scholarly journals Effect of Virtual Reality on Cognitive Impairment and Clinical Symptoms Among Patients with Schizophrenia in the Remission Stage: A Randomized Controlled Trial

2020 ◽  
Author(s):  
Shangda Li ◽  
Bin Sun ◽  
Ning Wei ◽  
Zhe Shen ◽  
Kangyu Jin ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Clinical Symptoms ◽  
Visual Learning ◽  
Training System ◽  
Chinese Patients ◽  
Antipsychotic Treatment ◽  
Treatment As Usual ◽  
General Psychopathology

Abstract Background: This is an intervention study which explores the effect of using virtual reality supermarket training system (VRSTS) to improve cognitive function deficiency and clinical symptoms in Han Chinese patients with schizophrenia in the remission stage. Methods:68 patients with schizophrenia in the remission stage were recruited for the interventional study and were randomly allocated to either virtual reality training (VRT) group or treatment-as-usual (TAU) group. For VRT group, patients received training with VRSTS for two weeks and antipsychotic treatment as usual while TAU group only received antipsychotic treatment as usual. Cognitive function and clinical symptoms before and after intervention were assessed by MATRICS Consensus Cognitive Battery (MCCB), Positive and Negative Syndrome Scale (PANSS), and the Personal and Social Performance Scale (PSP).Results:Results showed (1) VRSTS could improve MCCB composite scores and 4 out of 7 cognitive domains: speed of processing, working memory, visual learning, reasoning and problem solving, and (2) VRSTS could alleviate general psychopathology symptoms of PANSS but did not exert effects on positive and negative symptoms among patients with schizophrenia in the remission stageConclusion:A therapeutic effect of VRSTS was observed in patients with schizophrenia in the remission stage. It may improve cognitive impairment and general psychopathology symptoms.Trial registration: China Clinical Trial Registry, ChiVTR1800016121. Registered 13 May 2018, http://www.chictr.org.cn/showproj.aspx?proj=27233

scholarly journals Effect of virtual reality on cognitive impairment and clinical symptoms among patients with schizophrenia in the remission stage ： a randomized controlled trial

2020 ◽  
Author(s):  
Shangda Li ◽  
Bin Sun ◽  
Ning Wei ◽  
Zhe Shen ◽  
Kangyu Jin ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Clinical Symptoms ◽  
Visual Learning ◽  
Chinese Patients ◽  
Antipsychotic Treatment ◽  
Treatment As Usual ◽  
General Psychopathology ◽  
Psychopathology Symptoms

Abstract Background: This is an intervention study which explores the effect of using virtual reality supermarket training system (VRSTS) to improve cognitive function deficiency and clinical symptoms in Han Chinese patients with schizophrenia in the remission stage. Methods: 68 patients with schizophrenia in the remission stage were recruited for the interventional study and were randomly allocated to either virtual reality training (VRT) group or treatment-as-usual (TAU) group. For VRT group, patients received training with VRSTS for two weeks and antipsychotic treatment as usual while TAU group only received antipsychotic treatment as usual. Cognitive function and clinical symptoms before and after intervention were assessed by MATRICS Consensus Cognitive Battery (MCCB), Positive and Negative Syndrome Scale (PANSS), and the Personal and Social Performance Scale (PSP). Results: Results showed (1) VRSTS could improve MCCB composite scores and 4 out of 7 cognitive domains: speed of processing, working memory, visual learning, reasoning and problem solving, and (2) VRSTS could alleviate general psychopathology symptoms of PANSS but did not exert effects on positive and negative symptoms among patients with schizophrenia in the remission stage Conclusion: A therapeutic effect of VRSTS was observed in patients with schizophrenia in the remission stage. It may improve cognitive impairment and general psychopathology symptoms.

scholarly journals Verification of virtual reality to evaluate deficiencies in cognitive function among patients with schizophrenia in the remission stage: a cross-sectional study

2020 ◽  
Author(s):  
Manli Huang ◽  
Shangda Li ◽  
Bing Sun ◽  
Hailong Lyu ◽  
Weijuan Xu ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Real Life ◽  
Han Chinese ◽  
Training System ◽  
Chinese Patients ◽  
Clinical Trial Registry ◽  
Cross Sectional ◽  
Diagnosis Model

Abstract Background: Schizophrenia is associated with widespread cognitive impairments. The MATRICS Consensus Cognitive Battery (MCCB) is most frequently used to assess cognitive function. However, the MCCB test can be time consuming for the clinician. Virtual reality (VR) has emerged as an adjunctive tool to overcome this limitation, which provides a new means of assessing cognitive function. Methods: The study is to explore the validity and safety of using VR technology to assess cognitive function in Han Chinese patients with schizophrenia. The virtual reality supermarket training system (VRSTS), which simulates real-life supermarkets, was used to assess cognitive function. Thirty-two patients with schizophrenia (SZs) and 25 healthy controls (HCs) received the VRSTS and MCCB assessments. A diagnosis model was created based on the outcomes of VRSTS to classify SZs and HCs by cognitive impairment. Results: Significant differences in completion time between the SZs and HCs were detected on the VRSTS. SZs spent more time completing tasks than HCs. The outcome of VRSTS was significantly correlated with the MCCB. Moreover, the diagnosis model has a sensitivity of 88.89% and a specificity of 88.89%. Conclusions: These results provide support for VR technology in the assessment of cognitive impairment in schizophrenia among Han Chinese patients.Trial registration: China Clinical Trial Registry, ChiVTR1800016121. Registered 13 May 2018, http://www.chictr.org.cn/showproj.aspx?proj=27233

scholarly journals Verification of using virtual reality to evaluate deficiencies in cognitive function among patients with schizophrenia in the remission stage: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bochao Huang ◽  
Shangda Li ◽  
Bing Sun ◽  
Hailong lyu ◽  
Weijuan Xu ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Real Life ◽  
Han Chinese ◽  
Training System ◽  
Chinese Patients ◽  
Clinical Trial Registry ◽  
Cross Sectional ◽  
Diagnosis Model

Abstract Background Schizophrenia is associated with widespread cognitive impairment. The MATRICS Consensus Cognitive Battery (MCCB) is most frequently used to assess cognitive function. However, the MCCB test is time consuming for the clinician. Virtual reality (VR) has emerged as an adjunctive tool to overcome this limitation and provides a new means to assess cognitive function. Methods The present study examined the validity and safety of using VR technology to assess cognitive function in Han Chinese patients with schizophrenia (SZs). The VR cognition training system (VRCTS) was used to simulate real-life supermarkets and assess cognitive function. Thirty-two SZs and 25 healthy controls (HCs) underwent VRCTS and MCCB assessments. An auxiliary diagnosis model was created based on the outcomes of the VRCTS to classify SZs and HCs by cognitive impairment. Results Significant differences in completion time between the SZs and HCs were detected using the VRCTS. SZs spent more time completing tasks than HCs. The outcome of VRCTS significantly correlated with the MCCB. The auxiliary diagnosis model had a sensitivity of 88.89% and a specificity of 88.89%. Conclusions These results support the use of VR technology in the assessment of cognitive impairment in Han Chinese schizophrenia patients. Trial registration China Clinical Trial Registry, ChiVTR1800016121. Registered 13 May 2018, http://www.chictr.org.cn/showproj.aspx?proj=27233

Correlating cognitive functions to symptom domains and insight in Egyptian patients with schizophrenia

2020 ◽  
Vol 66 (3) ◽  
pp. 240-248 ◽  
Author(s):  
Afaf Hamed Khalil ◽  
Marwa Abd el-Meguid ◽  
Mostafa Bastawy ◽  
Samah Rabei ◽  
Ramy Ali ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Problem Solving ◽  
Cognitive Functions ◽  
Visual Learning ◽  
Verbal Learning ◽  
General Psychopathology ◽  
Cognitive Domains ◽  
Reasoning Problem ◽  
Egyptian Patients

Introduction: Cognitive impairment is one of the fundamental features among patients with schizophrenia. The relationship between schizophrenia symptoms, insight and cognitive domains remains controversial. We aimed to study these relations in a sample of Egyptian patients with schizophrenia. Methods: A total of 109 patients with schizophrenia were assessed using Structured Clinical Interview for DSM-IV ( Diagnostic and Statistical Manual of Mental Disorders (4th ed.)) Axis I diagnosis (SCID-I), Positive and Negative Syndrome Scale (PANSS) and Scale to Assess Unawareness of Medical Disorder (SUMD). Cognitive functions were assessed using the Wechsler Adult Intelligence Scale (WAIS), the Wisconsin Card Sorting Test (WCST) and the Wechsler Memory Scale (WMS). The cognitive functions would be distributed to cover six cognitive domains: attention/vigilance speed of processing, verbal learning, visual learning, working memory and reasoning/problem solving. Results: There was a significant correlation between all cognitive domains (except attention) and PANSS subscales. PANSS negative and general psychopathology subscales were significantly correlated with five cognitive domains: speed of processing, verbal learning, visual learning, working memory and reasoning/problem solving. PANSS negative subscale was significantly correlated with verbal learning (verbal paired association 1) and visual learning (visual paired association 1). There was a significant correlation between all cognitive domains and SUMD, except verbal and visual learning domains assessed by verbal and visual paired association 1 subtests, as well as attention assessed by failure to maintain set subtest. Only visual learning (trials administered), working memory (percentage error), and processing speed (perseverative responses, and trials to complete first category) were significantly negatively correlated to SUMD. Conclusion: Cognitive impairment in patients with schizophrenia is most likely to underlie negative symptoms, general psychopathology symptoms and poor insight, suggesting that treatment strategies minimizing these symptoms would improve cognitive impairment.

scholarly journals Feasibility and Tolerability of a Culture-Based Virtual Reality (VR) Training Program in Patients with Mild Cognitive Impairment: A Randomized Controlled Pilot Study

2020 ◽  
Vol 17 (9) ◽  
pp. 3030 ◽  
Author(s):  
Jong-Hwan Park ◽  
Yung Liao ◽  
Du-Ri Kim ◽  
Seunghwan Song ◽  
Jun Ho Lim ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Training Program ◽  
Test Performance ◽  
Digit Span ◽  
Training Group ◽  
Control Group ◽  
Vr Training

The present study examined whether a culture-based virtual reality (VR) training program is feasible and tolerable for patients with amnestic mild cognitive impairment (aMCI), and whether it could improve cognitive function in these patients. Twenty-one outpatients with aMCI were randomized to either the VR-based training group or the control group in a 1:1 ratio. The VR-based training group participated in training for 30 min/day, two days/week, for three months (24 times). The VR-based program was designed based on Korean traditional culture and used attention, processing speed, executive function and memory conditions to stimulate cognitive function. The adherence to the culture-based VR training program was 91.55% ± 6.41% in the VR group. The only adverse events observed in the VR group were dizziness (4.2%) and fatigue (8.3%). Analysis revealed that the VR-based training group exhibited no significant differences following the three-month VR program in Korean Mini-Mental State Examination (K-MMSE) scores, working memory functions such as performance on the digit span test, or in Stroop test performance and word fluency. We conclude that although the 12-week culture-based VR training program did not improve cognitive function, our findings revealed that the culture-based VR training program was feasible and tolerable for participants with aMCI.

scholarly journals Altered gut microbiota correlates with cognitive impairment in Chinese children with Down’s syndrome

2021 ◽  
Author(s):  
Shimeng Ren ◽  
Xinjuan Wang ◽  
Jiong Qin ◽  
Qing Mu ◽  
Shuai Ye ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Gut Microbiota ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Chromosome 21 ◽  
Chinese Patients ◽  
Rrna Gene ◽  
Microbiota Composition ◽  
Gut Microbiota Composition

AbstractDown's syndrome (DS), a common chromosomal disease caused by chromosome 21 trisomy, is the main cause of cognitive impairment in children worldwide. Emerging evidence suggests that the microbiota–gut–brain axis plays a potential role in cognitive impairment. However, data regarding gut microbiota alterations in DS patients remain scarce, especially data from children with DS. This case–control study was conducted to explore the gut microbiota composition in Chinese DS children. Additionally, the potential association between gut microbiota and cognitive function in DS was evaluated. Microbiota communities in the feces of 15 DS subjects and 15 matched controls were investigated using high-throughput Illumina Miseq sequencing targeting the V3–V4 region of 16S rRNA gene. The relationships between gut microbiota composition and DS cognitive function scores were analyzed. The structure and richness of the gut microbiota differed between DS patients and healthy controls. The abundance of Acidaminococcaceae was decreased in DS patients. Moreover, the Kyoto Encyclopedia of Genes and Genomes analysis showed increased modules related to peptidases and pyrimidine metabolism. Overall, we confirmed that gut microbiota alterations occurred in Chinese patients with DS. Additionally, the fecal microbiota was closely related to DS cognitive impairment. Larger cohorts are needed to confirm these findings and to clarify the mechanisms involved. Elucidating these novel findings in the field of microbiota-gut-brain axis will provide a promising strategy for future studies of DS cognitive impairment.

scholarly journals Validation of T-MoCA in the screening of mild cognitive impairment in Chinese patients with atrial fibrillation

2020 ◽  
Author(s):  
Yiwei Lai ◽  
Chao Jiang ◽  
Xin Du ◽  
Zhiyan Wang ◽  
Jingrui Zhang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Educational Level ◽  
Education Level ◽  
Chinese Patients ◽  
Receiver Operating Curve ◽  
High Educational Level ◽  
High Educational

Abstract Background: Atrial fibrillation (AF) is associated with high risk of mild cognitive impairment (MCI) and dementia. However, feasible and simple instruments that facilitates regular assessment of cognitive status in AF patients remain underdeveloped. Methods: Cognitive function of 136 AF patients was first evaluated using T-MoCA. Cognitive function of 101 patients was then assessed through in-person interview by physicians who are blinded to telephone interview results, using both Clinical Dementia Rating (CDR) and Mini-Mental Status Evaluation (MMSE). Using CDR=0.5 as a reference standard, the ability of T-MoCA and MMSE to discriminate cognitive dysfunction, stratified by education level, was tested by receiver-operating curve (ROC) analysis. Net reclassification index was calculated for comparison between the performance of T-MoCA and MMSE. Results: Thirty-five MCI patients were identified as MCI using the criteria of CDR=0.5. The areas under the ROC curve of T-MoCA were 0.80 (0.71-0.89), 0.83 (0.71-0.95), and 0.85 (0.64-0.92) for all patients, patients with high educational level, and patients with low education level, respectively. The optimal threshold was achieved at 16/17 with a sensitivity of 85.7% and a specificity of 69.7% in overall patients, 15/16 with a sensitivity of 88.2% and a specificity of 64.5% in the low educational level patients, and 16/17 with a sensitivity of 77.8% and a specificity of 87.9% in the high educational level patients. Compared to the criterion MMSE≤27 and MMSE norms for the Chinese community elderly, stratified T-MoCA threshold improves correct classification by 23.7% (p=0.033) and 30.3% (p=0.020) respectively. Conclusion: T-MoCA is a feasible and effective method for MCI screening in patients with AF.

Soluble Fas ligand (sFasL) as a predictor of reduction of general psychopathology in schizophrenia after antipsychotic treatment

2016 ◽  
Vol 33 (S1) ◽  
pp. S108-S108
Author(s):  
K. Szymona ◽  
H. Karakula-Juchnowicz ◽  
B. Zdzisinska ◽  
M. Flis ◽  
K. Kaławaj ◽  
...  
Keyword(s):  
Fas Ligand ◽  
Clinical Symptoms ◽  
Active Phase ◽  
Chronic Schizophrenia ◽  
Significant Negative Correlation ◽  
First Episode ◽  
Blood Levels ◽  
Antipsychotic Treatment ◽  
Blood Leukocytes ◽  
General Psychopathology

IntroductionDysregulation of the apoptotic process is associated with the etiopathogenesis of schizophrenia, which is observed at the brain and peripheral blood levels. A significant negative correlation between the duration of the disease and serum sFasL concentration was demonstrated by other authors. It was shown that an increased rate of apoptosis is more pronounced in neuroleptic-free patients with the first-episode of schizophrenia than in patients with chronic disease.AimSearch for a predictor of good response to antipsychotic treatment based on the analysis of the sFasL plasma level and its relationship with clinical symptoms.MethodsFifty-three patients with chronic schizophrenia and 46 healthy individuals were enrolled in the study. The concentration of sFasL was measured by ELISA. Clinical assessments (PANSS, SANS, SAPS) and blood analyses were conducted three times: during the active phase of disease (at admission), after 4 weeks of pharmacotherapy, and after reaching remission.ResultsIn the schizophrenia group, non-altered levels of sFasL (P = 0.1; U Mann-Whitney test), compared to the control, were detected at admission. The initial level of sFasL correlated negatively (r = −0.33; P = 0.04; Spearman's rank) with blood leukocyte count. Despite clinical improvement, no significant changes in the level of sFasL were observed. However, the sFasL level correlated negatively with the PANSS general psychopathology reduction after 4 weeks of pharmacotherapy (r = −0.7; P = 0.04) and after remission (r = −0.39; P = 0.026).ConclusionsThe results indicate a possible role of sFasL in apoptosis of blood leukocytes and suggest that the reduction of sFasL level can predict level of PANSS general psychopathology after antipsychotic treatment in schizophrenia.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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