scholarly journals Association Between Serum Microcystins Levels and Chronic Pelvic Inflammatory Disease: a Case-control Study

2021 ◽  
Author(s):  
Na Zhu ◽  
Xiaolan Wang ◽  
Jia Tan ◽  
Shuaishuai Xu ◽  
Yanhong Peng ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Protective Factor ◽  
Case Control Study ◽  
Binary Logistic Regression ◽  
Scientific Basis ◽  
Case Control ◽  
Central China ◽  
The Relationship ◽  
Control Study

Abstract Microcystins(MCs) have been reported to be closely related to the occurrence and development of inflammation by animal and cell experiments, but there are no study on the relationship between serum microcystin-LR(MC-LR) and chronic pelvic inflammatory disease (CPID) risk in populations. We designed a clinical case-control study to investigate the relationship between serum MC-LR and CPID risk. From October 2020 to March 2021, 50 patients diagnosed with CPID and 50 controls (frequency matched by age) were recruited from the First Hospital University of South China, in Hengyang, Central China. The basic information on lifestyle and history of disease was acquired through questionnaires. Blood samples were analyzed for MC-LR by ELISA. Binary logistic regression analyses and chi-square test were used to evaluate the effects of MC-LR on CPID risk. With the increase of serum MC-LR level (Q2, Q3 and Q4), the AOR of CPID risk increased (0.139, 0.167 and 0.040, respectively). The serum MC-LR(0.06 ~ 0.66µg/L) was an independent protective factor for CPID in humans, and the protective effect of concentrations ≥ 0.25μg/L was more obvious. Within the certain concentration range, MC-LR was an independent protective factor for the risk of CPID in humans, which will provide a scientific basis for the study of the relationship between serum microcystins and inflammation.

scholarly journals GSTT1 and GSTM1 Polymorphisms with Human Papillomavirus Infection in Women from Southern Brazil: A Case-control Study

2021 ◽  
Author(s):  
Ana Paula Reolon Bortolli ◽  
Valquíria Kulig Vieira ◽  
Indianara Carlotto Treco ◽  
Claudicéia Risso Pascotto ◽  
Guilherme Welter Wendt ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Protective Factor ◽  
Case Control Study ◽  
Smoking Habit ◽  
Case Control ◽  
Control Group ◽  
Southern Brazil ◽  
Female Population ◽  
The Relationship ◽  
Control Study

Abstract Background Some important factors for the most common sexually transmitted infection (STI) in the world caused by human papillomavirus (HPV) are well defined as early sexual activity, use of contraceptives, tobacco smoking, immunological and genetic factors. This study aimed to investigate the relationship between polymorphisms, GSTM1 and GSTT1, and HPV infection and associated risk factors in a group of women assisted in the public health system in southwestern Paraná, Brazil. Methods and results A case-control study was designed, in which the case group consisted of 21 women with HPV, matched by age, with the control group, 84 women without the virus. Viral detection was conducted via Polymerase Chain Reaction (PCR) and GSTM1 and GSTT1 genotyping by Multiplex PCR. The results showed that the GSTT1 null allele was a protective factor against infection (ORadj: 0.219; 95% CI 0.078-0.618; p=0.004). No relationship was observed for the GSTM1 gene. The smoking habit was defined as a risk factor (ORadj: 3.678; 95% CI 1.111-12.171; p=0.033), increasing the chance for the presence of HPV by up to 3.6 times.Conclusion In short, this study showed in an unprecedented way, the relationship between GSTM1 and GSTT1 genetic polymorphisms and HPV. The relationship found portrays protection from viral infection and not from susceptibility in the female population of southern Brazil.

scholarly journals O05.5 A case control study to examine the cervico-vaginal microbiota associated with pelvic inflammatory disease

2019 ◽  
Author(s):  
Wilhelmina Huston ◽  
Rami Mazraani ◽  
Catherine Burke ◽  
Jacques Ravel ◽  
Kirsteen Flemming ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Case Control Study ◽  
Case Control ◽  
Vaginal Microbiota ◽  
Control Study

scholarly journals Chlamydia infection as a risk factor in ectopic pregnancy: a case control study

2018 ◽  
Vol 7 (10) ◽  
pp. 4254
Author(s):  
Angela George ◽  
Shaila S.
Keyword(s):  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Case Control Study ◽  
Case Control ◽  
Chlamydia Infection ◽  
Increased Risk ◽  
History Of ◽  
Ectopic Pregnancies ◽  
Control Study

Background: Chlamydia trachomatis has been linked to 30-50% of all ectopic pregnancies, due to irreversible tissue damage.  Hence it is pertinent to explore the risk factors pertaining to Chlamydia infection and ectopic pregnancies. The aim is to study whether Chlamydia infection is a risk factor for ectopic pregnancy in comparison with early intrauterine pregnancy, and study other risk factors in ectopic pregnancyMethods: Case-control study conducted at Sree Avittom Thirunal Hospital, Thiruvananthapuram over a period of six months taking 43 subjects in each group, i.e., cases and controls. An interview followed by collection of venous blood sample was done, which was subjected to Enzyme linked immunoassay test to detect Immunoglobulin G antibodies to Chlamydia. Comparison of qualitative variables such as age, socioeconomic status, history of infertility, history of pelvic inflammatory disease, previous history of ectopic pregnancy, use of IUCD, history of IVF, use of OCP or progesterone only pills and presence of Chlamydia IgG antibodies - between two groups was analyzed by chi-square test and the strength of association expressed in terms of Odds Rati. A p-value <0.05 was considered statistically significant.Results: Out of 86 samples 54 were positive for Chlamydia infection. Subjects with Chlamydia infection had an increased risk of developing ectopic pregnancy. Among the other risk factorshistory of pelvic inflammatory disease and history of infertility were the most significant with Odds of 3.46 and 3.98 respectively. History of oral contraceptive use also had a significant risk associated with developing ectopic pregnancy. Other factors with significant association included, age more than 25 years, Upper Socioeconomic Class, previous ectopic pregnancy and history of IUCD use for more than 5 years.Conclusions: The increased number of Chlamydia infection and its increased risk for developing irreversible sequels such as ectopic pregnancy, it is pertinent to vigilantly diagnose, treat and prevent vaginal infection and pelvic inflammatory disease.

scholarly journals Prevalence of Balance Impairment and Factors Associated with Balance among Patients with Stroke. A Cross Sectional Retrospective Case Control Study

Healthcare ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 320
Author(s):  
Fayaz Khan ◽  
Mohamed Faisal Chevidikunnan
Keyword(s):  
Case Control Study ◽  
Binary Logistic Regression ◽  
Berg Balance Scale ◽  
Case Control ◽  
Knee Extensors ◽  
Retrospective Case ◽  
Cross Sectional ◽  
Balance Impairment ◽  
Factors Associated ◽  
Control Study

Stroke is a major cause of disability worldwide, and balance impairments are common disabling factors in patients with stroke, leading to falls. Thus, the study objectives were as follows: (i) To find the prevalence of balance impairment among patients with stroke. (ii) To find out the factors associated with balance impairment in patients with stroke. This cross-sectional retrospective case control study involved eighty-one post stroke patients with a mean age of 58.36 ± 14.06, recruited from six hospitals, who underwent an assessment of balance, walking speed, depression and isometric strength of the ankle and knee. These patients were later categorized into subjects with good balance (<45) in the Berg balance scale (BBS) and those with poor balance (≥45), as cases and controls, to assess the factors associated with balance impairment using binary logistic regression. The prevalence of balance impairment among patients with stroke was 48.1%. The reduction in power of knee flexors (OR = 0.858), knee extensors (OR = 0.880) and ankle dorsiflexors (OR = 0.820) was found to be significantly associated with balance impairment, along with speed (OR = 1.187 (95% CI = 1.100, 1.280)), depression (OR = 1.331 (95% CI = 1.055–1.679)) and activities of daily living (OR = 0.313 (95% CI = 0.150–0.650)). In summary, around half of the patients with stroke exhibited balance impairments, with females being more prone.

Sign in / Sign up

Export Citation Format

Share Document