scholarly journals Association of 45-bp ins/del polymorphism of uncoupling protein 2 (UCP2) and susceptibility to nonalcoholic fatty liver and type 2 diabetes mellitus in North-west of Iran

2020 ◽  
Author(s):  
Salehe Rezapour ◽  
Shiva Ahdi Khosroshahi ◽  
Hadi Farajnia ◽  
Fatemeh Mohseni ◽  
Manouchehr Khoshbaten ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fatty Liver ◽  
Uncoupling Protein ◽  
P Value ◽  
Uncoupling Protein 2 ◽  
Genotype Distribution ◽  
Healthy Controls

Abstract Objective: Uncoupling protein 2 (UCP2) plays a crucial role in energy homeostasis via regulation of insulin secretion, free fatty acid concentrations, and lipid metabolism. This study aimed to investigate the association of 45-bp ins/del polymorphism of UCP2 with susceptibility to NAFLD (Non Alcoholic Fatty Liver Disease) and T2DM (Type 2 Diabetes Mellitus). DNA was extracted from the white blood cells of the subjects, and the gene polymorphism was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In this study, 72 patients with NAFLD, 71 healthy individuals as control, 80 patients with T2DM, and 77 healthy controls were enrolled in the study.Results: A higher prevalence of insertion/insertion genotype was observed in T2DM patients compared to the controls (p- value˂ 0.05). But, there was no difference in genotype distribution between NAFLD patients and controls (p-value> 0.05). NAFLD patients with D/D, D/I genotype had higher triglyceride, ALT, and AST levels; however, their HDL levels were lower than healthy controls. Patients with T2DM with D/D or D/I genotype also had significantly higher fasting serum glucose (FSG). While we found an association between the 45bp I/D polymorphism in 3ʹUTR of UCP2 and T2DM, no any correlation between this polymorphism and NAFLD was identified.

scholarly journals Association of 45-bp Ins/del Polymorphism of Uncoupling Protein 2 (UCP2) and Susceptibility to Nonalcoholic Fatty Liver and Type 2 Diabetes Mellitus in North-west of Iran

2020 ◽  
Author(s):  
Salehe Rezapour ◽  
Shiva Ahdi Khosroshahi ◽  
Hadi Farajnia ◽  
Fatemeh Mohseni ◽  
Manouchehr Khoshbaten ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Liver ◽  
Uncoupling Protein ◽  
Close Association ◽  
Control Group ◽  
P Value ◽  
Uncoupling Protein 2 ◽  
Genotype Distribution ◽  
Nonalcoholic Fatty Liver

Abstract Objective Uncoupling protein 2 (UCP2) is a regulator of insulin secretion, free fatty acid (FFA) concentrations and lipid metabolism that plays crucial roles in energy homeostasis. Last decade reports have described close association between UCP2 polymorphisms and nonalcoholic fatty liver disease (NAFLD) and diabetes mellitus type 2 (T2DM). Results A higher prevalence of insertion/insertion genotype has been observed in T2DM patients compared with the control group (p value˂ 0.05). But, there was no difference in genotype distribution between NAFLD patients and control groups (p value > 0.05). NAFLD patients with D/D, D/I genotype had higher triglyceride, ALT and AST levels, and lower HDL level than healthy controls. Patients with T2DM together with D/D or D/I genotype also had significantly higher fasting serum glucose (FSG) level. While we found association between the 45 bp I/D polymorphism in 3ʹUTR of UCP2 and T2DM, existence of correlation between this polymorphism and NAFLD was not identified.

scholarly journals Correlation of Uric Acid with Oxidative Stress and Endothelial Dysfunction in Type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Siva Prasad Palem
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Endothelial Dysfunction ◽  
P Value ◽  
Healthy Controls ◽  
Antioxidant Power

Objective: To evaluate the correlation of uric acid with oxidative stress and endothelial dysfunction in type 2 diabetic subjects.Material and Methods: The study included 120 subjects, among when 60 were type 2 diabetes subjects and the remaining 60 were age and gender matched healthy controls. The biochemical parameters, blood glucose, lipid profile, uric acid and homocysteine, were measured by standard kits in an autoanalyzer. Oxidative stress was evaluated by measuring malondialdehyde (MDA) and total antioxidant power by manual methods such as thio-barbituric acid reactive substances and ferric reducing ability of plasma (FRAP). Endothelial dysfunction was assessed by measuring nitric oxide (NO) by the kinetic cadmium method.Results: A significant elevation of triglycerides, low density lipoprotein (LDL), and MDA were observed in the type 2 diabetes mellitus patients while FRAP and NO were significantly reduced compared to the healthy controls. In addition, the uric acid levels had a highly significant correlation with FRAP (r=0.212, p-value=0.020), and moderately significant correlation with triglycerides (r=0.173, p-value=0.057) and homocysteine (r=0.178, p-value=0.051). Uric acid was negatively correlated with MDA and positively correlated with NO, but not statistically significant.Conclusion: Our findings suggest that uric acid may have antioxidant properties since it had a significant positive correlation with FRAP.

scholarly journals Non-Alcoholic fatty liver disease in type 2 diabetes mellitus: A dangerous duo.

2021 ◽  
Vol 29 (01) ◽  
pp. 77-81
Author(s):  
Zainab Zaib ◽  
Sabir Khan Khattak ◽  
Asim Ali Shah ◽  
Ayesha Akhtar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
P Value ◽  
Alcoholic Fatty Liver ◽  
Increased Risk

Objective: To determine the frequency of nonalcoholic fatty liver disease in type 2 diabetes mellitus. Study Design: Cross sectional study. Setting: Department of Medicine Ayub Teaching Hospital Abbottabad. Period: August 2018 to Feb 2019. Material & Methods: A total of 153 patients, who were diagnosed case of diabetes were studied for the presence of NAFLD. Ultrasound abdomen was used to detect NAFLD. Data was recorded on a pro forma and analyzed using SPSS 20 version. Results: Out of 153 patients, there were 73 males (45.8%) whiles 83 females (54.2%). Patients were aged 30 – 80 years with mean ± SD as 54.60± 11.277 years. The mean duration of diabetes was 7.18±6.95 years. In our study 54.9 % (84) of the patients were having fatty liver on U/S scan, 35.3% have abnormal lipid profile and 35.3 % (54) were hypertensive, out of which 59.3% (32) were having fatty liver on scan with P value of 0.424. Conclusions: Type 2 diabetes patients have increased risk of development of NAFLD, prevalence being 54.9%. Post-menopausal females and those with dyslipidemia have more risk of developing of NAFLD among diabetics.

scholarly journals The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications

2011 ◽  
Vol 55 (4) ◽  
pp. 239-248 ◽  
Author(s):  
Bianca Marmontel de Souza ◽  
Taís Silveira Assmann ◽  
Lúcia Maria Kliemann ◽  
Jorge Luiz Gross ◽  
Luís Henrique Canani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Acid Metabolism ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Chronic Complications ◽  
Ucp2 Gene

It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus (DM2) and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors. Therefore, great efforts have been made to identify genes associated with DM2. Uncoupling protein 2 (UCP2) is expressed in several tissues, and acts in the protection against oxidative stress; in the negative regulation of insulin secretion by beta cells, and in fatty acid metabolism. All these mechanisms are associated with DM2 pathogenesis and its chronic complications. Therefore, UCP2 is a candidate gene for the development of these disorders. Indeed, several studies have reported that three common polymorphisms in UCP2 gene are possibly associated with DM2 and/or obesity. Only a few studies investigated these polymorphisms in relation to chronic complications of diabetes, with inconclusive results.

PREVALENCE OF HYPERTENSION AMID PATIENTS WITH TYPE-2 DIABETES MELLITUS- AT A TERTIARY LEVEL HOSPITAL IN CENTRAL INDIA

2021 ◽  
pp. 57-59
Author(s):  
Hakimuddin Malvi ◽  
Syed Maqsood Husain
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Central India ◽  
P Value ◽  
Tertiary Level ◽  
Cross Sectional ◽  
Study Results ◽  
Level Hospital

Background: India has been recognized as the diabetes capital of the world by the year of 2025 Hypertension is a signicant danger factor for cardiovascular infection, stroke and ischemic coronary illness. Objective: The aim of this paper is prevalence of hypertension amid patients with type 2 diabetes mellitus- at a tertiary level hospital in central India. Methods: Present work is hospital based cross-sectional study was conduct in Chirayu Medical College & Hospital, Bhopal. The study population consisted of total 300 subjects. Data obtained directly from patients and patients medical les, and the following data were included in the study . Results: The results showed that the after using chi-square test we found that hypertension was signicantly higher p value(<0.05) among female patients (69%),patients with long duration diabetes (77%)10 years and more, also it was signicantly higher among patients with current smokers (69%). Conclusion: In this study the prevalence of hypertension is increasing in patient with T2DM. Hypertension was the most danger factor for micro vascular and macro vascular confusion of T2DM.

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