Impact of Breast Cancer Treatments on Gonadal Function and Reproductive Health

2000 ◽  
Author(s):  
Patricia A. Ganz
Keyword(s):  
Breast Cancer ◽  
Reproductive Health ◽  
Gonadal Function ◽  
Cancer Treatments

scholarly journals Preferences of Canadian Patients and Physicians for Treatment of HR+/HER2− Advanced Breast Cancer

2021 ◽  
Vol 28 (1) ◽  
pp. 491-508
Author(s):  
Daniel Stellato ◽  
Marroon Thabane ◽  
Caitlin Eichten ◽  
Thomas E. Delea
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Cancer Progression ◽  
Past Research ◽  
Advanced Breast ◽  
Cancer Treatments ◽  
Patient Advocacy Group ◽  
Treatment Alternatives ◽  
E Mail

(1) Background: Past research suggests that patients with advanced breast cancer prefer treatments with improved clinical outcomes and lower risk of side effects. Evidence on preferences of Canadian patients and physicians for treatments for advanced breast cancer is limited. (2) Methods: Patients’ and physicians’ preferences for treatments for HR+/HER2−, pre-/peri-menopausal advanced breast cancer were assessed by an online discrete choice experiment (DCE). Treatment alternatives were characterized by seven attributes regarding dosing, efficacy, and toxicities, with levels corresponding to those for ribociclib plus a non-steroidal aromatase inhibitor (NSAI), NSAI, and tamoxifen. For patients, impacts of advanced breast cancer on quality of life (QOL) and ability to work/perform activities of daily living also were assessed. Patients were recruited by a Canadian breast cancer patient advocacy group through email and social media. Physicians were recruited by email. (3) Results: Among 118 patients starting the survey, 23 completed ≥ 1 DCE question (19%). Among 271 physicians who were sent the e-mail invitation, 21 completed ≥ 1 DCE question (8%). For both patients and physicians, the increased probability of remaining alive and without cancer progression over 2 years was the most important attribute. A treatment with attributes consistent with ribociclib plus NSAI was chosen by patients and physicians in 70% and 88% of the time, respectively. A substantial proportion of patients reported worrying about future diagnostic tests and their cancer getting worse; (4) Conclusions: Canadian patients and physicians are generally concordant in preference for advanced breast cancer treatments, preferring ribociclib plus NSAI to other options.

scholarly journals Fertility Age Couples Motivation On Cervical Cancer Early Detection

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
SITI NURUL KHOTIMAH
Keyword(s):  
Breast Cancer ◽  
Cervical Cancer ◽  
Reproductive Health ◽  
Early Detection ◽  
Sexual And Reproductive Health ◽  
Health Problems ◽  
Population Exposure ◽  
Second Cancer ◽  
Cancer Early Detection ◽  
Research Questions

Cervical cancer is most often attacking women. After breast cancer, cervical cancer becomes second cancer infecting women. (WHO, 2014). This research aims to get the results from the fertility age couples' motivation on cervical cancer early detection.The preparation of a scoping review adapted the Arksey O'Malley framework consisted of 5 stages: research questions with the PEOs framework (Population, Exposure, and Outcomes), searching literature using relevant databases. The 12 articles used to consist of 3 themes, namely sexual and reproductive health problems, sexual health problems, and sexual and reproductive health. 

scholarly journals Radiotherapy and cisplatin increase immunotherapy efficacy by enabling local and systemic intratumoral T-cell activity

2018 ◽  
Author(s):  
Paula Kroon ◽  
Elselien Frijlink ◽  
Victoria Iglesias-Guimarais ◽  
Andriy Volkov ◽  
Marit M van Buuren ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Cell Activity ◽  
Cytotoxic T Cell ◽  
Tumor Control ◽  
Cancer Treatments ◽  
Costimulatory Receptor ◽  
Breast Cancer Model ◽  
Mouse Breast Cancer ◽  
Summary Statement

AbstractTo increase cancer immunotherapy success, PD-1 blockade must be combined with rationally selected treatments. Here, we examined in a poorly immunogenic mouse breast cancer model the potential of antibody-based immunomodulation and conventional anti-cancer treatments to collaborate with anti-PD-1 treatment. One important requirement to improve anti-PD-1-mediated tumor control was to promote tumor-specific cytotoxic T cell (CTL) priming, which was achieved by stimulating the CD137 costimulatory receptor. A second requirement was to overrule PD-1-unrelated mechanisms of CTL suppression in the tumor micro-environment (TME). This was achieved by radiotherapy and cisplatin treatment. In the context of CD137/PD-1-targeting immunotherapy, radiotherapy allowed for tumor elimination by altering the TME, rather than intrinsic CTL functionality. Combining this radioimmunotherapy regimen with low-dose cisplatin improved CTL-dependent regression of a contralateral tumor outside the radiation field. Thus, systemic tumor control may be achieved by combining immunotherapy protocols that promote T cell priming with (chemo)radiation protocols that permit CTL activity in both the irradiated tumor and (occult) metastases.Summary statementThis study reveals that radiotherapy and cisplatin can be ‘re-purposed’ to improve antibody-based immunotherapy success in poorly immunogenic breast cancer by overruling PD-1 unrelated mechanisms of T cell suppression in the tumor micro-environment.

PO-1124 Is there a role for bolus in the modern era of breast cancer treatments? A retrospective analysis.

2021 ◽  
Vol 161 ◽  
pp. S934-S935
Author(s):  
C. Félix Penido Mendes de Sousa ◽  
M. Jenwei Chen ◽  
P.J. Joffily Pinto ◽  
S.L. Favareto ◽  
F. Ko Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Retrospective Analysis ◽  
Cancer Treatments ◽  
Modern Era

Livelihood vs. Life: The Occupational Well-Being of Women Musician Survivors of Breast Cancer

2012 ◽  
Vol 27 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Sarah Schmalenberger ◽  
Charles E Gessert ◽  
Jean E Giebenhain ◽  
Lisa D Starr
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Treatment ◽  
Body Movement ◽  
Well Being ◽  
Physical Symptoms ◽  
Breast Cancer Treatment ◽  
Upper Body ◽  
Long Term Effects ◽  
Cancer Treatments

The Life and Livelihood Study was designed to describe and understand the experience of women musicians treated for breast cancer. This report focuses on Phase I of the study, a web-based survey that examined subjects’ physical symptoms and side effects following breast cancer treatment. Subjects were recruited nationally, using advertisements in musicians’ publications and presentations at national meetings. Subjects were asked about specific side effects or symptoms they had experienced, their severity and duration, and the effects of symptoms on their capacity to make music. Subjects were also asked what aspect of their breast cancer treatment they associated with each symptom and were invited to provide comments. A total of 321 individuals logged on: 100 met all inclusion criteria. Of these, 90 completed the entire survey. Commonly reported symptoms included fatigue (70%), problems with cognition (53%), limitations in upper body movement (51%), and pain (45%). Many reported that their symptoms were of moderate or greater intensity, and that they persisted for >12 months or were ongoing. The survey documented that many subjects experienced diminished capacity to function as musicians, especially due to pain, limitations in upper body and extremity movement, numbness in the chest and/or arms, contracture/fibrosis, and shortness of breath. These findings are consistent with emerging studies that describe long-term effects of breast cancer treatments. In planning for breast cancer treatment, rehabilitation and survivorship, consideration should be given to how treatment is likely to affect fitness for ongoing professional work.

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