scholarly journals The Potential Utility of 68Ga-FAPI-04 As a Novel Broad-spectrum Tumor and Inflammatory Imaging Agent - Comparison With 18F-FDG

2021 ◽  
Author(s):  
Lin Qiu ◽  
Lianjun Lan ◽  
Hanxiang Liu ◽  
Yingwei Wang ◽  
Jia Deng ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Fdg Pet ◽  
Detection Rate ◽  
Imaging Agent ◽  
Benign Tumors ◽  
Diagnostic Efficacy ◽  
Predictive Values ◽  
Metastatic Lesions ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Objective: This study aimed to compare the diagnostic performance of 68Ga-FAPI-04 and 18F-FDG PET/CT in the patients with various oncological and non-oncological lesions. Patients and Methods: A total of 123 patients underwent contemporaneous 68Ga-FAPI-04 and 18F-FDG PET/CT were included in this prospective study. The maximum standard uptake value (SUVmax) was measured to compare oncological and non-oncological lesion uptake. The sensitivity, specificity, predictive values and accuracy of 18F-FDG and 68Ga-FAPI-04 PET/CT for detecting primary, metastatic, and non-oncological lesions were calculated and compared to evaluate the diagnostic efficacy. Results: The study subjects consisted of 123 patients (69 men and 54 women; mean age: 56.11±11.94). A total of 84 patients with 88 solid primary malignant tumors, 58 patients with 376 nodal metastases, 43 patients with 406 distant metastases, 8 patients with hematological neoplasms and 52 patients with 145 non-oncological lesions and benign tumors were detected. 68Ga-FAPI-04 PET/CT demonstrated a significantly higher uptake and detection rate for the primary (SUVmax: 10.98±5.83 vs. 8.36±6.43, p＜0.001; X2=0.538, p=0.021), nodal (SUVmax: 10.50±5.98 vs. 8.20±6.29, p=0.011; X2=2.067, p＜0.001) and distant metastatic lesions (SUVmax: 6.74±4.83 vs. 9.64±6.45; p＜0.001; X2=4.897, p＜0.001) of solid tumor than did 18F-FDG PET/CT. 68Ga-FAPI-04 PET/CT demonstrated a lower activity (SUVmax: 6.84±4.67 vs. 13.09±7.29, p＜0.001) and detection rate (X2=5.166, p＜0.001) for multiple myeloma and lymphoma compared to 18F-FDG PET/CT. 68Ga-FAPI-04 and 18F-FDG PET/CT PET/CT demonstrated a comparative diagnostic efficacy (SUVmax: 6.40±3.95 vs. 5.74±15.78, p = 0.729; X2 = 9.460, p = 0.007) for non-oncological lesion and benign tumor detection. Conclusions: Except for myeloma and lymphoma, 68Ga-FAPI-04 PET/CT showed a superior diagnostic efficacy for detecting various primary and metastatic lesions than 18F-FDG PET/CT. A comparative diagnostic utility for non-oncological lesion detection was obtained with both tracers. 68Ga-FAPI-04 could be used as a broad-spectrum tumor and inflammatory imaging agent in the clinical especially for various solid tumors and non-oncological lesions.

[68Ga]Ga-DOTA-FAPI-04 PET/CT in The Staging of Gastric Cancer: Improved Diagnostic Efficacy Confirmed By Postoperative Histopathology

2021 ◽  
Author(s):  
Rong Lin ◽  
Zefang Lin ◽  
Zhenying Chen ◽  
Shan Zheng ◽  
Jiaying Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Response To Treatment ◽  
Diagnostic Efficacy ◽  
Primary Tumors ◽  
Metastatic Lesions ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
N Staging

Abstract Purpose This study aimed to compare the diagnostic performance of [68Ga]Ga-DOTA-FAPI-04 and [18F]-FDG PET/CT in the primary and metastatic lesions of gastric cancer. Methods Fifty-six patients with histologically proven gastric carcinomas were enrolled in this study. Each patient underwent both [18F]-FDG and [68Ga]Ga-FAPI-04 PET/CT within one week. Activity of tracer accumulation in lesions were assessed by maximum standardized uptake value (SUVmax) and TBR (lesions SUVmax/ ascending aorta SUVmean). Histological work-up including immunohistochemical staining for FAP served as a standard of reference. Results [68Ga]Ga-FAPI PET/CT is superior in detecting primary tumors both in patient-based (100% [45/45] vs. 97.8% [44/45]) and lesion-based analyses (97.8% [45/46] vs. 95.7% [44/46]), showing higher SUVmax (10.25 vs. 8.13, P = 0.004) and TBR (11.63 vs. 5.83, P < 0.001), compared with [18F]-FDG PET/CT. The specificity and positive predictive value of [68Ga]Ga-FAPI were significantly higher than that of [18F]-FDG (100.0% vs. 97.7%, P < 0.001; 100.0% vs. 57.1%, P = 0.001) in determining the lymph node (LN) metastases. [68Ga]Ga-FAPI PET/CT was superior to [18F]-FDG PET/CT in N-staging (47.1% [8/17] vs. 23.5% [4/17]), and in evaluation for LN, peritoneum and bone metastases. [68Ga]Ga-FAPI PET/CT detected positive recurrent lesions in all patients and showed more positive lesions and clearer tumor delineation. Two patients underwent follow-up [68Ga]Ga-FAPI PET/CT scans after chemotherapy, which both showed remission. Conclusions [68Ga]Ga-FAPI PET/CT can better detect primary gastric cancer and metastatic lesions in peritoneum, abdominal LNs and bone, showing high usefulness in guiding N staging. Furthermore, [68Ga]Ga-FAPI PET/CT provides more information for patients with recurrence detection and also has great potential in monitoring response to treatment.

Can Dual-Time-Point18F-FDG PET/CT Differentiate Malignant Salivary Gland Tumors From Benign Tumors?

2013 ◽  
Vol 201 (3) ◽  
pp. 639-644 ◽  
Author(s):  
Akira Toriihara ◽  
Shin Nakamura ◽  
Kazunori Kubota ◽  
Tomoko Makino ◽  
Kiyoshi Okochi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Fdg Pet ◽  
Salivary Gland Tumors ◽  
Benign Tumors ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Malignant Salivary Gland Tumors

Does incidental FDG PET uptake in the prostate have significance?

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 115-115
Author(s):  
Anna Mary Brown ◽  
Maria Liza Lindenberg ◽  
Sandeep Sankineni ◽  
Linda M Johnson ◽  
Suneha Pruthy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fdg Pet ◽  
Final Analysis ◽  
Multiple Comparisons ◽  
Dynamic Contrast Enhancement ◽  
Predictive Values ◽  
Fdg Uptake ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
Fdg Pet Ct

115 Background: 18F-FDG PET/CT is widely used to diagnose malignancy, but is not recommended for localized prostate cancer. This study explores the value of multi-parametric MRI (mpMRI) in characterizing incidentally detected prostate FDG uptake. Methods: Thirty-one patients who underwent FDG PET/CT and prostate MRI were eligible for this study. 14 patients were excluded (n=8 insufficient histopathology, n=6 radical prostatectomy before PET), with final analysis of 17 patients. The mpMRI sequences included T2-weighted, dynamic contrast enhancement (DCE), apparent diffusion coefficient (ADC), and MR spectroscopy (MRS). Nuclear medicine physicians, blinded to clinicopathologic findings, identified suspicious areas and maximum standardized uptake values (SUVmax) on FDG PET/CT. The lesion and sector-based imaging findings were correlated with annotated histopathology from whole-mount or MRI/TRUS fusion biopsy samples. Positive predictive values (PPVs) were estimated using generalized estimating equations with logit link. Results were evaluated with Kruskal-Wallis and Dunn’s multiple comparisons tests. Results: The PPV of FDG PET alone in detecting prostate cancer was 0.56. Combining FDG (base parameter) with mpMRI modalities (T2, DCE, ADC, MRS) increased the sector-based PPV to 0.79, 0.82, 0.80, and 0.89, respectively. All benign lesions had SUVmax < 5, and malignant lesions had higher mean SUVmax values that correlated with Gleason scores [Table]. This relationship between SUVmax and Gleason score was significant, with p=0.012 on the Kruskal-Wallis test and p=0.015 on the Dunn’s multiple comparisons test for Gleason 0 vs Gleason ≥ 4+5. Conclusions: Incidental prostate FDG uptake has low clinical utility alone, but these areas may harbor high-grade prostate cancer, especially if the SUVmax is greater than 5. [Table: see text]

scholarly journals 99mTc-DMSA (V) in Evaluation of Osteosarcoma: Comparative Studies with 18F-FDG PET/CT in Detection of Primary and Malignant Lesions

ISRN Oncology ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-11
Author(s):  
G. P. Bandopadhyaya ◽  
Priyanka Gupta ◽  
Archana Singh ◽  
Jaya Shukla ◽  
S. Rastogi ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Lung Nodule ◽  
Inflammatory Lesion ◽  
Primary Site ◽  
Whole Body ◽  
Metastatic Lesions ◽  
Pet Ct ◽  
Malignant Lesions ◽  
Fdg Pet Ct

To evaluate the role of 99mTc-DMSA (V) and [18F]FDG PET-CT in management of patients with osteosarcoma, 22 patients were included in our study. All patients underwent both 99mTc-DMSA (V) and whole-body [18F]FDG PET-CT scans within an interval of 1 week. 555–740 MBq of 99mTc-DMSA (V) was injected i.v. the whole-body planar, SPECT images of primary site and chest were performed after 3-4 hours. [18F]FDG PET-CT images were obtained 60 minutes after i.v. injection of 370 MBq of F-18 FDG. Both FDG PET-CT (mean SUVmax = 7.1) and DMSA (V) scans showed abnormal uptake at primary site in all the 22 patients (100% sensitivity for both). Whole-body PET-CT detected metastasis in 11 pts (lung mets in 10 and lung + bone mets in 1 patient). Whole-body planar DMSA (V) and SPECT detected bone metastasis in one patient, lung mets in 7 patients and LN in 1 patient. HRCT of chest confirmed lung mets in 10 patients and inflammatory lesion in one patient. 7 patients positive for mets on DMSA (V) scan had higher uptake in lung lesions as compared to FDG uptake on PET-CT. Three patients who did not show any DMSA uptake had subcentimeter lung nodule. Resuts of both 99mTc-DMSA (V) (whole-body planar and SPECT imaging) and [18F]FDG PET-CT were comparable in evaluation of primary site lesions and metastatic lesions greater than 1 cm. Though 99mTc-DMSA (V) had higher uptake in the lesions as compared to [18F]FDG PET-CT, the only advantage [18F]FDG PET-CT had was that it could also detect subcentimeter lesions.

scholarly journals Staging of Primary Abdominal Lymphomas: Comparison of Whole-Body MRI with Diffusion-Weighted Imaging and18F-FDG-PET/CT

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Alessandro Stecco ◽  
Francesco Buemi ◽  
Martina Quagliozzi ◽  
Mariangela Lombardi ◽  
Alberto Santagostino ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Weighted Kappa ◽  
Whole Body ◽  
Gastrointestinal Lymphoma ◽  
Predictive Values ◽  
Whole Body Mri ◽  
Diffusion Weighted ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Kappa Agreement

Background. The purpose of this study was to compare the accuracy of whole-body MRI with diffusion-weighted sequences (WB-DW-MRI) with that of18F-FDG-PET/CT in the staging of patients with primary gastrointestinal lymphoma.Methods. This retrospective study involved 17 untreated patients with primary abdominal gastrointestinal lymphoma. All patients underwent18F-FDG-PET/CT and WB-DW-MRI. Histopathology findings or at least 6 months of clinical and radiological follow-up was the gold standard. The Musshoff-modified Ann Arbor system was used for staging, and diagnostic accuracy was evaluated on a per-node basis.Results. WB-DW-MRI exhibited 100% sensitivity, 96.3% specificity, and 96.1% and 100% positive and negative predictive values (PPV and NPV), respectively. The sensitivity, specificity, and PPV and NPV of PET/CT were 95.9%, 100%, and 100% and 96.4%, respectively. There were no statistically significant differences between the two techniquesp=0.05. The weighted kappa agreement statistics with a 95% confidence interval were 0.97 (0.95–0.99) between the two MRI readers and 0.87 (0.82–0.92) between the two methods.Conclusions. WB-DW-MRI appears to have a comparable diagnostic value to18F-FDG-PET/CT in staging patients with gastrointestinal lymphoma.

scholarly journals Multiparameter Analysis Using 18F-FDG PET/CT in the Differential Diagnosis of Pancreatic Cystic Neoplasms

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Guanyun Wang ◽  
Haodan Dang ◽  
Peng Yu ◽  
Honghong Liu ◽  
Yue Wu ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Fdg Pet ◽  
Diagnostic Value ◽  
Combined Model ◽  
Cystic Neoplasms ◽  
Diagnostic Efficacy ◽  
Multiple Parameters ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Purpose. To evaluate multiparametric analysis in differential diagnosis between pancreatic serous cystic neoplasms (SCNs) and mucinous cystic neoplasms (MCNs) as well as the differentiation of the benign and malignant MCNs with 18F-FDG (18-fluorodeoxyglucose) PET/CT (positron emission tomography). Methods. Forty patients with total of 41 lesions (SCNs: 27/41; MCNs: 14/41), who were preoperatively examined with 18F-FDG PET/CT, were retrospectively analyzed. Multiple quantitative parameters using conventional and texture features were included. The combined model was established with complementary PET/MR parameters. The differential diagnostic efficacy of each independent parameter and the combined model were evaluated with receiver operating characteristic (ROC) analysis. Integrated discriminatory improvement (IDI) and net reclassification improvement (NRI) were used to evaluate improvement of diagnostic efficacy by using combination of multiple parameters. Results. Among all independent parameters, the percentile 5th (0.88 ± 0.38 vs 0.47 ± 0.23, P < 0.001 ) showed the highest discriminative diagnostic value. The combination of multiple parameters can improve the differential diagnostic efficacy of SCNs and MCNs (sensitivity = 71.4%, specificity = 77.8%, and AUC = 0.788), and the addition of texture parameters to the conventional parameters allowed a significant reclassification with IDI = 0.236 (95% CI: 0.095–0.377) and categorical NRI = 0.434 (95% CI: 0.030–0.838). SURmax (tumor to normal pancreas ratio, T/P) and SURmax (tumor to aorta ratio, T/A) both showed the highest discriminative diagnostic value (sensitivity = 100.0%, specificity = 70.0%, AUC = 0.900, and Youden index = 0.700) in the differential diagnosis of benign and malignant MCNs, with the cutoff values of 0.84 and 0.90, respectively. Conclusion.Combination of multiple parameters using 18F-FDG PET/CT could further improve differentiation between pancreatic SCNs and MCNs. SURmax (T/P) and SURmax (T/A) could improve differential diagnosis of benign and malignant MCNs.

scholarly journals Maximizing FDG-PET/CT Utility in Staging of Follicular Lymphoma (FL): The Role of Spleen Involvement and Bone Standardized Uptake Values

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 2811-2811 ◽  
Author(s):  
Frederique St-Pierre ◽  
Stephen Broski ◽  
Betsy Laplant ◽  
Thomas M. Habermann ◽  
Thomas E. Witzig
Keyword(s):  
Sensitivity And Specificity ◽  
Fdg Pet ◽  
Iliac Crest ◽  
Bone Involvement ◽  
Routine Practice ◽  
Newly Diagnosed ◽  
Predictive Values ◽  
Posterior Iliac Crest ◽  
Pet Ct ◽  
Fdg Pet Ct

Background: FDG PET/CT and bone marrow biopsy (BMB) are considered standard procedures for the staging of patients with new, untreated FL. A key issue in FL is the early identification of patients who will fail early. We recently reported (Am J Hematology 2019) that the presence of ≥2 EN sites, spleen, bone or soft tissue involvement as detected by PET all predicted failure to achieve EFS24. In Hodgkin lymphoma and diffuse large B-cell NHL, PET has replaced the routine need for a staging BMB. However, there is no such evidence in FL. The goal of this study was to determine the value of FDG PET/CT in determining bone involvement in FL using BMB as the gold standard. Methods: Patients were identified using the Mayo Clinic Lymphoma Database. 548 patients with newly diagnosed FL grades 1-3A between years 2003-2016, available BMB results, and PET/CT imaging at diagnosis, were included in the analysis. The presence of bone and spleen involvement on PET/CT, SUVmax and SUVmean of the axial skeleton at L3, and BMB results were recorded and compared. Results: In all, 36% (197/548) of patients had a positive BMB, and 34% (189/548) had bone involvement detected on PET/CT. Compared to BMB, the sensitivity and specificity of PET/CT in detecting bone involvement as determined by BMB were 60% and 80%, respectively. We noted that 59 patients had focal bone involvement on PET/CT rather than a diffuse component, and found that 47% (28/59) of these patients had a negative BMB obtained in the posterior iliac crest. Excluding these patients, the sensitivity and specificity of PET/CT in detecting bone involvement were 53% and 88%, respectively (Table 1). With respect to the spleen, 29% (157/548) of patients had evidence of splenic FL involvement on PET/CT, and of these, 69% (109/157) also had a positive BMB. The sensitivity and specificity of spleen involvement on PET/CT in predicting bone involvement on BMB were 55% and 86%, respectively (Table 2). We recorded SUV data at L3 in the 439 patients who had either a diffuse pattern of bone involvement on PET/CT, or a PET/CT read as negative. We analyzed the positive and negative predictive values (PPV and NPV) of SUVmax and SUVmean at several cut-off points to determine whether axial bone SUV is reliable at determining patients with a positive or negative BMB. The NPV for an SUVmax of less than 2.0 was 96% (n=25 patients classified as negative). For SUVmean, the best cut-off point was at less than 1.4, where NPV was 100% (n=15 patients classified as negative). There was no logical cut-off point for a significant PPV > 95%. Conclusion: In newly diagnosed FL, the sensitivity and specificity of bone involvement on PET/CT are insufficient for PET/CT to routinely replace BMB. However, in patients where the need for BMB at staging is being debated, certain factors on PET/CT can help facilitate this decision. The detection of focal bone lesions, especially those that may be missed on posterior iliac crest BMB, can make BMB unnecessary. If both the spleen and bone appear involved on PET/CT, this confers a relatively high chance that BMB will be positive. If SUVmax at L3 is less than 2.0, or if SUVmean is less than 1.4, the BMB will likely be negative, with a NPV > 95%. This decision-making algorithm is outlined in Figure 1 and may serve as a useful guideline for clinical trials and routine practice. Disclosures No relevant conflicts of interest to declare.

Limited diagnostic and predictive values of dual-time-point 18F FDG PET/CT for differentiation of incidentally detected thyroid nodules

2011 ◽  
Vol 25 (5) ◽  
pp. 347-353 ◽  
Author(s):  
Seong-Jang Kim ◽  
Bo Hyun Kim ◽  
Yun Kyung Jeon ◽  
Sang Soo Kim ◽  
In Joo Kim
Keyword(s):  
Fdg Pet ◽  
Thyroid Nodules ◽  
Predictive Values ◽  
Pet Ct ◽  
18F Fdg ◽  
Dual Time Point ◽  
Fdg Pet Ct ◽  
Time Point
Sign in / Sign up

Export Citation Format

Share Document