The Hygiene Hypothesis and Breast Cancer: A Novel Application of an Etiologic Theory for Allergies, Asthma, and Other Immune Disorders

2009 ◽  
Author(s):  
Christina A. Clarke
Keyword(s):  
Breast Cancer ◽  
Hygiene Hypothesis ◽  
Immune Disorders

scholarly journals Intestinal Microbiota as an Alternative Therapeutic Target for Epilepsy

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jiaying Wu ◽  
Yuyu Zhang ◽  
Hongyu Yang ◽  
Yuefeng Rao ◽  
Jing Miao ◽  
...  
Keyword(s):  
Immune Responses ◽  
Intestinal Microbiota ◽  
Neurological Disorders ◽  
Digestive System ◽  
Hygiene Hypothesis ◽  
Host Susceptibility ◽  
Immune Disorders ◽  
The Central Nervous System ◽  
Symbiotic Microbiota

Epilepsy is one of the most widespread serious neurological disorders, and an aetiological explanation has not been fully identified. In recent decades, a growing body of evidence has highlighted the influential role of autoimmune mechanisms in the progression of epilepsy. The hygiene hypothesis draws people’s attention to the association between gut microbes and the onset of multiple immune disorders. It is also believed that, in addition to influencing digestive system function, symbiotic microbiota can bidirectionally and reversibly impact the programming of extraintestinal pathogenic immune responses during autoimmunity. Herein, we investigate the concept that the diversity of parasitifer sensitivity to commensal microbes and the specific constitution of the intestinal microbiota might impact host susceptibility to epilepsy through promotion of Th17 cell populations in the central nervous system (CNS).

State of homeostasis and immune disorders in the case of breast cancer

2016 ◽  
pp. 127-130
Author(s):  
V.E. Fedorov ◽  
I.N. Pavlova ◽  
M.Yu. Cheburkaeva
Keyword(s):  
Breast Cancer ◽  
Immune Disorders

Left-Handedness and Life Expectancy

1989 ◽  
Vol 68 (3_suppl) ◽  
pp. 1040-1042 ◽  
Author(s):  
Wayne P. London
Keyword(s):  
Breast Cancer ◽  
Life Expectancy ◽  
Causes Of Death ◽  
Immune Disorders ◽  
Left Handedness

Halpern and Coren recently described an association between left-handedness and a lower life expectancy. This finding is not unexpected because left-handedness has been linked to three leading causes of death in our society—alcoholism, smoking, and breast cancer—as well as to several neurological and immune disorders.

scholarly journals Loss of microbiota depletes cross-reactive Foxp3+ Tregs leading to selective immunopathologies

2017 ◽  
Author(s):  
Tirumalai Kamala ◽  
David Usharauli
Keyword(s):  
Innate Immunity ◽  
Immune System ◽  
Predictive Power ◽  
Hygiene Hypothesis ◽  
Immune Disorders ◽  
Evolutionary Time ◽  
Specific Nature ◽  
Vaccine Responses ◽  
Commensal Microbiota

The 'Hygiene hypothesis', a cornerstone model to account for the role of exogenous pathogens and later of endogenous microbiota in immune disorders, is currently presumed to operate at the innate immunity and metabolite levels to properly 'educate' the immune system. Doing so however fails to satisfactorily account for the antigen-specific nature of such disorders. SPIRAL is a novel interpretive framework that resolves this dilemma. It represents the periodic table of cross-reactive Foxp3+ regulatory T cell (Treg) epitopes selected from commensal microbiota over evolutionary time to mediate self-nonself discrimination and effector class regulation. Here, we utilize the SPIRAL's predictive power to provide a mechanistic antigen-specific basis for the initiation of allergies and autoimmune diseases as well as for the failure to mount effective anti-tumor and vaccine responses through selective loss of microbiota and corresponding cross-reactive Foxp3+ Tregs.

scholarly journals Differences of immune disorders between Alzheimer’s disease and breast cancer based on transcriptional regulation

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0180337 ◽  
Author(s):  
Wei Kong ◽  
Xiaoyang Mou ◽  
Jin Deng ◽  
Benteng Di ◽  
Ruxing Zhong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transcriptional Regulation ◽  
Immune Disorders

scholarly journals Loss of microbiota depletes cross-reactive Foxp3+ Tregs leading to selective immunopathologies

2017 ◽  
Author(s):  
Tirumalai Kamala ◽  
David Usharauli
Keyword(s):  
Innate Immunity ◽  
Immune System ◽  
Predictive Power ◽  
Hygiene Hypothesis ◽  
Immune Disorders ◽  
Evolutionary Time ◽  
Specific Nature ◽  
Vaccine Responses ◽  
Commensal Microbiota

The 'Hygiene hypothesis', a cornerstone model to account for the role of exogenous pathogens and later of endogenous microbiota in immune disorders, is currently presumed to operate at the innate immunity and metabolite levels to properly 'educate' the immune system. Doing so however fails to satisfactorily account for the antigen-specific nature of such disorders. SPIRAL is a novel interpretive framework that resolves this dilemma. It represents the periodic table of cross-reactive Foxp3+ regulatory T cell (Treg) epitopes selected from commensal microbiota over evolutionary time to mediate self-nonself discrimination and effector class regulation. Here, we utilize the SPIRAL's predictive power to provide a mechanistic antigen-specific basis for the initiation of allergies and autoimmune diseases as well as for the failure to mount effective anti-tumor and vaccine responses through selective loss of microbiota and corresponding cross-reactive Foxp3+ Tregs.

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

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