scholarly journals The association of triglyceride and glucose index, triglyceride to high density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: a large cross-sectional population study 

2021 ◽  
Author(s):  
fomin zhang ◽  
yingyi zhang ◽  
zhigang guo ◽  
hua yang ◽  
min ren ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Logistic Regression ◽  
Correlation Analysis ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Multiple Logistic Regression ◽  
Cross Sectional ◽  
Cholesterol Ratio ◽  
Tyg Index

Abstract Background Triglyceride and glucose index (TYG) and triglyceride to high density lipoprotein cholesterol ratio (TG/HDL-c) not only were significant association with hypertension, but also were related to prehypertension. However, few of these studies have large subjects to study the relationship between TyG ,TG/HDL and hypertension, prehypertension in the same population. Therefore, We conducted a large cross-sectional study to explore the association of TG/HDL-c, TyG index with prehypertension and hypertension in the same normoglycemic subjects from China, Tianjin . Methods A total of 32,124 adults were eligible for this study. According to the level of blood pressure, the enrolled individuals were divided into three groups, Which were normotension, prehypertension and hypertension. All participants completed a questionnaire, followed by a physical examination and blood sample test. Spearman’s correlation analysis was used to determine the correlation between TyG index, TG/HDL-c and their related parameters, Multiple Logistic regression analyses were applied to explore the association of TyG indexes and TG/HDL quartiles with prehypertension and hypertension. Results The association between TyG index ,TG/HDL-c and age, heart rate(HR),Body Mass Index(BMI), systolic blood pressure(SBP), diastolic blood pressure(DBP), total cholesterol(TC), triglycerides(TG), LDL-cholesterol(LDL-c), fasting glucose(GLU) were positive correlation, while HDL-cholesterol(HDL-c) was negative correlation in spearman correlation analysis(p < 0.001). In multiple logistic regression analysis, there was a significant difference in the risk of prehypertension and hypertension when comparing the highest TyG index to the lowest TyG index and corresponding ORs were 1.795(1.638,1.968) and 2.439(2.205,2.698), respectively. For TG/HDL-c, the corresponding ORs were 1.514(1.382,1.658) and 1.934(1.751,2.137), respectively. Furthermore, When comparing the fourth quartile to the first quartile of TyG and TG/HDL, respectively, and both corresponding ORs of hypertension were higher than prehypertension. Conclusions Elevated TyG index and TG/HDL-c levels were associated with an increased risk of incident Prehypertension and Hypertension in normoglycemic individuals. They have the potential to become cost-effective and complementary monitors in the hierarchical management of prehypertension and hypertension.

scholarly journals High-intensity activity is more strongly associated with metabolic health in children compared to sedentary time: a cross-sectional study of the I.Family cohort

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Jonatan Fridolfsson ◽  
Christoph Buck ◽  
Monica Hunsberger ◽  
Joanna Baran ◽  
Fabio Lauria ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Body Mass Index ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Cross Sectional ◽  
Intensity Physical Activity

Abstract Background Physical activity (PA) during childhood is important for preventing future metabolic syndrome (MetS). To examine the relationship between PA and MetS in more detail, accurate measures of PA are needed. Previous studies have only utilized a small part of the information available from accelerometer measured PA. This study investigated the association between measured PA and MetS in children with a new method for data processing and analyses that enable more detailed interpretation of PA intensity level. Methods The association between PA pattern and risk factors related to MetS was investigated in a cross- sectional sample of children (n = 2592, mean age 10.9 years, 49.4% male) participating in the European multicenter I. Family study. The risk factors examined include body mass index, blood pressure, high-density lipoprotein cholesterol, insulin resistance and a combined risk factor score (MetS score). PA was measured by triaxial accelerometers and raw data was processed using the 10 Hz frequency extended method (FEM). The PA output was divided into an intensity spectrum and the association with MetS risk factors was analyzed by partial least squares regression. Results PA patterns differed between the European countries investigated, with Swedish children being most active and Italian children least active. Moderate intensity physical activity was associated with lower insulin resistance (R2 = 2.8%), while vigorous intensity physical activity was associated with lower body mass index (R2 = 3.6%), MetS score (R2 = 3.1%) and higher high-density lipoprotein cholesterol (R2 = 2.3%). PA of all intensities was associated with lower systolic- and diastolic blood pressure, although the associations were weaker than for the other risk factors (R2 = 1.5% and R2 = 1.4%). However, the multivariate analysis implies that the entire PA pattern must be considered. The main difference in PA was observed between normal weight and overweight children. Conclusions The present study suggests a greater importance of more PA corresponding to an intensity of at least brisk walking with inclusion of high-intense exercise, rather than a limited time spent sedentary, in the association to metabolic health in children. The methods of data processing and statistical analysis enabled accurate analysis and interpretation of the health benefits of high intensity PA that have not been shown previously.

Comparison of the Diagnostic Value Between Triglyceride-Glucose Index and Triglyceride-to-High Density Lipoprotein Cholesterol Ratio in MAFLD Patients: A Retrospective Cross-Sectional Study

2022 ◽  
Author(s):  
Zhi Liu ◽  
He He ◽  
Yuzhao Dai ◽  
Shenling Liao ◽  
Zhenmei An ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cholesterol Ratio

Abstract Background The triglyceride and glucose index (TyG) and triglyceride-to-high density lipoprotein cholesterol ratio (TG/HDL-C) were found to be substitute markers of insulin resistance (IR). We aimed to compare the efficacy of the two indicators in the diagnosis of Metabolic-Associated Fatty Liver Disease (MAFLD), which was rarely covered in the literature, and to construct a novel disease diagnosis model.Methods A retrospective cross-sectional study was carried out in West China Hospital of Sichuan University and 229 people (97 MAFLD and 132 Non-MAFLD) were included. Biochemical indexes were collected and analyzed by logistic regression to screen out indicators that expressed differently in MAFLD patients and healthy controls and incorporate them into a diagnostic model. MAFLD was diagnosed by Ultrasound.Results After adjusting for age, gender and BMI, Serum ALT, AST, AST/ALT (A/A), FPG, Cys-C, URIC, TG, HDL-C, ALP, GGT, nonHDL-C, LDL-C/HDL-C, nonHDL-C/HDL-C, TG/HDL-C, TC/HDL-C, TyG and TyG-BMI were risk factors of MAFLD through binary logistics regression analysis. The odds ratio of TG/HDL-C and TyG were 5.387 (95%CI: 2.986-9,718) and 107.945 (95% CI: 25.824-451.222). In identifying MAFLD, TyG, TG/HDL-C and TG were found to be the most vital indexes by the random forest method and the area under the curve (AUC) of them are all greater than 0.9 respectively. In addition, the combination of gender, BMI, ALT, TG, HDL-C, TyG and TyG-BMI had a great diagnostic efficiency for MAFLD.Conclusions TyG and TG/HDL-C were potential risk factors for MAFLD and the former made a better performance in diagnosing MAFLD. The combination of gender, BMI, ALT, TG, HDL-C, TyG and TyG-BMI improved the diagnostic capability of MAFLD.

scholarly journals Low−/high-density lipoprotein cholesterol ratio and carotid plaques in patients with coronary heart disease: a Chinese cohort study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhu Li ◽  
Qi Cheng ◽  
Yijia Liu ◽  
Xufeng Cheng ◽  
Shuo Wang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Logistic Regression ◽  
Heart Disease ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Healthy Lifestyle ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Carotid Plaques ◽  
Cholesterol Ratio

Abstract Background Evidence on the relationship between the low−/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and carotid plaques remains limited. This study aimed to examine the association between LDL-C/HDL-C and carotid plaques in participants with coronary heart disease (CHD) and to further explore the extent to which a healthy lifestyle reduces the risk of LDL-C/HDL-C-related carotid plaques. Methods This large-scale and multi-centre retrospective study included 9426 CHD patients (aged 35–75 years) between January 1, 2014 and September 30, 2020. The LDL-C/HDL-C values were converted to the following tertiles: lowest (< 2.15), middle (2.15–3), and highest (> 3). Healthy lifestyle-related factors referred to whether or not the participant was a non-smoker and non-drinker. Participants were divided into an unfavourable group (those who did not adhere to healthy lifestyle factors), intermediate (only one unhealthy factor), and favourable (neither of the two unhealthy factors). Logistic regression was used for statistical analyses. Results Of the 9426 participants, 6989 (74.15%) CHD patients had carotid plaques. After adjustment for confounders, each unit increase in the LDL-C/HDL-C was significantly associated with carotid plaques (OR: 1.61; 95%CI: 1.43–1.84; P <  0.001). Multivariate logistic regression revealed that carotid plaques risk for the highest tertile (> 3) was 1.18 times that of the lowest quartile (< 2.15). Compared with an unfavourable lifestyle, an intermediate or a favourable lifestyle was associated with a significant 30% (OR: 0.70; 95%CI: 0.64–0.78; P <  0.001) or 67% (OR: 0.33; 95%CI: 0.29–0.37; P <  0.001) reduction in carotid plaques risk, respectively, among CHD patients with high LDL-C/HDL-C. There were significantly additive and multiplicative interactions between lifestyle and LDL-C/HDL-C with regards to carotid plaques. Conclusion A high LDL-C/HDL-C is associated with a risk of carotid plaques developing in CHD patients. Adhering to a healthy lifestyle has additive beneficial effects on reducing the risk of carotid plaques, especially in relation to the highest LDL-C/HDL-C. Graphical abstract

Association of Monocytes to High-Density Lipoprotein Cholesterol Ratio With Metabolic Syndrome and Its Components

2021 ◽  
Vol 34 (8) ◽  
pp. 888-889
Author(s):  
Ting-jun Wang ◽  
Xiao-qi Cai ◽  
Jin Gong ◽  
Qun-fang Xie ◽  
Guo-yan Xu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
High Density Lipoprotein ◽  
Receiver Operating Characteristic ◽  
High Density Lipoprotein Cholesterol ◽  
Operating Characteristic ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Regression Analyses ◽  
Cholesterol Ratio

Abstract Background To investigate the association of monocytes to high-density lipoprotein cholesterol ratio (MHR) with metabolic syndrome (MS) and its components. Methods A cross-sectional clinical study was conducted from February 2018 to January 2019 in the First Affiliated Hospital of Fujian Medical University. A total of 890 inpatients or outpatients aged 30–79 years old were enrolled, and their clinical data were collected. MS and its components were defined according to the National Cholesterol Education Program Adult Treatment Panel III (NECP-ATPIII) diagnostic criteria. Spearman correlation and logistic regression analyses were used to analyze the association of MHR with MS and its components. A receiver operating characteristic analysis was used to evaluate the diagnostic efficacy of MHR for MS. Results The monocyte counts and MHR were significantly higher in subjects with MS than those without MS (P &lt; 0.001). The percentage of subjects carrying 3 or more MS components increased with the increment of MHR tertiles (13.7%, 32.7%, and 44.6%, P &lt; 0.001). MHR was correlated with multiple metabolic components, including body mass index, waist circumstance, visceral fat content, total cholesterol, triglyceride, fasting plasma glucose, glycosylated hemoglobin, and systolic blood pressure (all P &lt; 0.001). Logistic regression analyses showed that MHR was independently associated with MS after adjusting for age, gender, multiple metabolic components, and the use of antihypertensive and antihyperglycemic medications. Compared with the lowest tertile of MHR, the risk of MS increased by 2.386 and 3.233 times in moderate (P = 0.010) and highest (P = 0.001) tertiles, respectively. Receiver operating characteristic curve analyses indicated that the best cutoff value of MHR was 6.59 × 105/mg for the diagnosis of MS, with a sensitivity of 75.2% and a specificity of 52.7%. Conclusions Elevated MHR is associated with an increased risk of MS and the accumulation of its components.

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