scholarly journals The Frequency of Class1 and 2 and 3 Integrons in Vancomycin-resistant and Aminoglycoside Resistance Enterococcus Strains Isolated From Burn Patients in Southwest Iran

2021 ◽  
Author(s):  
Effat Abbasi Montazeri ◽  
Azar Dokht Khosravi ◽  
Khadijah Ahmadi ◽  
Maryam Afzali ◽  
Aram Asareh zadegan dezfuli
Keyword(s):  
Resistance Pattern ◽  
Burn Patients ◽  
Vancomycin Resistant Enterococcus ◽  
Enterococcus Species ◽  
Aminoglycoside Resistance ◽  
Vancomycin Resistant ◽  
Southwest Iran

Abstract Background: This study aimed to detect the frequency of class1 and 2 and 3 integrons in vancomycin-resistant enterococcus (VRE) and aminoglycoside resistance strains isolated from burn patients in Taleghani burn hospital, AhvazResults: Out of the 129 Enterococcus species 42% were E. faecalis and 57% isolated were E. faecium. 34% were resistant to vancomycin. In the E. faecium isolates, 21% were XDR and 67%) were MDR. In the E. faecalis isolates, 74% were MDR isolates. Among 129 Enterococci spp. Isolates 45% E. faecium and 20% E. faecalis isolates were positive for the presence of vanA genes. In addition, 20% E. faecium and 0.04% E. faecalis isolates were positive for the presence of vanB genes. Thirty-one E Enterococci spp including E. faecium 79% and E. faecium 58% isolates carried int 1. In VRE E. faecalis 57.1% isolates positive for the presence of int 1and 57.1% isolates positive for the presence of int 1. Conclusion: we showed a detailed resistance pattern of clinically isolated Enterococci species to common antibiotics. Accordingly, the results confirmed the association between simultaneous resistance to vancomycin. These results can guide antibiotic prescriptions against Enterococci infections.

scholarly journals The Frequency of Class1 and 2 and 3 Integrons in Vancomycin-resistant and Aminoglycoside Resistance Enterococcus Strains Isolated From Burn Patients in Southwest Iran

2022 ◽  
Keyword(s):  
Full Text ◽  
Burn Patients ◽  
Aminoglycoside Resistance ◽  
Vancomycin Resistant ◽  
Southwest Iran

Abstract The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.

PREVALENCE OF HIGH LEVEL AMINOGLYCOSIDE RESISTANCE AND VANCOMYCIN RESISTANT ENTEROCOCCI IN ENTEROCOCCAL ISOLATES IN A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 3-5
Author(s):  
Sunita Agarwal ◽  
Nazneen Pathan ◽  
Shivra Batra ◽  
Rajni Sharma
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Tertiary Care ◽  
Automated System ◽  
Care Hospital ◽  
Enterococcus Species ◽  
Aminoglycoside Resistance ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant ◽  
High Level

Introduction: The emergence of High Level Aminoglycoside Resistance (Resistant to Gentamycin and Streptomycin) and Vancomycin Resistant Enterococci among Indoor and Intensive Care Unit admitted patient presents a serious challenge for clinicians. Objective: To determine Enterococcal burden in blood and urine specimens and to detect the prevalence of High Level Aminoglycoside Resistance and Vancomycin Resistant Enterococci. Material & Methods: One hundred ten Enterococci were isolated from blood and urine samples and processed according to standard laboratory protocol. Species identication and sensitivity was done using the VITEK 2 automated system (Biomerieux France) with the cards GPID and AST 67 respectively. Results: Out of 110 Enterococci isolates, 36 were from blood and 74 from urine were detected. Different Species isolated were Enterococcal faecium (59%), Enterococcal faecalis (34%), Enterococcal rafnosus (2.7%), Enterococcal gallinarum (1.8%), Enterococcal casseliavus (0.9%) and Enterococcal duran (0.9%).Out of 36 blood isolates, 14 (38%) were found to be both High Level Gentamycin Resistant (HLGR) & High Level Streptomycin Resistant (HLSR), 10 (27%) were only HLGR and 8 (22%) were only HLSR. 20 strain (55%) of Enterococcus species isolated in blood were VRE. All VRE strains were found to be resistant to both aminoglycosides ( HLAR).Among the 74 urinary isolates, 24 (34%) were found to be both HLGR & HLSR, only HLGR was observed in 20 (27%) and HLSR was observed in 11 (14%) isolates. 24 strains (34%) of Enterococcus species were found to be vancomycin resistant in urine. 23 strains out of 24 were resistant to high level of aminoglycosides. Conclusion: The prevalence of HLAR and VRE is very high among Enterococcus specimens from indoor/ intensive care unit patients. Early species identication and antibiotic sensitivity result can help in better clinical outcome.

scholarly journals The Kinocidin Interleukin-26 Shows Immediate Antimicrobial Effects Even to Multi-resistant Isolates

2021 ◽  
Vol 12 ◽  
Author(s):  
Bjoern-Thore Hansen ◽  
Gregor Maschkowitz ◽  
Rainer Podschun ◽  
Helmut Fickenscher
Keyword(s):  
Candida Albicans ◽  
Proinflammatory Cytokine ◽  
Bacterial Species ◽  
Vancomycin Resistant Enterococcus ◽  
Enterococcus Species ◽  
Gram Positive Bacteria ◽  
Carbapenem Resistant ◽  
Vancomycin Resistant ◽  
Bactericidal Activities ◽  
Interleukin 26

The cationic proinflammatory cytokine Interleukin 26 (IL-26) shows antibacterial activity and inhibits the replication of cytomegalovirus and hepatitis C virus. This study evaluates the early microbicidal activities of IL-26 against major bacterial species including multi-resistant variants and Candida albicans. Recombinant IL-26 was bacterially expressed and studied for its microbicidal effects in culture. We show that IL-26 has strong 90% bactericidal activities against Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, and Acinetobacter baumannii. Similarly, IL-26 sensitivity was also detectable in vancomycin-resistant Enterococcus species, methicillin-resistant S. aureus, and carbapenem-resistant A. baumannii clinical isolates. Additionally, a significant, albeit weak fungicidal effect against Candida albicans was observed. Activities against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa were not detectable. The proinflammatory cytokine and kinocidin IL-26 shows strong bactericidal activities against A. baumannii and, almost selectively, against Gram-positive bacteria.

Vancomycin-resistant Enterococcus species: Antimicrobial resistance and virulence genes profile

Gene Reports ◽  
2021 ◽  
pp. 101338
Author(s):  
Dadras Maleki ◽  
Meysam Manouchehrifar ◽  
Malek Namaki Kheljan ◽  
Seyed Hossein Mossavi ◽  
Elham Jannati ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Virulence Genes ◽  
Vancomycin Resistant Enterococcus ◽  
Enterococcus Species ◽  
Vancomycin Resistant
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