Impact of COVID-19 on brain and psychological health, its possible mechanisms, and coping strategies
Abstract COVID-19 pandemic has been depicted to possess a robust association with psychological disorders. SARS-CoV-2 is the most recent virus of the coronavirus family and has the potential to bind angiotensin-converting enzyme (ACE) receptor. The receptor is majorly present peripherally, and up to some extent in the brain. Different psychological and neurodegenerative disorders can arise due to peripheral origin of destruction. These triggers could be inflammatory pathways releasing pro-inflammatory cytokines reaching the brain and causing neuroinflammation. In continuation with traditional viruses, SARS-CoV-2 too might lead to brain diseases like meningitis, encephalitis, etc. Besides, several peripheral hormonal changes like cortisol can influence the neurochemical alterations, thereby inflicting mood-related activities and psychological phenomenon. In this regard, health care workers, frontline line worriers, family and relatives of COVID-19 patients can be the secondary victims; however, patients with COVID-19 themselves remain the primary ones prone to neurological health problems. Several strategies like socialization, engagement, physical activity, etc. are well-opted measures to get relief from and check the psychiatric disturbances.