scholarly journals ELECTROCHEMICAL LYSIS IN ONCOLOGY: LITERATURE REVIEW

2021 ◽  
Vol 20 (3) ◽  
pp. 124-133
Author(s):  
E. V. Anikanova ◽  
G. P. Guens ◽  
K. B. Kolontarev ◽  
S. A. Muslov
Keyword(s):  
Minimally Invasive ◽  
Electric Current ◽  
Low Voltage ◽  
Treatment Modalities ◽  
Physical Factors ◽  
Invasive Treatment ◽  
Tumor Destruction ◽  
Clinical Recommendation ◽  
Invasive Method

Recently, minimally invasive treatment modalities based on the application of various physical factors have been widely used in anticancer therapy. Electrochemical lysis is a method in which tumor cells are destroyed by local exposure to a constant low voltage electric current.Purpose: to present the current results of using electrochemical lysis in the treatment of various tumors, to describe the mechanism of tumor destruction and methods of delivering electric current to the tumor, as well as to evaluate the electrical parameters and positioning of the electrodes.Material and Methods.aliterature search included the Medical literatureanalysis and Retrieval system Online (Medline), the excerpta Medica data Base (embase), Web of science, scopus, Russian citation index. All articles were published before december 2019. The review included studies on the investigation electrochemical lysis in vitro, in vivo, as well as clinical observations and clinical studies in which electrochemical lysis has been used as an independent treatment, or in combination with other methods of anticancer treatment since 1984.Results. This review provides information regarding the electrochemical mechanisms of tumor destruction, anti-tumoral effects of electrochemical therapy, methodology for planning and distributing the dose of electrical lysis and positioning of electrodes. We have evaluated complications and oncological results. Electrochemical lysis is a safe, simple, effective, and relatively non-invasive method of antitumor treatment.Conclusion. The electrochemical lysis is a promising minimally invasive method which can be used for the treatment of tumors. However, long-term data are needed to validate this treatment before it can be included into clinical recommendation for the treatment of cancer patients.

Efficiency and safety of sclerotherapy for recurrent nodular goiter

2020 ◽  
pp. 39-51
Author(s):  
G. V. Rodoman ◽  
I. R. Sumedi ◽  
N. V. Sviridenko ◽  
T. I. Shalaeva ◽  
M. M. Meloyan
Keyword(s):  
Minimally Invasive ◽  
Severe Pain ◽  
Nodular Goiter ◽  
Treatment Method ◽  
Age Group ◽  
Invasive Treatment ◽  
The Third ◽  
Invasive Method ◽  
Functional Autonomy

At present, patients with recurrent nodular goiter account for a significant portion of patients operated on for nodular goiter. At the same time, the comorbid background characteristic of this age group and the technical difficulties of the intervention on cicatricial tissues of the neck cause a high risk of complications of the operation, 3–7 times higher than with primary thyroid interventions. The aim of the study was to evaluate the effectiveness and safety of treatment of recurrent nodular goiter using an alternative minimally invasive method — sclerotherapy. The study included 30 patients previously operated on for nodular goiter. All had 4 courses of sclerotherapy, each included 5 sessions with a frequency of 1 session per week, followed by a follow-up period of 3 months. Polydocanol was used as a sclerosant. The analysis showed that sclerotherapy for recurrent nodular goiter allows all patients to reduce recurrent nodular formations, and in almost a third of cases, complete reduction of the nodes. On average, the decrease in the volume of thyroid residues was 9.6 ± 1.5 ml, and the size of nodular formations decreased by 17.2 ± 1.3 mm (3.7 times — from 23.6 ± 1.4 mm to 6.4 ± 0.7 mm, P <0.001). Nodes more than 3 cm, initially 19 %, ceased to be detected after the third course of sclerotherapy. In all cases, managed to eliminate hormonal imbalances in patients who initially had functional autonomy, as well as signs of compression of the neck organs. At the same time, sclerotherapy of nodules of the thyroid gland using polydocanol as a sclerosant is a safe minimally invasive treatment method, is not accompanied by severe pain and the risk of hypoparathyroidism and laryngeal paresis.

scholarly journals The Novel and Minimally Invasive Treatment Modalities for Female Pelvic Floor Muscle Dysfunction; Beyond the Traditional

2018 ◽  
Vol 35 (5) ◽  
pp. 358-366
Author(s):  
Yiğit Akın ◽  
Matthew Young ◽  
Muhammad Elmussareh ◽  
Nickolaus Charalampogiannis ◽  
Ali Serdar Gözen
Keyword(s):  
Minimally Invasive ◽  
Pelvic Floor ◽  
Pelvic Floor Muscle ◽  
Minimally Invasive Treatment ◽  
Treatment Modalities ◽  
Muscle Dysfunction ◽  
The Novel ◽  
Invasive Treatment ◽  
Female Pelvic Floor

CHIVA, ASVAL and related techniques – Concepts and evidence

2015 ◽  
Vol 30 (2_suppl) ◽  
pp. 42-45 ◽  
Author(s):  
Sarah Onida ◽  
Alun H Davies
Keyword(s):  
Minimally Invasive ◽  
Varicose Veins ◽  
Disease Process ◽  
Chronic Venous Disease ◽  
Treatment Modalities ◽  
Venous Disease ◽  
Invasive Treatment ◽  
Venous Circulation ◽  
Underlying Pathophysiology

Chronic venous disease (CVD) is a highly prevalent condition with significant effects on patients’ quality of life. Despite this, the underlying pathophysiology of venous disease still remains unclear. Two schools of thought exist, explaining the development and propagation of venous disease as an “ascending” and “descending” process, respectively. The descending theory, stating that CVD is secondary to proximal disease (e.g. saphenofemoral/saphenous incompetence), is the most widely accepted when planning treatment aiming to remove or destroy the junction or truncal veins. The ascending theory, describing the disease process as developing in the lower most part of the leg and propagating cranially, aims to re-route the venous circulation via minimally invasive interventions. Classically, superficial venous insufficiency has been treated with the removal of the incompetent trunk, via open surgery or, increasingly, with endovenous interventions. Minimally invasive treatment modalities aiming to preserve the saphenous trunk, such as CHIVA and ASVAL, may also play an important role in the treatment of the patient with varicose veins.

scholarly journals Transarterial Embolization of Acute Gastrointestinal Bleeding

2021 ◽  
Vol 38 (SI-1) ◽  
pp. 56-60
Author(s):  
Ayşegül İDİL SOYLU ◽  
Fatih UZUNKAYA ◽  
Ümit BELET ◽  
Hüseyin AKAN
Keyword(s):  
Minimally Invasive ◽  
Gastrointestinal Bleeding ◽  
Transarterial Embolization ◽  
Treatment Method ◽  
Invasive Treatment ◽  
Tumor Vascularity ◽  
Technical Success Rate ◽  
Acute Gastrointestinal Bleeding ◽  
Invasive Method ◽  
Polyvinyl Alcohol Particles

Transarterial embolization (TAE) is a minimally invasive treatment method developed alternative to surgery for acute gastrointestinal bleeding (AGIB). The aim of this study was to evaluate the efficacy and outcome of TAE in AGIB patients. The data of 30 patients who underwent TAE with complaint of AGIB between January 2007- May 2020 was collected retrospectively. The etiology of hemorrhage, localization and type of lesion, embolizing agent used, and postprocedural complications were recorded. Lesions were classified as pseudoaneurysm (PA), extravasation, pathological tumor vascularity and vasospasm. A total of 22 patients, 5 females, were included in the study. The most common underlying cause was tumors (n=15, 50%). The most common lesion detected on angiograms was pathological tumor vascularity. Embolizing agents used were Nbutyl-2-cyanoacrylate in five patients, coils in three patients, polyvinyl alcohol particles in six patients and microsphere in seven patients. The technical success rate was 90.9%, and two patients developed rebleeding in the early postprocedural period. TAE is a safe, effective and minimally invasive method in emergency treatment of patients with AGIB.

Minimally invasive treatment of intracerebral hemorrhage with magnetic resonance–guided focused ultrasound

2013 ◽  
Vol 118 (5) ◽  
pp. 1035-1045 ◽  
Author(s):  
Stephen J. Monteith ◽  
Sagi Harnof ◽  
Ricky Medel ◽  
Britney Popp ◽  
Max Wintermark ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Minimally Invasive ◽  
Intracerebral Hemorrhage ◽  
Focused Ultrasound ◽  
Safety Data ◽  
Surgical Techniques ◽  
Minimally Invasive Treatment ◽  
Swine Model ◽  
Invasive Treatment

Object Intracerebral hemorrhage (ICH) is a major cause of death and disability throughout the world. Surgical techniques are limited by their invasive nature and the associated disability caused during clot removal. Preliminary data have shown promise for the feasibility of transcranial MR-guided focused ultrasound (MRgFUS) sonothrombolysis in liquefying the clotted blood in ICH and thereby facilitating minimally invasive evacuation of the clot via a twist-drill craniostomy and aspiration tube. Methods and Results In an in vitro model, the following optimum transcranial sonothrombolysis parameters were determined: transducer center frequency 230 kHz, power 3950 W, pulse repetition rate 1 kHz, duty cycle 10%, and sonication duration 30 seconds. Safety studies were performed in swine (n = 20). In a swine model of ICH, MRgFUS sonothrombolysis of 4 ml ICH was performed. Magnetic resonance imaging and histological examination demonstrated complete lysis of the ICH without additional brain injury, blood-brain barrier breakdown, or thermal necrosis due to sonothrombolysis. A novel cadaveric model of ICH was developed with 40-ml clots implanted into fresh cadaveric brains (n = 10). Intracerebral hemorrhages were successfully liquefied (> 95%) with transcranial MRgFUS in a highly accurate fashion, permitting minimally invasive aspiration of the lysate under MRI guidance. Conclusions The feasibility of transcranial MRgFUS sonothrombolysis was demonstrated in in vitro and cadaveric models of ICH. Initial in vivo safety data in a swine model of ICH suggest the process to be safe. Minimally invasive treatment of ICH with MRgFUS warrants evaluation in the setting of a clinical trial.

scholarly journals Decision Making in Patients With Metastatic Spine. The Role of Minimally Invasive Treatment Modalities

2019 ◽  
Vol 9 ◽  
Author(s):  
Alfredo Conti ◽  
Güliz Acker ◽  
Anne Kluge ◽  
Franziska Loebel ◽  
Anita Kreimeier ◽  
...  
Keyword(s):  
Decision Making ◽  
Minimally Invasive ◽  
Minimally Invasive Treatment ◽  
Treatment Modalities ◽  
Invasive Treatment

Subglottic Stenosis: Development of a Clinically Relevant Endoscopic Animal Model

2020 ◽  
Vol 162 (6) ◽  
pp. 905-913
Author(s):  
Leila J. Mady ◽  
Matthew Criado ◽  
James Park ◽  
Khalil Baddour ◽  
Ali Mubin Aral ◽  
...  
Keyword(s):  
Animal Model ◽  
Minimally Invasive ◽  
Research University ◽  
Subglottic Stenosis ◽  
Laboratory Animals ◽  
Treatment Modalities ◽  
Source Image ◽  
Invasive Treatment ◽  
Cross Sectional ◽  
Airway Injury

Objective Develop a clinically relevant and reproducible endoscopic animal model for subglottic stenosis amenable to testing of minimally invasive therapeutic modalities. Study Design Cohort study. Setting Division of Laboratory Animals Research, University of Pittsburgh. Subjects and Methods Subglottic stenosis was induced endoscopically via microsuspension laryngoscopy in 26 New Zealand white rabbits. A trimmed polypropylene brush connected to a novel electronic stenosis induction apparatus was used to create circumferential trauma to the subglottis. By using open source image analysis software, the cross-sectional areas of the stenotic and native airways were compared to calculate the percentage of stenosis and the Myer-Cotton classification grade. Results Of the 26 rabbits, 24 (92%) exhibited stenosis after the first attempt. The mean percentage of airway stenosis was 57% (range, 34%-85%; SD, 15%). Five rabbits (19.2%) died on the day of stenosis induction from procedural complications. Of the 21 rabbits, 2 demonstrated no stenosis 7 days after initial injury and so underwent reinduction of airway injury, upon which they developed stenosis. Overall, 14 of the 21 rabbits (67%) exhibited moderate to severe stenosis (grade 2 or 3). Conclusion The stenosis induction apparatus reliably induced stenosis with a low mortality rate as compared with that of other methods in the literature. The device could be improved to generate a predetermined potentially reproducible grade of stenosis as desired by the operator. This method sets the stage for a clinically relevant and reproducible subglottic stenosis disease model that is amenable to testing of minimally invasive treatment modalities.

scholarly journals New and experimental techniques in the treatment of benign prostatic diseases

2014 ◽  
Vol 61 (1) ◽  
pp. 75-80
Author(s):  
Tomislav Pejcic ◽  
Zoran Dzamic ◽  
Miodrag Acimovic ◽  
Boris Kajmakovic ◽  
Jovan Hadzi-Djokic
Keyword(s):  
Minimally Invasive ◽  
Treatment Modalities ◽  
Artery Embolization ◽  
Invasive Treatment ◽  
Urinary Tract Symptoms ◽  
High Prevalence ◽  
Prostatic Diseases ◽  
Invasive Techniques ◽  
Near Future ◽  
Lower Urinary

Background: Benign prostatic hyperplasia (BPH) and chronic prostatitis (CP) are disorders with high prevalence and have a great impact on overall morbidity in men. The patients that do not respond to medical therapy for lower urinary tract symptoms (LUTS) related to BPH are candidates for surgery. However, the number of men with BPH/LUTS seeking for non- surgical, or for less invasive treatment is growing. Aim: To present the basic information about minimally invasive treatment modalities for BPH and CP: intraprostatic injections, urethral lift procedures, modifications of transurethral microwave thermotherapy (TUMT), prostatic artery embolization etc. Conclusion: The majority of these techniques is still in experimental phase and not widely accepted. However, it is very likely that new, safe and minimally invasive techniques will appear in the near future.

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