scholarly journals Production of α-glucosidase Inhibitor in the Intestines by Bacillus Licheniformis

2021 ◽  
Author(s):  
Hee-Woong Kim ◽  
Deug-Chan Lee ◽  
Hae-Ik Rhee
Keyword(s):  
High Fat Diet ◽  
Diet Group ◽  
High Fat ◽  
Constant Amount ◽  
Glucosidase Inhibitor ◽  
Calorie Diet ◽  
Alpha Glucosidase ◽  
High Calorie Diet ◽  
Anaerobic Environment ◽  
High Calorie

Abstract Alpha-glucosidase (EC.3.2.1.20) is involved in the absorption of monosaccharides in the small intestine of animals. We aimed to find a microorganism capable of proliferating in the intestine and producing α-glucosidase inhibitor. We developed a strain capable of forming spores from dry grass and growing in an anaerobic environment was selected as Bacillus lichenformis. Mixing spores of this strain with a high-fat diet and high-carbohydrate diet, it was confirmed that the weight gain was significantly reduced than the high-calorie diet group without spores. Furthermore it was confirmed that Bacillus lichenformis administered as spores efficiently proliferated in the intestine and consistently produced α-glucosidase inhibitor by securing a constant amount of the strain and α-glucosidase inhibitor in feces after a certain period. This study shows an efficient process in which microorganisms capable of proliferating in the intestine directly produce and supply specific secondary metabolites in the intestine.

Effect of weight cycling on susceptibility to dietary obesity

1990 ◽  
Vol 259 (6) ◽  
pp. R1096-R1102 ◽  
Author(s):  
B. Graham ◽  
S. Chang ◽  
D. Lin ◽  
F. Yakubu ◽  
J. O. Hill
Keyword(s):  
Weight Gain ◽  
Food Intake ◽  
Body Fat ◽  
High Fat Diet ◽  
Weight Cycling ◽  
High Fat ◽  
Calorie Diet ◽  
Short Run ◽  
High Calorie Diet ◽  
High Calorie

Weight cycling, defined as repeated episodes of weight loss followed by weight regain, has been suggested to make rats more energy efficient and produce a state of energy balance favoring accumulation of excess body fat. In addition, weight cycling may favor accumulation of fat in central vs. peripheral adipose depots. In the present study, we gave two groups of female Wistar rats ad libitum access to an obesity-producing high-fat diet (60% of calories from fat). Both groups had previously eaten a low-fat stock diet, but one group had been subjected to three bouts of weight cycling. Rats that were previously weight cycled gained less body weight and body fat when given the high-fat diet than did controls. The lower rate of weight gain was due to a lesser increase in food intake, since daily energy expenditure was significantly lower in previously cycled rats than in controls. In summary, weight cycling does not appear to predispose rats to becoming obese on a high-calorie diet and apparently produces some effect on food intake that reduces, at least in the short run, weight gain on the high-calorie diet.

scholarly journals A 5-Day High-Fat, High-Calorie Diet Impairs Insulin Sensitivity in Healthy, Young South Asian Men but Not in Caucasian Men

Diabetes ◽  
2013 ◽  
Vol 63 (1) ◽  
pp. 248-258 ◽  
Author(s):  
L. E. H. Bakker ◽  
L. D. van Schinkel ◽  
B. Guigas ◽  
T. C. M. Streefland ◽  
J. T. Jonker ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
South Asian ◽  
High Fat ◽  
Asian Men ◽  
Caucasian Men ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
High Calorie

scholarly journals Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184455 ◽  
Author(s):  
Hui-Hua Chang ◽  
Aune Moro ◽  
Kazuki Takakura ◽  
Hsin-Yuan Su ◽  
Allen Mo ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
High Fat ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
High Calorie

Acceleration of pancreatic cancer development in the conditional KrasG12D mouse model by a high fat and high calorie diet

Pancreatology ◽  
2013 ◽  
Vol 13 (2) ◽  
pp. e3-e4
Author(s):  
A. Moro ◽  
A. Lugea ◽  
D.W. Dawson ◽  
S. Pandol ◽  
A. Gukovskaya ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Model ◽  
Cancer Development ◽  
High Fat ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
High Calorie

scholarly journals Levels of dopamine, 5-hydroxytryptamine and their metabolites in the striatum of rats of various strains receiving a high-calorie diet

2021 ◽  
Vol 66 (4) ◽  
Author(s):  
Sergey Apryatin ◽  
Evgenia Efimova ◽  
Zoya Fesenko ◽  
Antonina Shumakova ◽  
Ivan Gmoshinski
Keyword(s):  
High Performance Liquid Chromatography ◽  
High Performance ◽  
Wistar Rats ◽  
Homovanillic Acid ◽  
Control Diet ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
High Calorie

The aim of this work was to study the effect of a high fat and carbohydrate diet (HFCD) and quercetin supplementation on the levels of dopamine (DA), serotonin (5-HT) and their metabolites in Wistar, DA transporter knockout (DAT-KO) and obese Zucker fa/fa rats. Animals received a control diet or HFCD for 62 days. Wistar and Zucker fa/fa rats received quercetin. The contents of DA, 5-HT, norepinephrine (NE), dioxyphenyl acetate (DOPAC), homovanillic acid (HVA) and 5-hydroxyindolyl acetate (5-HIIA) in the striatum were determined by high-performance liquid chromatography (HPLC). DAT-KO homozygotes had lowered DA and increased HVA and DOPAC compared to Wistar rats. HFCD did not affect the content of NE and 5-HT. 5-HT was increased in DAT-KO homozygotes compared with Wistar receiving a control diet. 5-HIIA accumulated in larger amounts in DAT-KO compared to Wistar with the exception of those receiving quercetin with a control diet. Quercetin did not affect the levels of DA, 5-HT and their metabolites.

scholarly journals THE INFLUENCE OF KIDNEY BEANS ( PHASEOLUS VULGARIS ) PODS EXTRACT ON OBESITY DEVELOPMENT

2016 ◽  
Vol 72 (2) ◽  
pp. 86-88
Author(s):  
A. Yurchenko ◽  
N. Raksha ◽  
O. Savchuk
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Food Intake ◽  
Phaseolus Vulgaris ◽  
Body Mass ◽  
Diet Group ◽  
Kidney Beans ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
High Calorie

The influence of kidney beans pods extract on obesity development was investigated. It was found that administration of P. vulgaris pods extract led to decrease of body weight and body mass index of the animals which were on high-calorie diet. Found changes could be result of decrease of food intake by rats treated with extract in compare with rats in high-calorie diet group.

Sa1450 Differential Proteomic Signatures of Male versus Female KrasG12D Mice during High Fat/High Calorie Diet-induced Pancreatic Tumorigenesis

2016 ◽  
Vol 150 (4) ◽  
pp. S318-S319
Author(s):  
Richard Waldron ◽  
Hui-Hua Chang ◽  
Aune Moro ◽  
Hsin-Yuan Su ◽  
Jiayue Yang ◽  
...  
Keyword(s):  
High Fat ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
High Calorie
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