Comparison of Liver Scintigraphy and the Liver-Spleen Contrast in Gd-EOB-DTPA-Enhanced MRI on Liver Function Tests

2021 ◽  
Author(s):  
Hiroshige Mori ◽  
Hanaka Machimura ◽  
Amika Iwaya ◽  
Masaru Baba ◽  
Ken Furuya
Keyword(s):  
Liver Function ◽  
Total Bilirubin ◽  
Clinical Stage ◽  
Correlation Coefficients ◽  
Liver Function Tests ◽  
Coefficient Of Determination ◽  
Hepatobiliary Phase ◽  
Biochemical Tests ◽  
Liver Scintigraphy ◽  
Phase Images

Abstract The liver-spleen contrast (LSC) using hepatobiliary-phase images could replace the receptor index (LHL15) in liver scintigraphy; however, few comparative studies exist. This study aimed to verify the convertibility from LSC into LHL15. In 136 patients, the LSC, not at 20 min, but at 60 min after injecting gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid was compared with the LHL15, albumin–bilirubin (ALBI) score, and the related laboratory parameters. The LHL15 was also compared with their biochemical tests. The correlation coefficients of LSC with LHL15, ALBI score, total bilirubin, and albumin were 0.740, − 0.624, − 0.606, and 0.523 (P < 0.00001), respectively. The correlation coefficients of LHL15 with ALBI score, total bilirubin, and albumin were − 0.647, − 0.553, and 0.569 (P < 0.00001), respectively. The linear regression equation on the estimated LHL15 (eLHL15) from LSC was eLHL15 = 0.460 • LSC + 0.727 (P < 0.00001) and the coefficient of determination was 0.548. Regarding a contingency table using imaging-based clinical stage classification, the degree of agreement between eLHL15 and LHL15 was 65.4 %, and Cramer's V was 0.568 (P < 0.00001). Therefore, although the LSC may be influenced by high total bilirubin, the eLHL15 can replace the LSC as an index to evaluate liver function.

scholarly journals Comparison of liver scintigraphy and the liver-spleen contrast in Gd-EOB-DTPA-enhanced MRI on liver function tests

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiroshige Mori ◽  
Hanaka Machimura ◽  
Amika Iwaya ◽  
Masaru Baba ◽  
Ken Furuya
Keyword(s):  
Liver Function ◽  
Total Bilirubin ◽  
Clinical Stage ◽  
Correlation Coefficients ◽  
Liver Function Tests ◽  
Coefficient Of Determination ◽  
Hepatobiliary Phase ◽  
Biochemical Tests ◽  
Liver Scintigraphy ◽  
Phase Images

AbstractThe liver-spleen contrast (LSC) using hepatobiliary-phase images could replace the receptor index (LHL15) in liver scintigraphy; however, few comparative studies exist. This study aimed to verify the convertibility from LSC into LHL15. In 136 patients, the LSC, not at 20 min, but at 60 min after injecting gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid was compared with the LHL15, albumin–bilirubin (ALBI) score, and the related laboratory parameters. The LHL15 was also compared with their biochemical tests. The correlation coefficients of LSC with LHL15, ALBI score, total bilirubin, and albumin were 0.740, –0.624, –0.606, and 0.523 (P < 0.00001), respectively. The correlation coefficients of LHL15 with ALBI score, total bilirubin, and albumin were –0.647, –0.553, and 0.569 (P < 0.00001), respectively. The linear regression equation on the estimated LHL15 (eLHL15) from LSC was eLHL15 = 0.460 · LSC + 0.727 (P < 0.00001) and the coefficient of determination was 0.548. Regarding a contingency table using imaging-based clinical stage classification, the degree of agreement between eLHL15 and LHL15 was 65.4%, and Cramer's V was 0.568 (P < 0.00001). Therefore, although the LSC may be influenced by high total bilirubin, the eLHL15 can replace the LSC as an index to evaluate liver function.

scholarly journals EFFECT OF ACUTE APPENDICITIS AND ITS COMPLICATIONS ON THE PARAMETERS OF LIVER FUNCTION TESTS

2020 ◽  
pp. 26-27
Author(s):  
Shouryabrata Choudhury ◽  
Neelanjana Paul ◽  
Bhaskar Sharma
Keyword(s):  
Liver Function ◽  
Acute Appendicitis ◽  
Bilirubin Level ◽  
Total Bilirubin ◽  
Disease Process ◽  
Total Bilirubin Level ◽  
Liver Function Tests ◽  
Biochemical Tests ◽  
Function Tests ◽  
Perforated Appendix

BACKGROUND AND OBJECTIVES: Acute appendicitis is one of the most common surgical conditions encountered by the surgeons worldwide. In acute appendicitis, liver function test is one of the biochemical tests used to predict the severity of disease process. Blood from the abdominal organs reaches the liver via portal vein which not only carries the nutrients but also bacteria and toxins absorbed from the gut. When the load is more than the functional capacity of the liver, it leads to parenchymal damage to the liver, which is reflected as deranged parameters of liver function tests. The present study has been designed to evaluate the effect of acute appendicitis and its complications on liver function tests. MATERIAL AND METHOD: This observational prospective study was conducted on 55 cases of acute appendicitis and its complications. Patients of all ages and of either sex presenting with acute appendicitis (ALVARADO score >9 and confirmed by USG) were included in the study and were subjected to Liver function tests (LFT) and histopathology examination report were collected after appendicectomy. RESULTS: On histopathological and intraoperative examination, 5.45% had normal appendix, 54.54% had inflamed appendix, 40% had gangrenous or perforated appendix. Liver function tests were evaluated in these subjects. We found that in subjects with inflamed appendix, 16.6%, 10% and 6.6% had elevated levels of total bilirubin, AST, ALT respectively and none had elevated ALP. Similarly, in subjects with perforated/gangrenous appendix, 72.7%, 54.5%, 18.2% and 9.1% had elevated total bilirubin, AST, ALT and ALP levels respectively. The LFT parameters are deranged in pathological appendix and more specifically the total bilirubin level is high for gangrenous and perforated appendix. CONCLUSION: LFT parameters are deranged in complicated appendicitis and more specifically the total bilirubin level.

Hepatic and Renal Dysfunction following Nafcillin Administration

1992 ◽  
Vol 26 (7-8) ◽  
pp. 985-990 ◽  
Author(s):  
Mitchell R. Lestico ◽  
Karen E. Vick ◽  
Cyril M. Hetsko
Keyword(s):  
Risk Factors ◽  
Adverse Event ◽  
Lactate Dehydrogenase ◽  
Liver Function ◽  
Total Bilirubin ◽  
Renal Toxicity ◽  
Liver Function Tests ◽  
Hepatic Function ◽  
Data Sources ◽  
Data Synthesis

OBJECTIVE: To review four cases of combined hepatic and renal toxicity that may be associated with the administration of nafcillin in adults. This type of adverse event with the use of nafcillin has not been previously documented in the literature. DATA SOURCES: References from pertinent articles are identified throughout the text. DATA SYNTHESIS: Nafcillin is a widely used penicillinase-resistant penicillin. In four patients receiving nafcillin doses greater than 9 g/24 hours, changes in renal and hepatic function markers were noted within 72 hours of the initiation of nafcillin therapy. Laboratory values returned toward baseline when nafcillin therapy was discontinued. Elevations in blood urea nitrogen, creatinine, total bilirubin, and lactate dehydrogenase have been previously described in the literature for penicillin-like agents other than nafcillin. The exact mechanism for such toxicities as well as patient risk factors have not been clearly established. CONCLUSIONS: Caution should be taken when initiating nafcillin therapy. Evaluation of renal and liver function tests prior to initiating nafcillin therapy and within the first 72 hours appears warranted. If hepatic and/or renal toxicity is observed, discontinuation of nafcillin should be considered.

scholarly journals Methimazole induced hepatotoxicity: A rare adverse reaction

2019 ◽  
Vol 6 (3) ◽  
pp. 1
Author(s):  
Kevin C. Kohm ◽  
Lauren Pioppo ◽  
Jack Xu ◽  
Preston Keiffer ◽  
Eric Pagan ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Function ◽  
Side Effect ◽  
Hepatic Injury ◽  
Total Bilirubin ◽  
Liver Function Tests ◽  
Side Effect Profile ◽  
Function Tests ◽  
Painless Jaundice ◽  
Graves Orbitopathy

Methimazole (MMI) is a commonly used medication in the treatment of hyperthyroidism. The side effect profile is extensive and includes the rare but serious side effect of drug associated liver injury. We report the case of a 51-year-old female who presented with painless jaundice several weeks after initiating MMI therapy for treatment of hyperthyroidism complicated by Graves’ orbitopathy. Liver function tests on presentation showed alanine aminotransferase (ALT) 1366 IU/L, aspartate aminotransferase (AST) 853 IU/L, total bilirubin 26.2 mg/dl, alkaline phosphatase 954 IU/L. Workup of structural, infectious, and autoimmune causes of hepatic injury was negative. The patient was therefore found to have MMI associated liver injury. MMI was discontinued and the patient was started on ursodiol, resulting in resolution of her jaundice and improvement of her liver function tests.

scholarly journals Bilirubin Metabolism — Preliminary Investigation

1976 ◽  
Vol 3 (4) ◽  
pp. 365-372 ◽  
Author(s):  
A. Barbeau ◽  
G. Breton ◽  
B. Lemieux ◽  
R.F. Butterworth
Keyword(s):  
Liver Function ◽  
Membrane Transport ◽  
Total Bilirubin ◽  
Preliminary Investigation ◽  
Normal Liver ◽  
Liver Function Tests ◽  
Bimodal Distribution ◽  
Secondary Component ◽  
Normal Liver Function ◽  
Bilirubin Metabolism

SUMMARY:In our studies, high total bilirubin values in the plasma were noted in cases of Friedreich's ataxia. A bimodal distribution of the values indicated the possible presence of two subgroups of patients. In these kindred, we demonstrated an elevation in unconjugated bilirubin with features similar to those reported in Gilbert's syndrome: normal liver function tests, elevation after fasting and day to day variability. We also report preliminary experiments indicating that bilirubin levels may be taurine dependent. We postulate that the defect could be a secondary component of the ataxic disease, possibly indicating a defect in membrane transport.

scholarly journals Comparison of postoperative liver function between different dissection techniques during laparoscopic cholecystectomy

2020 ◽  
pp. FSO462
Author(s):  
Tagleb S Mazahreh ◽  
Abdelwahab J Aleshawi ◽  
Nabil A Al-Zoubi ◽  
Mohammad Altabari ◽  
Qusai Aljarrah
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Liver Function ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Total Bilirubin ◽  
Liver Function Tests ◽  
Different Types ◽  
Group A ◽  
Dissection Techniques ◽  
Group B

Aim: In this study, we investigated and compared the effect of different types of dissector (Maryland vs Hook) on changes in liver function tests (LFTs) after laparoscopic cholecystectomy. Patients & methods: The enrolled patients were divided into two groups. Group A patients underwent dissection by Maryland dissecting forceps, group B by Hook dissecting instrument. LFTs were measured preoperatively and at 1 day and 1 week, postoperatively. Results: For both Maryland and Hook dissection, the 1-day postoperative values for total bilirubin, alanine aminotransferase and aspartate aminotransferase were significantly higher than the preoperative values. Also, there were no statistical differences between Hook and Maryland. Conclusion: The elevation of LFTs seems to be attributed to other factors.

scholarly journals Abnormal Liver Function Tests of Patients with Coronavirus Disease 2019 in Mainland China: A Systematic Review and Meta- Analysis

2020 ◽  
Vol 29 (2) ◽  
pp. 219-226 ◽  
Author(s):  
Shengliang Xin ◽  
Jinghang Xu ◽  
Yanyan Yu
Keyword(s):  
Liver Function ◽  
Literature Search ◽  
Total Bilirubin ◽  
Meta Analysis ◽  
Mainland China ◽  
Liver Function Tests ◽  
Abnormal Liver Function ◽  
Cochrane Library ◽  
Random Effects Models ◽  
Function Tests

Aims: Comparing the risk of abnormal liver function tests between severe and non-severe patients with coronavirus disease 2019 (COVID-19) by meta-analysis. Methods: A literature search was conducted using the databases PubMed, Embase, and Cochrane Library. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using fixed- or random-effects models. Publication bias was detected by the Harbord test. Results: We included 8 articles comprising 7,467 COVID-19 patients. When compared between severe and non-severe COVID-19 patients, the pooled ORs of elevated alanine aminotransferase, aspartate aminotransferase, total bilirubin, and lactate dehydrogenase levels were 2.35 (95% CI 1.38-3.98), 3.21 (95% CI 2.59-3.98), 1.87 (95% CI 1.32-2.65), and 4.83 (95% CI 2.90-8.05), respectively. Conclusions: The severity of COVID-19 is associated with liver damage, and can be a risk factor for abnormal liver function tests.

scholarly journals Correlation of liver enhancement in gadoxetic acid–enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial

2021 ◽  
Author(s):  
Osman Öcal ◽  
Bora Peynircioglu ◽  
Christian Loewe ◽  
Otto van Delden ◽  
Vincent Vandecaveye ◽  
...  
Keyword(s):  
Liver Function ◽  
Total Bilirubin ◽  
Clinical Findings ◽  
Gadoxetic Acid ◽  
Imaging Biomarker ◽  
Hepatobiliary Phase ◽  
Platelet Counts ◽  
Enhanced Mri ◽  
Grading Systems ◽  
Liver Functions

Abstract Objectives To evaluate the correlation between liver enhancement on hepatobiliary phase and liver function parameters in a multicenter, multivendor study. Methods A total of 359 patients who underwent gadoxetic acid–enhanced MRI using a standardized protocol with various scanners within a prospective multicenter phase II trial (SORAMIC) were evaluated. The correlation between liver enhancement on hepatobiliary phase normalized to the spleen (liver-to-spleen ratio, LSR) and biochemical laboratory parameters, clinical findings related to liver functions, liver function grading systems (Child-Pugh and Albumin-Bilirubin [ALBI]), and scanner characteristics were analyzed using uni- and multivariate analyses. Results There was a significant positive correlation between LSR and albumin (rho = 0.193; p < 0.001), platelet counts (rho = 0.148; p = 0.004), and sodium (rho = 0.161; p = 0.002); and a negative correlation between LSR and total bilirubin (rho = −0.215; p < 0.001) and AST (rho = −0.191; p < 0.001). Multivariate analysis confirmed independent significance for each of albumin (p = 0.022), total bilirubin (p = 0.045), AST (p = 0.031), platelet counts (p = 0.012), and sodium (p = 0.006). The presence of ascites (1.47 vs. 1.69, p < 0.001) and varices (1.55 vs. 1.69, p = 0.006) was related to significantly lower LSR. Similarly, patients with ALBI grade 1 had significantly higher LSR than patients with grade 2 (1.74 ± 0.447 vs. 1.56 ± 0.408, p < 0.001); and Child-Pugh A patients had a significantly higher LSR than Child-Pugh B (1.67 ± 0.44 vs. 1.49 ± 0.33, p = 0.021). Also, LSR was negatively correlated with MELD-Na scores (rho = −0.137; p = 0.013). However, one scanner brand was significantly associated with lower LSR (p < 0.001). Conclusions The liver enhancement on the hepatobiliary phase of gadoxetic acid–enhanced MRI is correlated with biomarkers of liver functions in a multicenter cohort. However, this correlation shows variations between scanner brands. Key Points • The correlation between liver enhancement on the hepatobiliary phase of gadoxetic acid–enhanced MRI and liver function is consistent in a multicenter-multivendor cohort. • Signal intensity–based indices (liver-to-spleen ratio) can be used as an imaging biomarker of liver function. • However, absolute values might change between vendors.

scholarly journals DIFFERENCES OF LIVER FUNCTION TESTS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH AND WITHOUT CORONARY ARTERY DISEASE

2018 ◽  
Vol 24 (3) ◽  
pp. 266
Author(s):  
Hendra Saputra ◽  
Burhanuddin Nasution ◽  
Santi Syafril
Keyword(s):  
Diabetes Mellitus ◽  
Liver Function ◽  
Total Bilirubin ◽  
Liver Function Tests ◽  
Arterial Disease ◽  
Direct Bilirubin ◽  
Coronary Arterial Disease ◽  
Type 2 Dm ◽  
Significant Difference

One of the macroangiopathic complications of Diabetes Mellitus (DM) is Coronary Arterial Disease (CAD). Several studies showed that the liver was one of the organs involved in the pathological development of diabetes.The aim of this study was to find the differences of liver function in type 2 DM patients with CAD and without CAD. This was an analytical observational study with cross-sectional design. Forty-four type 2 DM patients with and without CAD at the Adam Malik Hospital Medan who came during June - August 2016 were studied for liver function (total bilirubin, direct bilirubin, AST and ALT). In this study, the average values of total bilirubin and direct bilirubin level in patients with CAD were found to be lower than without CAD. Statistically a significant difference revealed a total bilirubin (p < 0.001) and direct bilirubin (p = 0.001) in type 2 DM patients with and without CAD. There was a significant difference in liver function tests in DM type 2 patients with, and without coronary arterial disease, these data suggested that total billirubin and direct billirubin levels in type 2 DM patients with CAD were found lower than those without CAD. 

scholarly journals Ο ρόλος της μαγνητικής χολαγγειοπαγκρεατογραφίας (MRCP) στα παιδιά με ιδιοπαθή φλεγμονώδη νόσο του εντέρου (ΙΦΝΕ)

2014 ◽  
Author(s):  
Πόλυς Ξενοφώντος
Keyword(s):  
Alkaline Phosphatase ◽  
Magnetic Resonance ◽  
Liver Function ◽  
Total Bilirubin ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Liver Function Tests ◽  
Alanine Transaminase ◽  
Aspartate Transaminase ◽  
Normal Limits ◽  
Glutamyl Transferase

ΣΚΟΠΟΙ: (i) Ο υπολογισμός της συχνότητας των αλλοιώσεων τύπου πρωτοπαθούς σκληρυντικής χολαγγειίτιδας (ΠΣΧ) ή/και χρόνιας παγκρεατίτιδας (ΧΠ) στη μαγνητική χολαγγειοπαγκρεατογραφία (magnetic resonance cholangiopancreatography, MRCP), σε παιδιά με ιδιοπαθή φλεγμονώδη νόσο του εντέρου (ΙΦΝΕ)· (ii) η διερεύνηση της αποτελεσματικότητας ορισμένων δεδομένων, συγκεκριμένα δημογραφικών, εργαστηριακών (ίδε δοκιμασίες ηπατικής λειτουργίας, liver function tests, LFTs) και απεικονιστικών (εκ της μαγνητικής εντερογραφίας και της αξιολόγησης της άνω κοιλίας στη μαγνητική τομογραφία), στην ανίχνευση των ανωτέρω αλλοιώσεων στον ίδιο πληθυσμό. ΜΕΘΟΔΟΙ: Τα δεδομένα 94 παιδιών με ΙΦΝΕ συσχετίστηκαν συγχρονικά με τη βασισθείσα στην MRCP διάγνωση. ΑΠΟΤΕΛΕΣΜΑΤΑ: Δεκαοκτώ (19.1%) συν ένας (1.1%) ασθενείς με αλλοιώσεις τύπου ΠΣΧ και ΧΠ, αντιστοίχως, σχημάτισαν την Ομάδα ΠΣΧ/ΧΠ (20.2%). Κατ’ αρχάς, τα δημογραφικά και απεικονιστικά δεδομένα δεν συσχετίστηκαν με το αποτέλεσμα της MRCP. Περαιτέρω, στην Ομάδα ΠΣΧ/ΧΠ ήταν σημαντικά υψηλότερες: (i) oι τιμές των LFTs περί την πρωτοδιάγνωση ΙΦΝΕ και περί την MRCP (πλην της γ-γλουταμυλικής τρανσφεράσης, γ-glutamyl transferase, γ-GT περί την MRCP)· και (ii) οι συχνότητες των παθολογικών τιμών των ασπαρτικής τρανσαμινάσης (aspartate transaminase, AST), αλανινικής τρανσαμινάσης (alanine transaminase, ALT) και γ-GT περί την πρωτοδιάγνωση ΙΦΝΕ, καθώς και των AST, ALT, γ-GT και άμεσης χολερυθρίνης (direct bilirubin, DBil) περί την MRCP. Ωστόσο, οι τιμές και οι συχνότητες των παθολογικών τιμών των LFTs κυμάνθηκαν χαμηλά στην ίδια ομάδα (~40-128% των ανώτερων φυσιολογικών ορίων, upper normal limits, UNL και ~15-53%, αντιστοίχως). Επιπλέον, οι AST, ALT και γ-GT περί την πρωτοδιάγνωση ΙΦΝΕ, καθώς και οι AST, ALT, γ-GT και DBil περί την MRCP, συνδέθηκαν με αυξημένο κίνδυνο απεικόνισης των επίμαχων αλλοιώσεων, επί εμφάνισης παθολογικών τιμών. Ακόμη, μία σημαντική γραμμική συσχέτιση ανέκυψε μεταξύ του ανωτέρω κινδύνου και των τιμών των: (i) AST, ALT, αλκαλικής φωσφατάσης (alkaline phosphatase, ALP), γ-GT και ολικής χολερυθρίνης (total bilirubin, TBil) περί την πρωτοδιάγνωση ΙΦΝΕ· και (ii) AST, ALT, ALP, γ-GT και DBil περί την MRCP. Τέλος, τα αποκρινόμενα στο μέγιστο άθροισμα ευαισθησίας και ειδικότητας όρια αποκοπής των LFTs έλαβαν χαμηλές τιμές (~33-156% των UNL), ενώ οι αντίστοιχες, προγνωστικές για τις αλλοιώσεις δοκιμασίες των AST και ALT περί την πρωτοδιάγνωση ΙΦΝΕ θεωρήθηκαν σχεδόν βέλτιστες (θετική/ αρνητική προγνωστική αξία: ~90%/~90%, ~80%/~90%, αντιστοίχως).ΣΥΜΠΕΡΑΣΜΑΤΑ: Ο αληθής επιπολασμός των αλλοιώσεων τύπου ΠΣΧ στα παιδιά με ΙΦΝΕ εμφανίζεται απροσδόκητα υψηλός, ενώ η απεικόνιση βλαβών τύπου ΠΣΧ ή/και ΧΠ κρίνεται πιθανή ακόμη και στην απουσία ισχυρώς συνηγορούντων βιοχημικών δεδομένων. Επίσης, ο κίνδυνος ανεύρεσης των αλλοιώσεων ελέγχεται αυξημένος επί απορρύθμισης μίας σειράς LFTs και γραμμικώς συσχετιζόμενος με αρκετές μεταβλητές του είδους. Περαιτέρω, ανάμεσα στις LFTs, οι τρανσαμινάσες περί την πρωτοδιάγνωση ΙΦΝΕ φαίνεται να παρέχουν τις καταλληλότερες δοκιμασίες πρόγνωσης της απεικόνισης των αλλοιώσεων. Πάντως, αν καθοριστούν όρια αποκοπής των LFTs για τη λήψη ενδεδειγμένης απόφασης διεξαγωγής MRCP στον υπό εξέταση πληθυσμό, αυτά οφείλουν να είναι αισθητά χαμηλά, ενδεχομένως εντός φυσιολογικών τιμών.

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