A Gene Expression Profile of BRCAness that Predicts for Responsiveness to Platinum and PARP Inhibitors

2014 ◽  
Author(s):  
Panagiotis Konstantinopoulos
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Parp Inhibitors

A gene expression profile of BRCAness that correlates with responsiveness to platinum and PARP inhibitors.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 5004-5004 ◽  
Author(s):  
P. Konstantinopoulos ◽  
D. Spentzos ◽  
B. Karlan ◽  
T. Taniguchi ◽  
E. Fountzilas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Parp Inhibitors

1134: Gene Expression Profile Changes using CDNA Microarray Technology in Patients with Neurogenic Bladder Secondary to Spinal Cord Injury

2005 ◽  
Vol 173 (4S) ◽  
pp. 308-308
Author(s):  
Jeffrey L. Evans ◽  
Henry Lai ◽  
Mustafa Ozen ◽  
Bhuvaneswari Krishnan ◽  
Michael Ittmann ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Gene Expression Profile ◽  
Neurogenic Bladder ◽  
Cdna Microarray ◽  
Expression Profile ◽  
Microarray Technology ◽  
Cord Injury ◽  
Profile Changes

Gene Expression Profile in Persons Exposed to the WTC With and Without PTSD

2009 ◽  
Author(s):  
Rachel Yehuda ◽  
Julia Golier ◽  
Sandro Galea ◽  
Marcus Ising ◽  
Florian Holsborer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile

scholarly journals Gene expression profile in functioning and non-functioning nodules of autonomous multinodular goiter from an area of iodine deficiency: unexpected common characteristics between the two entities

2021 ◽  
Author(s):  
P. Agretti ◽  
G. De Marco ◽  
E. Ferrarini ◽  
C. Di Cosmo ◽  
L. Montanelli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Multinodular Goiter ◽  
Kinase Inhibitor ◽  
Wnt Signaling Pathway ◽  
Iodine Intake ◽  
Healthy Tissue ◽  
Specific Gene ◽  
Complement Components

Abstract Purpose Toxic multinodular goiter is a heterogeneous disease associated with hyperthyroidism frequently detected in areas with deficient iodine intake, and functioning and non-functioning nodules, characterized by increased proliferation but opposite functional activity, may coexist in the same gland. To understand the distinct molecular pathology of each entity present in the same gland, the gene expression profile was evaluated by using the Affymetrix technology. Methods Total RNA was extracted from nodular and healthy tissues of two patients and double-strand cDNA was synthesized. Biotinylated cRNA was obtained and, after chemical fragmentation, was hybridized on U133A and B arrays. Each array was stained and the acquired images were analyzed to obtain the expression levels of the transcripts. Both functioning and non-functioning nodules were compared versus healthy tissue of the corresponding patient. Results About 16% of genes were modulated in functioning nodules, while in non-functioning nodules only 9% of genes were modulated with respect to the healthy tissue. In functioning nodules of both patients and up-regulation of cyclin D1 and cyclin-dependent kinase inhibitor 1 was observed, suggesting the presence of a possible feedback control of proliferation. Complement components C1s, C7 and C3 were down-regulated in both types of nodules, suggesting a silencing of the innate immune response. Cellular fibronectin precursor was up-regulated in both functioning nodules suggesting a possible increase of endothelial cells. Finally, Frizzled-1 was down-regulated only in functioning nodules, suggesting a role of Wnt signaling pathway in the proliferation and differentiation of these tumors. None of the thyroid-specific gene was deregulated in microarray analysis. Conclusion In conclusion, the main finding from our data is a similar modulation for both kinds of nodules in genes possibly implicated in thyroid growth.

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