Cytoprotective Effect and Clinical Outcome of Perioperative Progesterone in Brain Tumors. A Novel Randomized Mono-Centeric Microscopic Evidence Based Research.

Abstract Objectives.The primary end-point of the current study was to to provide contemporary estimate about both cytoplasmic and nuclear effects of intramuscular progesterone therapy prior to craniotomy. Secondary end-points were to track post-operative course and short term (3 months) neurological sequele.Measurments.Cellular neuronal microscopic examination by immuno-histochemistry (Progesterone receptor density ) and by H&E. Allred score for nuclear staining for PR receptors . Post-operative course included time to wean from mechanical ventilation (hours), Length of ICU stay (days) and brain neuro-imaging by brain CT). Short term outcome included sensory, motor and autonomic assessment. Patients.Two hundred fifty two (252) adult patients of both sexes aged 18–60 years, American society of anesthesia (ASA class І-ІІ ) candidate for intra-parenchymal intra-axial elective brain tumors resection , Excluded candidates included refusal to sign document for intervention, urgent craniotomy, history of endometrial or ovarian neoplasia, redo craniotomy, stented coronary arteries or history of deep venous thrombosis. Design. This research was a randomized, double-blind, placebo controlled single center study. Intervention. Two groups, the control group and Progesterone (PR) group. PR group received 1mg/ kg intramuscular progesterone five days before and five days after craniotomy, while Control group received intramuscular isotonic saline daily, five days before and five days after surgery.Setting.Fixtures performed in Minia university hospital, Neurosurgery operative theatre, Floor two (non trauma floor). The study was registered in local ethical committee on April 2020. First patient enrollment was on first of June 2020 and the patient allocation in the rank ended on 30 of December 2020. Main resultsProgesterone therapy successfully increased expression of active nuclear PR receptors on oligodendrocytes and astrocytes, provided cytoplasmic and nuclear neuro-quiescence. Progesterone gave better neurological outcome on 3 month follow- up.Conclusions.Neuronal biopsy examination represented a leap in confirming anti-neuro-inflammatory action offered by progesterone.Name of the registry. Clinical trial .gov.Trial registration number. NCT04414020.Date of registration. 30 of May 2020.URL of trial registry record. ttps://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S0009WLW&selectaction=Edit&uid=U0004XC5&ts=2&cx=-vrqng9

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School Phobia: A Therapeutic Trial with Clomipramine and Short-Term Outcome

The British Journal of Psychiatry ◽

10.1192/bjp.138.2.110 ◽

1981 ◽

Vol 138 (2) ◽

pp. 110-118 ◽

Cited By ~ 142

Author(s):

T. Berney ◽

I. Kolvin ◽

S. R. Bhate ◽

R. F. Garside ◽

J. Jeans ◽

...

Keyword(s):

School Refusal ◽

Therapeutic Trial ◽

Short Term ◽

Neurotic Disorder ◽

Double Blind ◽

Term Outcome ◽

School Phobia ◽

Short Term Outcome ◽

Rapid Relief ◽

Better Than

SummaryA double-blind trial failed to demonstrate any significant short-term effects of clomipramine in doses recommended for use in general practice (in addition to the usual range of psychotherapeutic help) in the treatment of children with school refusal and neurotic disorder. Patterns of improvement were also studied for the sample as a whole irrespective of treatment. Neither age nor sex were significantly related to improvement, except on one behavioural measure where girls initially did better than boys. In addition, it was found that there was a rapid relief of depression but neurotic symptomatology tended to persist.

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Assessment of short-term outcome with TiO2 mesh in laparoscopic repair of large paraesophageal hiatal hernias

BMC Surgery ◽

10.1186/s12893-019-0607-4 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Islam Khaled ◽

Pablo Priego ◽

Mohammed Faisal ◽

Marta Cuadrado ◽

Francisca García-Moreno ◽

...

Keyword(s):

Hiatal Hernia ◽

Laparoscopic Repair ◽

Postoperative Recurrence ◽

University Hospital ◽

Suture Repair ◽

Short Term ◽

Recurrence Rates ◽

Term Outcome ◽

Clinical Recurrence

Abstract Background Laparoscopic large para-oesophageal hiatal hernia (LPHH) repair using mesh reinforcement significantly reduces postoperative recurrence rates compared to conventional suture repair, especially within short follow-up times. However, the ideal strategy for repairing LPHH remains disputable because no clear guidelines are given regarding indications, mesh type, shape or position. The aim of this study was to survey our short-term results of LPHH management with a biosynthetic monofilament polypropylene mesh coated with titanium dioxide to enhance biocompatibility (TiO2Mesh™). Methods A retrospective study was performed at Ramon y Cajal University Hospital, Spain from December 2014 to October 2018. Data were collected on 27 consecutive patients with extensive hiatal hernia defects greater than 5 cm for which a laparoscopic repair was performed by primary suture and additional reinforcement with a TiO2Mesh™. Study outcomes were investigated, including clinical and radiological recurrences, dysphagia and mesh-related drawbacks. Results Twenty-seven patients were included in our analysis; 10 patients were male, and 17 were female. The mean age was 73 years (range, 63–79 years). All operations were performed laparoscopically. The median postoperative hospital stay was 3 days. After a mean follow-up of 18 months (range, 8-29 months), only 3 patients developed clinical recurrence of reflux symptoms (11%), and 2 had radiological recurrences (7%). No mesh-related complications occurred. Conclusions TiO2Mesh™ was found to be safe for laparoscopic repair of LPHH with a fairly low recurrence rate in this short-term study. Long-term studies conducted over a period of years with large sample sizes will be essential for confirming whether this mesh is suitable as a standard method of care with few drawbacks.

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Effect of Simvastatin on Arterial Stiffness in Patients with Statin Myalgia

Advances in Preventive Medicine ◽

10.1155/2015/351059 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 6

Author(s):

Kevin D. Ballard ◽

Lindsay Lorson ◽

C. Michael White ◽

Paul D. Thompson ◽

Beth A. Taylor

Keyword(s):

Smooth Muscle ◽

Arterial Stiffness ◽

Serum Lipids ◽

Pulse Wave ◽

Short Term ◽

Double Blind ◽

Simvastatin Treatment ◽

Time Interaction ◽

Before And After ◽

History Of

Statins reduce arterial stiffness but are also associated with mild muscle complaints. It is unclear whether individuals with muscle symptoms experience the same vascular benefit or whether statins affect striated and smooth muscle cells differently. We examined the effect of simvastatin treatment on arterial stiffness in patients who did versus those who did not exhibit muscle symptoms. Patients with a history of statin-related muscle complaints (n=115) completed an 8 wk randomized, double-blind, cross-over trial of daily simvastatin 20 mg and placebo. Serum lipids and pulse wave velocity (PWV) were assessed before and after each treatment. Muscle symptoms with daily simvastatin treatment were reported by 38 patients (33%). Compared to baseline, central PWV decreased (P=0.01) following simvastatin treatment but not placebo (drug ∗ time interaction:P=0.047). Changes in central PWV with simvastatin treatment were not influenced by myalgia status or time on simvastatin (P≥0.15). Change in central PWV after simvastatin treatment was inversely correlated with age (r=-0.207,P=0.030), suggesting that advancing age is associated with enhanced statin-mediated arterial destiffening. In patients with a history of statin-related muscle complaints, the development of myalgia with short-term simvastatin treatment did not attenuate the improvement in arterial stiffness.

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Oxytocin amplifies sex differences in human mate choice

10.1101/416198 ◽

2018 ◽

Cited By ~ 1

Author(s):

Lei Xu ◽

Benjamin Becker ◽

Ruixue Luo ◽

Xiaoxiao Zheng ◽

Weihua Zhao ◽

...

Keyword(s):

Sex Differences ◽

Mate Choice ◽

Sexual Relationships ◽

Blind Study ◽

Double Blind Study ◽

Short Term ◽

Double Blind ◽

Oxytocin Release ◽

History Of

AbstractInfidelity is the major cause of breakups and individuals with a history of infidelity are more likely to repeat it, but may also present a greater opportunity for short-term sexual relationships. Here in a pre-registered, double-blind study involving 160 subjects we report that while both sexes valued faithful individuals most for long-term relationships, both single men and those in a relationship were more interested in having short-term relationships with previously unfaithful individuals than women. Oxytocin administration resulted in men rating the faces of unfaithful women as more attractive but in women rating those of unfaithful men as less attractive and also finding them less memorable. Oxytocin also increased men’s interest in having short-term relationships with previously unfaithful women whereas it increased women’s interest in having long-term relationships with faithful men. Thus, oxytocin release during courtship may first act to amplify sex-dependent priorities in attraction and mate choice before subsequently promoting romantic bonds.

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A 2- TO 3-YEAR OUTCOME AFTER BRONCHIOLITIS

PEDIATRICS ◽

10.1542/peds.94.2.254a ◽

1994 ◽

Vol 94 (2) ◽

pp. 254-254

Author(s):

Nancy Ostrom

Keyword(s):

Family History ◽

Positive Family History ◽

Control Group ◽

Short Term ◽

Term Outcome ◽

Significant Difference ◽

Socioeconomic Diversity ◽

History Of ◽

Study Population ◽

Viral Etiologies

Purpose of the Study. To evaluate risk factors and short term outcome for subsequent wheezing in children with early bronchiolitis or pneumonia. Study Population. One hundred twenty-seven children (0 to 2 years old) hospitalized for wheezing (83) or pneumonia in a 1-year period in two hospitals in Finland. Methods. Patients with a history of hospitalization for wheezing with respiratory infection (including bronchiolitis) versus pneumonia were examined, and their parents were interviewed at 1 month, 1.5 to 2 years, and 2.5 to 3 years. Family history of atopy, environmental factors, breast feeding history, and other atopy (eczema, elevated IgE) were noted using a standardized questionnaire and physician-documented wheezing episodes were quantified. Statistical χ2 tests were analyzed comparing the wheezing group to the control group of patients with pneumonia not associated with wheezing. Findings. There was no significant difference between the groups in bacterial versus viral etiology of their lower respiratory symptoms. Subsequent wheezing after bronchiolitis occurred in 76% of children 1-2 years of age and 58% of children at 2-3 years of age. This compares with 9% and 16% (respectively by age) of the group with "non-wheezing" pneumonia. Atopic diathesis, particularly a positive family history of asthma was the host factor best associated with initial wheezing. Parenthetically, parental smoking was found in 61% of the wheezing group and 45% of the pneumonia group. Reviewer's Comments. This is a sound study, perhaps limited, in its comparability to our clinical populations with wider racial and socioeconomic diversity. Of note is the finding of no differences between the wheezing and nonwheezing groups in bacterial and viral etiologies.

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Controlled efficacy study of fluoxetine in dysthymia

The British Journal of Psychiatry ◽

10.1192/bjp.170.4.345 ◽

1997 ◽

Vol 170 (4) ◽

pp. 345-350 ◽

Cited By ~ 49

Author(s):

Jean-Marie Vanelle ◽

Dominique Attar-Levy ◽

Marie-France Poirier ◽

Myriam Bouhassira ◽

Patrick Blin ◽

...

Keyword(s):

Additional Treatment ◽

Group 14 ◽

Short Term ◽

Double Blind ◽

Term Outcome ◽

Long Term Outcome ◽

Randomised Study ◽

End Point

BackgroundThere have been very few controlled studies of antidepressants in dysthymia, particularly in samples diagnosed reliably and with an adequate length of follow-up. In this investigation, we measured the long-term outcome in a large group of patients meeting DSM – III -R criteria for dysthymia. This study was designed to investigate whether fluoxetine is effective in the treatment of dysthymia.MethodThis randomised study, including 140 patients, compared fluoxetine (91 patients) and placebo (49 patients) on a double-blind basis in two distinct phases: a short-term end-point (3 months with 20 mg/day fluoxetine) and a medium-term end-point (6 months) where the initial responders continued double-blind treatment unchanged and non-responders received an additional treatment of 20 mg/day fluoxetine.ResultsAfter three months of treatment, response was seen more frequently in the fluoxetine group (42/72) than in the placebo group (14/39, P <0.0001). Improved patients at 3 months were still improved at 6 months. Furthermore, 50% of the non-responders at 3 months improved and rated as responders at 6 months, after fluoxetine was increased to 40 mg daily.ConclusionsThis study showed the significant and persistent action of fluoxetine on dysthymia. The finding that 50% of the non-responders at 3 months were improved at 6 months, after fluoxetine dosage was increased to 40 mg daily, argues in favour of treating dysthymic patients for at least 6 months, and with a higher dosage if the initial doses are ineffective.

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Future Imperfect: the Long-Term Outcome of Depression

The British Journal of Psychiatry ◽

10.1192/bjp.164.3.327 ◽

1994 ◽

Vol 164 (3) ◽

pp. 327-341 ◽

Cited By ~ 74

Author(s):

P. G. Surtees ◽

C. Barkley

Keyword(s):

Depressive Illness ◽

Consecutive Series ◽

Longitudinal Assessment ◽

Short Term ◽

Term Outcome ◽

Entire Study ◽

Long Term Outcome ◽

History Of

During 1976, 80 patients with a primary depressive illness were selected from a consecutive series of referrals to the Royal Edinburgh Hospital for a short-term follow-up study. This paper concerns the 12-year longitudinal assessment of the survivors. During the follow-up, mortality risk for the sample was almost doubled. Of the series, 35% had experienced a recurrence within 2 years of the initial interview, and just over 60% within the entire study time of 12 years. The risk of recurrence was enhanced for those aged over 45 years at index, for those with a history of depressive disorder and for those who had not engaged in parasuicidal behaviour during the index episode. The observed effect of previous episodes was largely accounted for by age. The chance of recurrence was not affected by whether the treatment of the index episode included ECT, or by whether diagnosis was ‘endogenous’ or ‘neurotic’. Application of the Lee-Murray outcome criteria showed that about one-third of the Edinburgh series experienced a very poor outcome. Results are presented concerning the prediction of long-term outcome as represented by the Depression Outcome Scale (DOS), a measure specially constructed for this study.

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