scholarly journals Is Aerated Soft Drink and Packaged Juice Consumption an Independent Risk Factor to Cause Non-Alcoholic Fatty Liver Disease

2020 ◽  
Vol 7 (7) ◽  
pp. A349-354
Author(s):  
Kukreja Kunal ◽  
Kinra Prateek ◽  
Tevatia MS
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Fatty Liver ◽  
Soft Drink ◽  
Daily Intake ◽  
Soft Drinks ◽  
Control Population ◽  
Sugar Consumption ◽  
Alcoholic Fatty Liver ◽  
Grade Ii

BACKGROUND: There has been an increase in consumption of aerated sweetened soft drinks and packaged juices high in carbohydrates/fructose by humans across the globe. There have been various studies with contradictory inferences of association of chronic sweetened soft drink (rich in high fructose corn syrup) intake and NAFLD. This study was undertaken with the aim to determine the quantity, frequency, duration and type of sweet soft drinks /packaged fruit juices consumption in patients with NAFLD as compared to that in control population. Other objectives included assessment of the independent role of sweetened soft drinks as a risk factor for NAFLD in the absence of metabolic syndrome and to correlate the level of steatosis (objectively graded by ultrasonography) with the amount of intake of soft drinks in patients of NAFLD. METHOD : 50 patients of NAFLD as diagnosed clinically and by ultrasonography were identified and compared with 50 age matched control population reporting to the hospital with ailments other than NAFLD. The presence or absence of metabolic syndrome was noted in all the patients. The history of soft drink intake was obtained from the patient under following heads: a) quantity consumed, b) type of soft drink/packaged juice consumed, c) period of ingestion and d) frequency of consumption. RESULT : The average monthly consumption, duration of consumption and the mean total sugar consumption of sweetened soft drinks / packaged juices were significantly higher in patients with NAFLD versus those in the control group (p=0.0002; <0.0001; p=0.002 respectively). The quantity and chronicity of intake correlated well with the grade of NAFLD. As the average monthly consumption and mean sugar consumption increased the grade of fatty liver on USG also increased (p= 0.004). A total of 11 patients out of all the 100 patients (study and control groups combined) had a daily intake of 150-300ml of SSD for a period ranging from 5 to 20 years. Two of these had grade I NAFLD whereas 9 had grade II-III NAFLD. Five of these 11 patients had a daily intake of 250ml or greater. All these 5 patients had grade II-III NAFLD documented on ultrasound findings. Conclusion The consumption of sweetened soft drinks and packaged juice is on the rise in India. The intake of these drinks is significantly higher in patients with NAFLD.

scholarly journals Mechanisms of Non-Alcoholic Fatty Liver Disease in the Metabolic Syndrome. A Narrative Review

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 270
Author(s):  
Luca Rinaldi ◽  
Pia Clara Pafundi ◽  
Raffaele Galiero ◽  
Alfredo Caturano ◽  
Maria Vittoria Morone ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Smoking Habit ◽  
Lifestyle Modifications ◽  
Alcoholic Fatty Liver ◽  
The Metabolic Syndrome ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are two different entities sharing common clinical and physio-pathological features, with insulin resistance (IR) as the most relevant. Large evidence leads to consider it as a risk factor for cardiovascular disease, regardless of age, sex, smoking habit, cholesterolemia, and other elements of MS. Therapeutic strategies remain still unclear, but lifestyle modifications (diet, physical exercise, and weight loss) determine an improvement in IR, MS, and both clinical and histologic liver picture. NAFLD and IR are bidirectionally correlated and, consequently, the development of pre-diabetes and diabetes is the most direct consequence at the extrahepatic level. In turn, type 2 diabetes is a well-known risk factor for multiorgan damage, including an involvement of cardiovascular system, kidney and peripheral nervous system. The increased MS incidence worldwide, above all due to changes in diet and lifestyle, is associated with an equally significant increase in NAFLD, with a subsequent rise in both morbidity and mortality due to both metabolic, hepatic and cardiovascular diseases. Therefore, the slowdown in the increase of the “bad company” constituted by MS and NAFLD, with all the consequent direct and indirect costs, represents one of the main challenges for the National Health Systems.

scholarly journals Association of Non-Alcoholic Fatty Liver Disease with Metabolic Syndrome: A Single Center Study

2022 ◽  
Vol 8 (1) ◽  
pp. 310-317
Author(s):  
Debasish Dutta
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Liver Disease ◽  
Waist Circumference ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
College Hospital ◽  
Alcoholic Fatty Liver ◽  
Grade Ii ◽  
Alcoholic Fatty Liver Disease

Background: NAFLD is a condition defined by excessive fat accumulation in the form of triglycerides (steatosis) in the liver (> 5% of hepatocytes histologically). Non-alcoholic fatty liver disease is increasingly being recognized as a major cause of liver-related morbidity and mortality among 15-40% of the general population. Aim of the study: To evaluate the clinical profile of patients with non-alcoholic fatty liver disease and its association with metabolic syndrome.Methods:The present cross-sectional, retro-spective study was conducted as outdoor patient basis in the Department of Medicine, Jashore medical college hospital & a private diagnostic centre, Jashore.. A total of 74 cases were included for the study. All patients in the study underwent routine investigations including complete blood counts, blood sugar, liver function tests, HBsAg, anti-HCV, lipid profile andUSG of whole abdomen. The data was collected during OPD treatment and was recorded in predesigned and pretested proforma and analyzed.Results:Mean age of the patient was 53.70±7.22 years. On physical examination findings showed the mean BMI was 27.6±4.39 kg/m2, mean waist circumference was 74.22±7.44 cm. Mean diastolic blood pressure (mm Hg) was 92.87±6.25 and mean systolic blood pressure (mm Hg) 132.0±18.17. Maximum 52% patients had triglycerides >150 mg/dl while low serum HDL level was seen in 37% patients and increased waist circumference was found in 32% patients. Altered ALT ≥41 IU was observed in 10 (62.50%) of Grade II of patients with NAFLD with metabolic syndrome. Central obesity was observed in 12 (75.00%) of Grade II patients with NAFLD with metabolic syndrome. While 14 (87.50%) Grade II of patients with NAFLD with metabolic syndrome showed impaired fasting glucose (>110 mg/dl). Hypertriglyceridemia (>150 mg/dl) in 12 (70.58%) seen in Grade I of patients with NAFLD without metabolic syndrome.Conclusion:Higher prevalence of all the components of metabolic syndrome in cases of NAFLD was observed. It can be concluded that symptoms and signs of NAFLD are non-specific and occur later in the course of the disease hence the physician should have a high index of suspicion in order to detect NAFLD early in the course of the disease.

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