scholarly journals Epidemiologic profile of viral hepatitis B and C in North of Iran: Results from PERSIAN Guilan Cohort Study (PGCS)

2020 ◽  
Author(s):  
Fariborz Mansour-Ghanaei ◽  
Farahnaz Joukar ◽  
Mohammadreza Naghipour ◽  
Soheil Hassanipour ◽  
Sara Yeganeh ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hepatitis B ◽  
Urine Analysis ◽  
Health Impact ◽  
Serum Samples ◽  
Hcv Prevalence ◽  
Viral Hepatitis B ◽  
Epidemiologic Profile ◽  
North Of Iran ◽  
Hcv Genotyping

Abstract Objective Hepatitis B (HBV) and C (HCV) viruses are two severe infectious diseases with a high global health impact. This study aimed to evaluate the prevalence of HBV and HCV in the Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan Cohort Study through immunological and molecular methods. Results The blood samples were obtained from 10520 enrolled participants. Complete biochemical and hematological assessments plus urine analysis were done. The presence of HBsAg, anti-HBs, anti-HBc, and anti-HCV antibodies for all participants and HBeAg and anti-HBe antibody for HBV positive patients were evaluated. HBV genomic DNA and HCV genomic RNA were extracted from positive serum samples. The real-time PCR assay was done to quantify HBV and HCV genomes. HCV genotyping was also performed. The HBV and HCV prevalence was 0.24% (95% CI, 0.16% to 0.35%) and 0.11% (95% CI, 0.06% to 0.19%), respectively. Rural participants were significantly more HBV positive than urban peoples (P = 0.045) while male individuals were significantly more HCV positive than female participants (P = 0.013). Our detected HBV and HCV prevalence were lower than other cities/provinces of Iran, which may be due to lifestyle or other unknown reasons.

scholarly journals Epidemiologic profile of viral hepatitis B and C in North of Iran: Results from PERSIAN Guilan Cohort Study (PGCS)

2020 ◽  
Author(s):  
Fariborz Mansour-Ghanaei ◽  
Farahnaz Joukar ◽  
Mohammadreza Naghipour ◽  
Soheil Hassanipour ◽  
Sara Yeganeh ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hepatitis B ◽  
Urine Analysis ◽  
Health Impact ◽  
Serum Samples ◽  
Hcv Prevalence ◽  
Viral Hepatitis B ◽  
Epidemiologic Profile ◽  
North Of Iran ◽  
Hcv Genotyping

Abstract Objective: Hepatitis B (HBV) and C (HCV) viruses are two severe infectious diseases with a high global health impact. This study aimed to evaluate the prevalence of HBV and HCV in the Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan Cohort Study through immunological and molecular methods. Results: The blood samples were obtained from 10520 enrolled participants. Complete biochemical and hematological assessments plus urine analysis were done. The presence of HBsAg, anti-HBs, anti-HBc, and anti-HCV antibodies for all participants and HBeAg and anti-HBe antibody for HBV positive patients were evaluated. HBV genomic DNA and HCV genomic RNA were extracted from positive serum samples. The real-time PCR assay was done to quantify HBV and HCV genomes. HCV genotyping was also performed. The HBV and HCV prevalence was 0.24% (95% CI, 0.16 % to 0.35%) and 0.11% (95% CI, 0.06 % to 0.19%), respectively. Rural participants were significantly more HBV positive than urban peoples (P=0.045) while male individuals were significantly more HCV positive than female participants (P=0.013). Our detected HBV and HCV prevalence were lower than other cities/provinces of Iran, which may be due to lifestyle or other unknown reasons.

scholarly journals Epidemiologic profile of viral hepatitis B and C in North of Iran: Results from PERSIAN Guilan Cohort Study (PGCS)

2021 ◽  
Author(s):  
Fariborz Mansour-Ghanaei ◽  
Farahnaz Joukar ◽  
Mohammadreza Naghipour ◽  
Soheil Hassanipour ◽  
Sara Yeganeh ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hepatitis B ◽  
Urine Analysis ◽  
Health Impact ◽  
Serum Samples ◽  
Viral Hepatitis B ◽  
Epidemiologic Profile ◽  
North Of Iran ◽  
Urban People ◽  
Geographical Locations

Abstract Objective: Hepatitis B (HB) and C (HC) are two severe infectious diseases with a high global health impact. This study aimed to evaluate the prevalence of HB and HC in the Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan Cohort Study through immunological and molecular methods. Results: The blood samples were obtained from 10520 enrolled participants. Complete biochemical and hematological assessments plus urine analysis were done. The presence of HBsAg, anti-HBs, anti-HBc, and anti-HCV antibodies for all participants, and HBeAg and anti-HBe antibodies for HB positive patients were evaluated. HB genomic DNA and HC genomic RNA were extracted from positive serum samples. The real-time PCR assay was done to quantify HB and HC genomes. HC genotyping was also performed. The HB and HC prevalence was 0.24% (95% CI, 0.16 % to 0.35%) and 0.11% (95% CI, 0.06 % to 0.19%), respectively. Rural participants were significantly more HB positive than urban people (P=0.045), while male individuals were significantly more HC positive than female participants (P=0.013). The obtained showed the prevalence of HB and HC in this area were lower than other geographical locations of Iran, which may be due to different lifestyles or other unknown reasons.

scholarly journals Comprehensive investigation of the prevalence and risk factors of viral hepatitis B and C in PERSIAN Guilan Cohort Study

2019 ◽  
Author(s):  
Farahnaz Joukar ◽  
Mohammadreza Naghipour ◽  
Soheil Hassanipour ◽  
Sara Yeganeh ◽  
Soheil Soltanipour ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hepatitis B ◽  
Urine Analysis ◽  
Health Impact ◽  
Pcr Assay ◽  
Serum Samples ◽  
Hcv Prevalence ◽  
Positive Serum ◽  
Viral Hepatitis B ◽  
Hcv Genotyping

Abstract Background Hepatitis B (HBV) and C (HCV) viruses are two serious infectious diseases with high global health impact. The aim of this study was to evaluate the prevalence of HBV and HCV in the Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan Cohort Study through immunological and molecular methods.Methods The blood samples were obtained from 10520 enrolled participant. Complete biochemical and hematological assessments plus urine analysis were done. The presence of HBsAg, anti-HBs, anti-HBc and anti-HCV antibodies for all participants and HBeAg and anti-HBe antibody for HBV positive patients were evaluated. HBV genomic DNA and HCV genomic RNA were extracted from positive serum samples. Real time PCR assay was done to quantify HBV and HCV genomes. HCV genotyping was also performed.Results Most of our participants were female (53.5%), rural (56.1%), married (97.2%) with primary education (72.1%) without smoking (75.2%) or alcohol consumption (85.3%). The HBV and HCV prevalence was 0.24% (95% CI, 0.16% to 0.35%) and 0.11% (95% CI, 0.06% to 0.19%), respectively. Rural participants were significantly more HBV positive than urban peoples (P=0.045) while male individuals were significantly more HCV positive than female participants (P=0.013).Conclusion Our detected HBV and HCV prevalence were lower than other cities/provinces of Iran, which may be due to the lifestyle or other unknown reasons.

scholarly journals Epidemiologic profile of viral hepatitis B and C in North of Iran: results from PERSIAN Guilan Cohort Study (PGCS)

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Fariborz Mansour-Ghanaei ◽  
Farahnaz Joukar ◽  
Mohammadreza Naghipour ◽  
Soheil Hassanipour ◽  
Sara Yeganeh ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hepatitis B ◽  
Urine Analysis ◽  
Serum Samples ◽  
Gene Copies ◽  
Epidemiologic Profile ◽  
North Of Iran ◽  
Urban People ◽  
Geographical Locations ◽  
Hematological Tests

Abstract Objective Hepatitis B (HB) and C (HC) are two severe viral infectious diseases with a deleterious impact on global health. This study aimed to evaluate the prevalence of HB and HC in the Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan Cohort Study using immunological and molecular methods. Results The blood samples were obtained from 10,520 enrolled participants. Complete biochemical and hematological tests, as well as urine analysis, were assessed. The presence of HBsAg, anti-HBs, anti-HBc, and anti-HCV antibodies for all participant and HBeAg and anti-HBe antibodies for HB-positive patients were evaluated. Moreover, HB genomic DNA and HC genomic RNA were extracted from serum samples of HB-positive patients. The real-time PCR assay was employed to quantify the gene copies of hepatitis B and C viruses. HC genotyping was also performed. The prevalence of HB and HC was 0.24% (95% CI 0.16–0.35) and 0.11% (95% CI 0.06–0.19), respectively. Rural participants were significantly more HB-positive than the urban people (P = 0.045), while males were significantly more HC-positive than the females (P = 0.013). The prevalence of HB and HC in this area were lower than those of other geographical locations of Iran, which may be due to different lifestyles or other unknown reasons.

scholarly journals Sensitivity and specificity of commercially available rapid diagnostic tests for viral hepatitis B and C screening in serum samples

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0235036
Author(s):  
Ganbolor Jargalsaikhan ◽  
Miriam Eichner ◽  
Delgerbat Boldbaatar ◽  
Purevjargal Bat-Ulzii ◽  
Oyungerel Lkhagva-Ochir ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Sensitivity And Specificity ◽  
Diagnostic Tests ◽  
Rapid Diagnostic Tests ◽  
Serum Samples ◽  
Viral Hepatitis B

scholarly journals Clinical epidemiology of chronic viral hepatitis B: A Tuscany real-word large-scale cohort study

2018 ◽  
Vol 10 (5) ◽  
pp. 409-416 ◽  
Author(s):  
Cristina Stasi ◽  
Caterina Silvestri ◽  
Roberto Berni ◽  
Maurizia Rossana Brunetto ◽  
Anna Linda Zignego ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Large Scale ◽  
Clinical Epidemiology ◽  
Chronic Viral Hepatitis ◽  
Real Word ◽  
Viral Hepatitis B

scholarly journals Prevalence of viral hepatitis B and C in Sierra Leone—current knowledge and knowledge gaps: a narrative review

2021 ◽  
Author(s):  
Sulaiman Lakoh ◽  
Noemí García-Tardón ◽  
Olukemi Adekanmbi ◽  
Marc van der Valk ◽  
Samuel J Smith ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Sierra Leone ◽  
Blood Donors ◽  
Current Knowledge ◽  
School Age Children ◽  
Knowledge Gaps ◽  
Hcv Prevalence ◽  
Viral Hepatitis B ◽  
Control And Prevention

Abstract There are no comprehensive data on viral hepatitis from Sierra Leone; however, a huge disease burden has been observed in different subpopulations. This review summarizes available data on hepatitis B and C virus (HBV and HCV) prevalence in Sierra Leone and identifies knowledge gaps. Despite the non-uniformity of the studies and the lack of systematic case recording, different reports published in recent decades yielded a hepatitis B prevalence of 8.7% among healthcare workers, 11.3% among pregnant women, 15.2% among blood donors and 16.7% in school-age children. The actual HBV prevalence in the general population was reported as 21.7%; similar to what was reported for people living with human immunodeficiency virus (PLHIV). HCV prevalence is 8% and 7% in male and female blood donors, respectively, 4.1% in PLHIV and 2.0% in school children. There are significant knowledge gaps regarding the prevalence of viral hepatitis B and C in Sierra Leone, despite the high burden reported in a few studies. There are limited programmatic interventions on the control and prevention of viral hepatitis in the country. Therefore, well-structured representative studies should provide a solid understanding of the true prevalence of hepatitis B and C to inform best possible public health measures in Sierra Leone.

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