scholarly journals Comparison of postoperative liver function between different dissection techniques during laparoscopic cholecystectomy

2020 ◽  
pp. FSO462
Author(s):  
Tagleb S Mazahreh ◽  
Abdelwahab J Aleshawi ◽  
Nabil A Al-Zoubi ◽  
Mohammad Altabari ◽  
Qusai Aljarrah
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Liver Function ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Total Bilirubin ◽  
Liver Function Tests ◽  
Different Types ◽  
Group A ◽  
Dissection Techniques ◽  
Group B

Aim: In this study, we investigated and compared the effect of different types of dissector (Maryland vs Hook) on changes in liver function tests (LFTs) after laparoscopic cholecystectomy. Patients & methods: The enrolled patients were divided into two groups. Group A patients underwent dissection by Maryland dissecting forceps, group B by Hook dissecting instrument. LFTs were measured preoperatively and at 1 day and 1 week, postoperatively. Results: For both Maryland and Hook dissection, the 1-day postoperative values for total bilirubin, alanine aminotransferase and aspartate aminotransferase were significantly higher than the preoperative values. Also, there were no statistical differences between Hook and Maryland. Conclusion: The elevation of LFTs seems to be attributed to other factors.

scholarly journals A comparative study between two techniques of subtotal laparoscopic cholecystectomy in goats

2014 ◽  
Vol 38 (2) ◽  
pp. 114-122
Author(s):  
M. J. Eesa
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Liver Function ◽  
Cystic Duct ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Liver Function Tests ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Group A ◽  
Group B

     A comparison between two techniques of subtotal laparoscopic cholecystectomy was studied to find the best technique for treating severe cholecystitis and to study the fate of the remaining part of the gallbladder. All experimental animals had inducing cholecystitis by clipping the cystic duct for five days which was enough for inducing cholecystitis in goats. 24 adult female goats were used in this study, which were divided randomly into two equal groups; subtotal laparoscopic cholecystectomy with cystic duct and cystic artery clipping by titanium clips (group A) and laparoscopic subtotal cholecystectomy with cystic duct clipping only (group B). Operations were performed under general anesthesia by using thiopental sodium at a dose of 15 mg/Kg. B.W. intravenously to maintain the inhalation anesthesia by endotracheal tube with a mixture of halothane (1.5- 2.5 %) and oxygen (2-3 %). The intraabdominal pressure with CO2 was used at a low pressure 8-10 mmHg. The liver function tests including; alkaline phosphates (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total serum bilirubin and C- reactive protein were measured in different intervals; before operation (zero day) and at 1hr, 1st, 3rd, 5th and 7th postoperative day. The liver function tests showed a significant elevation (P< 0.05) in alkaline phosphates (ALP) and in the total bilirubin values in group B (P> 0.05)  comparison with group A and no significant difference in alanine aminotransferase (ALT), aspartate aminotransferase (AST) and C- reactive protein between all experimental groups as well as time intervals. The biopsies were taken at the 3rd, 7th and 15th postoperative day for histopathological of the remaining part of gallbladder which showed that subtotal cholecystectomies could be performed successfully with the two techniques, appeared degeneration in the remaining part of the gallbladder and offers best in the healing stages.

scholarly journals Study of Liver and Kidney functions in non-pregnant, pregnant and preeclamptic women

2012 ◽  
Vol 9 (2) ◽  
pp. 277-284 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Pregnant Women ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Total Bilirubin ◽  
Spectrophotometric Analysis ◽  
Serum Alanine Aminotransferase ◽  
Liver And Kidney ◽  
Group A ◽  
Group B ◽  
Kidney Functions

Three groups of subjects have been divided (25/group): healthy normotensive non-pregnant women (Group A), normal normotensive pregnant women (Group B), and women with preeclampsia (Group C).The levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin , creatinine , blood urea nitrogen, triglyceride , total cholesterol and glucose have been estimated in all subjects. All measured parameters were determined by spectrophotometric analysis. The results showed a significant(P

scholarly journals Effect of Vitamin C Supplementation on Serum Ascorbic Acid Level and Liver Function Profile in Healthy Individuals

2020 ◽  
pp. 28-39
Author(s):  
Iffat Nayila
Keyword(s):  
Ascorbic Acid ◽  
Liver Function ◽  
Vitamin C ◽  
Total Bilirubin ◽  
Acid Supplementation ◽  
Vitamin C Supplementation ◽  
Group A ◽  
Group B ◽  
Function Profile ◽  
Ascorbic Acid Supplementation

This study was conducted to explore the effects of ascorbic acid supplementation on serum liver function tests in healthy individuals. A total of 200 subjects were selected randomly. 100 were given ascorbic acid supplementation for 30 days. The other 100 were not given ascorbic acid supplementation, and serum ascorbic acid level and liver function profile was observed before and after intake of ascorbic acid in group A and without intake in group B. The liver function parameters determined were aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), serum total bilirubin, direct bilirubin, indirect bilirubin and serum protein (total protein, albumin and globulin). These parameters along with serum ascorbic acid were measured before and 30 days after vitamin C supplementation. Various parameters of liver function profile were improved swiftly when compared to other group which was not given ascorbic acid supplementation. While comparing the two treatment groups for 30 days, statistically significant improvement was seen in serum ascorbic acid levels (p<0.001) along with improvement in some components of liver function profile such as serum ALT (p<0.01), AST (p<0.01), Total Bilirubin (p<0.01) and Direct bilirubin (p<0.001), Total Proteins (p<0.01) and Albumin (p<0.001) in group A as compared to Group B (without vitamin C supplementation intake). Conclusively, Liver Functions were significantly improved with vitamin C supplementation, giving the supportive evidence of the use of vitamin C as an antioxidant.

scholarly journals Comparison of oral rifampicin with observation alone in treatment of acute central serous Chorioretinopathy

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Anum Badar ◽  
Sadaf Khan ◽  
Sobia Usman Shah ◽  
Mohammad Tahir ◽  
Saman Babree
Keyword(s):  
Liver Function ◽  
Central Serous Chorioretinopathy ◽  
Liver Function Tests ◽  
Macular Thickness ◽  
Function Tests ◽  
Single Person ◽  
Significant Difference ◽  
Group A ◽  
Acute Central Serous Chorioretinopathy ◽  
Group B

Introduction: A randomized control trial To compare efficacy of oral rifampicin in terms of drying of macula and decrease macular thickness with observation alone in patients of acute central serous Chorioretinopathy done in Layton Rahmatulla Benevolent Trust (LRBT) Free Eye and Cancer Hospital, Lahore from January 2017 to June 2017 Methods: After getting approval from hospital Ethical committee 140 patients of CSR were included in the study. The demographic details were noted and patients were randomized by lottery methods in two groups (group A& B). Group-A was observed for spontaneous resolution, routine treatment started if no improvement noted after 6 weeks of observation alone. Group B was given oral rifampicin 600mg per day for four weeks with liver function tests being done before commencement of treatment and after 2 weeks. Oral rifampicin was stopped if patient developed deranged liver function tests. Patients were followed up at 4 weeks for macular dryness and decrease macular thickness on optical coherence tomography(OCT). All the readings were carried out and noted by single person in order to minimize bias. Results: A total of 140 patents, 70 in each group, were included In study with mean age 38.77+7.74 in Group-A and 39.14+7.97 years in Group-B. regarding gender distribution 65.71 %(n=46) in Group-A and 613.43%(n=43) in Group-B were male.   Comparison of outcome of treatment of acute central serous chorioretinopathy with oral rifampicin vs observation showed that 18.57 %(n=13) in Group-A and 41.43%(n=29) in Group-B had dry macula. Conclusion: We concluded that there is a significant difference in drying of macula in acute central serous chorioretinopathy with Rifampicin versus observation alone.

scholarly journals Influence of Eclipta alba on serum alanine aminotransferase and aspartate aminotransferase activity in rabbits

2018 ◽  
Vol 7 (7) ◽  
pp. 1243
Author(s):  
B. P. Kale ◽  
Mujawar Jahir Rauf
Keyword(s):  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Treated Group ◽  
Biologically Active ◽  
Control Group ◽  
Serum Alanine Aminotransferase ◽  
Eclipta Alba ◽  
Group A ◽  
High Doses ◽  
Group B

Background: Paracetamol is a recognized antipyretic, analgesic drug which produces hepatic necrosis in high doses. Eclipta alba elaborates a vast array of biologically active compounds that are chemically diverse and structurally complex.Methods: Randomized open controlled experimental study Estimated levels of Serum aspartate aminotransferase (AST), Serum alanine aminotransferase (ALT) and Hepatoprotective action of in High doses of Paracetamol on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity.Results: ALT in all the groups including Control group (A) was (51.8±4.56IU/L). Paracetamol treated group (B) the ALT level increased at 48 hours and continued to be high up to 60 days (136.4±20.73IU/L) then decreased to (113.7±11.35IU/L) at 90 days. AST in all the groups including Control group (A) was (22.5±1.23IU/L). Appropriate antioxidant in appropriate doses as a matter of routine whenever hepatotoxic or potentially hepatotoxic drugs are prescribed. In Paracetamol treated group (B) the AST level increased at 48 hours and continued to be high up to 60 days (99.4±9.73IU/L) then decreased to (85.4±7.39IU/L) at 90 days.Conclusions: Appropriate antioxidant in appropriate doses as a matter of routine whenever hepatotoxic or potentially hepatotoxic drugs are prescribed.

TP6.2.3 Abnormal liver function tests: A helpful diagnostic test and a predictor of severity in acute appendicitis

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Muwaffaq Telfah ◽  
Mathew Mason ◽  
Marianne Hollyman ◽  
Hamish Noble ◽  
David Mahon ◽  
...  
Keyword(s):  
Liver Function ◽  
Acute Appendicitis ◽  
Hospital Stay ◽  
District General Hospital ◽  
Liver Function Tests ◽  
Average Hospital ◽  
Function Tests ◽  
Group A ◽  
Negative Appendicectomy ◽  
Group B

Abstract Aim: Acute appendicitis (AA) is the commonest surgical emergency worldwide. The diagnosis usually is clinical but imaging and bloods tests are helpful. The study aims to establish the role of abnormalities in liver function tests (LFTs) in the diagnosis and in predicting the severity of AA. Methods Retrospective, observational study performed in district general hospital between June 2018 and June 2019. Patients with abdominal pain and appendicectomy (excluding children &lt;16 years with isolated ALP rise) were categorized into two groups based on presence (Group-A) or absence (Group-B) of abnormal LFTs. Demographics data, diagnosis and severity of appendicitis, hospital stay and postoperative complications were analysed. Results Two hundred and seventy nine patients were included: Group-A (n = 146, mean age 37.5 years, M: F 1.3/1.0) and Group-B (n = 133, mean age 29.7 years, M:F 1.0/1.8). Appendicitis occurred in 85.6% of Group-A (125/146) and in 62.4% (83/133) of Group-B with positive predictive value 85.6%. The appendix was normal in 14.4% of Group-A (21/146) and in 37.6% of Group-B (50/133) with specificity of 70%. Laparotomy was required in 6.1% in Group-A (9/146) compared to 1.5% in Group-B (2/133). Average hospital stay was 4.7 days (range: 1-21) in Group-A versus 2.7 days (range 1-14) in Group-B. Readmission rate due to a postoperative complication was 16.4% in Group-A (24/146) compared to 6% in Group-B (8/ 133). Conclusion: Deranged LFTs is an additional diagnostic tool in AA and a good predictor of its severity. This may help to decrease the negative appendicectomy rate and guide surgeon in the decision-making process.

scholarly journals Gangguan Fungsi Hati pada Coronavirus Disease 2019

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Tasha Salsabila ◽  
Bradley J. Waleleng ◽  
Karel Pandelaki
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Function ◽  
Literature Review ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Total Bilirubin ◽  
Abnormal Liver Function ◽  
Gamma Glutamyl Transferase ◽  
Elevated Alkaline Phosphatase ◽  
Glutamyl Transferase

Abstract: The incidence and death rate of COVID-19 in North Sulawesi Province continues to increase and data regarding abnormal liver function in COVID-19 is not yet available. This study was aimed to obtain the liver function in COVID-19 patients. This was a literature review study using two databases, namely Pubmed and ClinicalKey. Keywords used were abnormal liver function AND COVID-19, elevated alanine aminotransferase AND COVID-19, elevated aspartate aminotransferase AND COVID-19, elevated gamma-glutamyl transferase AND COVID-19, elevated alkaline phosphatase AND COVID-19, elevated total bilirubin AND COVID-19. After being selected, 10 literatures were obtained based on inclusion and exclusion criteria. The results showed that increased liver function often occurred in cases of COVID-19, but the increase did not reach twice of the normal value. The most frequent increases were in GGT, followed by ALT and AST, total bilirubin, and the least was the increase in ALP. All literatures reported that increased liver function was more common in males, and in severe COVID-19 patients reported by eight literatures. Five literatures reported that elevated liver function increased mortality in COVID-19 cases. In conclusion, there are increases in ALT, AST, ALP, GGT, and total bilirubin levels in COVID-19 patients.Keywords: abnormal liver function, COVID-19 Abstrak: Angka kejadian dan angka kematian COVID-19 di Provinsi Sulawesi Utara terus bertambah sedangkan data mengenai gambaran gangguan fungsi hati pada COVID-19 belum tersedia. Penelitian ini bertujuan untuk mengetahui gambaran fungsi hati pada COVID-19. Jenis penelitian ialah literature review dengan pencarian data menggunakan dua database yaitu Pubmed dan ClinicalKey. Kata kunci yang digunakan yaitu abnormal liver function AND COVID-19, elevated alanine aminotransferase AND COVID-19, elevated aspartate aminotransferase AND COVID-19, elevated gamma-glutamyl transferase AND COVID-19, elevated alkaline phosphatase AND COVID-19, elevated total bilirubin AND COVID-19. Setelah diseleksi, didapatkan 10 literatur berdasarkan kriteria inklusi dan eksklusi. Penelitian ini mendapatkan bahwa peningkatan fungsi hati sering terjadi pada kasus COVID-19 namun peningkatannya tidak mencapai dua kali nilai normal. Peningkatan paling sering terjadi pada GGT, diikuti oleh ALT dan AST, bilirubin total, dan paling sedikit yaitu pada peningkatan ALP. Seluruh literatur melaporkan peningkatan fungsi hati lebih sering terjadi pada laki-laki dan pada kasus COVID-19 gejala berat dilaporkan oleh delapan literatur. Lima literatur melaporkan peningkatan fungsi hati meningkatkan mortalitas pada kasus COVID-19. Simpulan penelitian ini ialah, terdapat peningkatan kadar ALT, AST, ALP, GGT, dan bilirubin total pada penderita COVID-19.Kata kunci: gangguan fungsi Hati, COVID-19

Pregabalin As A Premedicant To Attenuate Pressor Response In Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study

2020 ◽  
Vol 11 (3) ◽  
pp. 3418-3423
Author(s):  
Sweety Agrawal ◽  
Shubdha Bhagat ◽  
Pratibha Deshmukh ◽  
Amol Singham
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Pressor Response ◽  
Controlled Study ◽  
Double Blind ◽  
Co2 Insufflation ◽  
Ramsay Sedation Scale ◽  
Minute Interval ◽  
Group A ◽  
Group B ◽  
Induction Of Anaesthesia

The present study was done to evaluate the ability of oral pregabalin to attenuate the pressor response to airway instrumentation in patients undergoing laparoscopic cholecystectomy under general anesthesia. Sixty-four adult patients aged between 25-55 year of either gender belonging to ASA-1 or ASA2 physical status weighing 50-70 kg were enrolled in this study. Thirty-two patients each were randomized to group A, or group B. Patients in group A received tablet Pregabalin (150mg) and those in group B received placebo orally one hour before induction of anaesthesia. Heart rate, blood pressure, and sedation were assessed preoperatively before giving the tablets and after 30 minutes, and just before induction of anaesthesia. Intraoperative, pulse rate, mean arterial pressure, ECG in the lead II, SPO2 and ETCO2 were monitored. All the above parameters were noted during laryngoscopy and intubation, 3 minutes after CO2 insufflation, and then at every 10-minute interval till the end of surgery. These parameters were also recorded after extubating the patient. The Ramsay sedation scale was used to assess the sedation at the baseline, one hour after drug intake , one hour after extubation and 4 hour after surgery. Any adverse effects in the postoperative period were recorded. The result of our study shows that pre-emptive administration of oral pregabalin 150 mg significantly reduced the pressor response at the time of laryngoscopy and intubation, after CO2 insufflation and just after extubation. We conclude that oral pregabalin premedication is effective in successful attenuation of hemodynamic pressor response to laryngoscopy, intubation and pneumoperitoneum in patients undergoing laparoscopic cholecystectomy

Explore the mechanism of Swertia mussotii Franch. for hepatoprotective effects with iTRAQ-LC-MS/MS

2020 ◽  
Vol 23 ◽  
Author(s):  
Haixia Yun ◽  
Xinyu Wu ◽  
Yiwei Ding ◽  
Wendou Xiong ◽  
Xianglan Duan ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Total Bilirubin ◽  
Acute Liver Injury ◽  
Proteome Analysis ◽  
Ppi Networks ◽  
Hepatoprotective Effects

Background and Objective : A Tibetan traditional herb named Swertia mussotii Franch., also called “Zangyinchen” by the local people of Qinghai-Tibet area, has been used to protect the liver from injury for many years. However, the curative effect and molecular mechanism of the herb have not been demonstrated clearly. Materials and Methods: In our study, serum alanine aminotransferase, aspartate aminotransferase, total bilirubin levels were examined after S. mussotii Franch. treatment in the acute liver injury of the carbon tetrachloride-induced rat model. Then, Proteome Analysis was applied to explore the potential mechanism of SMT for hepatoprotective effects after iTRAQLC-MS/MS analysis (isobaric tag for relative and absolute quantification-liquid chromatograph-mass spectrometer with tandem mass spectrometry). Results: Serum results showed, alanine aminotransferase, aspartate aminotransferase, total bilirubin levels of rats with acute liver injury were all improved with SMT treatment. Moreover, Proteome Analysis suggested that, with S. Mussotii Franch. treatment, the levels of lipid catabolic process and lipid homeostasis were all enhanced. And the results of protein-protein interaction (PPI) analysis illustrated that these proteins assembled in PPI networks were found almost significantly enriched in response to lipid, negative regulation of lipase activity, response to lipopolysaccharide etc. Furthermore, the downregulated MRP14 and MRP8 proteins were found involved in the lipid metabolism, which may indicate the mechanism of SMT protection liver from ALI induced by carbon tetrachloride. Conclusion: SMT herb could play a role in hepatoprotection and alleviate the effect of acute liver injury by impacting the lipid metabolism associated biological process.

scholarly journals Eribulin, Child-Pugh score, and liver-function tests: lessons from pivotal breast cancer studies 301 and 305

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Iain R. Macpherson ◽  
Yaohua He ◽  
Carlo Palmieri
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Liver Function ◽  
Liver Metastases ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Hepatic Impairment ◽  
Metastatic Breast ◽  
Dose Modifications ◽  
Group D

Abstract Background The recommended starting dose of eribulin in patients with hepatic impairment is based on the Child-Pugh score, largely informed by a pharmacokinetic study of 18 patients. In the pivotal studies of eribulin in metastatic breast cancer (Study 301 and Study 305 [EMBRACE]), entry criteria and dose modifications were based on liver-function test (LFT) results rather than Child-Pugh score. In populations such as patients with metastatic breast cancer, in which metastatic infiltration is the predominant cause of hepatic impairment, using Child-Pugh score may be problematic; in clinical practice, it has been more common for oncologists to make dosing decisions based on LFTs. To address this, the effects of abnormal baseline LFT results on eribulin efficacy and safety were investigated. Methods In this pooled post hoc analysis, 1062 patients who were randomized to receive eribulin in Studies 301 and 305 were divided into 4 groups: (A) no elevated LFT results (no liver impairment); (B) increased levels of aspartate aminotransferase and/or alanine aminotransferase; (C) decreased albumin and/or increased levels of aspartate aminotransferase and/or alanine aminotransferase but not increased bilirubin; and (D) increased bilirubin. Patients were subcategorized by presence of liver metastasis. Drug exposure, dose intensity, and treatment-emergent adverse events (TEAEs) were analyzed. Results Eribulin mesylate mean dosage was 0.82 (group A)–0.65 mg/m2/week (group D). Group D had shorter treatment, more dose reductions/delays, more TEAEs leading to dose modifications, and numerically lower objective response rates and clinical benefit rates versus groups A–C. TEAE rates leading to dose modification were similar between group D (45.5%) and groups A–C (range, 43.5–54.9%) in the absence of liver metastases, but higher in group D (91.3%) compared with groups A–C (range, 41.7–54.3%) if liver metastases were present. Conclusions Mild elevations in bilirubin levels were associated with increased toxicity and a greater requirement for dose modifications. Based both on these study data and existing recommendations, we propose a novel scheme to guide initial dose selection in patients with metastatic breast cancer and hepatic impairment that is based on LFTs rather than Child-Pugh score.

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