scholarly journals The Spatiotemporal Transmission Dynamics of COVID-19 among Multiple Regions: A Modeling Study in China

Author(s):  
Qiaojuan Jia ◽  
Jiali Li ◽  
Hualiang Lin ◽  
Fei Tian ◽  
Guanghu Zhu

Abstract Current explosive outbreak of COVID-19 around the world is a complex spatiotemporal process with hidden interactions between viruses and humans. This study aims at clarifying the transmission patterns and the driving mechanism that contributed to the COVID-19 epidemics across the provinces of China. Thus a new dynamical transmission model is established by ordinary differential system. The model takes into account the hidden circulation of COVID-19 virus among/within humans, which incorporates the spatial diffusion of infection by parameterizing human mobility. Theoretical analysis indicates that the basic reproduction number is a unique epidemic threshold, which can unite infectivity in each region by human mobility, and can totally determine whether COVID-19 proceeds among multiple regions. By validating the model with real epidemic data in China, it is found that (1) if without any intervention, COVID-19 would overrun China within three months, resulting in more than 1.1 billion infections; (2) high frequency of human mobility can trigger COVID-19 diffusion across each province in China, no matter where the initial infection locates; (3) travel restrictions and other non-pharmaceutical interventions must be implemented simultaneously for disease control; and (4) infection sites in central and east (rather than west and northeast) of China would easily stimulate quick diffusion of COVID-19 in the whole country.

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Meng-Chun Chang ◽  
Rebecca Kahn ◽  
Yu-An Li ◽  
Cheng-Sheng Lee ◽  
Caroline O. Buckee ◽  
...  

Abstract Background As COVID-19 continues to spread around the world, understanding how patterns of human mobility and connectivity affect outbreak dynamics, especially before outbreaks establish locally, is critical for informing response efforts. In Taiwan, most cases to date were imported or linked to imported cases. Methods In collaboration with Facebook Data for Good, we characterized changes in movement patterns in Taiwan since February 2020, and built metapopulation models that incorporate human movement data to identify the high risk areas of disease spread and assess the potential effects of local travel restrictions in Taiwan. Results We found that mobility changed with the number of local cases in Taiwan in the past few months. For each city, we identified the most highly connected areas that may serve as sources of importation during an outbreak. We showed that the risk of an outbreak in Taiwan is enhanced if initial infections occur around holidays. Intracity travel reductions have a higher impact on the risk of an outbreak than intercity travel reductions, while intercity travel reductions can narrow the scope of the outbreak and help target resources. The timing, duration, and level of travel reduction together determine the impact of travel reductions on the number of infections, and multiple combinations of these can result in similar impact. Conclusions To prepare for the potential spread within Taiwan, we utilized Facebook’s aggregated and anonymized movement and colocation data to identify cities with higher risk of infection and regional importation. We developed an interactive application that allows users to vary inputs and assumptions and shows the spatial spread of the disease and the impact of intercity and intracity travel reduction under different initial conditions. Our results can be used readily if local transmission occurs in Taiwan after relaxation of border control, providing important insights into future disease surveillance and policies for travel restrictions.


2019 ◽  
Vol 651 ◽  
pp. 969-978 ◽  
Author(s):  
Guanghu Zhu ◽  
Tao Liu ◽  
Jianpeng Xiao ◽  
Bing Zhang ◽  
Tie Song ◽  
...  

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Hamish Gibbs ◽  
◽  
Yang Liu ◽  
Carl A. B. Pearson ◽  
Christopher I. Jarvis ◽  
...  

Abstract Understanding changes in human mobility in the early stages of the COVID-19 pandemic is crucial for assessing the impacts of travel restrictions designed to reduce disease spread. Here, relying on data from mainland China, we investigate the spatio-temporal characteristics of human mobility between 1st January and 1st March 2020, and discuss their public health implications. An outbound travel surge from Wuhan before travel restrictions were implemented was also observed across China due to the Lunar New Year, indicating that holiday travel may have played a larger role in mobility changes compared to impending travel restrictions. Holiday travel also shifted healthcare pressure related to COVID-19 towards locations with lower healthcare capacity. Network analyses showed no sign of major changes in the transportation network after Lunar New Year. Changes observed were temporary and did not lead to structural reorganisation of the transportation network during the study period.


2020 ◽  
Vol 6 (49) ◽  
pp. eabd6370 ◽  
Author(s):  
Sen Pei ◽  
Sasikiran Kandula ◽  
Jeffrey Shaman

Assessing the effects of early nonpharmaceutical interventions on coronavirus disease 2019 (COVID-19) spread is crucial for understanding and planning future control measures to combat the pandemic. We use observations of reported infections and deaths, human mobility data, and a metapopulation transmission model to quantify changes in disease transmission rates in U.S. counties from 15 March to 3 May 2020. We find that marked, asynchronous reductions of the basic reproductive number occurred throughout the United States in association with social distancing and other control measures. Counterfactual simulations indicate that, had these same measures been implemented 1 to 2 weeks earlier, substantial cases and deaths could have been averted and that delayed responses to future increased incidence will facilitate a stronger rebound of infections and death. Our findings underscore the importance of early intervention and aggressive control in combatting the COVID-19 pandemic.


2020 ◽  
Vol 9 (1) ◽  
pp. 44-62
Author(s):  
Xiyuan Ren ◽  
De Wang

The high-frequency mobility of a massive population has caused an enormous influence on the urban internal structure, which is unable to be described by traditional data sources. While recent advances in location-based technologies provides new opportunities for researchers to understand daily human movements and the structure as a whole. The article aims to explore human spatial movements and their aggregate distribution in Shanghai using large-scale cell phone data. The trajectory of each individual is extracted from cell phone data after data cleansing. Then, an indicator system which includes mobility intensity, mobility stability, influential range, and temporal variation is developed to describe collective human mobility features in census tracts scale. Finally, spatial elements are extracted using the indicator system and the structure of human mobility in Shanghai is discussed.


AIP Advances ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 035308 ◽  
Author(s):  
Peng Yang ◽  
Jingzhi Wu ◽  
Rongrong Zhao ◽  
Jianning Han

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e16591 ◽  
Author(s):  
Paolo Bajardi ◽  
Chiara Poletto ◽  
Jose J. Ramasco ◽  
Michele Tizzoni ◽  
Vittoria Colizza ◽  
...  

1999 ◽  
Vol 121 (1) ◽  
pp. 139-147 ◽  
Author(s):  
Eric G. Paterson ◽  
Fred Stern

In this two-part paper, time-accurate solutions of the Reynolds-averaged Navier-Stokes equations are presented, which address through model problems, the response of turbulent propeller-blade boundary layers and wakes to external-flow traveling waves. In Part 1, the Massachusetts Institute of Technology flapping-foil experiment was simulated and the results validated through comparisons with data. The response was shown to be significantly more complex than classical unsteady boundary layer and unsteady lifting flows thus motivating further study. In Part 2, the effects of frequency, waveform, and foil geometry are investigated. The results demonstrate that uniquely different response occurs for low and high frequency. High-frequency response agrees with behavior seen in the flapping-foil experiment, whereas low-frequency response displays a temporal behavior which more closely agrees with classical inviscid-flow theories. Study of waveform and geometry show that, for high frequency, the driving mechanism of the response is a viscous-inviscid interaction created by a near-wake peak in the displacement thickness which, in turn, is directly related to unsteady lift and the oscillatory wake sheet. Pressure waves radiate upstream and downstream of the displacement thickness peak for high frequency flows. Secondary effects, which are primarily due to geometry, include gust deformation due to steady-unsteady interaction and trailing-edge counter-rotating vortices which create a two-layered amplitude and phase-angle profile across the boundary layer.


Author(s):  
Moritz U.G. Kraemer ◽  
Chia-Hung Yang ◽  
Bernardo Gutierrez ◽  
Chieh-Hsi Wu ◽  
Brennan Klein ◽  
...  

AbstractThe ongoing COVID-19 outbreak has expanded rapidly throughout China. Major behavioral, clinical, and state interventions are underway currently to mitigate the epidemic and prevent the persistence of the virus in human populations in China and worldwide. It remains unclear how these unprecedented interventions, including travel restrictions, have affected COVID-19 spread in China. We use real-time mobility data from Wuhan and detailed case data including travel history to elucidate the role of case importation on transmission in cities across China and ascertain the impact of control measures. Early on, the spatial distribution of COVID-19 cases in China was well explained by human mobility data. Following the implementation of control measures, this correlation dropped and growth rates became negative in most locations, although shifts in the demographics of reported cases are still indicative of local chains of transmission outside Wuhan. This study shows that the drastic control measures implemented in China have substantially mitigated the spread of COVID-19.


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