scholarly journals Applicability of Different Estimated Glomerular Filtration Rate Equations in Chinese Healthy Population: A Cross-Sectional Study

Mapping Intimacies â—½  
2021 â—½  
Author(s):  
Lu Wei â—½  
Xue Shen â—½  
Juan Zhang â—½  
Zhenzhu Yong â—½  
Qun Zhang â—½  
...  

Abstract Objective: To estimate kidney function with aging by equations based on serum creatinine (Scr) and investigate the applicability of these equations in estimated glomerular filtration rate (eGFR) in healthy Chinese population. Patients and methods: A total of 34,416 healthy individuals were enrolled in this study, eGFR was calculated by CKD-EPI, FAS and Xiangya equations. Plotted scatter diagrams were adopted to show the difference between eGFR by above three equations. Agreement analysis between these equations was quantified by the linear weighted κ statistic.Results: eGFRs by CKD-EPI and Xiangya equation had a constant decline with aging. eGFR by FAS equation was approximately 116.5 mL/min/1.73m2 under 40 years, then decreased with a rate of 1.27 mL/min/1.73 m2/year. The difference was relatively small, and substantial agreement was observed between CKD-EPI and FAS equations with Scr levels above 0.9 mg/dL in males (κ =0.798) or 0.7 mg/dL in females (κ =0.745). The agreement between CKD-EPI and FAS equations was moderate to near-perfect in non-elderly (κ 0.617-0.901 for males and 0.536-0.861 for females), whereas was fair to moderate in older adults (κ 0.494-0.513 for males and 0.373-0.526 for females). eGFR by CKD-EPI was slightly higher than which by FAS equation in older population. The agreement between Xiangya and CKD-EPI or FAS equation was all slight (κ<0.2).Conclusion: FAS equation could be used to evaluate declining rate of eGFR in healthy population. We recommend FAS or CKD-EPI equation in non-elderly adults, and FAS equation in older adults to calculate eGFR. More verification is needed, especially in older adults and population with low Scr level.

2018 â—½  
Vol 666 â—½  
pp. 127-132 â—½  
Author(s):  
Qian Liu â—½  
Yan-xun Li â—½  
Zhi-hao Hu â—½  
Xiao-yan Jiang â—½  
Shu-juan Li â—½  
...  

PLoS ONE â—½  
2019 â—½  
Vol 14 (8) â—½  
pp. e0218290 â—½  
Author(s):  
Tomoe Kimura â—½  
Toshinori Ueno â—½  
Shigehiro Doi â—½  
Ayumu Nakashima â—½  
Toshiki Doi â—½  
...  

Endocrine Practice â—½  
10.4158/ep12282.or â—½  
2013 â—½  
Vol 19 (3) â—½  
pp. 397-403 â—½  
Author(s):  
Yicong Ye â—½  
Xiaorong Gai â—½  
Hongzhi Xie â—½  
Li Jiao â—½  
Shuyang Zhang

2015 â—½  
Vol 37 (2) â—½  
pp. 121
Author(s):  
Ima Septia â—½  
Rismawati Yaswir â—½  
Lillah Lillah â—½  
Efrida Efrida

AbstrakPenelitian ini bertujuan mengetahui korelasi indeks massa tubuh (IMT) dengan estimated Glomerular Filtration Rate (eGFR) berdasarkan formula MDRD pada populasi sehat di kota Padang. Penelitian analitik dengan rancangan potong lintang ini mengikutsertakan 121 orang peserta medical check up pada beberapa rumah sakit di Kota Padang pada bulan Agustus 2013-Oktober 2014. Nilai eGFR dihitung menurut persamaan MDRD, kadar kreatinin diperiksa dengan metode enzimatik yang telah distandarisasi. Korelasi IMT dengan eGFR berdasarkan formula MDRD dianalisis menggunakan korelasi Pearson. Kemaknaan secara statistik ditentukan jika nilai p < 0,05. Korelasi IMT dengan eGFR berdasarkan formula MDRD adalah korelasi negatif yang sangat lemah dan tidak bermakna (r = -0,19 ; p > 0,05). Simpulan: tidak didapatkan korelasi antara IMT dengan eGFR berdasarkan formula MDRD.AbstractThe purpose of this study was to evaluate the correlation between BMI and eGFR by MDRD formula among healthy population in Padang. This cross-sectional analytic study enrolled 121 participants taking medical check-up in several hospitals in Padang from August 2013 to October 2014. Value of eGFR was determined by MDRD formula, and a standardized enzimatic method was used for measuring creatinine levels. The correlation between BMI and eGFR by MDRD formula was analyzed using Pearson correlation. Statistical significancy was concluded if the value of p < 0.05. The correlation of BMI and eGFR by MDRD formula was found very weak, negative, and not significant (r = -0.19, p >0.05). Thus, there was no correlation between BMI and eGFR by MDRD formula.


BMC Nephrology â—½  
2017 â—½  
Vol 18 (1) â—½  
Author(s):  
Wen Hu â—½  
Xiao-Juan Wu â—½  
Yao-Jun Ni â—½  
Hai-Rong Hao â—½  
Wei-Nan Yu â—½  
...  

2019 â—½  
Vol 24 (3) â—½  
pp. 216-224 â—½  
Author(s):  
Yasuko Yamaguchi â—½  
Mitsuyo Itabashi â—½  
Wako Yumura â—½  
Takashi Takei

2017 â—½  
Vol 2017 â—½  
pp. 1-7 â—½  
Author(s):  
Maisarah Jalalonmuhali â—½  
Ng Kok Peng â—½  
Lim Soo Kun

Aim. To validate the accuracy of estimated glomerular filtration rate (eGFR) equations in Malay population attending our hospital in comparison with radiolabeled measured GFR.Methods. A cross-sectional study recruiting volunteered patients in the outpatient setting. Chromium EDTA (51Cr-EDTA) was used as measured GFR. The predictive capabilities of Cockcroft-Gault equation corrected for body surface area (CGBSA), four-variable Modification of Diet in Renal Disease (4-MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were calculated.Results. A total of 51 subjects were recruited with mean measured GFR 42.04 (17.70–111.10) ml/min/1.73 m2. Estimated GFR based on CGBSA, 4-MDRD, and CKD-EPI were 40.47 (16.52–115.52), 35.90 (14.00–98.00), and 37.24 (14.00–121.00), respectively. Higher accuracy was noted in 4-MDRD equations throughout all GFR groups except for subgroup of GFR ≥ 60 ml/min/1.73 m2where CGBSA was better.Conclusions. The 4-MDRD equation seems to perform better in estimating GFR in Malay CKD patients generally and specifically in the subgroup of GFR < 60 ml/min/1.73 m2and both BMI subgroups.


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