Functional Interactions of Human Rad54 with the Rad51 Recombinase

2002 ◽  
Author(s):  
Stephen J. van Komen
Keyword(s):  
Functional Interactions

FUNCTIONAL INTERACTIONS OF PERTUSSIS TOXIN-SENSITIVE G-PROTEINS WITH THE TRANSFECTED μ-OPIOID RECEPTOR IN RAT 1 FIBROBLASTS

Analgesia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 438-441
Author(s):  
Zafiroula Georgoussi ◽  
Ian Mullaney ◽  
Alan Wise ◽  
Craig Carr ◽  
Graeme Milligan
Keyword(s):  
G Proteins ◽  
Opioid Receptor ◽  
Pertussis Toxin ◽  
Functional Interactions ◽  
Μ Opioid Receptor

Dual Functional Interactions of Substance P and Opioids in Nociceptive Transmission: Review and Reconciliation

Analgesia ◽  
1998 ◽  
Vol 3 (4) ◽  
pp. 259-268 ◽  
Author(s):  
Iwona Maszczynska ◽  
Andrzej W. Lipkowski ◽  
Daniel B. Carr ◽  
Richard M. Kream
Keyword(s):  
Substance P ◽  
Nociceptive Transmission ◽  
Functional Interactions ◽  
Dual Functional

Possible Functional Interactions of Apolipoprotein B-100 Segments That Associate With Cell Proteoglycans and the ApoB/E Receptor

1997 ◽  
Vol 17 (1) ◽  
pp. 149-155 ◽  
Author(s):  
Urban Olsson ◽  
Germán Camejo ◽  
Eva Hurt-Camejo ◽  
Karin Elfsber ◽  
Olof Wiklund ◽  
...  
Keyword(s):  
Apolipoprotein B ◽  
Functional Interactions

scholarly journals Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Athea Vichas ◽  
Amanda K. Riley ◽  
Naomi T. Nkinsi ◽  
Shriya Kamlapurkar ◽  
Phoebe C. R. Parrish ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Spindle Assembly Checkpoint ◽  
Spindle Assembly ◽  
Genetic Data ◽  
Multiple Models ◽  
Ras Pathway ◽  
Functional Interactions ◽  
Genome Wide ◽  
A Genome ◽  
Mutant Cells

AbstractCRISPR-based cancer dependency maps are accelerating advances in cancer precision medicine, but adequate functional maps are limited to the most common oncogenes. To identify opportunities for therapeutic intervention in other rarer subsets of cancer, we investigate the oncogene-specific dependencies conferred by the lung cancer oncogene, RIT1. Here, genome-wide CRISPR screening in KRAS, EGFR, and RIT1-mutant isogenic lung cancer cells identifies shared and unique vulnerabilities of each oncogene. Combining this genetic data with small-molecule sensitivity profiling, we identify a unique vulnerability of RIT1-mutant cells to loss of spindle assembly checkpoint regulators. Oncogenic RIT1M90I weakens the spindle assembly checkpoint and perturbs mitotic timing, resulting in sensitivity to Aurora A inhibition. In addition, we observe synergy between mutant RIT1 and activation of YAP1 in multiple models and frequent nuclear overexpression of YAP1 in human primary RIT1-mutant lung tumors. These results provide a genome-wide atlas of oncogenic RIT1 functional interactions and identify components of the RAS pathway, spindle assembly checkpoint, and Hippo/YAP1 network as candidate therapeutic targets in RIT1-mutant lung cancer.

Sign in / Sign up

Export Citation Format

Share Document