scholarly journals Impact of COVID-19 on brain and psychological health, its possible mechanisms, and coping strategies

Author(s):  
Faizan Zarreen Simnani ◽  
Dibyangshee Singh ◽  
Anmol Choudhury ◽  
Ansab Akhtar

Abstract COVID-19 pandemic has been depicted to possess a robust association with psychological disorders. SARS-CoV-2 is the most recent virus of the coronavirus family and has the potential to bind angiotensin-converting enzyme (ACE) receptor. The receptor is majorly present peripherally, and up to some extent in the brain. Different psychological and neurodegenerative disorders can arise due to peripheral origin of destruction. These triggers could be inflammatory pathways releasing pro-inflammatory cytokines reaching the brain and causing neuroinflammation. In continuation with traditional viruses, SARS-CoV-2 too might lead to brain diseases like meningitis, encephalitis, etc. Besides, several peripheral hormonal changes like cortisol can influence the neurochemical alterations, thereby inflicting mood-related activities and psychological phenomenon. In this regard, health care workers, frontline line worriers, family and relatives of COVID-19 patients can be the secondary victims; however, patients with COVID-19 themselves remain the primary ones prone to neurological health problems. Several strategies like socialization, engagement, physical activity, etc. are well-opted measures to get relief from and check the psychiatric disturbances.

2021 ◽  
Vol 27 (2) ◽  
pp. 148-163
Author(s):  
Fatemeh Mohammadzadeh ◽  
◽  
Ali Delshad Noghabi ◽  
Javad Bazeli ◽  
Hamidreza Karimi ◽  
...  

Aims: The emergence of COVID-19 disease has created significant stress and anxiety for health care workers. This study aimed to investigate the stressors and coping strategies in the staff of Allameh Bohlool Hospital in Gonabad City, Iran, during the outbreak of the COVID-19 disease. Methods & Materials: This cross-sectional study was performed on 252 employees of Allameh Bohlool Hospital in Gonabad from March 2020 to April 2020. Study tools included a brief form of coping styles (Brief-COPE) and a researcher-made questionnaire of stressors due to the emergence of COVID-19 among health care workers. The obtained data were analyzed using linear regression and ordinal regression models at the significance level of 0.05. Findings: About 74.2%, 69.4%, 52.7%, 52.7%, and 99.2% of the hospital staff had moderate to high stress in the domains of internal, family-social, workplace-related, infection control, and government measures, respectively. The degree of using adaptive and maladaptive coping styles used by staff were 52.0% and 23.8% at the moderate to the high level, respectively. Maladaptive coping styles had a positive and significant relationship with stress intensity so that for each unit increase in maladaptive coping score, the odds of experiencing higher levels of stress increased 1.24 to 1.45 times (P<0.001). Also, the odds of experiencing higher levels of stress in those who had sports activities was 24% to 76% lower (P=0.003). Conclusion: The findings of the present study indicated a high level of stress among hospital staff. Also, the use of maladaptive coping styles and sports activities had a significant positive and negative relationship with stress intensity, respectively. Therefore, designing effective interventions focusing on reducing maladaptive coping patterns among hospital staff and encouraging people to engage in sports activities can help manage stress as much as possible due to the outbreak of COVID-19 disease.


BioMedica ◽  
2020 ◽  
Vol 36 (2S) ◽  
pp. 223-227
Author(s):  
Zaina Jabeen ◽  
Aysha Rani ◽  
Sohaib Ahmed ◽  
Sadaf Ghaffar ◽  
Tazaeen Hina Kazmi ◽  
...  

<p><strong>Background and Objective</strong>: The Coronavirus disease 2019 (COVID-19) pandemic has affected more than four million people in 213 countries. Health care workers (HCWs) who deal with COVID-19 patients have a high chance of getting infected. They have got valid concerns regarding their own health as well as the impact it can have on the wellbeing of their family and acquaintances. The current study aims to assess the prevalence of psychological problems among HCWs during the COVID-19 pandemic. <strong>Methods:</strong> A cross-sectional study was conducted among HCWs of Wah Medical College and Pakistan Ordnance Factories (POF) Hospital Wah Cantt from 1st May 2020 to 7th May 2020 after an ethical approval by ethical review board. A total of 340 HCWs participated by filling an online questionairre; questions on demographic profile and validated Depression, Anxiety and Stress Scale&ndash;21 (DASS-21) score were included. Frequency of depression, anxiety and stress and mean DASS-21 scores between house officers and all other healthcare workers and between Medicine and allied department and other departments was assessed. Data was analysed using Statistical Package for the Social Sciences (SPSS)-23. P-value &le; 0.05 was considered statistically significant. <strong>Results:</strong> Among 340 HCWs majority i.e. 66.8% were less than 35 years of age and the mean age of participants was 40.65 &plusmn; 11.64 years. There was a female proponderance with a F:M ratio of 1.7:1. Most (55.3%) of the participants were single and there was a high percentage of house officers with 45% among all. The overall prevalence of depressiom, anxiety and stress among all HCWs was 32.9%, 25% and 23.5% respectively. The depression, anxiety and stress among house officers than other HCWs and higher prevalence in Medicine and Allied Departments than other departments. <strong>Conclusion:</strong> As the global threat of COVID-19 continues to emerge, it is important not to underestimate the psychological impact of this pandemic on HCWs. Interventions and support to especially vulnerable groups of HCWs will help improve psychological health, which in turn will help improve the quality of patient care.</p>


2012 ◽  
Vol 42 (1) ◽  
pp. 66 ◽  
Author(s):  
In Sook Lee ◽  
Kwang Ok Lee ◽  
Hee Sun Kang ◽  
Yeon-Hwan Park

2021 ◽  
pp. 102685
Author(s):  
Jawahar Singh ◽  
Mamta Sood ◽  
Rakesh K Chadda ◽  
Vishwajeet Singh ◽  
Dheeraj Kattula

2021 ◽  
Author(s):  
Bingxin Zhao ◽  
Tengfei Li ◽  
Zirui Fan ◽  
Yue Yang ◽  
Xifeng Wang ◽  
...  

Cardiovascular health interacts with cognitive and psychological health in complex ways. Yet, little is known about the phenotypic and genetic links of heart-brain systems. Using cardiac and brain magnetic resonance imaging (CMR and brain MRI) data from over 40,000 UK Biobank subjects, we developed detailed analyses of the structural and functional connections between the heart and the brain. CMR measures of the cardiovascular system were strongly correlated with brain basic morphometry, structural connectivity, and functional connectivity after controlling for body size and body mass index. The effects of cardiovascular risk factors on the brain were partially mediated by cardiac structures and functions. Using 82 CMR traits, genome-wide association study identified 80 CMR-associated genomic loci (P < 6.09 * 10^{-10}), which were colocalized with a wide spectrum of heart and brain diseases. Genetic correlations were observed between CMR traits and brain-related complex traits and disorders, including schizophrenia, bipolar disorder, anorexia nervosa, stroke, cognitive function, and neuroticism. Our results reveal a strong heart-brain connection and the shared genetic influences at play, advancing a multi-organ perspective on human health and clinical outcomes.


2020 ◽  
Author(s):  
Myung Hee Ahn ◽  
Yong-Wook Shin ◽  
Sooyeon Suh ◽  
Jeong Hye Kim ◽  
Hwa Jung Kim ◽  
...  

BACKGROUND The COVID-19 outbreak had a severe impact on health care workers' psychological health. It is important to establish a process for psychological assessment and intervention for health care workers during epidemics. OBJECTIVE We investigated risk factors associated with psychological impacts for each health care worker group, to help optimize psychological interventions for health care workers in countries affected by the COVID-19 pandemic. METHODS Respondents (n=1787) from 2 hospitals in Korea completed a web-based survey during the period from April 14 to 30, 2020. The web-based survey collected demographic information, psychiatric history, and responses to the 9-item Stress and Anxiety to Viral Epidemics (SAVE-9), 9-item Patient Health Questionnaire (PHQ-9), and 7-item Generalized Anxiety Disorder-7 (GAD-7) scales. We performed logistic regression to assess contributing factors as predictor variables, using health care workers’ depression as outcome variables. RESULTS Among 1783 health care workers, nursing professionals had significantly higher levels of depression (PHQ-9 score: meannurse 5.5, SD 4.6; meanother 3.8, SD 4.2; <i>P</i>&lt;.001), general anxiety (GAD-7 score: meannurse 4.0, SD 4.1; meanother 2.7, SD 3.6; <i>P</i>&lt;.001), and virus-related anxiety symptoms (SAVE-9 score: meannurse 21.6, SD 5.9; meanother 18.6, SD 6.3; <i>P</i>&lt;.001). Among nursing professionals, single workers reported more severe depressive symptoms than married workers (PHQ-9 score ≥10; meannurse 20.3%; meanother 14.1%; <i>P</i>=.02), and junior (&lt;40 years) workers reported more anxiety about the viral epidemic (SAVE-9 anxiety score; meannurse 15.6, SD 4.1; meanother 14.7, SD 4.4; <i>P</i>=.002). Logistic regression revealed that hospital (adjusted odds ratio [OR] 1.45, 95% CI 1.06-1.99), nursing professionals (adjusted OR 1.37, 95% CI 1.02-1.98), single workers (adjusted OR 1.51, 95% CI 1.05-2.16), higher stress and anxiety to the viral infection (high SAVE-9 score, adjusted OR 1.20, 95% CI 1.17-1.24), and past psychiatric history (adjusted OR 3.26, 95% CI 2.15-4.96) were positively associated with depression. CONCLUSIONS Psychological support and interventions should be considered for health care workers, especially nursing professionals, those who are single, and those with high SAVE-9 scores. CLINICALTRIAL


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