scholarly journals Comparison of Progestin-Primed Ovarian Stimulation Regimen and Antagonist Regimen in Diminished Ovarian Reserve Patients Over 35 Years of Age

2021 ◽  
Author(s):  
Mohan Wang ◽  
Ruixue Wang ◽  
Qi Xi ◽  
Yuting Jiang ◽  
Hongguo Zhang ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Diminished Ovarian Reserve ◽  
Cross Sectional ◽  
Lh Surge ◽  
Vitro Fertilization ◽  
Significant Difference ◽  
Premature Lh Surge ◽  
Antagonist Group

Abstract Background the aim of this study was to compare the efficacy of progestin-primed ovarian stimulation (PPOS) regimen and GnRH antagonist regimen in infertile patients older than 35 years with diminished ovarian reserve (DOR). Methods a retrospective cross-sectional study of 196 in vitro fertilization (IVF) cycles between January 2016 and January 2020 was performed. The measured outcomes included the number of retrieved oocytes, incidence of premature LH surge, laboratory indicators and frozen embryo transfer (FET) outcome. Results the number of oocytes retrieved in the antagonist group was higher than those in the PPOS group (p < 0.05). Incidence of premature LH surge in two groups showed no difference (p > 0.05). E2 and P on HCG administration day of antagonist group were higher than those of PPOS group (p < 0.05). And there was no significant difference between two groups of FET outcome indicators (p > 0.05). Conclusions for DOR patients over 35 years of age, antagonist regimen would retrieve more oocytes than PPOS regimen. Therefore, from the perspective of oocyte retrieving, the antagonist regimen might be more suitable for DOR patients over 35 years old.

The transcriptional profile of cumulus cells in women with diminished ovarian reserve in ovarian stimulation protocols in different phases of the menstrual cycle in in vitro fertilization programs

2017 ◽  
Vol 12_2017 ◽  
pp. 68-77
Author(s):  
Bogatyreva Kh.A. Bogatyreva ◽  
Mishieva N.G. Mishieva ◽  
Burmenskaya O.V. Burmenskaya ◽  
Trofimov D.Yu. Trofimov D ◽  
Martazanova B.A. Martazanova ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
In Vitro Fertilization ◽  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Cumulus Cells ◽  
Transcriptional Profile ◽  
Diminished Ovarian Reserve ◽  
Vitro Fertilization

scholarly journals CH50 Activity and its Relationship to Antimüllerian Hormone in Patients with Infertility

2021 ◽  
Vol 1 (3) ◽  
Author(s):  
José Manuel Lozano Sánchez
Keyword(s):  
Ovarian Reserve ◽  
Spearman Correlation ◽  
Complement Pathway ◽  
Cross Sectional ◽  
Vitro Fertilization ◽  
Tertiary Referral Center ◽  
Antimullerian Hormone ◽  
Age Related ◽  
Antimüllerian Hormone

Objective: To study the importance of immunological screening (CH50, C3, C4) to determine the correlation between the ovarian reserve and complement pathway. Design: A cross-sectional multivariate study. Setting: Single tertiary referral center. Patients: 40 Women with infertility diagnosis who underwent In Vitro Fertilization (IVF). Intervention(s): Basal blood samples collected to measure complement pathway and antimüllerian hormone. Main Outcome Measure(s): To correlate complement pathways (CH50 levels) with AMH. Results: The complement system and ovarian reserve were studied in 40 women aged from 28-48 years (mean=37.87 years), finding the values of CH50 65-268 CAE (mean=153.2 CAE), C3 13.9- 183mg/dl (mean=128.52mg/dl), C4 11.5-106mg/dl (mean=29.86mg/dl), AMH 0.10-3.9ng/dl (mean=1.32ng/dl). A multivariate analysis comparison was also conducted yielding significant results: negative correlation between AMH and age (Spearman correlation -0.6; P=0.001), as well as between AMH and CH50 (Spearman correlation -0.4; P=0.0129). Conclusion: High CH50 levels are correlated with an AMH decrease and it could be accordingly associated with age-related chronic inflammation. Capsule: High levels of CH50 are correlated with a decrease in AMH levels and could also be considered as a marker of poor response in IVF cycles.

The effectiveness of tubal infertility treatment in ART programs depending on ovarian stimulation protocol

2017 ◽  
pp. 114-116
Author(s):  
O.V. Bagatko ◽  
◽  
N.O. Dankovich ◽  
Keyword(s):  
Ovarian Stimulation ◽  
Treatment Effectiveness ◽  
Medical Center ◽  
Medical Documentation ◽  
Stimulation Protocol ◽  
Tubal Infertility ◽  
Vitro Fertilization ◽  
Significant Difference ◽  
Long Protocol

The objective: of the investigation was to study the effectiveness of treatment of women with tubal infertility, depending on the protocol of ovarian stimulation. Materials and methods. To achieve tht goal, the medical documentation of patients who contacted the «Mother and Child» Medical Center in 2012-2013 was analyzed. To compare the efficacy of different ovarian stimulation protocols were selected 387 patients under the age of 35 years with tubal infertility, who were stimulated by standard protocols with further separation into two groups: S (short stimulation protocol, n=246) and L (long stimulation protocol, n=141). In both groups, an intracytoplasmic sperm injection (ICSI) was performed. Results.The mean duration of stimulation in a long protocol was on 2 days longer. The total amount of spent rFSH was also significantly (by 300 IU) more. There was no significant difference between the number of blastocysts and high quality blastocysts. The cumulative efficacy of treatment after 1 year was 82.33% and 77.30% (p>0.05). Conclusion. The retrospective study showed that women with tubal infertility in a long protocol require a longer stimulation, using a larger total dose of recombinant FSH, with the same end-point effectiveness. Key words: tubal peritoneal infertility, in vitro fertilization, stimulation of superovulation, treatment effectiveness.

scholarly journals Surgical diminished ovarian reserve after endometrioma cystectomy versus idiopathic DOR: comparison of in vitro fertilization outcome

2015 ◽  
Vol 30 (4) ◽  
pp. 840-847 ◽  
Author(s):  
A. Roustan ◽  
J. Perrin ◽  
M. Debals-Gonthier ◽  
O. Paulmyer-Lacroix ◽  
A. Agostini ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Ovarian Reserve ◽  
Diminished Ovarian Reserve ◽  
Vitro Fertilization

scholarly journals ADA activity in the follicular fluid of infertile women with diminished ovarian reserve can act as a predictor of ovarian reserve

2021 ◽  
Vol 10 (2) ◽  
pp. 452
Author(s):  
Gülşah İlhan ◽  
Besim H. Bacanakgil ◽  
Ayşe Köse ◽  
Ayben Atıcı ◽  
Şener Yalçınkaya ◽  
...  
Keyword(s):  
Follicular Fluid ◽  
Ovarian Reserve ◽  
Reproductive Tract ◽  
Vitro Fertilization ◽  
Infertile Women ◽  
Significant Difference ◽  
Human Reproductive ◽  
Ovarian Reserve Markers ◽  
Work Up

Background: Adenosine deaminase (ADA) catalyses the deamination of adenosine to inosine. In the human reproductive tract, the importance of enzymes that affect metabolism of adenosine, particularly ADA, has been emphasized. It is aimed to evaluate the plasma and follicular fluid (FF) activities of total ADA (ADAT) in infertile women and to determine its relation with ovarian reserve markers and in vitro fertilization (IVF) outcomes.Methods: Plasma and FF activities of ADAT were measured in 106 infertile women. Its relation with ovarian reserve markers and IVF outcomes were determined.Results: There was a significant difference in the ADAT activities between plasma and FF of infertile women (p<0.01). The activity of plasma ADAT was higher than FF ADAT in infertile women (p<0.01). The activity of FF ADAT in DOR group was higher than that of the others (p<0.01). In DOR group; the activity of FF ADAT activity had a negative correlation with BMI and a positive correlation with FSH and no relation with IVF outcomes.Conclusions: Increased ADAT activity can lead to reduced adenosine levels, which might be resulted in disturbed fertility process. The activity of FF ADAT activity might be important for fertility work-up. Further studies are needed.

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