Dynamics of Sandwaves under Combined Wave - Current Forcing and Mine Burial Processes, and Instrumentation for Measuring Nearshore Morphologic Change and Hydrodynamic Forcing

2012 ◽  
Author(s):  
Peter A. Traykovski ◽  
W. R. Geyer
Keyword(s):  
Morphologic Change

Neuroprotective Effects of Extracts from the Radix Curcuma aromatica on H2O2-induced Damage in PC12 Cells

2018 ◽  
Vol 21 (8) ◽  
pp. 571-582 ◽  
Author(s):  
Juxiang Liu ◽  
Lianli Zhang ◽  
Dan Liu ◽  
Baocai Li ◽  
Mi Zhang
Keyword(s):  
Oxidative Stress ◽  
Pc12 Cells ◽  
Caspase 3 ◽  
Cell Damage ◽  
Positive Control ◽  
Neuroprotective Activity ◽  
Antioxidant Enzyme Activities ◽  
Morphologic Change ◽  
Neuroprotective Effects ◽  
Etoh Extract

Aim & Objectives: Curcuminoids are characteristic constituents in Curcuma, displaying obviously neuroprotective activities against oxidative stress. As one of the Traditional Chinese Medicines from Curcuma, the radix of Curcuma aromatica is also rich in those chemicals, but its neuroprotective activity and mechanism remain unknown. The aim of the current study is to evaluate the neuroprotective effects of extracts from the radix of C. aromatica (ECAs) on H2O2-damaged PC12 cells. Material and Methods: The model of oxidative stress damage was established by treatment of 400 µM H2O2 on PC12 to induce cell damage. After the treatment of ECWs for 24 h, the cell viability, LDH, SOD, CAT and GSH were measured to evaluate the neuroprotection of ECAs on that model. The potential action mechanism was studied by measurement of level of ROS, cell apoptosis rate, mitochondrial membrane potential (MMP), morphologic change, the intracellular Ca2+ content (F340/F380) and the expressions of Bcl-2, Bax and Caspase-3. Additionally, the constituents from tested extracts were analyzed by HPLC-DAD-Q-TOF-MS method. Results: Compared with a positive control, Vitamin E, 10 µg/ml of 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) can markedly increase the rate of cell survival and enhance the antioxidant enzyme activities of SOD, CAT, increase the levels of GSH, decrease LDH release and the level of ROS, attenuate the intracellular Ca2+ overloading, reduce the cell apoptotic rate and stabilize MMP, down-regulate Bcl-2 expression, up-regulate Bax and caspase-3 expression, and improve the change of cell morphology. The chemical analysis showed that diarylheptanoids and sesquiterpenoids are the major chemicals in tested extracts and the former were richer in HCECA and MCECA than others. Conclusions: These findings indicated that the effects of HCECA and MCECA on inhibiting the cells damage induced by H2O2 in PC12 are better than other extracts from the radix of C. aromatica, and the active constituents with neuroprotective effects consisting in those two active extracts are diarylheptanoids.

QGG J. HOOVER MACKIN AWARD: CHANNEL MORPHOLOGIC CHANGE ASSOCIATED WITH INVASIVE VEGETATION REMOVAL

2020 ◽  
Author(s):  
Celeste Wieting ◽  
◽  
Sara L. Rathburn ◽  
Jonathan M. Friedman
Keyword(s):  
Morphologic Change ◽  
Vegetation Removal

scholarly journals Morphological Change of Dhaka City Over a Period of 55 Years: A Case Study of Two Wards

1970 ◽  
Vol 2 ◽  
pp. 30-38 ◽  
Author(s):  
Bayes Ahmed ◽  
Muhammad Rakibul Hasan Raj ◽  
KM Maniruzzaman
Keyword(s):  
Urban Form ◽  
Spatial Dynamics ◽  
Morphological Structure ◽  
General Interest ◽  
Morphologic Change ◽  
Dhaka City ◽  
Territorial Expansion ◽  
Physical Form ◽  
The Many

Dhaka City has undergone radical changes in its physical form, not only by territorial expansion, but also through internal physical transformations over the last decades. These have created entirely new kinds of fabric. With these changes, the elements of urban form have changed. Plots and open spaces have been transformed into building areas, open squares into car parks, low land and water bodies into reclaimed built-up lands etc. This research has its general interest in the morphologic change of Dhaka City. It focuses on the spatial dynamics of urban growth of Dhaka over the last 55 years from 1952-2007. In the research, the transformation of urban form has been examined through space syntax. The aim behind using this technique is to describe aspects of relationships between the morphological structure of man-made environments and social structures and events. To conduct this research, Wards 49 and 72 of Dhaka City Corporation were selected as the study areas, of which Ward 72 is an indigenous and Ward 49 is a planned type of settlement. Being a planned residential area, the syntactic measures from this morphological analysis are showing quite unchanged and high values in all phases for Ward 49 and the physical characteristics of Ward 72 (Old Dhaka) still represent the past. The syntactic values are found to be higher for Ward 72 and than Ward 49. Higher values indicate that the street network is highly connective among each other. Time affects differently the layout of cities and the architecture of buildings. Of the many human creations, street systems are among the most resistant to change. This has been emphasized in this study, thereby facilitating the comparison of urban layouts across space and time. The interpretation of history in the light of quantitative accounts, as demonstrated in this study, will be of value to urban planners and urban designers for the future planning of modern Dhaka City.DOI: http://dx.doi.org/10.3329/jbip.v2i0.9554  Journal of Bangladesh Institute of Planners Vol. 2, December 2009, pp. 30-38

MR Imaging of Herniated Lumbar Disc: Morphologic Change between Supine and Flexed-Prone Position

1997 ◽  
Vol 37 (6) ◽  
pp. 999
Author(s):  
Jin Yong Seong ◽  
Seung Ro Lee ◽  
Sung Tae Kim ◽  
Won Jin Moon ◽  
Dong Woo Park ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Prone Position ◽  
Lumbar Disc ◽  
Morphologic Change ◽  
Herniated Lumbar Disc

scholarly journals ORMDL1 is upregulated and associated with favorable outcome in colorectal cancer

2020 ◽  
Author(s):  
Qian Wang ◽  
Wanjun Liu ◽  
Si Chen ◽  
Qianxin Luo ◽  
Yichen Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Colony Formation ◽  
Transmembrane Protein ◽  
Cohort Analysis ◽  
Negative Regulator ◽  
Morphologic Change ◽  
Mesenchymal Transition

AbstractBackgroundORMDL1 gene encodes a transmembrane protein for endoplasmic reticulum and is known as crucial negative regulator for sphingolipid biogenesis. However, it has been rarely studied in tumor-related context. Therefore, its prognostic value and functional significance in colorectal cancer (CRC) remain to be explored.MethodsTCGA CRC cohort analysis, qRT-PCR, and immunohistochemistry (IHC) were used to examine the ORMDL1 expression level. The association between ORMDL1 expression and various clinical characteristics were analyzed by Chi-square tests. CRC patients’ overall survival (OS) was analyzed by Kaplan-Meier analysis. In vitro and in vivo cell-based assays were performed to explore the role of ORMDL1 in cell proliferation, invasion and migration. Transcriptional changes of cells either with ORMDL1 knockdowned or overexpressed were compared and analyzed.ResultsORMDL1 was upregulated in CRC tissues either in TCGA cohort or in our cohort. Interestingly, its expression was significantly lower in patients with metastasis compared to patients without metastasis, and high expression group had longer OS than low expression group. Knockdown of ORMDL1 expression can promote proliferation, colony formation and invasion, while attenuate migration in CRC cell lines. In opposite, forced overexpression of ORMDL1 reduced cell proliferation, colony formation and invasion, while enhanced cell migration. Epithelial-to-mesenchymal transition (EMT) related genes were enriched among differentially expressed genes when ORMDL1 was knockdowned in cells, which was consistent with morphologic change by microscopy observation. Finally, stable knockdown of ORMDL1 can promote cancer cell proliferation in vivo to some extent.ConclusionORMDL1 is upregulated and may serve as biomarker to predict favourable outcome in colorectal cancer.

Gross and Histologic Changes in the Developing Rabbit Subglottis in Response to a Controlled Depth of Injury

2002 ◽  
Vol 127 (5) ◽  
pp. 442-447 ◽  
Author(s):  
Leila A. Mankarious ◽  
Shilpa R. Cherukupally ◽  
Allison B. Adams
Keyword(s):  
Pilot Study ◽  
Soft Tissues ◽  
Cricoid Cartilage ◽  
Fibrous Tissue ◽  
Biochemical Changes ◽  
Morphologic Change ◽  
Age Group ◽  
Prolonged Intubation ◽  
Structural Support ◽  
Histologic Changes

OBJECTIVE: Our goal was to determine the effects of both perichondrial and intracartilaginous injury in the developing rabbit subglottis versus normal development. DESIGN: We conducted a descriptive, pilot study of changes in the shape and histology of the subglottis after a controlled depth of injury in 27 New Zealand White rabbits, ages 4 weeks, 8 weeks, and 1 1/2 years. INTERVENTION: Within each age group, 3 animals underwent no surgery, 3 underwent perichondrial injury, and 3 underwent intracartilaginous injury. RESULTS: Perichondrially injured animals in the 4-week age group developed a marked abnormality in the shape of the cricoid cartilage in the injured region. Cartilage of the perichondriallly injured animals in the 8-week and 1 1/2-year groups became histologically consistent with fibrous tissue. The cartilage of all animals that underwent intracartilaginous injury was replaced with fibrous tissue. CONCLUSION: In this observational study, we identified 3 relevant findings. First, the responses of the cartilage to a perichondrial injury suggest that the luminal soft tissues may exert some morphologic control in developmentally young animals. Second, only the 4-week-old group's cartilage was tolerant of a perichondrial injury with continued growth of the ring. Third, no animal's cartilage could withstand an intracartilaginous injury regardless of age. Acquired or congenital cricoid cartilage abnormalities are a frequent source of airway distress in both pediatric and adult populations. Narrowing of the cricoid cartilage, as seen in subglottic stenosis (SGS), creates a significant increase in morbidity and mortality rates 1 with an array of surgical interventions described extensively in the otolaryngology literature. The acquired form of SGS usually is iatrogenic, resulting from prolonged intubation or surgical intervention. Few published reports exist describing the histologic changes associated with SGS. Of the published studies, the source of SGS appears to be both cartilage ring abnormalities and concomitant mucosal fibrosis. 2–5 Histologic examination of injured cricoid samples suggests that the abnormal cricoid growth and development may be due to a combination of (1) inflammation within the cartilage leading to loss of chondrocytes, (2) replacement of the cartilage with fibrosis leading to decreased cartilage extracellular matrix and loss of structural support, and/or (3) alterations in the shape of the ring. It is generally accepted that intubation is better tolerated in younger patients than in older patients. Premature infants can be intubated for up to 4 to 5 months, but adults can be intubated for a maximum of 2 to 3 weeks before an alternate airway is sought. However, no exact guidelines exist for the duration of intubation as a function of age. Even physicians who care for intubated patients disagree about when to consider tracheotomy. We began our series of experiments attempting to understand the biochemical changes that would explain the difference in tolerance to intubation and the mechanisms behind loss of the structural support of the cricoid ring. In preparing the experimental substrate for these studies, we identified an interesting age-dependent and depth of injury-dependent morphologic change in the rabbit subglottis that was not expected. Biochemical changes in the rabbit subglottis will follow in future reports; however, herein we report on the observed morphologic changes. Due to the limited number of animals in this study, the data presented represent a pilot study.

Morphologic change of PCL of MRI in the tear of ACL

1996 ◽  
Vol 31 (2) ◽  
pp. 371 ◽  
Author(s):  
Nam Hong Choi ◽  
Myung Ku Kim ◽  
Yong Jin Yoon ◽  
Jae Doo Yoo ◽  
Ho Min Lee
Keyword(s):  
Morphologic Change
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