scholarly journals Genetic analysis of SARS-CoV-2 and the common golden nucleotides to human gene

2021 ◽  
Author(s):  
Hamed Babaee
Keyword(s):  
Dna Replication ◽  
Nucleotide Sequence ◽  
Genetic Analysis ◽  
Human Genome ◽  
Human Gene ◽  
Human Genes ◽  
Reference Virus ◽  
The Common ◽  
Disease Factor

Abstract BackgroundThe coronavirus disease pandemic began in 2019 in Wuhan, China, and continues into 2021, as new mutant viruses appear and require new solutions and treatments. Methods and ResultsIn this study, by genetic analysis of data from 24 SARS-CoV-2 samples from different countries and their alignment with each other and the Wuhan reference virus as well as the human genome, the disease factor is looked at from another angle. The result is the identification of genetic differences in viruses, and the finding of a unique 17-nucleotide sequence between human genes, viruses, and enzymes that can contribute to the onset and progression of the disease. ConclusionsThe role of this sequence in DNA replication and the production of new proteins and its alignment with the EPPK1 gene that may cause disease and its various symptoms are likely.

scholarly journals The role of genetic polymorphism in the formation of atherosclerosis in the vessels of lower extremities

2012 ◽  
Vol 93 (3) ◽  
pp. 513-516
Author(s):  
M N Katina ◽  
R F Gayfullina ◽  
V V Valiullin ◽  
A A Rizvanov ◽  
R F Khamitov ◽  
...  
Keyword(s):  
Human Genome ◽  
Literature Search ◽  
Lower Extremities ◽  
Disease Course ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Human Genes ◽  
Genomics And Proteomics ◽  
The Individual

Personalized medicine involves the use of methods of genomics and proteomics by physicians for early diagnosis, prediction of the nature of the disease course and the choice of medicines and their doses based on personalized characteristics of the individual patient. Advances in the study of the human genome make it possible to reveal the interrelation between the individual mutations in the human genes (polymorphisms) and predisposition to certain diseases. Currently there are more than 10 million single-nucleotide polymorphisms in the human genome, however their biological role remains poorly understood. On the basis of a literature search of electronic full-text and abstract-only versions of articles, which was conducted in the PUBMED, OMIM and GENE databases, collected was the information on genetic predisposition to systemic atherosclerosis. The review is dedicated to polymorphisms of the major genes that play a role in the pathophysiology of atherosclerosis of the lower extremities.

scholarly journals Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
A. A. Makashov ◽  
S. V. Malov ◽  
A. P. Kozlov
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Human Gene ◽  
Tumor Biology ◽  
The Other ◽  
Human Genes ◽  
Hereditary Tumors ◽  
Evolutionary Role ◽  
Predominant Expression

Abstract Earlier we showed that human genome contains many evolutionarily young or novel genes with tumor-specific or tumor-predominant expression. We suggest calling such genes Tumor Specifically Expressed, Evolutionarily New (TSEEN) genes. In this paper we performed a study of the evolutionary ages of different classes of human genes, using homology searches in genomes of different taxa in human lineage. We discovered that different classes of human genes have different evolutionary ages and confirmed the existence of TSEEN gene classes. On the other hand, we found that oncogenes, tumor-suppressor genes and differentiation genes are among the oldest gene classes in humans and their evolution occurs concurrently. These findings confirm non-trivial predictions made by our hypothesis of the possible evolutionary role of hereditary tumors. The results may be important for better understanding of tumor biology. TSEEN genes may become the best tumor markers.

scholarly journals Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently

2018 ◽  
Author(s):  
A. Makashov ◽  
S.V. Malov ◽  
A.P. Kozlov
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Human Gene ◽  
The Other ◽  
Human Lineage ◽  
Human Genes ◽  
Hereditary Tumors ◽  
Evolutionary Role ◽  
Predominant Expression

AbstractEarlier we showed that human genome contains many evolutionarily young or novel genes with tumor-specific or tumor-predominant expression. We suggested to call them TSEEN genes, i.e. Tumor Specifically Expressed, Evolutionarily New genes. In this paper we performed a study of the evolutionary ages of different classes of human genes, using homology searches in genomes of different taxa in human lineage. We discovered that different classes of human genes have different evolutionary ages and confirmed the existence of TSEEN gene classes. On the other hand, we found that oncogenes, tumor-suppressor genes and differentiation genes are among the oldest gene classes in humans and their evolution occurs concurrently. These findings confirm predictions made by our hypothesis of the possible evolutionary role of hereditary tumors.

Nucleotide sequence and genetic analysis of the Rhodobacter capsulatus ORF6-nifU I SVW gene region: possible role of Nif W in homocitrate processing

1993 ◽  
Vol 238 (3) ◽  
pp. 369-382 ◽  
Author(s):  
Bernd Masepohl ◽  
Sieglinde Angermüller ◽  
Silke Hennecke ◽  
Philipp Hübner ◽  
Conrado Moreno-Vivian ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Genetic Analysis ◽  
Rhodobacter Capsulatus ◽  
Gene Region

scholarly journals Definition of the Gene Content of the Human Genome: The Need for Deep Experimental Verification

2001 ◽  
Vol 2 (3) ◽  
pp. 169-175 ◽  
Author(s):  
Andrew J. G. Simpson ◽  
Sandro J. de Souza ◽  
Anamaria A. Camargo ◽  
Ricardo R. Brentani
Keyword(s):  
Human Genome ◽  
Gene Structure ◽  
Experimental Verification ◽  
Human Gene ◽  
Sequence Data ◽  
Gene Prediction ◽  
Human Genes ◽  
Number Of Genes ◽  
Definition Of

Based on the analysis of the drafts of the human genome sequence, it is being speculated that our species may possess an unexpectedly low number of genes. The quality of the drafts, the impossibility of accurate gene prediction and the lack of sufficient transcript sequence data, however, render such speculations very premature. The complexity of human gene structure requires additional and extensive experimental verification of transcripts that may result in major revisions of these early estimates of the number of human genes.

DNA methylation in satellite repeats disorders

2019 ◽  
Vol 63 (6) ◽  
pp. 757-771 ◽  
Author(s):  
Claire Francastel ◽  
Frédérique Magdinier
Keyword(s):  
Dna Methylation ◽  
Human Genome ◽  
Repetitive Dna ◽  
Dna Sequences ◽  
Satellite Repeats ◽  
Tremendous Progress ◽  
Genes Encoding ◽  
Dna Elements ◽  
Near Future

Abstract Despite the tremendous progress made in recent years in assembling the human genome, tandemly repeated DNA elements remain poorly characterized. These sequences account for the vast majority of methylated sites in the human genome and their methylated state is necessary for this repetitive DNA to function properly and to maintain genome integrity. Furthermore, recent advances highlight the emerging role of these sequences in regulating the functions of the human genome and its variability during evolution, among individuals, or in disease susceptibility. In addition, a number of inherited rare diseases are directly linked to the alteration of some of these repetitive DNA sequences, either through changes in the organization or size of the tandem repeat arrays or through mutations in genes encoding chromatin modifiers involved in the epigenetic regulation of these elements. Although largely overlooked so far in the functional annotation of the human genome, satellite elements play key roles in its architectural and topological organization. This includes functions as boundary elements delimitating functional domains or assembly of repressive nuclear compartments, with local or distal impact on gene expression. Thus, the consideration of satellite repeats organization and their associated epigenetic landmarks, including DNA methylation (DNAme), will become unavoidable in the near future to fully decipher human phenotypes and associated diseases.

On everyday academic research

2017 ◽  
pp. 98-134 ◽  
Author(s):  
J. Tirole
Keyword(s):  
Common Good ◽  
Academic Research ◽  
Research Quality ◽  
Economic Research ◽  
Relevant Research ◽  
The Common ◽  
Verification Of Models ◽  
Science And Research

In the fourth chapter of the book “The economy of the common good”, the nature of economics as a science and research practices in their theoretical and empirical aspects are discussed. The author considers the processes of modeling, empirical verification of models and evaluation of research quality. In addition, the features of economic cognition and the role of mathematics in economic research are analyzed, including the example of relevant research in game theory and information theory.

Contemplative Principles of a Non-dual Praxis: the Unmediated Practices of the Tibetan ‘Heart Essence’ (sNying thig) Tradition

2015 ◽  
Vol 31 (2) ◽  
pp. 215-240
Author(s):  
Eran Laish
Keyword(s):  
Contemplative Practice ◽  
Tibetan Buddhist ◽  
Buddhist Tradition ◽  
The Common

This article focuses on the main contemplative principles of the ‘Heart Essence’ (sNying thig), a Tibetan Buddhist tradition that is characterized by a vision of non-duality and primordial wholeness. Due to this vision, which asserts an original reality that is not divided into perceiving subject and perceived object, the ‘Heart Essence’ advocates a contemplative practice that undermines the usual intuitions of temporality and enclosed selfhood. Hence, unlike the common principles of intentional praxis, such as deliberate concentration and gradual purification, the ‘Heart Essence’ affirms four contemplative principles of non-objectiveness, openness, spontaneity and singleness. As these principles transcend intentionality, temporality, and multiplicity, they are seen to directly disclose the nature of primordial awareness, in which the meanings of knowing and being are radically transformed. Therefore, the article will also consider the role of these non-dual contemplative principles in deeply changing our understanding of being and knowing alike.

Charles de Gaulle and European Community

2020 ◽  
Vol 2020 (10-3) ◽  
pp. 70-81
Author(s):  
David Ramiro Troitino ◽  
Tanel Kerikmae ◽  
Olga Shumilo
Keyword(s):  
World War Ii ◽  
European Community ◽  
World War ◽  
Charles De Gaulle ◽  
The United Kingdom ◽  
History Of ◽  
The Common ◽  
Post War ◽  
De Gaulle

This article highlights the role of Charles de Gaulle in the history of united post-war Europe, his approaches to the internal and foreign French policies, also vetoing the membership of the United Kingdom in the European Community. The authors describe the emergence of De Gaulle as a politician, his uneasy relationship with Roosevelt and Churchill during World War II, also the roots of developing a “nationalistic” approach to regional policy after the end of the war. The article also considers the emergence of the Common Agricultural Policy (hereinafter - CAP), one of Charles de Gaulle’s biggest achievements in foreign policy, and the reasons for the Fouchet Plan defeat.

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