, and 5-year CSSs were 97.0%, 87.1%, and 79.9%, respectively. Age, grade, histology, N stage, carcinoembryonic antigen (CEA), and radiation were independent prognostic factors for OS and CSS. For patients that survived for 1 year, 3 years, and 5 years, their COS3s were 81.7%, 83.9%, and 87.0%, respectively. The CCS3s were 85.5%, 88.3%, and 92.0% respectively. In patients with poor clinicopathological factors, COS3 and CCS3 increased significantly, and the survival gap between OS and COS3, CSS and CCS3 was more obvious.Conclusions: CS for appendiceal tumors were dynamic and increased over time, especially in patients with poor prognosis.

scholarly journals The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Cuifen Zhang ◽  
Xiaohong Zhang ◽  
Zeyu Liu ◽  
Jiahao Tao ◽  
Lizhu Lin ◽  
...  
Keyword(s):  
Multivariate Regression Analysis ◽  
Confounding Factors ◽  
Seer Database ◽  
Cancer Specific Survival ◽  
Term Survival ◽  
Non Hodgkin Lymphoma ◽  
Before And After ◽  
The Impact ◽  
Specific Impact

AbstractEvidence regarding the need for surgery for primary intestinal non-Hodgkin lymphoma (PINHL) patients with chemotherapy is limited and controversial. We aimed to investigate the specific impact of surgery on survival of PINHL patients. Data from PINHL patients (aged > 18 years) with chemotherapy between 1983 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We concerned about overall survival (OS) and improved cancer-specific survival (CSS). Propensity score matching (PSM) analysis was also used to explore the reliability of the results to further control for confounding factors. Finally, we screened 3537 patients. Multivariate regression analysis showed that patients with surgery and chemotherapy had better OS (hazard ratio [HR] 0.83; 95% confidence interval [CI] 0.75–0.93; p = 0.0009) and CSS (HR 0.87; 95% CI 0.77–0.99; p = 0.0404) compared with the non-operation group after adjusting for confounding factors. After PSM analysis, compared with non-surgery, surgery remained associated with improved OS (HR 0.77; 95% CI 0.68–0.87; p < 0.0001) and improved CSS (HR 0.82; 95% CI 0.72–0.95; p = 0.008) adjusted for baseline differences. In the large cohort of PINHL patients with chemotherapy older than 18 years, surgery was associated with significantly improved OS and CSS before and after PSM analysis.

scholarly journals Maximal lymph nodal diameter on N stage of nasopharyngeal carcinoma

Medicine ◽  
2021 ◽  
Vol 100 (26) ◽  
pp. e26543
Author(s):  
Shi-Ting Huang ◽  
Song Qu ◽  
Ling Li ◽  
Kai-Hua Chen ◽  
Xiao-Dong Zhu ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Nodal Diameter ◽  
N Stage

scholarly journals Construction and verification of prognostic nomogram for early-onset esophageal cancer

2021 ◽  
Author(s):  
Xiaoxiao Liu ◽  
Wei Guo ◽  
Xiaobo Shi ◽  
Yue Ke ◽  
Yuxing Li ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Early Onset ◽  
Older Patients ◽  
Clinicopathological Characteristics ◽  
Calibration Plot ◽  
Seer Database ◽  
Training Set ◽  
Related Factors ◽  
Cancer Specific Survival ◽  
Validation Set

This study aimed to build up nomogram models to evaluate overall survival (OS) and cancer-specific survival (CSS) in early-onset esophageal cancer (EOEC). Patients diagnosed with esophageal cancer (EC) from 2004 to 2015 were extracted from the Surveillance Epidemiology and End Results (SEER) database. Clinicopathological characteristics of younger versus older patients were compared, and survival analysis was performed in both groups. Independent related factors influencing the prognosis of EOEC were identified by univariate and multivariate Cox analysis, which were incorporated to construct a nomogram. The predictive capability of the nomogram was estimated by the concordance index (C-index), calibration plot, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA). A total of 534 younger and 17,243 older patients were available from the SEER database. Younger patients were randomly segmented into a training set (n=266) and a validation set (n=268). In terms of the training set, the C-index of the OS nomogram was 0.740 (95% CI: 0.707-0.773), and that of the CSS nomogram was 0.752 (95% CI: 0.719-0.785). In view of the validation set, the C-index of OS and CSS were 0.706 (95% CI: 0.671-0.741) and 0.723 (95%CI: 0.690-0.756), respectively. Calibration curves demonstrated the consistent degree of fit between actual and predicted values in nomogram models. From the perspective of DCA, the nomogram models were more beneficial than the tumor-node-metastasis (TNM) and the SEER stage for EOEC. In brief, the nomogram model can be considered as an individualized quantitative tool to predict the prognosis of EOEC patients to assist clinicians in making treatment decisions.

scholarly journals The Influence of Marital Status on Survival in Patients with Nasopharyngeal Carcinoma: A Surveillance, Epidemiology, and End Results (SEER) Database Analysis

2019 ◽  
Author(s):  
Bin Yu ◽  
Hong Ning ◽  
Shan Xu ◽  
Li Qin ◽  
Bin-wei Lin ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Nasopharyngeal Carcinoma ◽  
Marital Status ◽  
Psychosocial Support ◽  
Independent Prognostic Factor ◽  
Elderly Subjects ◽  
Seer Database ◽  
Increased Risk ◽  
Cox Proportional Hazard Regression ◽  
End Results

Abstract Purpose: To assess the influence of marital status on survival in patients with nasopharyngeal carcinoma (NPC). Methods: We used the Surveillance, Epidemiology, and End Results (SEER) database to analyze 5477 patients who were diagnosed with NPC from 2004 to 2016. Kaplan–Meier survival analysis and Cox proportional hazard regression were used to analyze the influences of marital status on cause-specific survival (CSS) and overall survival (OS). Subgroup analyses was used to assess the influences of marital status on CSS based on different factors. Results: The 5477 patients were divided into three groups, with 61.5%, 22.4%, and 16.1% of patients being married, single/unmarried, and separated/widowed/divorced, respectively. The separated/widowed/divorced group were more likely to be female ( P <0.001); had the highest proportion of elderly subjects ( P <0.001); were mostly Caucasian ( P <0.001); had pathological grading I/II ( P <0.001); were likely to receive surgery ( P =0.032); and were registered at the northeast, north central, and south ( P < 0.001) regions. The 5-year CSS was 92.6%, 92.4%, and 85.1% in the married, single/unmarried, and separated/widowed/divorced groups, respectively ( P <0.001); and respective 5-year OS was 60.7%, 54.6%, and 40.1% ( P <0.001). Marital status was the independent prognostic factor for NPC. Compared with married patients, separated/widowed/divorced patients had a significantly increased risk of NPC-related death (hazard ratio [HR]=2.180, 95% confidence interval [CI] 1.721–2.757, P <0.001). The single/unmarried ( P =0.355) group had a similar CSS as that of the group. Conclusion: Marital status is an independent prognostic factor for survival of NCP patients. Separated/widowed/divorced status increases the risk of NPC mortality; hence, more social and psychosocial support should be given to patients who are separated, widowed, or divorced.

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