scholarly journals A correlation of lactate dehydrogenase (LDH) enzyme levels in hypertensive disorders of pregnancy with severity of disease, maternal and perinatal outcome

2020 ◽  
Vol 7 (1) ◽  
pp. 20-25
Author(s):  
Varsha Laxmikant Deshmukh ◽  
Ashwini Kollur ◽  
Shrinivas N Gadappa
Keyword(s):  
Lactate Dehydrogenase ◽  
Perinatal Outcome ◽  
Hypertensive Disorders Of Pregnancy ◽  
Severity Of Disease ◽  
Hypertensive Disorders

scholarly journals A correlation of lactate dehydrogenase enzyme levels in pregnancy induced hypertensive disorders with severity of disease, maternal and perinatal outcome

2017 ◽  
Vol 6 (10) ◽  
pp. 4302 ◽  
Author(s):  
Neha V. Bhave ◽  
Parmanand K. Shah
Keyword(s):  
Lactate Dehydrogenase ◽  
Pregnant Women ◽  
Vascular Function ◽  
Perinatal Outcome ◽  
Gestational Hypertension ◽  
Hypertensive Disorder ◽  
Severity Of Disease ◽  
Hypertensive Disorders ◽  
Dehydrogenase Enzyme ◽  
In Pregnancy

Background: A spectrum of hypertensive disorders in pregnancy contribute to maternal and perinatal morbidity and mortality. For prediction and early diagnosis of preeclampsia various biochemical markers, vascular function test and renal markers have been developed. The objective of the study is to measure the lactate dehydrogenase enzyme (LDH) levels in pregnant women with pregnancy induced hypertensive disorders and correlate the levels with the severity of condition, maternal and the perinatal outcome.Methods: In this prospective observational study, a total of 150 pregnant women were studied. Out of these 150 women, 30 women had normal blood pressure, 30 women had gestational hypertension, 30 women had mild preeclampsia, 30 women had severe preeclampsia and 30 women had eclampsia. The serum LDH levels were measured in third trimester and patients followed up until early postpartum period and babies were followed up till early neonatal period to assess the maternal and neonatal outcomes.Results: Higher lactate dehydrogenase enzyme (LDH) levels were observed in pregnant women with severe form of hypertensive disorder and those who had a poor maternal and perinatal outcome. This is statistically significant (p<0.001).Conclusions: Lactate dehydrogenase enzyme (LDH) level is a useful biochemical marker to assess and predict the severity of disease, maternal and perinatal outcome as higher levels of the enzyme are associated with worsening severity of disease, a poor maternal and perinatal outcome.

scholarly journals STUDY OF PREVALENCE OF HYPERTENSIVE DISORDERS OF PREGNANCY AND THEIR MATERNAL AND PERINATAL OUTCOME AT GOVERNMENT VICTORIA HOSPITAL, VISAKHAPATNAM

2019 ◽  
Vol 6 (31) ◽  
pp. 2097-2100
Author(s):  
Chodavarapu Sailaja ◽  
Badam Rajani Kumari ◽  
Dongabanti Hemalatha Devi ◽  
Badugu V. V. Chandra Satya Vani ◽  
Maddela Yamuna
Keyword(s):  
Perinatal Outcome ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders

scholarly journals The presence of coexisting sleep-disordered breathing among women with hypertensive disorders of pregnancy does not worsen perinatal outcome

PLoS ONE ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. e0229568 ◽  
Author(s):  
Danielle L. Wilson ◽  
Mark E. Howard ◽  
Alison M. Fung ◽  
Fergal J. O’Donoghue ◽  
Maree Barnes ◽  
...  
Keyword(s):  
Perinatal Outcome ◽  
Sleep Disordered Breathing ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Disordered Breathing

scholarly journals Evaluation of serum lactate dehydrogenase in hypertensive disorders of pregnancy and its comparison with normal pregnancy

2020 ◽  
Vol 9 (8) ◽  
pp. 3270
Author(s):  
Anil Kumar ◽  
Kushla Pathania ◽  
Meenakshi Kandoria
Keyword(s):  
Lactate Dehydrogenase ◽  
Pregnant Women ◽  
Lactic Dehydrogenase ◽  
Serum Lactate ◽  
Morbidity And Mortality ◽  
Serum Lactate Dehydrogenase ◽  
Close Monitoring ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Subsequent Decrease

Background: Hypertensive disorders of pregnancy and their complications rank as one of the major causes of maternal morbidity and mortality. The objective of the study was to compare the level of serum LDH in normotensive and hypertensive pregnant women and to correlate the levels with maternal and foetal outcome.Methods: Study was conducted in department of obstetrics and gynecology Kamla Nehru State Hospital for Mother and Child, Indira Gandhi Medical College, Shimla w.e.f. 15th July, 2014 to 14th July, 2015. Pregnant women enrolled in the study were divided into following groups: - Group 1- Age and parity matched 202 normotensive pregnant women. Group 2- 202 women with hypertensive disorders of pregnancy as per the inclusion and exclusion criteria. Subjects were also divided according to the serum LDH levels into following groups: LDH <600 IU/L, LDH-600-800 IU/L and LDH >800IU/L. The maternal and foetal outcome was correlated with the serum level of LDH. One-way analysis of variance (ANOVA) and the chi-square test were used to compare the results. Differences were considered significant when p<0.05.Results: Severely preeclamptic and eclamptic patients were significantly younger, with low gravidity and parity. The symptoms and complications of preeclampsia and eclampsia along with perinatal mortality were increased significantly in patients with LDH >800 IU/L as compared with those who had lower levels.Conclusions: Lactate dehydrogenase is a useful biochemical marker that reflects the severity of and the occurrence of complications of preeclampsia and eclampsia. Identification of high-risk patients with elevated levels of lactic dehydrogenase, their close monitoring, and prompt, correct management may prevent these complications, with a subsequent decrease in maternal foetal morbidity and mortality.

P89 Hypertensive disorders of pregnancy: maternal and perinatal outcome of a Brazilian referral center

2010 ◽  
Vol 1 ◽  
pp. S66
Author(s):  
Vera Therezinha Borges ◽  
Luciana Mazoni Alves ◽  
Juliane Rosa Poiati ◽  
Claudia Garcia Magalhaes ◽  
Anice Maria Martins ◽  
...  
Keyword(s):  
Perinatal Outcome ◽  
Hypertensive Disorders Of Pregnancy ◽  
Referral Center ◽  
Hypertensive Disorders

scholarly journals Predictive Value of Middle Cerebral Artery to Uterine Artery Pulsatility Index Ratio in Hypertensive Disorders of Pregnancy

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Prashanth Adiga ◽  
Indumathi Kantharaja ◽  
Shripad Hebbar ◽  
Lavanya Rai ◽  
Shyamala Guruvare ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Perinatal Outcome ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Perinatal Outcomes ◽  
Hypertensive Disorders Of Pregnancy ◽  
Adverse Perinatal Outcome ◽  
Hypertensive Disorders

Aims and Objectives. (i) To determine the predictive value of cerebrouterine (CU) ratio (middle cerebral artery to uterine artery pulsatility index, MCA/UT PI) in assessing perinatal outcome among hypertensive disorders of pregnancy. (ii) To compare between CU ratio and CP ratio (MCA/Umbilical artery PI) as a predictor of adverse perinatal outcome.Methods. A prospective observational study was done in a tertiary medical college hospital, from September 2012 to August 2013. One hundred singleton pregnancies complicated by hypertension peculiar to pregnancy were enrolled. Both CU and CP ratios were estimated. The perinatal outcomes were studied.Results. Both cerebrouterine and cerebroplacental ratios had a better negative predictive value in predicting adverse perinatal outcome. However, both CU and CP ratios when applied together were able to predict adverse outcomes better than individual ratios. The sensitivity, specificity, positive predictive value, and the negative predictive values for an adverse neonatal outcome with CU ratio were 61.3%, 70.3%, 56%, and 78.9%, respectively, compared to 42%, 57.5%, 62%, and 76% as with CP ratio.Conclusion.Cerebrouterine ratio and cerebroplacental ratio were complementary to each other in predicting the adverse perinatal outcomes. Individually, both ratios were reassuring for favorable perinatal outcome with high negative predictive value.

Perinatal Outcome in Women with Hypertensive Disorders of Pregnancy in Rural Tertiary Center of Northern India: A Retrospective Cohort Study”

2020 ◽  
Vol 16 (1) ◽  
pp. 71-78
Author(s):  
Naina Kumar ◽  
Ashu Yadav
Keyword(s):  
Perinatal Outcome ◽  
Gestational Hypertension ◽  
Severe Disease ◽  
Chronic Hypertension ◽  
Hypertensive Disorder ◽  
Hypertensive Disorders Of Pregnancy ◽  
Northern India ◽  
Hypertensive Disorders ◽  
Tertiary Center ◽  
Group 2

Background: Hypertensive disorder of pregnancy is associated with adverse maternal, perinatal outcome. Objective: To know the perinatal outcome in women with hypertensive disorders of pregnancy. Methods: Present retrospective cohort study was conducted in the Obstetrics and Gynecology department of the rural tertiary center of Northern India over one year (January-December 2018) on 205 antenatal women with hypertensive disorders of pregnancy at gestation ≥28 weeks. All the participants on the basis of diagnosis were divided into four groups: Group 1 Gestational hypertension; Group 2 Pre-eclampsia; Group 3 Eclampsia and Group 4 with Chronic Hypertension. Demographic features, gestational age, the onset of labor, mode of delivery and perinatal outcome including birthweight, Apgar scores, morbidity and mortality were recorded and compared between four groups. Statistical analysis was done using software SPSS 22.0. version. Results: Of 205 participants, 93 had Gestational Hypertension, 68 Pre-eclampsia; 36 Eclampsia, 06 Chronic Hypertension. The mean age of presentation was 24.96±3.535 years. Average gestation at birth for group 1 was 37.91±2.38 weeks, group 2: 36.50±3.312 weeks, group 3: 34.44±4.062 weeks and group 4: 37.97±1.524 weeks. The majority of participants had induced labor especially in preeclampsia and eclampsia groups with a spontaneous vaginal delivery as the most common mode. 1 and 5-minute Apgar scores, birth weight were lower in eclampsia and pre-eclampsia women. Severe disease was associated with the adverse perinatal outcome with maximum neonatal morbidity and mortality in eclampsia and pre-eclampsia group. Conclusion: Hence, hypertensive disorder of pregnancy was associated with adverse perinatal outcome, especially in women with severe disease (Eclampsia and Pre-eclampsia).

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